Amino acid dipepetide frequency for archaeon HR01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.431AlaAla: 8.431 ± 0.173	0.8AlaCys: 0.8 ± 0.049	3.556AlaAsp: 3.556 ± 0.079	6.2AlaGlu: 6.2 ± 0.11	2.896AlaPhe: 2.896 ± 0.082	7.702AlaGly: 7.702 ± 0.144	1.216AlaHis: 1.216 ± 0.049	4.96AlaIle: 4.96 ± 0.105	3.29AlaLys: 3.29 ± 0.077	8.847AlaLeu: 8.847 ± 0.161	1.816AlaMet: 1.816 ± 0.056	1.739AlaAsn: 1.739 ± 0.056	2.607AlaPro: 2.607 ± 0.07	1.543AlaGln: 1.543 ± 0.049	5.454AlaArg: 5.454 ± 0.101	5.619AlaSer: 5.619 ± 0.107	3.691AlaThr: 3.691 ± 0.102	8.373AlaVal: 8.373 ± 0.142	0.778AlaTrp: 0.778 ± 0.039	2.909AlaTyr: 2.909 ± 0.076	0.0AlaXaa: 0.0 ± 0.0
Cys	0.465CysAla: 0.465 ± 0.032	0.082CysCys: 0.082 ± 0.014	0.41CysAsp: 0.41 ± 0.031	0.448CysGlu: 0.448 ± 0.032	0.311CysPhe: 0.311 ± 0.026	1.141CysGly: 1.141 ± 0.048	0.202CysHis: 0.202 ± 0.021	0.598CysIle: 0.598 ± 0.037	0.27CysLys: 0.27 ± 0.021	0.742CysLeu: 0.742 ± 0.04	0.219CysMet: 0.219 ± 0.019	0.246CysAsn: 0.246 ± 0.025	0.602CysPro: 0.602 ± 0.038	0.171CysGln: 0.171 ± 0.018	0.8CysArg: 0.8 ± 0.042	0.592CysSer: 0.592 ± 0.032	0.366CysThr: 0.366 ± 0.026	0.667CysVal: 0.667 ± 0.033	0.092CysTrp: 0.092 ± 0.016	0.332CysTyr: 0.332 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.37AspAla: 3.37 ± 0.084	0.399AspCys: 0.399 ± 0.027	2.071AspAsp: 2.071 ± 0.076	3.865AspGlu: 3.865 ± 0.09	1.977AspPhe: 1.977 ± 0.056	4.29AspGly: 4.29 ± 0.107	0.707AspHis: 0.707 ± 0.039	3.781AspIle: 3.781 ± 0.09	1.717AspLys: 1.717 ± 0.057	4.332AspLeu: 4.332 ± 0.089	1.269AspMet: 1.269 ± 0.05	1.02AspAsn: 1.02 ± 0.046	2.388AspPro: 2.388 ± 0.082	0.74AspGln: 0.74 ± 0.04	3.271AspArg: 3.271 ± 0.081	2.487AspSer: 2.487 ± 0.064	2.024AspThr: 2.024 ± 0.065	4.645AspVal: 4.645 ± 0.093	0.585AspTrp: 0.585 ± 0.035	1.739AspTyr: 1.739 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	6.27GluAla: 6.27 ± 0.128	0.427GluCys: 0.427 ± 0.026	3.198GluAsp: 3.198 ± 0.078	5.619GluGlu: 5.619 ± 0.124	2.007GluPhe: 2.007 ± 0.077	4.763GluGly: 4.763 ± 0.106	1.089GluHis: 1.089 ± 0.046	4.913GluIle: 4.913 ± 0.103	5.053GluLys: 5.053 ± 0.128	7.083GluLeu: 7.083 ± 0.11	2.15GluMet: 2.15 ± 0.073	2.349GluAsn: 2.349 ± 0.077	2.609GluPro: 2.609 ± 0.082	1.387GluGln: 1.387 ± 0.05	5.271GluArg: 5.271 ± 0.093	3.316GluSer: 3.316 ± 0.084	3.241GluThr: 3.241 ± 0.081	5.767GluVal: 5.767 ± 0.108	0.729GluTrp: 0.729 ± 0.037	2.375GluTyr: 2.375 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.259PheAla: 2.259 ± 0.068	0.281PheCys: 0.281 ± 0.021	1.631PheAsp: 1.631 ± 0.055	2.182PheGlu: 2.182 ± 0.067	1.612PhePhe: 1.612 ± 0.064	2.845PheGly: 2.845 ± 0.069	0.682PheHis: 0.682 ± 0.038	2.581PheIle: 2.581 ± 0.073	1.764PheLys: 1.764 ± 0.06	3.76PheLeu: 3.76 ± 0.09	0.858PheMet: 0.858 ± 0.037	1.301PheAsn: 1.301 ± 0.049	1.483PhePro: 1.483 ± 0.057	1.005PheGln: 1.005 ± 0.043	2.577PheArg: 2.577 ± 0.076	2.559PheSer: 2.559 ± 0.068	2.414PheThr: 2.414 ± 0.066	2.244PheVal: 2.244 ± 0.062	0.534PheTrp: 0.534 ± 0.035	1.391PheTyr: 1.391 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	5.625GlyAla: 5.625 ± 0.122	0.883GlyCys: 0.883 ± 0.044	3.852GlyAsp: 3.852 ± 0.087	5.603GlyGlu: 5.603 ± 0.114	3.473GlyPhe: 3.473 ± 0.087	7.361GlyGly: 7.361 ± 0.135	1.316GlyHis: 1.316 ± 0.042	4.502GlyIle: 4.502 ± 0.087	3.678GlyLys: 3.678 ± 0.079	9.303GlyLeu: 9.303 ± 0.137	2.208GlyMet: 2.208 ± 0.068	1.685GlyAsn: 1.685 ± 0.064	2.962GlyPro: 2.962 ± 0.073	1.884GlyGln: 1.884 ± 0.068	6.686GlyArg: 6.686 ± 0.114	4.517GlySer: 4.517 ± 0.09	3.179GlyThr: 3.179 ± 0.095	8.234GlyVal: 8.234 ± 0.139	1.258GlyTrp: 1.258 ± 0.047	3.316GlyTyr: 3.316 ± 0.09	0.0GlyXaa: 0.0 ± 0.0
His	1.158HisAla: 1.158 ± 0.049	0.182HisCys: 0.182 ± 0.017	0.679HisAsp: 0.679 ± 0.036	1.016HisGlu: 1.016 ± 0.042	0.609HisPhe: 0.609 ± 0.036	1.558HisGly: 1.558 ± 0.049	0.422HisHis: 0.422 ± 0.033	1.389HisIle: 1.389 ± 0.052	0.574HisLys: 0.574 ± 0.032	2.021HisLeu: 2.021 ± 0.066	0.377HisMet: 0.377 ± 0.027	0.484HisAsn: 0.484 ± 0.032	1.273HisPro: 1.273 ± 0.051	0.403HisGln: 0.403 ± 0.027	1.186HisArg: 1.186 ± 0.049	0.971HisSer: 0.971 ± 0.038	0.858HisThr: 0.858 ± 0.041	1.567HisVal: 1.567 ± 0.059	0.184HisTrp: 0.184 ± 0.021	0.65HisTyr: 0.65 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.526IleAla: 5.526 ± 0.104	0.624IleCys: 0.624 ± 0.032	2.965IleAsp: 2.965 ± 0.07	3.618IleGlu: 3.618 ± 0.089	2.589IlePhe: 2.589 ± 0.078	4.643IleGly: 4.643 ± 0.093	1.402IleHis: 1.402 ± 0.05	4.026IleIle: 4.026 ± 0.106	2.484IleLys: 2.484 ± 0.076	7.483IleLeu: 7.483 ± 0.153	1.426IleMet: 1.426 ± 0.052	1.689IleAsn: 1.689 ± 0.061	4.0IlePro: 4.0 ± 0.092	1.505IleGln: 1.505 ± 0.052	4.09IleArg: 4.09 ± 0.098	5.001IleSer: 5.001 ± 0.107	3.445IleThr: 3.445 ± 0.095	5.306IleVal: 5.306 ± 0.114	0.658IleTrp: 0.658 ± 0.038	2.57IleTyr: 2.57 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	4.538LysAla: 4.538 ± 0.104	0.41LysCys: 0.41 ± 0.029	1.886LysAsp: 1.886 ± 0.067	2.752LysGlu: 2.752 ± 0.077	1.143LysPhe: 1.143 ± 0.046	3.104LysGly: 3.104 ± 0.072	0.808LysHis: 0.808 ± 0.041	3.966LysIle: 3.966 ± 0.082	2.365LysLys: 2.365 ± 0.091	4.611LysLeu: 4.611 ± 0.103	1.434LysMet: 1.434 ± 0.047	1.567LysAsn: 1.567 ± 0.057	2.761LysPro: 2.761 ± 0.069	0.843LysGln: 0.843 ± 0.056	2.827LysArg: 2.827 ± 0.078	2.589LysSer: 2.589 ± 0.071	3.168LysThr: 3.168 ± 0.074	3.852LysVal: 3.852 ± 0.092	0.478LysTrp: 0.478 ± 0.032	1.661LysTyr: 1.661 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	10.153LeuAla: 10.153 ± 0.176	0.746LeuCys: 0.746 ± 0.036	5.301LeuAsp: 5.301 ± 0.124	8.178LeuGlu: 8.178 ± 0.155	3.196LeuPhe: 3.196 ± 0.089	9.006LeuGly: 9.006 ± 0.147	1.796LeuHis: 1.796 ± 0.066	5.846LeuIle: 5.846 ± 0.121	5.835LeuLys: 5.835 ± 0.114	10.631LeuLeu: 10.631 ± 0.186	2.564LeuMet: 2.564 ± 0.074	2.962LeuAsn: 2.962 ± 0.083	4.339LeuPro: 4.339 ± 0.091	2.495LeuGln: 2.495 ± 0.073	7.741LeuArg: 7.741 ± 0.142	7.621LeuSer: 7.621 ± 0.134	5.483LeuThr: 5.483 ± 0.105	7.944LeuVal: 7.944 ± 0.119	1.012LeuTrp: 1.012 ± 0.045	3.293LeuTyr: 3.293 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	2.849MetAla: 2.849 ± 0.073	0.178MetCys: 0.178 ± 0.018	1.28MetAsp: 1.28 ± 0.047	1.672MetGlu: 1.672 ± 0.059	0.705MetPhe: 0.705 ± 0.038	2.217MetGly: 2.217 ± 0.058	0.36MetHis: 0.36 ± 0.025	1.335MetIle: 1.335 ± 0.053	1.252MetLys: 1.252 ± 0.046	2.729MetLeu: 2.729 ± 0.067	0.68MetMet: 0.68 ± 0.037	0.637MetAsn: 0.637 ± 0.034	1.164MetPro: 1.164 ± 0.042	0.429MetGln: 0.429 ± 0.03	1.989MetArg: 1.989 ± 0.06	1.646MetSer: 1.646 ± 0.059	1.194MetThr: 1.194 ± 0.046	2.186MetVal: 2.186 ± 0.062	0.277MetTrp: 0.277 ± 0.024	0.553MetTyr: 0.553 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	1.88AsnAla: 1.88 ± 0.068	0.223AsnCys: 0.223 ± 0.022	0.905AsnAsp: 0.905 ± 0.044	1.211AsnGlu: 1.211 ± 0.056	0.945AsnPhe: 0.945 ± 0.037	1.831AsnGly: 1.831 ± 0.065	0.465AsnHis: 0.465 ± 0.032	2.54AsnIle: 2.54 ± 0.072	0.967AsnLys: 0.967 ± 0.046	3.231AsnLeu: 3.231 ± 0.074	0.842AsnMet: 0.842 ± 0.042	0.795AsnAsn: 0.795 ± 0.037	2.285AsnPro: 2.285 ± 0.064	0.579AsnGln: 0.579 ± 0.034	1.704AsnArg: 1.704 ± 0.061	1.524AsnSer: 1.524 ± 0.047	1.524AsnThr: 1.524 ± 0.053	2.201AsnVal: 2.201 ± 0.069	0.249AsnTrp: 0.249 ± 0.022	0.892AsnTyr: 0.892 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.475ProAla: 3.475 ± 0.088	0.311ProCys: 0.311 ± 0.024	2.521ProAsp: 2.521 ± 0.072	3.473ProGlu: 3.473 ± 0.085	1.743ProPhe: 1.743 ± 0.06	3.34ProGly: 3.34 ± 0.086	1.072ProHis: 1.072 ± 0.047	2.78ProIle: 2.78 ± 0.082	1.854ProLys: 1.854 ± 0.057	4.598ProLeu: 4.598 ± 0.115	0.96ProMet: 0.96 ± 0.044	1.333ProAsn: 1.333 ± 0.044	2.707ProPro: 2.707 ± 0.09	1.284ProGln: 1.284 ± 0.054	2.789ProArg: 2.789 ± 0.068	3.481ProSer: 3.481 ± 0.073	2.401ProThr: 2.401 ± 0.07	3.932ProVal: 3.932 ± 0.091	0.622ProTrp: 0.622 ± 0.043	1.979ProTyr: 1.979 ± 0.06	0.0ProXaa: 0.0 ± 0.0
Gln	2.049GlnAla: 2.049 ± 0.07	0.137GlnCys: 0.137 ± 0.016	0.888GlnAsp: 0.888 ± 0.046	1.335GlnGlu: 1.335 ± 0.053	0.637GlnPhe: 0.637 ± 0.035	1.37GlnGly: 1.37 ± 0.058	0.474GlnHis: 0.474 ± 0.032	1.509GlnIle: 1.509 ± 0.059	1.035GlnLys: 1.035 ± 0.045	2.615GlnLeu: 2.615 ± 0.079	0.62GlnMet: 0.62 ± 0.042	0.649GlnAsn: 0.649 ± 0.035	1.171GlnPro: 1.171 ± 0.047	0.774GlnGln: 0.774 ± 0.043	1.543GlnArg: 1.543 ± 0.057	1.265GlnSer: 1.265 ± 0.048	1.267GlnThr: 1.267 ± 0.057	1.798GlnVal: 1.798 ± 0.061	0.221GlnTrp: 0.221 ± 0.024	0.84GlnTyr: 0.84 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	4.765ArgAla: 4.765 ± 0.103	0.853ArgCys: 0.853 ± 0.042	3.595ArgAsp: 3.595 ± 0.078	5.544ArgGlu: 5.544 ± 0.107	2.652ArgPhe: 2.652 ± 0.077	5.231ArgGly: 5.231 ± 0.093	1.271ArgHis: 1.271 ± 0.042	4.888ArgIle: 4.888 ± 0.1	3.428ArgLys: 3.428 ± 0.09	8.324ArgLeu: 8.324 ± 0.149	2.141ArgMet: 2.141 ± 0.066	1.887ArgAsn: 1.887 ± 0.059	3.115ArgPro: 3.115 ± 0.088	1.7ArgGln: 1.7 ± 0.059	6.512ArgArg: 6.512 ± 0.151	3.415ArgSer: 3.415 ± 0.079	2.785ArgThr: 2.785 ± 0.076	5.842ArgVal: 5.842 ± 0.108	0.905ArgTrp: 0.905 ± 0.037	2.898ArgTyr: 2.898 ± 0.072	0.0ArgXaa: 0.0 ± 0.0
Ser	4.328SerAla: 4.328 ± 0.091	0.574SerCys: 0.574 ± 0.04	2.847SerAsp: 2.847 ± 0.074	4.071SerGlu: 4.071 ± 0.087	2.613SerPhe: 2.613 ± 0.069	5.421SerGly: 5.421 ± 0.114	1.216SerHis: 1.216 ± 0.052	4.334SerIle: 4.334 ± 0.097	3.076SerLys: 3.076 ± 0.073	7.11SerLeu: 7.11 ± 0.127	1.661SerMet: 1.661 ± 0.056	1.526SerAsn: 1.526 ± 0.057	3.108SerPro: 3.108 ± 0.081	1.794SerGln: 1.794 ± 0.06	4.812SerArg: 4.812 ± 0.101	4.3SerSer: 4.3 ± 0.095	3.008SerThr: 3.008 ± 0.081	4.502SerVal: 4.502 ± 0.093	0.898SerTrp: 0.898 ± 0.04	2.223SerTyr: 2.223 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.528ThrAla: 4.528 ± 0.096	0.416ThrCys: 0.416 ± 0.026	1.869ThrAsp: 1.869 ± 0.076	2.403ThrGlu: 2.403 ± 0.068	1.685ThrPhe: 1.685 ± 0.053	4.388ThrGly: 4.388 ± 0.093	0.969ThrHis: 0.969 ± 0.041	3.316ThrIle: 3.316 ± 0.09	1.471ThrLys: 1.471 ± 0.061	5.543ThrLeu: 5.543 ± 0.111	1.05ThrMet: 1.05 ± 0.043	1.087ThrAsn: 1.087 ± 0.045	3.162ThrPro: 3.162 ± 0.07	1.055ThrGln: 1.055 ± 0.05	2.611ThrArg: 2.611 ± 0.063	3.556ThrSer: 3.556 ± 0.079	2.823ThrThr: 2.823 ± 0.115	5.029ThrVal: 5.029 ± 0.122	0.639ThrTrp: 0.639 ± 0.036	1.816ThrTyr: 1.816 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	7.357ValAla: 7.357 ± 0.122	0.739ValCys: 0.739 ± 0.039	4.815ValAsp: 4.815 ± 0.102	7.499ValGlu: 7.499 ± 0.13	3.34ValPhe: 3.34 ± 0.072	7.113ValGly: 7.113 ± 0.14	1.205ValHis: 1.205 ± 0.041	4.783ValIle: 4.783 ± 0.1	4.982ValLys: 4.982 ± 0.1	8.028ValLeu: 8.028 ± 0.115	1.893ValMet: 1.893 ± 0.059	2.465ValAsn: 2.465 ± 0.063	2.62ValPro: 2.62 ± 0.062	1.546ValGln: 1.546 ± 0.053	6.058ValArg: 6.058 ± 0.11	5.837ValSer: 5.837 ± 0.102	3.977ValThr: 3.977 ± 0.111	8.384ValVal: 8.384 ± 0.151	0.954ValTrp: 0.954 ± 0.046	2.864ValTyr: 2.864 ± 0.074	0.0ValXaa: 0.0 ± 0.0
Trp	0.815TrpAla: 0.815 ± 0.041	0.122TrpCys: 0.122 ± 0.016	0.594TrpAsp: 0.594 ± 0.034	0.744TrpGlu: 0.744 ± 0.038	0.495TrpPhe: 0.495 ± 0.032	0.892TrpGly: 0.892 ± 0.047	0.221TrpHis: 0.221 ± 0.021	0.69TrpIle: 0.69 ± 0.036	0.519TrpLys: 0.519 ± 0.029	1.248TrpLeu: 1.248 ± 0.051	0.36TrpMet: 0.36 ± 0.024	0.369TrpAsn: 0.369 ± 0.029	0.446TrpPro: 0.446 ± 0.032	0.272TrpGln: 0.272 ± 0.024	1.065TrpArg: 1.065 ± 0.046	0.791TrpSer: 0.791 ± 0.041	0.5TrpThr: 0.5 ± 0.03	1.025TrpVal: 1.025 ± 0.045	0.189TrpTrp: 0.189 ± 0.018	0.33TrpTyr: 0.33 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.587TyrAla: 2.587 ± 0.065	0.369TyrCys: 0.369 ± 0.026	1.814TyrAsp: 1.814 ± 0.066	2.184TyrGlu: 2.184 ± 0.071	1.333TyrPhe: 1.333 ± 0.052	3.305TyrGly: 3.305 ± 0.076	0.665TyrHis: 0.665 ± 0.037	2.313TyrIle: 2.313 ± 0.066	1.149TyrLys: 1.149 ± 0.056	3.904TyrLeu: 3.904 ± 0.095	0.802TyrMet: 0.802 ± 0.037	1.005TyrAsn: 1.005 ± 0.044	1.856TyrPro: 1.856 ± 0.056	0.787TyrGln: 0.787 ± 0.039	2.768TyrArg: 2.768 ± 0.075	2.334TyrSer: 2.334 ± 0.064	2.067TyrThr: 2.067 ± 0.063	2.963TyrVal: 2.963 ± 0.079	0.425TyrTrp: 0.425 ± 0.034	1.181TyrTyr: 1.181 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1916 proteins (533512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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