Amino acid dipepetide frequency for Penicillium arizonense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.56AlaAla: 8.56 ± 0.057	1.084AlaCys: 1.084 ± 0.014	4.233AlaAsp: 4.233 ± 0.031	5.054AlaGlu: 5.054 ± 0.044	3.231AlaPhe: 3.231 ± 0.03	5.79AlaGly: 5.79 ± 0.038	1.796AlaHis: 1.796 ± 0.018	4.436AlaIle: 4.436 ± 0.031	3.863AlaLys: 3.863 ± 0.032	7.891AlaLeu: 7.891 ± 0.045	2.046AlaMet: 2.046 ± 0.023	3.038AlaAsn: 3.038 ± 0.023	4.731AlaPro: 4.731 ± 0.041	3.414AlaGln: 3.414 ± 0.027	4.674AlaArg: 4.674 ± 0.03	7.311AlaSer: 7.311 ± 0.045	5.271AlaThr: 5.271 ± 0.035	5.383AlaVal: 5.383 ± 0.035	1.215AlaTrp: 1.215 ± 0.017	2.207AlaTyr: 2.207 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.958CysAla: 0.958 ± 0.015	0.234CysCys: 0.234 ± 0.007	0.673CysAsp: 0.673 ± 0.012	0.582CysGlu: 0.582 ± 0.011	0.561CysPhe: 0.561 ± 0.01	0.941CysGly: 0.941 ± 0.012	0.336CysHis: 0.336 ± 0.008	0.719CysIle: 0.719 ± 0.012	0.476CysLys: 0.476 ± 0.009	1.298CysLeu: 1.298 ± 0.018	0.293CysMet: 0.293 ± 0.008	0.443CysAsn: 0.443 ± 0.009	0.64CysPro: 0.64 ± 0.014	0.469CysGln: 0.469 ± 0.01	0.716CysArg: 0.716 ± 0.012	0.911CysSer: 0.911 ± 0.014	0.683CysThr: 0.683 ± 0.011	0.838CysVal: 0.838 ± 0.014	0.199CysTrp: 0.199 ± 0.006	0.359CysTyr: 0.359 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.59AspAla: 4.59 ± 0.029	0.612AspCys: 0.612 ± 0.012	3.804AspAsp: 3.804 ± 0.037	4.216AspGlu: 4.216 ± 0.035	2.187AspPhe: 2.187 ± 0.021	3.904AspGly: 3.904 ± 0.03	1.338AspHis: 1.338 ± 0.017	3.166AspIle: 3.166 ± 0.024	2.285AspLys: 2.285 ± 0.026	5.206AspLeu: 5.206 ± 0.034	1.309AspMet: 1.309 ± 0.016	1.94AspAsn: 1.94 ± 0.023	3.389AspPro: 3.389 ± 0.027	2.083AspGln: 2.083 ± 0.019	3.043AspArg: 3.043 ± 0.03	4.203AspSer: 4.203 ± 0.033	3.07AspThr: 3.07 ± 0.027	3.6AspVal: 3.6 ± 0.025	0.912AspTrp: 0.912 ± 0.015	1.613AspTyr: 1.613 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.226GluAla: 5.226 ± 0.037	0.613GluCys: 0.613 ± 0.011	4.042GluAsp: 4.042 ± 0.032	5.083GluGlu: 5.083 ± 0.054	1.958GluPhe: 1.958 ± 0.02	3.651GluGly: 3.651 ± 0.027	1.398GluHis: 1.398 ± 0.018	3.176GluIle: 3.176 ± 0.024	3.504GluLys: 3.504 ± 0.027	5.079GluLeu: 5.079 ± 0.039	1.515GluMet: 1.515 ± 0.017	2.384GluAsn: 2.384 ± 0.02	2.777GluPro: 2.777 ± 0.038	2.442GluGln: 2.442 ± 0.02	3.701GluArg: 3.701 ± 0.031	4.395GluSer: 4.395 ± 0.032	3.644GluThr: 3.644 ± 0.029	3.431GluVal: 3.431 ± 0.028	0.885GluTrp: 0.885 ± 0.014	1.692GluTyr: 1.692 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.118PheAla: 3.118 ± 0.028	0.587PheCys: 0.587 ± 0.009	2.35PheAsp: 2.35 ± 0.023	2.156PheGlu: 2.156 ± 0.018	1.742PhePhe: 1.742 ± 0.02	2.974PheGly: 2.974 ± 0.026	0.958PheHis: 0.958 ± 0.014	1.939PheIle: 1.939 ± 0.02	1.497PheLys: 1.497 ± 0.018	3.583PheLeu: 3.583 ± 0.027	0.87PheMet: 0.87 ± 0.012	1.499PheAsn: 1.499 ± 0.018	2.014PhePro: 2.014 ± 0.02	1.494PheGln: 1.494 ± 0.018	1.953PheArg: 1.953 ± 0.02	3.096PheSer: 3.096 ± 0.025	2.217PheThr: 2.217 ± 0.021	2.46PheVal: 2.46 ± 0.023	0.672PheTrp: 0.672 ± 0.011	1.176PheTyr: 1.176 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.422GlyAla: 5.422 ± 0.035	0.885GlyCys: 0.885 ± 0.014	3.599GlyAsp: 3.599 ± 0.027	3.482GlyGlu: 3.482 ± 0.024	2.955GlyPhe: 2.955 ± 0.025	5.415GlyGly: 5.415 ± 0.05	1.745GlyHis: 1.745 ± 0.023	3.768GlyIle: 3.768 ± 0.029	3.286GlyLys: 3.286 ± 0.026	6.274GlyLeu: 6.274 ± 0.035	1.647GlyMet: 1.647 ± 0.018	2.611GlyAsn: 2.611 ± 0.024	3.337GlyPro: 3.337 ± 0.031	2.61GlyGln: 2.61 ± 0.028	3.926GlyArg: 3.926 ± 0.033	5.857GlySer: 5.857 ± 0.043	4.033GlyThr: 4.033 ± 0.029	4.383GlyVal: 4.383 ± 0.033	1.19GlyTrp: 1.19 ± 0.015	2.21GlyTyr: 2.21 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.873HisAla: 1.873 ± 0.022	0.337HisCys: 0.337 ± 0.009	1.327HisAsp: 1.327 ± 0.016	1.35HisGlu: 1.35 ± 0.018	0.968HisPhe: 0.968 ± 0.014	1.749HisGly: 1.749 ± 0.02	0.777HisHis: 0.777 ± 0.013	1.278HisIle: 1.278 ± 0.017	0.873HisLys: 0.873 ± 0.012	2.323HisLeu: 2.323 ± 0.02	0.515HisMet: 0.515 ± 0.01	0.878HisAsn: 0.878 ± 0.014	1.654HisPro: 1.654 ± 0.024	0.973HisGln: 0.973 ± 0.012	1.544HisArg: 1.544 ± 0.018	1.913HisSer: 1.913 ± 0.021	1.282HisThr: 1.282 ± 0.014	1.444HisVal: 1.444 ± 0.015	0.374HisTrp: 0.374 ± 0.008	0.701HisTyr: 0.701 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.371IleAla: 4.371 ± 0.035	0.791IleCys: 0.791 ± 0.013	2.942IleAsp: 2.942 ± 0.024	2.931IleGlu: 2.931 ± 0.023	2.182IlePhe: 2.182 ± 0.019	3.451IleGly: 3.451 ± 0.029	1.246IleHis: 1.246 ± 0.015	2.663IleIle: 2.663 ± 0.026	2.113IleLys: 2.113 ± 0.021	4.75IleLeu: 4.75 ± 0.033	1.07IleMet: 1.07 ± 0.015	1.886IleAsn: 1.886 ± 0.018	3.231IlePro: 3.231 ± 0.025	2.053IleGln: 2.053 ± 0.019	2.769IleArg: 2.769 ± 0.025	4.087IleSer: 4.087 ± 0.031	2.909IleThr: 2.909 ± 0.02	3.269IleVal: 3.269 ± 0.029	0.77IleTrp: 0.77 ± 0.013	1.487IleTyr: 1.487 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.986LysAla: 3.986 ± 0.032	0.489LysCys: 0.489 ± 0.011	2.716LysAsp: 2.716 ± 0.03	3.15LysGlu: 3.15 ± 0.029	1.436LysPhe: 1.436 ± 0.016	2.881LysGly: 2.881 ± 0.025	1.076LysHis: 1.076 ± 0.014	2.24LysIle: 2.24 ± 0.022	2.971LysLys: 2.971 ± 0.04	3.892LysLeu: 3.892 ± 0.026	0.989LysMet: 0.989 ± 0.013	1.763LysAsn: 1.763 ± 0.02	2.607LysPro: 2.607 ± 0.026	1.794LysGln: 1.794 ± 0.019	3.136LysArg: 3.136 ± 0.031	3.447LysSer: 3.447 ± 0.03	2.754LysThr: 2.754 ± 0.026	2.677LysVal: 2.677 ± 0.021	0.67LysTrp: 0.67 ± 0.011	1.347LysTyr: 1.347 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.915LeuAla: 7.915 ± 0.042	1.262LeuCys: 1.262 ± 0.019	5.277LeuAsp: 5.277 ± 0.031	5.493LeuGlu: 5.493 ± 0.035	3.463LeuPhe: 3.463 ± 0.031	6.112LeuGly: 6.112 ± 0.034	2.28LeuHis: 2.28 ± 0.02	4.147LeuIle: 4.147 ± 0.03	4.026LeuLys: 4.026 ± 0.03	8.462LeuLeu: 8.462 ± 0.063	1.928LeuMet: 1.928 ± 0.02	3.298LeuAsn: 3.298 ± 0.026	5.412LeuPro: 5.412 ± 0.034	3.919LeuGln: 3.919 ± 0.025	5.677LeuArg: 5.677 ± 0.039	7.509LeuSer: 7.509 ± 0.047	4.814LeuThr: 4.814 ± 0.029	5.531LeuVal: 5.531 ± 0.035	1.248LeuTrp: 1.248 ± 0.019	2.422LeuTyr: 2.422 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.293MetAla: 2.293 ± 0.022	0.252MetCys: 0.252 ± 0.007	1.341MetAsp: 1.341 ± 0.016	1.318MetGlu: 1.318 ± 0.017	0.807MetPhe: 0.807 ± 0.012	1.555MetGly: 1.555 ± 0.018	0.514MetHis: 0.514 ± 0.01	1.093MetIle: 1.093 ± 0.015	1.005MetLys: 1.005 ± 0.014	1.895MetLeu: 1.895 ± 0.018	0.577MetMet: 0.577 ± 0.01	0.878MetAsn: 0.878 ± 0.014	1.296MetPro: 1.296 ± 0.017	0.905MetGln: 0.905 ± 0.013	1.229MetArg: 1.229 ± 0.014	1.972MetSer: 1.972 ± 0.019	1.379MetThr: 1.379 ± 0.014	1.394MetVal: 1.394 ± 0.017	0.284MetTrp: 0.284 ± 0.008	0.522MetTyr: 0.522 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.217AsnAla: 3.217 ± 0.028	0.46AsnCys: 0.46 ± 0.01	2.028AsnAsp: 2.028 ± 0.022	2.097AsnGlu: 2.097 ± 0.021	1.418AsnPhe: 1.418 ± 0.018	2.982AsnGly: 2.982 ± 0.027	0.872AsnHis: 0.872 ± 0.013	2.178AsnIle: 2.178 ± 0.018	1.546AsnLys: 1.546 ± 0.018	3.411AsnLeu: 3.411 ± 0.027	0.891AsnMet: 0.891 ± 0.013	1.475AsnAsn: 1.475 ± 0.021	2.567AsnPro: 2.567 ± 0.022	1.42AsnGln: 1.42 ± 0.018	1.97AsnArg: 1.97 ± 0.019	2.808AsnSer: 2.808 ± 0.022	2.302AsnThr: 2.302 ± 0.021	2.37AsnVal: 2.37 ± 0.02	0.598AsnTrp: 0.598 ± 0.011	1.113AsnTyr: 1.113 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.188ProAla: 5.188 ± 0.046	0.513ProCys: 0.513 ± 0.01	3.202ProAsp: 3.202 ± 0.027	3.957ProGlu: 3.957 ± 0.035	2.12ProPhe: 2.12 ± 0.019	3.895ProGly: 3.895 ± 0.03	1.332ProHis: 1.332 ± 0.018	2.631ProIle: 2.631 ± 0.019	2.608ProLys: 2.608 ± 0.022	4.695ProLeu: 4.695 ± 0.037	1.148ProMet: 1.148 ± 0.015	2.254ProAsn: 2.254 ± 0.022	4.434ProPro: 4.434 ± 0.059	2.411ProGln: 2.411 ± 0.027	3.308ProArg: 3.308 ± 0.03	5.925ProSer: 5.925 ± 0.044	4.003ProThr: 4.003 ± 0.031	3.628ProVal: 3.628 ± 0.03	0.794ProTrp: 0.794 ± 0.013	1.53ProTyr: 1.53 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.414GlnAla: 3.414 ± 0.027	0.462GlnCys: 0.462 ± 0.01	2.082GlnAsp: 2.082 ± 0.022	2.401GlnGlu: 2.401 ± 0.022	1.381GlnPhe: 1.381 ± 0.014	2.467GlnGly: 2.467 ± 0.023	1.021GlnHis: 1.021 ± 0.016	2.0GlnIle: 2.0 ± 0.02	1.968GlnLys: 1.968 ± 0.019	3.518GlnLeu: 3.518 ± 0.026	0.972GlnMet: 0.972 ± 0.014	1.651GlnAsn: 1.651 ± 0.019	2.556GlnPro: 2.556 ± 0.03	2.183GlnGln: 2.183 ± 0.03	2.569GlnArg: 2.569 ± 0.025	3.312GlnSer: 3.312 ± 0.024	2.438GlnThr: 2.438 ± 0.022	2.258GlnVal: 2.258 ± 0.023	0.614GlnTrp: 0.614 ± 0.01	1.212GlnTyr: 1.212 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.516ArgAla: 4.516 ± 0.031	0.669ArgCys: 0.669 ± 0.013	3.267ArgAsp: 3.267 ± 0.027	3.618ArgGlu: 3.618 ± 0.03	2.17ArgPhe: 2.17 ± 0.02	3.636ArgGly: 3.636 ± 0.032	1.524ArgHis: 1.524 ± 0.016	2.846ArgIle: 2.846 ± 0.024	3.178ArgLys: 3.178 ± 0.028	5.394ArgLeu: 5.394 ± 0.035	1.279ArgMet: 1.279 ± 0.016	2.193ArgAsn: 2.193 ± 0.022	3.351ArgPro: 3.351 ± 0.027	2.535ArgGln: 2.535 ± 0.024	4.716ArgArg: 4.716 ± 0.043	4.675ArgSer: 4.675 ± 0.035	3.198ArgThr: 3.198 ± 0.024	3.339ArgVal: 3.339 ± 0.026	0.935ArgTrp: 0.935 ± 0.015	1.638ArgTyr: 1.638 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	6.717SerAla: 6.717 ± 0.037	0.904SerCys: 0.904 ± 0.015	4.368SerAsp: 4.368 ± 0.033	4.29SerGlu: 4.29 ± 0.029	3.131SerPhe: 3.131 ± 0.023	5.731SerGly: 5.731 ± 0.039	2.035SerHis: 2.035 ± 0.022	4.121SerIle: 4.121 ± 0.027	3.628SerLys: 3.628 ± 0.031	7.404SerLeu: 7.404 ± 0.04	1.811SerMet: 1.811 ± 0.018	3.141SerAsn: 3.141 ± 0.022	5.475SerPro: 5.475 ± 0.046	3.426SerGln: 3.426 ± 0.026	4.892SerArg: 4.892 ± 0.038	8.514SerSer: 8.514 ± 0.062	5.629SerThr: 5.629 ± 0.042	4.828SerVal: 4.828 ± 0.032	1.172SerTrp: 1.172 ± 0.017	2.164SerTyr: 2.164 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.227ThrAla: 5.227 ± 0.035	0.726ThrCys: 0.726 ± 0.014	2.964ThrAsp: 2.964 ± 0.026	3.301ThrGlu: 3.301 ± 0.03	2.276ThrPhe: 2.276 ± 0.023	4.325ThrGly: 4.325 ± 0.034	1.319ThrHis: 1.319 ± 0.014	3.188ThrIle: 3.188 ± 0.025	2.583ThrLys: 2.583 ± 0.023	5.36ThrLeu: 5.36 ± 0.034	1.215ThrMet: 1.215 ± 0.015	2.183ThrAsn: 2.183 ± 0.025	4.324ThrPro: 4.324 ± 0.036	2.162ThrGln: 2.162 ± 0.023	3.021ThrArg: 3.021 ± 0.025	5.266ThrSer: 5.266 ± 0.041	4.066ThrThr: 4.066 ± 0.037	3.897ThrVal: 3.897 ± 0.028	0.887ThrTrp: 0.887 ± 0.012	1.643ThrTyr: 1.643 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.243ValAla: 5.243 ± 0.032	0.849ValCys: 0.849 ± 0.013	3.696ValAsp: 3.696 ± 0.025	3.729ValGlu: 3.729 ± 0.029	2.583ValPhe: 2.583 ± 0.024	4.041ValGly: 4.041 ± 0.031	1.422ValHis: 1.422 ± 0.016	3.124ValIle: 3.124 ± 0.026	2.705ValLys: 2.705 ± 0.022	5.614ValLeu: 5.614 ± 0.036	1.378ValMet: 1.378 ± 0.017	2.371ValAsn: 2.371 ± 0.02	3.629ValPro: 3.629 ± 0.03	2.429ValGln: 2.429 ± 0.021	3.281ValArg: 3.281 ± 0.027	4.886ValSer: 4.886 ± 0.03	3.655ValThr: 3.655 ± 0.031	4.261ValVal: 4.261 ± 0.031	0.848ValTrp: 0.848 ± 0.013	1.789ValTyr: 1.789 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.192TrpAla: 1.192 ± 0.017	0.197TrpCys: 0.197 ± 0.006	0.928TrpAsp: 0.928 ± 0.016	0.85TrpGlu: 0.85 ± 0.014	0.555TrpPhe: 0.555 ± 0.009	0.962TrpGly: 0.962 ± 0.015	0.366TrpHis: 0.366 ± 0.008	0.807TrpIle: 0.807 ± 0.012	0.824TrpLys: 0.824 ± 0.013	1.385TrpLeu: 1.385 ± 0.017	0.392TrpMet: 0.392 ± 0.009	0.685TrpAsn: 0.685 ± 0.01	0.614TrpPro: 0.614 ± 0.011	0.588TrpGln: 0.588 ± 0.01	0.945TrpArg: 0.945 ± 0.013	1.137TrpSer: 1.137 ± 0.016	0.931TrpThr: 0.931 ± 0.014	0.914TrpVal: 0.914 ± 0.012	0.283TrpTrp: 0.283 ± 0.009	0.456TrpTyr: 0.456 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.203TyrAla: 2.203 ± 0.022	0.404TyrCys: 0.404 ± 0.008	1.634TyrAsp: 1.634 ± 0.018	1.542TyrGlu: 1.542 ± 0.015	1.229TyrPhe: 1.229 ± 0.016	2.173TyrGly: 2.173 ± 0.024	0.777TyrHis: 0.777 ± 0.01	1.452TyrIle: 1.452 ± 0.018	1.08TyrLys: 1.08 ± 0.014	2.763TyrLeu: 2.763 ± 0.024	0.66TyrMet: 0.66 ± 0.011	1.154TyrAsn: 1.154 ± 0.014	1.535TyrPro: 1.535 ± 0.018	1.167TyrGln: 1.167 ± 0.015	1.606TyrArg: 1.606 ± 0.016	2.156TyrSer: 2.156 ± 0.023	1.654TyrThr: 1.654 ± 0.016	1.629TyrVal: 1.629 ± 0.017	0.462TyrTrp: 0.462 ± 0.009	0.97TyrTyr: 0.97 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12121 proteins (5759560 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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