Amino acid dipepetide frequency for Brugia pahangi (Filarial nematode worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.835AlaAla: 4.835 ± 0.053	1.168AlaCys: 1.168 ± 0.019	2.943AlaAsp: 2.943 ± 0.029	3.928AlaGlu: 3.928 ± 0.033	2.549AlaPhe: 2.549 ± 0.024	2.883AlaGly: 2.883 ± 0.027	1.317AlaHis: 1.317 ± 0.019	4.117AlaIle: 4.117 ± 0.028	3.565AlaLys: 3.565 ± 0.033	5.817AlaLeu: 5.817 ± 0.046	1.511AlaMet: 1.511 ± 0.017	2.908AlaAsn: 2.908 ± 0.029	2.215AlaPro: 2.215 ± 0.028	2.318AlaGln: 2.318 ± 0.025	2.962AlaArg: 2.962 ± 0.031	4.566AlaSer: 4.566 ± 0.038	3.637AlaThr: 3.637 ± 0.031	4.435AlaVal: 4.435 ± 0.037	0.552AlaTrp: 0.552 ± 0.01	1.79AlaTyr: 1.79 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.289CysAla: 1.289 ± 0.021	0.702CysCys: 0.702 ± 0.016	1.294CysAsp: 1.294 ± 0.028	1.281CysGlu: 1.281 ± 0.025	1.068CysPhe: 1.068 ± 0.017	1.354CysGly: 1.354 ± 0.024	0.608CysHis: 0.608 ± 0.014	1.544CysIle: 1.544 ± 0.029	1.257CysLys: 1.257 ± 0.023	2.0CysLeu: 2.0 ± 0.025	0.539CysMet: 0.539 ± 0.012	1.13CysAsn: 1.13 ± 0.019	1.044CysPro: 1.044 ± 0.028	0.846CysGln: 0.846 ± 0.018	1.305CysArg: 1.305 ± 0.02	1.996CysSer: 1.996 ± 0.027	1.184CysThr: 1.184 ± 0.017	1.223CysVal: 1.223 ± 0.018	0.258CysTrp: 0.258 ± 0.007	0.767CysTyr: 0.767 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.088AspAla: 3.088 ± 0.028	1.122AspCys: 1.122 ± 0.021	4.172AspAsp: 4.172 ± 0.064	4.583AspGlu: 4.583 ± 0.043	2.378AspPhe: 2.378 ± 0.024	3.29AspGly: 3.29 ± 0.043	1.115AspHis: 1.115 ± 0.017	3.612AspIle: 3.612 ± 0.03	2.904AspLys: 2.904 ± 0.027	4.631AspLeu: 4.631 ± 0.036	1.242AspMet: 1.242 ± 0.018	2.689AspAsn: 2.689 ± 0.029	1.937AspPro: 1.937 ± 0.024	1.772AspGln: 1.772 ± 0.019	2.74AspArg: 2.74 ± 0.028	3.959AspSer: 3.959 ± 0.029	2.435AspThr: 2.435 ± 0.021	3.289AspVal: 3.289 ± 0.027	0.626AspTrp: 0.626 ± 0.011	1.807AspTyr: 1.807 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	3.719GluAla: 3.719 ± 0.035	1.316GluCys: 1.316 ± 0.026	3.176GluAsp: 3.176 ± 0.034	5.312GluGlu: 5.312 ± 0.066	2.25GluPhe: 2.25 ± 0.024	2.627GluGly: 2.627 ± 0.026	1.426GluHis: 1.426 ± 0.018	4.471GluIle: 4.471 ± 0.035	5.302GluLys: 5.302 ± 0.046	5.843GluLeu: 5.843 ± 0.041	2.033GluMet: 2.033 ± 0.022	3.854GluAsn: 3.854 ± 0.031	2.008GluPro: 2.008 ± 0.026	3.123GluGln: 3.123 ± 0.036	4.051GluArg: 4.051 ± 0.041	4.345GluSer: 4.345 ± 0.04	3.438GluThr: 3.438 ± 0.031	3.478GluVal: 3.478 ± 0.03	0.743GluTrp: 0.743 ± 0.012	1.957GluTyr: 1.957 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	2.691PheAla: 2.691 ± 0.027	1.169PheCys: 1.169 ± 0.019	2.5PheAsp: 2.5 ± 0.023	2.509PheGlu: 2.509 ± 0.024	2.294PhePhe: 2.294 ± 0.03	2.628PheGly: 2.628 ± 0.027	1.133PheHis: 1.133 ± 0.015	3.13PheIle: 3.13 ± 0.03	2.029PheLys: 2.029 ± 0.02	4.202PheLeu: 4.202 ± 0.034	1.087PheMet: 1.087 ± 0.018	1.973PheAsn: 1.973 ± 0.019	1.782PhePro: 1.782 ± 0.023	1.558PheGln: 1.558 ± 0.018	2.261PheArg: 2.261 ± 0.023	3.514PheSer: 3.514 ± 0.028	2.398PheThr: 2.398 ± 0.023	2.773PheVal: 2.773 ± 0.028	0.541PheTrp: 0.541 ± 0.009	1.572PheTyr: 1.572 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	2.794GlyAla: 2.794 ± 0.028	1.1GlyCys: 1.1 ± 0.021	2.674GlyAsp: 2.674 ± 0.032	2.979GlyGlu: 2.979 ± 0.026	2.193GlyPhe: 2.193 ± 0.024	3.07GlyGly: 3.07 ± 0.045	1.227GlyHis: 1.227 ± 0.017	3.545GlyIle: 3.545 ± 0.031	3.211GlyLys: 3.211 ± 0.031	4.013GlyLeu: 4.013 ± 0.037	1.277GlyMet: 1.277 ± 0.019	2.674GlyAsn: 2.674 ± 0.023	1.838GlyPro: 1.838 ± 0.039	1.921GlyGln: 1.921 ± 0.023	3.004GlyArg: 3.004 ± 0.029	4.046GlySer: 4.046 ± 0.035	3.025GlyThr: 3.025 ± 0.029	2.742GlyVal: 2.742 ± 0.027	0.619GlyTrp: 0.619 ± 0.013	1.801GlyTyr: 1.801 ± 0.027	0.001GlyXaa: 0.001 ± 0.0
His	1.302HisAla: 1.302 ± 0.016	0.701HisCys: 0.701 ± 0.015	1.085HisAsp: 1.085 ± 0.014	1.343HisGlu: 1.343 ± 0.018	1.344HisPhe: 1.344 ± 0.017	1.218HisGly: 1.218 ± 0.017	0.832HisHis: 0.832 ± 0.026	1.636HisIle: 1.636 ± 0.02	1.156HisLys: 1.156 ± 0.017	2.486HisLeu: 2.486 ± 0.024	0.628HisMet: 0.628 ± 0.015	1.101HisAsn: 1.101 ± 0.014	1.139HisPro: 1.139 ± 0.018	1.045HisGln: 1.045 ± 0.019	1.489HisArg: 1.489 ± 0.018	2.112HisSer: 2.112 ± 0.027	1.164HisThr: 1.164 ± 0.016	1.3HisVal: 1.3 ± 0.018	0.315HisTrp: 0.315 ± 0.007	0.955HisTyr: 0.955 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.44IleAla: 4.44 ± 0.033	1.772IleCys: 1.772 ± 0.026	3.841IleAsp: 3.841 ± 0.033	3.945IleGlu: 3.945 ± 0.034	3.103IlePhe: 3.103 ± 0.028	3.407IleGly: 3.407 ± 0.032	1.604IleHis: 1.604 ± 0.018	4.784IleIle: 4.784 ± 0.057	3.507IleLys: 3.507 ± 0.031	6.002IleLeu: 6.002 ± 0.036	1.546IleMet: 1.546 ± 0.018	3.372IleAsn: 3.372 ± 0.033	3.082IlePro: 3.082 ± 0.032	2.418IleGln: 2.418 ± 0.024	3.75IleArg: 3.75 ± 0.029	6.011IleSer: 6.011 ± 0.038	3.995IleThr: 3.995 ± 0.037	3.983IleVal: 3.983 ± 0.03	0.758IleTrp: 0.758 ± 0.012	2.218IleTyr: 2.218 ± 0.024	0.001IleXaa: 0.001 ± 0.0
Lys	3.281LysAla: 3.281 ± 0.033	1.403LysCys: 1.403 ± 0.022	2.924LysAsp: 2.924 ± 0.028	4.396LysGlu: 4.396 ± 0.044	2.398LysPhe: 2.398 ± 0.022	2.563LysGly: 2.563 ± 0.03	1.528LysHis: 1.528 ± 0.017	4.151LysIle: 4.151 ± 0.032	5.085LysLys: 5.085 ± 0.047	5.926LysLeu: 5.926 ± 0.042	1.808LysMet: 1.808 ± 0.021	3.341LysAsn: 3.341 ± 0.029	2.296LysPro: 2.296 ± 0.026	2.877LysGln: 2.877 ± 0.026	4.07LysArg: 4.07 ± 0.038	4.295LysSer: 4.295 ± 0.034	3.243LysThr: 3.243 ± 0.031	3.299LysVal: 3.299 ± 0.028	0.74LysTrp: 0.74 ± 0.012	2.145LysTyr: 2.145 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	5.571LeuAla: 5.571 ± 0.039	2.138LeuCys: 2.138 ± 0.028	4.551LeuAsp: 4.551 ± 0.036	5.63LeuGlu: 5.63 ± 0.042	4.244LeuPhe: 4.244 ± 0.037	3.683LeuGly: 3.683 ± 0.031	2.517LeuHis: 2.517 ± 0.023	6.105LeuIle: 6.105 ± 0.046	6.054LeuLys: 6.054 ± 0.042	10.077LeuLeu: 10.077 ± 0.076	2.352LeuMet: 2.352 ± 0.023	4.687LeuAsn: 4.687 ± 0.035	4.574LeuPro: 4.574 ± 0.036	4.353LeuGln: 4.353 ± 0.04	5.5LeuArg: 5.5 ± 0.042	8.021LeuSer: 8.021 ± 0.051	4.947LeuThr: 4.947 ± 0.036	4.764LeuVal: 4.764 ± 0.034	1.007LeuTrp: 1.007 ± 0.015	2.888LeuTyr: 2.888 ± 0.031	0.001LeuXaa: 0.001 ± 0.0
Met	1.543MetAla: 1.543 ± 0.018	0.474MetCys: 0.474 ± 0.011	1.448MetAsp: 1.448 ± 0.017	1.884MetGlu: 1.884 ± 0.022	0.96MetPhe: 0.96 ± 0.014	1.059MetGly: 1.059 ± 0.016	0.667MetHis: 0.667 ± 0.013	1.705MetIle: 1.705 ± 0.023	1.942MetLys: 1.942 ± 0.022	2.46MetLeu: 2.46 ± 0.025	0.746MetMet: 0.746 ± 0.019	1.437MetAsn: 1.437 ± 0.021	1.046MetPro: 1.046 ± 0.017	1.251MetGln: 1.251 ± 0.017	1.405MetArg: 1.405 ± 0.018	1.814MetSer: 1.814 ± 0.018	1.351MetThr: 1.351 ± 0.017	1.394MetVal: 1.394 ± 0.018	0.234MetTrp: 0.234 ± 0.007	0.694MetTyr: 0.694 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.165AsnAla: 3.165 ± 0.025	1.208AsnCys: 1.208 ± 0.021	3.416AsnAsp: 3.416 ± 0.032	3.901AsnGlu: 3.901 ± 0.037	2.354AsnPhe: 2.354 ± 0.022	3.163AsnGly: 3.163 ± 0.029	1.145AsnHis: 1.145 ± 0.016	3.587AsnIle: 3.587 ± 0.029	2.757AsnLys: 2.757 ± 0.022	4.481AsnLeu: 4.481 ± 0.032	1.26AsnMet: 1.26 ± 0.016	2.999AsnAsn: 2.999 ± 0.035	1.866AsnPro: 1.866 ± 0.021	1.824AsnGln: 1.824 ± 0.022	2.681AsnArg: 2.681 ± 0.023	4.232AsnSer: 4.232 ± 0.034	2.52AsnThr: 2.52 ± 0.025	3.213AsnVal: 3.213 ± 0.032	0.568AsnTrp: 0.568 ± 0.011	1.756AsnTyr: 1.756 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	2.247ProAla: 2.247 ± 0.026	0.782ProCys: 0.782 ± 0.018	2.037ProAsp: 2.037 ± 0.022	2.621ProGlu: 2.621 ± 0.025	1.839ProPhe: 1.839 ± 0.019	2.251ProGly: 2.251 ± 0.068	0.911ProHis: 0.911 ± 0.013	2.587ProIle: 2.587 ± 0.026	2.256ProLys: 2.256 ± 0.023	3.797ProLeu: 3.797 ± 0.032	0.907ProMet: 0.907 ± 0.017	2.026ProAsn: 2.026 ± 0.021	2.885ProPro: 2.885 ± 0.053	1.634ProGln: 1.634 ± 0.027	1.934ProArg: 1.934 ± 0.021	3.861ProSer: 3.861 ± 0.037	2.478ProThr: 2.478 ± 0.031	2.75ProVal: 2.75 ± 0.025	0.409ProTrp: 0.409 ± 0.011	1.446ProTyr: 1.446 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.112GlnAla: 2.112 ± 0.025	1.003GlnCys: 1.003 ± 0.021	1.392GlnAsp: 1.392 ± 0.019	2.283GlnGlu: 2.283 ± 0.027	1.776GlnPhe: 1.776 ± 0.019	1.439GlnGly: 1.439 ± 0.017	1.132GlnHis: 1.132 ± 0.017	2.883GlnIle: 2.883 ± 0.026	2.853GlnLys: 2.853 ± 0.027	4.483GlnLeu: 4.483 ± 0.042	1.29GlnMet: 1.29 ± 0.015	2.253GlnAsn: 2.253 ± 0.026	1.693GlnPro: 1.693 ± 0.029	3.604GlnGln: 3.604 ± 0.096	2.54GlnArg: 2.54 ± 0.028	3.047GlnSer: 3.047 ± 0.033	2.194GlnThr: 2.194 ± 0.025	2.026GlnVal: 2.026 ± 0.023	0.507GlnTrp: 0.507 ± 0.011	1.4GlnTyr: 1.4 ± 0.017	0.001GlnXaa: 0.001 ± 0.0
Arg	2.851ArgAla: 2.851 ± 0.027	1.348ArgCys: 1.348 ± 0.027	2.621ArgAsp: 2.621 ± 0.029	3.427ArgGlu: 3.427 ± 0.036	2.406ArgPhe: 2.406 ± 0.023	2.481ArgGly: 2.481 ± 0.031	1.499ArgHis: 1.499 ± 0.02	3.878ArgIle: 3.878 ± 0.03	4.248ArgLys: 4.248 ± 0.039	5.321ArgLeu: 5.321 ± 0.039	1.465ArgMet: 1.465 ± 0.018	3.314ArgAsn: 3.314 ± 0.03	2.075ArgPro: 2.075 ± 0.023	2.473ArgGln: 2.473 ± 0.024	4.238ArgArg: 4.238 ± 0.042	4.44ArgSer: 4.44 ± 0.044	2.967ArgThr: 2.967 ± 0.026	2.729ArgVal: 2.729 ± 0.026	0.659ArgTrp: 0.659 ± 0.013	1.949ArgTyr: 1.949 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	4.956SerAla: 4.956 ± 0.042	1.701SerCys: 1.701 ± 0.025	4.517SerAsp: 4.517 ± 0.037	4.704SerGlu: 4.704 ± 0.043	3.638SerPhe: 3.638 ± 0.028	4.512SerGly: 4.512 ± 0.036	1.826SerHis: 1.826 ± 0.024	4.982SerIle: 4.982 ± 0.035	4.565SerLys: 4.565 ± 0.032	7.521SerLeu: 7.521 ± 0.045	1.894SerMet: 1.894 ± 0.018	4.326SerAsn: 4.326 ± 0.035	3.368SerPro: 3.368 ± 0.038	2.94SerGln: 2.94 ± 0.033	4.183SerArg: 4.183 ± 0.039	9.101SerSer: 9.101 ± 0.095	5.163SerThr: 5.163 ± 0.045	5.153SerVal: 5.153 ± 0.035	0.794SerTrp: 0.794 ± 0.013	2.372SerTyr: 2.372 ± 0.024	0.001SerXaa: 0.001 ± 0.0
Thr	3.862ThrAla: 3.862 ± 0.035	1.133ThrCys: 1.133 ± 0.021	3.021ThrAsp: 3.021 ± 0.029	3.329ThrGlu: 3.329 ± 0.028	2.387ThrPhe: 2.387 ± 0.023	2.916ThrGly: 2.916 ± 0.03	1.191ThrHis: 1.191 ± 0.017	3.828ThrIle: 3.828 ± 0.035	3.113ThrLys: 3.113 ± 0.029	4.93ThrLeu: 4.93 ± 0.03	1.281ThrMet: 1.281 ± 0.013	2.926ThrAsn: 2.926 ± 0.03	2.398ThrPro: 2.398 ± 0.028	1.808ThrGln: 1.808 ± 0.022	2.463ThrArg: 2.463 ± 0.024	4.991ThrSer: 4.991 ± 0.047	4.358ThrThr: 4.358 ± 0.067	4.085ThrVal: 4.085 ± 0.029	0.501ThrTrp: 0.501 ± 0.012	1.643ThrTyr: 1.643 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	3.849ValAla: 3.849 ± 0.033	1.317ValCys: 1.317 ± 0.02	3.342ValAsp: 3.342 ± 0.028	3.899ValGlu: 3.899 ± 0.029	2.399ValPhe: 2.399 ± 0.024	2.839ValGly: 2.839 ± 0.029	1.426ValHis: 1.426 ± 0.016	4.13ValIle: 4.13 ± 0.031	3.451ValLys: 3.451 ± 0.03	5.493ValLeu: 5.493 ± 0.038	1.481ValMet: 1.481 ± 0.018	2.822ValAsn: 2.822 ± 0.024	2.651ValPro: 2.651 ± 0.028	2.368ValGln: 2.368 ± 0.025	3.116ValArg: 3.116 ± 0.03	4.5ValSer: 4.5 ± 0.034	3.504ValThr: 3.504 ± 0.031	3.89ValVal: 3.89 ± 0.033	0.607ValTrp: 0.607 ± 0.01	1.808ValTyr: 1.808 ± 0.018	0.001ValXaa: 0.001 ± 0.0
Trp	0.538TrpAla: 0.538 ± 0.01	0.242TrpCys: 0.242 ± 0.007	0.547TrpAsp: 0.547 ± 0.011	0.578TrpGlu: 0.578 ± 0.012	0.514TrpPhe: 0.514 ± 0.01	0.403TrpGly: 0.403 ± 0.011	0.292TrpHis: 0.292 ± 0.007	0.81TrpIle: 0.81 ± 0.013	0.843TrpLys: 0.843 ± 0.013	1.146TrpLeu: 1.146 ± 0.016	0.347TrpMet: 0.347 ± 0.01	0.695TrpAsn: 0.695 ± 0.013	0.431TrpPro: 0.431 ± 0.01	0.457TrpGln: 0.457 ± 0.011	0.685TrpArg: 0.685 ± 0.012	0.856TrpSer: 0.856 ± 0.015	0.623TrpThr: 0.623 ± 0.012	0.461TrpVal: 0.461 ± 0.01	0.169TrpTrp: 0.169 ± 0.007	0.382TrpTyr: 0.382 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.883TyrAla: 1.883 ± 0.023	0.887TyrCys: 0.887 ± 0.015	1.893TyrAsp: 1.893 ± 0.02	1.941TyrGlu: 1.941 ± 0.02	1.651TyrPhe: 1.651 ± 0.021	1.969TyrGly: 1.969 ± 0.024	0.954TyrHis: 0.954 ± 0.013	2.052TyrIle: 2.052 ± 0.023	1.668TyrLys: 1.668 ± 0.019	3.037TyrLeu: 3.037 ± 0.029	0.819TyrMet: 0.819 ± 0.012	1.566TyrAsn: 1.566 ± 0.02	1.33TyrPro: 1.33 ± 0.019	1.322TyrGln: 1.322 ± 0.018	2.012TyrArg: 2.012 ± 0.023	2.509TyrSer: 2.509 ± 0.027	1.541TyrThr: 1.541 ± 0.018	1.905TyrVal: 1.905 ± 0.02	0.411TyrTrp: 0.411 ± 0.011	1.357TyrTyr: 1.357 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.033XaaXaa: 0.033 ± 0.015

Statistics based on 14545 proteins (5004100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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