Amino acid dipepetide frequency for Nonomuraea zeae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.019AlaAla: 21.019 ± 0.11	1.119AlaCys: 1.119 ± 0.017	7.626AlaAsp: 7.626 ± 0.05	8.408AlaGlu: 8.408 ± 0.062	3.714AlaPhe: 3.714 ± 0.032	14.059AlaGly: 14.059 ± 0.076	2.614AlaHis: 2.614 ± 0.024	4.477AlaIle: 4.477 ± 0.041	2.781AlaLys: 2.781 ± 0.027	14.316AlaLeu: 14.316 ± 0.081	2.735AlaMet: 2.735 ± 0.028	2.082AlaAsn: 2.082 ± 0.025	6.124AlaPro: 6.124 ± 0.04	3.673AlaGln: 3.673 ± 0.031	10.204AlaArg: 10.204 ± 0.065	5.669AlaSer: 5.669 ± 0.04	7.117AlaThr: 7.117 ± 0.05	11.597AlaVal: 11.597 ± 0.072	1.949AlaTrp: 1.949 ± 0.024	2.864AlaTyr: 2.864 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.034CysAla: 1.034 ± 0.017	0.1CysCys: 0.1 ± 0.006	0.485CysAsp: 0.485 ± 0.012	0.39CysGlu: 0.39 ± 0.009	0.234CysPhe: 0.234 ± 0.007	0.933CysGly: 0.933 ± 0.019	0.197CysHis: 0.197 ± 0.007	0.144CysIle: 0.144 ± 0.006	0.112CysLys: 0.112 ± 0.005	0.782CysLeu: 0.782 ± 0.016	0.125CysMet: 0.125 ± 0.005	0.128CysAsn: 0.128 ± 0.006	0.494CysPro: 0.494 ± 0.013	0.176CysGln: 0.176 ± 0.007	0.587CysArg: 0.587 ± 0.015	0.419CysSer: 0.419 ± 0.012	0.436CysThr: 0.436 ± 0.011	0.654CysVal: 0.654 ± 0.013	0.128CysTrp: 0.128 ± 0.006	0.174CysTyr: 0.174 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	6.686AspAla: 6.686 ± 0.045	0.357AspCys: 0.357 ± 0.008	3.488AspAsp: 3.488 ± 0.033	3.537AspGlu: 3.537 ± 0.032	1.563AspPhe: 1.563 ± 0.025	6.134AspGly: 6.134 ± 0.049	1.351AspHis: 1.351 ± 0.018	1.732AspIle: 1.732 ± 0.022	1.051AspLys: 1.051 ± 0.021	6.646AspLeu: 6.646 ± 0.046	0.802AspMet: 0.802 ± 0.015	0.909AspAsn: 0.909 ± 0.017	4.469AspPro: 4.469 ± 0.039	1.659AspGln: 1.659 ± 0.023	4.704AspArg: 4.704 ± 0.035	2.246AspSer: 2.246 ± 0.025	2.575AspThr: 2.575 ± 0.029	4.856AspVal: 4.856 ± 0.038	0.987AspTrp: 0.987 ± 0.018	1.264AspTyr: 1.264 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	6.669GluAla: 6.669 ± 0.047	0.345GluCys: 0.345 ± 0.009	2.415GluAsp: 2.415 ± 0.026	3.393GluGlu: 3.393 ± 0.042	1.429GluPhe: 1.429 ± 0.02	3.913GluGly: 3.913 ± 0.03	1.59GluHis: 1.59 ± 0.022	2.474GluIle: 2.474 ± 0.031	1.04GluLys: 1.04 ± 0.019	7.17GluLeu: 7.17 ± 0.052	0.887GluMet: 0.887 ± 0.016	0.855GluAsn: 0.855 ± 0.017	3.434GluPro: 3.434 ± 0.034	2.233GluGln: 2.233 ± 0.026	5.673GluArg: 5.673 ± 0.049	2.723GluSer: 2.723 ± 0.024	2.682GluThr: 2.682 ± 0.029	4.636GluVal: 4.636 ± 0.037	0.809GluTrp: 0.809 ± 0.014	1.008GluTyr: 1.008 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.897PheAla: 3.897 ± 0.03	0.264PheCys: 0.264 ± 0.009	2.102PheAsp: 2.102 ± 0.027	1.502PheGlu: 1.502 ± 0.022	0.928PhePhe: 0.928 ± 0.018	3.11PheGly: 3.11 ± 0.031	0.619PheHis: 0.619 ± 0.012	0.813PheIle: 0.813 ± 0.015	0.531PheLys: 0.531 ± 0.014	2.692PheLeu: 2.692 ± 0.029	0.44PheMet: 0.44 ± 0.011	0.609PheAsn: 0.609 ± 0.013	1.442PhePro: 1.442 ± 0.019	0.743PheGln: 0.743 ± 0.014	1.821PheArg: 1.821 ± 0.025	1.497PheSer: 1.497 ± 0.021	2.021PheThr: 2.021 ± 0.026	2.348PheVal: 2.348 ± 0.027	0.467PheTrp: 0.467 ± 0.011	0.646PheTyr: 0.646 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	10.58GlyAla: 10.58 ± 0.066	0.837GlyCys: 0.837 ± 0.016	5.285GlyAsp: 5.285 ± 0.04	5.187GlyGlu: 5.187 ± 0.039	2.964GlyPhe: 2.964 ± 0.032	8.775GlyGly: 8.775 ± 0.064	2.308GlyHis: 2.308 ± 0.027	3.376GlyIle: 3.376 ± 0.032	2.399GlyLys: 2.399 ± 0.035	10.22GlyLeu: 10.22 ± 0.066	2.019GlyMet: 2.019 ± 0.023	1.743GlyAsn: 1.743 ± 0.029	5.075GlyPro: 5.075 ± 0.038	2.881GlyGln: 2.881 ± 0.035	7.888GlyArg: 7.888 ± 0.05	5.067GlySer: 5.067 ± 0.038	5.835GlyThr: 5.835 ± 0.044	7.969GlyVal: 7.969 ± 0.052	1.795GlyTrp: 1.795 ± 0.023	2.453GlyTyr: 2.453 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	2.663HisAla: 2.663 ± 0.029	0.197HisCys: 0.197 ± 0.006	1.383HisAsp: 1.383 ± 0.017	1.245HisGlu: 1.245 ± 0.017	0.603HisPhe: 0.603 ± 0.012	2.196HisGly: 2.196 ± 0.025	0.685HisHis: 0.685 ± 0.013	0.65HisIle: 0.65 ± 0.012	0.302HisLys: 0.302 ± 0.009	2.506HisLeu: 2.506 ± 0.026	0.328HisMet: 0.328 ± 0.01	0.384HisAsn: 0.384 ± 0.01	1.686HisPro: 1.686 ± 0.022	0.638HisGln: 0.638 ± 0.014	1.9HisArg: 1.9 ± 0.02	0.951HisSer: 0.951 ± 0.016	1.093HisThr: 1.093 ± 0.017	1.859HisVal: 1.859 ± 0.022	0.366HisTrp: 0.366 ± 0.01	0.501HisTyr: 0.501 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.299IleAla: 5.299 ± 0.038	0.323IleCys: 0.323 ± 0.009	2.543IleAsp: 2.543 ± 0.024	2.286IleGlu: 2.286 ± 0.027	0.9IlePhe: 0.9 ± 0.018	3.827IleGly: 3.827 ± 0.034	0.659IleHis: 0.659 ± 0.013	1.139IleIle: 1.139 ± 0.021	0.851IleLys: 0.851 ± 0.014	2.756IleLeu: 2.756 ± 0.027	0.607IleMet: 0.607 ± 0.014	0.739IleAsn: 0.739 ± 0.016	1.921IlePro: 1.921 ± 0.021	0.818IleGln: 0.818 ± 0.014	2.509IleArg: 2.509 ± 0.029	2.038IleSer: 2.038 ± 0.022	2.471IleThr: 2.471 ± 0.027	3.292IleVal: 3.292 ± 0.035	0.486IleTrp: 0.486 ± 0.012	0.672IleTyr: 0.672 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	2.577LysAla: 2.577 ± 0.029	0.113LysCys: 0.113 ± 0.006	1.142LysAsp: 1.142 ± 0.02	1.132LysGlu: 1.132 ± 0.019	0.456LysPhe: 0.456 ± 0.011	1.712LysGly: 1.712 ± 0.022	0.425LysHis: 0.425 ± 0.01	0.98LysIle: 0.98 ± 0.02	0.633LysLys: 0.633 ± 0.017	1.997LysLeu: 1.997 ± 0.027	0.363LysMet: 0.363 ± 0.01	0.452LysAsn: 0.452 ± 0.012	1.296LysPro: 1.296 ± 0.018	0.669LysGln: 0.669 ± 0.015	1.399LysArg: 1.399 ± 0.022	1.117LysSer: 1.117 ± 0.02	1.229LysThr: 1.229 ± 0.02	1.913LysVal: 1.913 ± 0.025	0.291LysTrp: 0.291 ± 0.01	0.426LysTyr: 0.426 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	16.377LeuAla: 16.377 ± 0.088	0.778LeuCys: 0.778 ± 0.014	6.665LeuAsp: 6.665 ± 0.045	4.731LeuGlu: 4.731 ± 0.038	2.815LeuPhe: 2.815 ± 0.03	9.795LeuGly: 9.795 ± 0.057	2.165LeuHis: 2.165 ± 0.024	4.049LeuIle: 4.049 ± 0.041	1.934LeuLys: 1.934 ± 0.028	11.617LeuLeu: 11.617 ± 0.076	1.792LeuMet: 1.792 ± 0.022	1.788LeuAsn: 1.788 ± 0.022	6.541LeuPro: 6.541 ± 0.041	2.225LeuGln: 2.225 ± 0.027	8.883LeuArg: 8.883 ± 0.056	5.913LeuSer: 5.913 ± 0.039	6.78LeuThr: 6.78 ± 0.045	8.979LeuVal: 8.979 ± 0.068	1.377LeuTrp: 1.377 ± 0.021	1.94LeuTyr: 1.94 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.364MetAla: 2.364 ± 0.027	0.132MetCys: 0.132 ± 0.006	0.895MetAsp: 0.895 ± 0.014	0.812MetGlu: 0.812 ± 0.014	0.521MetPhe: 0.521 ± 0.013	1.365MetGly: 1.365 ± 0.019	0.352MetHis: 0.352 ± 0.01	0.881MetIle: 0.881 ± 0.016	0.435MetLys: 0.435 ± 0.01	1.918MetLeu: 1.918 ± 0.021	0.336MetMet: 0.336 ± 0.009	0.455MetAsn: 0.455 ± 0.011	1.123MetPro: 1.123 ± 0.021	0.422MetGln: 0.422 ± 0.01	1.673MetArg: 1.673 ± 0.021	1.381MetSer: 1.381 ± 0.018	1.537MetThr: 1.537 ± 0.021	1.403MetVal: 1.403 ± 0.02	0.235MetTrp: 0.235 ± 0.008	0.328MetTyr: 0.328 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.187AsnAla: 2.187 ± 0.026	0.153AsnCys: 0.153 ± 0.006	0.955AsnAsp: 0.955 ± 0.018	0.832AsnGlu: 0.832 ± 0.016	0.492AsnPhe: 0.492 ± 0.012	1.905AsnGly: 1.905 ± 0.027	0.375AsnHis: 0.375 ± 0.01	0.654AsnIle: 0.654 ± 0.014	0.37AsnLys: 0.37 ± 0.011	1.86AsnLeu: 1.86 ± 0.027	0.301AsnMet: 0.301 ± 0.009	0.417AsnAsn: 0.417 ± 0.013	1.398AsnPro: 1.398 ± 0.021	0.521AsnGln: 0.521 ± 0.01	1.276AsnArg: 1.276 ± 0.019	0.849AsnSer: 0.849 ± 0.017	1.051AsnThr: 1.051 ± 0.019	1.56AsnVal: 1.56 ± 0.023	0.298AsnTrp: 0.298 ± 0.01	0.421AsnTyr: 0.421 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.607ProAla: 8.607 ± 0.053	0.336ProCys: 0.336 ± 0.01	4.188ProAsp: 4.188 ± 0.035	4.093ProGlu: 4.093 ± 0.036	1.628ProPhe: 1.628 ± 0.024	6.825ProGly: 6.825 ± 0.049	1.211ProHis: 1.211 ± 0.019	1.849ProIle: 1.849 ± 0.021	1.156ProLys: 1.156 ± 0.02	5.308ProLeu: 5.308 ± 0.041	1.143ProMet: 1.143 ± 0.018	0.923ProAsn: 0.923 ± 0.017	3.662ProPro: 3.662 ± 0.044	1.6ProGln: 1.6 ± 0.022	3.723ProArg: 3.723 ± 0.034	3.163ProSer: 3.163 ± 0.035	2.75ProThr: 2.75 ± 0.032	5.198ProVal: 5.198 ± 0.041	0.942ProTrp: 0.942 ± 0.014	1.496ProTyr: 1.496 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	4.189GlnAla: 4.189 ± 0.038	0.168GlnCys: 0.168 ± 0.006	1.363GlnAsp: 1.363 ± 0.018	1.478GlnGlu: 1.478 ± 0.022	0.693GlnPhe: 0.693 ± 0.014	2.249GlnGly: 2.249 ± 0.027	0.609GlnHis: 0.609 ± 0.014	1.225GlnIle: 1.225 ± 0.019	0.497GlnLys: 0.497 ± 0.011	2.892GlnLeu: 2.892 ± 0.028	0.457GlnMet: 0.457 ± 0.012	0.501GlnAsn: 0.501 ± 0.013	1.775GlnPro: 1.775 ± 0.028	1.096GlnGln: 1.096 ± 0.026	2.338GlnArg: 2.338 ± 0.024	1.28GlnSer: 1.28 ± 0.021	1.318GlnThr: 1.318 ± 0.02	2.7GlnVal: 2.7 ± 0.027	0.461GlnTrp: 0.461 ± 0.011	0.534GlnTyr: 0.534 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	9.654ArgAla: 9.654 ± 0.058	0.583ArgCys: 0.583 ± 0.015	4.294ArgAsp: 4.294 ± 0.033	4.569ArgGlu: 4.569 ± 0.04	2.428ArgPhe: 2.428 ± 0.028	5.651ArgGly: 5.651 ± 0.047	2.189ArgHis: 2.189 ± 0.021	3.2ArgIle: 3.2 ± 0.025	1.599ArgLys: 1.599 ± 0.02	9.724ArgLeu: 9.724 ± 0.057	1.85ArgMet: 1.85 ± 0.022	1.375ArgAsn: 1.375 ± 0.021	4.963ArgPro: 4.963 ± 0.043	2.489ArgGln: 2.489 ± 0.028	7.775ArgArg: 7.775 ± 0.054	3.936ArgSer: 3.936 ± 0.03	4.614ArgThr: 4.614 ± 0.039	6.104ArgVal: 6.104 ± 0.041	1.431ArgTrp: 1.431 ± 0.02	1.921ArgTyr: 1.921 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.655SerAla: 6.655 ± 0.048	0.412SerCys: 0.412 ± 0.011	2.572SerAsp: 2.572 ± 0.024	2.402SerGlu: 2.402 ± 0.025	1.629SerPhe: 1.629 ± 0.023	6.026SerGly: 6.026 ± 0.047	0.98SerHis: 0.98 ± 0.016	1.803SerIle: 1.803 ± 0.021	1.01SerLys: 1.01 ± 0.019	4.944SerLeu: 4.944 ± 0.039	1.226SerMet: 1.226 ± 0.022	0.874SerAsn: 0.874 ± 0.018	3.262SerPro: 3.262 ± 0.032	1.265SerGln: 1.265 ± 0.02	3.755SerArg: 3.755 ± 0.032	2.836SerSer: 2.836 ± 0.03	2.864SerThr: 2.864 ± 0.031	4.237SerVal: 4.237 ± 0.035	1.012SerTrp: 1.012 ± 0.018	1.27SerTyr: 1.27 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	7.774ThrAla: 7.774 ± 0.045	0.464ThrCys: 0.464 ± 0.011	2.904ThrAsp: 2.904 ± 0.033	2.717ThrGlu: 2.717 ± 0.028	1.79ThrPhe: 1.79 ± 0.022	6.48ThrGly: 6.48 ± 0.049	1.106ThrHis: 1.106 ± 0.017	2.128ThrIle: 2.128 ± 0.024	1.129ThrLys: 1.129 ± 0.018	5.806ThrLeu: 5.806 ± 0.04	1.106ThrMet: 1.106 ± 0.018	0.978ThrAsn: 0.978 ± 0.016	3.9ThrPro: 3.9 ± 0.034	1.356ThrGln: 1.356 ± 0.021	3.909ThrArg: 3.909 ± 0.037	3.176ThrSer: 3.176 ± 0.029	3.618ThrThr: 3.618 ± 0.04	5.456ThrVal: 5.456 ± 0.041	0.996ThrTrp: 0.996 ± 0.017	1.356ThrTyr: 1.356 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	11.431ValAla: 11.431 ± 0.074	0.708ValCys: 0.708 ± 0.014	4.389ValAsp: 4.389 ± 0.037	4.699ValGlu: 4.699 ± 0.035	2.514ValPhe: 2.514 ± 0.025	6.298ValGly: 6.298 ± 0.044	1.818ValHis: 1.818 ± 0.021	3.398ValIle: 3.398 ± 0.027	1.788ValLys: 1.788 ± 0.025	9.685ValLeu: 9.685 ± 0.058	1.463ValMet: 1.463 ± 0.021	1.768ValAsn: 1.768 ± 0.024	5.208ValPro: 5.208 ± 0.036	2.063ValGln: 2.063 ± 0.024	6.946ValArg: 6.946 ± 0.044	4.719ValSer: 4.719 ± 0.033	5.869ValThr: 5.869 ± 0.042	7.796ValVal: 7.796 ± 0.056	1.153ValTrp: 1.153 ± 0.022	1.718ValTyr: 1.718 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.715TrpAla: 1.715 ± 0.024	0.153TrpCys: 0.153 ± 0.006	0.837TrpAsp: 0.837 ± 0.019	0.754TrpGlu: 0.754 ± 0.012	0.509TrpPhe: 0.509 ± 0.014	1.094TrpGly: 1.094 ± 0.017	0.425TrpHis: 0.425 ± 0.011	0.618TrpIle: 0.618 ± 0.012	0.334TrpLys: 0.334 ± 0.01	1.932TrpLeu: 1.932 ± 0.027	0.315TrpMet: 0.315 ± 0.008	0.437TrpAsn: 0.437 ± 0.011	0.868TrpPro: 0.868 ± 0.018	0.633TrpGln: 0.633 ± 0.012	1.483TrpArg: 1.483 ± 0.019	1.029TrpSer: 1.029 ± 0.018	1.028TrpThr: 1.028 ± 0.018	1.026TrpVal: 1.026 ± 0.016	0.366TrpTrp: 0.366 ± 0.01	0.378TrpTyr: 0.378 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.771TyrAla: 2.771 ± 0.029	0.191TyrCys: 0.191 ± 0.007	1.486TyrAsp: 1.486 ± 0.027	1.209TyrGlu: 1.209 ± 0.018	0.685TyrPhe: 0.685 ± 0.014	2.309TyrGly: 2.309 ± 0.028	0.457TyrHis: 0.457 ± 0.011	0.547TyrIle: 0.547 ± 0.013	0.372TyrLys: 0.372 ± 0.011	2.373TyrLeu: 2.373 ± 0.027	0.272TyrMet: 0.272 ± 0.009	0.457TyrAsn: 0.457 ± 0.013	1.158TyrPro: 1.158 ± 0.02	0.66TyrGln: 0.66 ± 0.015	1.901TyrArg: 1.901 ± 0.025	1.027TyrSer: 1.027 ± 0.017	1.264TyrThr: 1.264 ± 0.022	1.847TyrVal: 1.847 ± 0.024	0.383TyrTrp: 0.383 ± 0.01	0.516TyrTyr: 0.516 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12011 proteins (3909505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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