Amino acid dipepetide frequency for Schistosoma haematobium (Blood fluke)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.292AlaAla: 3.292 ± 0.041
1.02AlaCys: 1.02 ± 0.016
2.241AlaAsp: 2.241 ± 0.025
2.503AlaGlu: 2.503 ± 0.028
2.001AlaPhe: 2.001 ± 0.023
2.092AlaGly: 2.092 ± 0.032
1.035AlaHis: 1.035 ± 0.013
2.831AlaIle: 2.831 ± 0.025
2.401AlaLys: 2.401 ± 0.028
4.497AlaLeu: 4.497 ± 0.035
0.934AlaMet: 0.934 ± 0.014
2.47AlaAsn: 2.47 ± 0.024
1.77AlaPro: 1.77 ± 0.021
1.649AlaGln: 1.649 ± 0.02
2.355AlaArg: 2.355 ± 0.024
4.142AlaSer: 4.142 ± 0.033
2.797AlaThr: 2.797 ± 0.027
2.932AlaVal: 2.932 ± 0.029
0.466AlaTrp: 0.466 ± 0.011
1.588AlaTyr: 1.588 ± 0.019
0.0AlaXaa: 0.0 ± 0.0
Cys
0.932CysAla: 0.932 ± 0.015
0.565CysCys: 0.565 ± 0.013
1.158CysAsp: 1.158 ± 0.018
1.122CysGlu: 1.122 ± 0.016
0.937CysPhe: 0.937 ± 0.014
1.076CysGly: 1.076 ± 0.015
0.641CysHis: 0.641 ± 0.013
1.572CysIle: 1.572 ± 0.019
1.143CysLys: 1.143 ± 0.019
2.541CysLeu: 2.541 ± 0.028
0.378CysMet: 0.378 ± 0.008
1.196CysAsn: 1.196 ± 0.017
1.078CysPro: 1.078 ± 0.019
0.913CysGln: 0.913 ± 0.015
1.159CysArg: 1.159 ± 0.016
2.175CysSer: 2.175 ± 0.024
1.255CysThr: 1.255 ± 0.017
1.13CysVal: 1.13 ± 0.016
0.265CysTrp: 0.265 ± 0.006
0.649CysTyr: 0.649 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
2.161AspAla: 2.161 ± 0.025
1.075AspCys: 1.075 ± 0.014
3.921AspAsp: 3.921 ± 0.054
3.573AspGlu: 3.573 ± 0.034
2.028AspPhe: 2.028 ± 0.019
2.514AspGly: 2.514 ± 0.057
1.656AspHis: 1.656 ± 0.023
3.584AspIle: 3.584 ± 0.023
2.827AspLys: 2.827 ± 0.025
4.994AspLeu: 4.994 ± 0.031
0.993AspMet: 0.993 ± 0.013
3.676AspAsn: 3.676 ± 0.036
2.194AspPro: 2.194 ± 0.02
2.014AspGln: 2.014 ± 0.019
2.42AspArg: 2.42 ± 0.024
4.682AspSer: 4.682 ± 0.034
2.617AspThr: 2.617 ± 0.02
2.943AspVal: 2.943 ± 0.026
0.654AspTrp: 0.654 ± 0.012
1.87AspTyr: 1.87 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
2.788GluAla: 2.788 ± 0.033
1.076GluCys: 1.076 ± 0.018
2.858GluAsp: 2.858 ± 0.038
3.801GluGlu: 3.801 ± 0.043
2.193GluPhe: 2.193 ± 0.021
1.816GluGly: 1.816 ± 0.023
1.419GluHis: 1.419 ± 0.018
3.666GluIle: 3.666 ± 0.028
3.669GluLys: 3.669 ± 0.042
5.699GluLeu: 5.699 ± 0.047
1.206GluMet: 1.206 ± 0.017
3.815GluAsn: 3.815 ± 0.033
1.721GluPro: 1.721 ± 0.025
2.493GluGln: 2.493 ± 0.025
2.757GluArg: 2.757 ± 0.032
4.525GluSer: 4.525 ± 0.034
3.258GluThr: 3.258 ± 0.025
2.903GluVal: 2.903 ± 0.027
0.569GluTrp: 0.569 ± 0.011
1.826GluTyr: 1.826 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
1.718PheAla: 1.718 ± 0.022
0.872PheCys: 0.872 ± 0.015
2.17PheAsp: 2.17 ± 0.024
1.898PheGlu: 1.898 ± 0.021
1.373PhePhe: 1.373 ± 0.018
2.016PheGly: 2.016 ± 0.024
1.227PheHis: 1.227 ± 0.016
2.909PheIle: 2.909 ± 0.029
1.99PheLys: 1.99 ± 0.019
3.657PheLeu: 3.657 ± 0.029
0.784PheMet: 0.784 ± 0.012
2.651PheAsn: 2.651 ± 0.025
1.747PhePro: 1.747 ± 0.019
1.562PheGln: 1.562 ± 0.017
1.922PheArg: 1.922 ± 0.02
3.706PheSer: 3.706 ± 0.033
2.587PheThr: 2.587 ± 0.022
2.231PheVal: 2.231 ± 0.023
0.419PheTrp: 0.419 ± 0.01
1.373PheTyr: 1.373 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
1.911GlyAla: 1.911 ± 0.027
1.043GlyCys: 1.043 ± 0.017
2.267GlyAsp: 2.267 ± 0.043
2.218GlyGlu: 2.218 ± 0.046
1.909GlyPhe: 1.909 ± 0.024
2.636GlyGly: 2.636 ± 0.038
1.317GlyHis: 1.317 ± 0.016
3.0GlyIle: 3.0 ± 0.039
2.421GlyLys: 2.421 ± 0.028
4.409GlyLeu: 4.409 ± 0.044
0.839GlyMet: 0.839 ± 0.014
2.408GlyAsn: 2.408 ± 0.023
1.893GlyPro: 1.893 ± 0.053
1.77GlyGln: 1.77 ± 0.023
2.521GlyArg: 2.521 ± 0.031
4.188GlySer: 4.188 ± 0.038
2.419GlyThr: 2.419 ± 0.023
2.71GlyVal: 2.71 ± 0.028
0.599GlyTrp: 0.599 ± 0.012
1.568GlyTyr: 1.568 ± 0.02
0.0GlyXaa: 0.0 ± 0.0
His
0.996HisAla: 0.996 ± 0.013
0.707HisCys: 0.707 ± 0.012
1.319HisAsp: 1.319 ± 0.016
1.425HisGlu: 1.425 ± 0.016
1.177HisPhe: 1.177 ± 0.015
1.227HisGly: 1.227 ± 0.016
1.59HisHis: 1.59 ± 0.032
1.874HisIle: 1.874 ± 0.019
1.512HisLys: 1.512 ± 0.021
3.186HisLeu: 3.186 ± 0.028
0.519HisMet: 0.519 ± 0.009
1.874HisAsn: 1.874 ± 0.025
1.375HisPro: 1.375 ± 0.018
1.473HisGln: 1.473 ± 0.018
1.752HisArg: 1.752 ± 0.024
3.019HisSer: 3.019 ± 0.035
1.595HisThr: 1.595 ± 0.016
1.505HisVal: 1.505 ± 0.017
0.363HisTrp: 0.363 ± 0.009
1.038HisTyr: 1.038 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
2.78IleAla: 2.78 ± 0.024
1.528IleCys: 1.528 ± 0.018
3.84IleAsp: 3.84 ± 0.032
3.514IleGlu: 3.514 ± 0.03
2.445IlePhe: 2.445 ± 0.023
2.968IleGly: 2.968 ± 0.028
2.2IleHis: 2.2 ± 0.022
4.535IleIle: 4.535 ± 0.044
3.76IleLys: 3.76 ± 0.033
5.968IleLeu: 5.968 ± 0.043
1.238IleMet: 1.238 ± 0.014
5.027IleAsn: 5.027 ± 0.05
3.421IlePro: 3.421 ± 0.037
3.097IleGln: 3.097 ± 0.026
3.261IleArg: 3.261 ± 0.026
6.431IleSer: 6.431 ± 0.038
4.261IleThr: 4.261 ± 0.035
3.31IleVal: 3.31 ± 0.028
0.733IleTrp: 0.733 ± 0.013
2.224IleTyr: 2.224 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
2.703LysAla: 2.703 ± 0.026
1.327LysCys: 1.327 ± 0.019
2.557LysAsp: 2.557 ± 0.022
3.291LysGlu: 3.291 ± 0.033
2.075LysPhe: 2.075 ± 0.019
1.893LysGly: 1.893 ± 0.04
1.772LysHis: 1.772 ± 0.021
3.46LysIle: 3.46 ± 0.029
3.542LysLys: 3.542 ± 0.037
5.988LysLeu: 5.988 ± 0.043
1.192LysMet: 1.192 ± 0.014
3.303LysAsn: 3.303 ± 0.03
2.575LysPro: 2.575 ± 0.028
2.952LysGln: 2.952 ± 0.027
3.426LysArg: 3.426 ± 0.029
5.746LysSer: 5.746 ± 0.038
3.407LysThr: 3.407 ± 0.027
2.691LysVal: 2.691 ± 0.027
0.591LysTrp: 0.591 ± 0.011
2.017LysTyr: 2.017 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
4.793LeuAla: 4.793 ± 0.034
2.17LeuCys: 2.17 ± 0.026
4.786LeuAsp: 4.786 ± 0.027
5.042LeuGlu: 5.042 ± 0.049
4.061LeuPhe: 4.061 ± 0.035
3.944LeuGly: 3.944 ± 0.031
2.746LeuHis: 2.746 ± 0.021
6.475LeuIle: 6.475 ± 0.047
5.878LeuLys: 5.878 ± 0.038
10.176LeuLeu: 10.176 ± 0.059
1.915LeuMet: 1.915 ± 0.019
6.53LeuAsn: 6.53 ± 0.055
5.147LeuPro: 5.147 ± 0.036
4.063LeuGln: 4.063 ± 0.03
5.308LeuArg: 5.308 ± 0.04
10.003LeuSer: 10.003 ± 0.06
6.122LeuThr: 6.122 ± 0.037
4.907LeuVal: 4.907 ± 0.037
1.062LeuTrp: 1.062 ± 0.017
2.944LeuTyr: 2.944 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
0.974MetAla: 0.974 ± 0.015
0.365MetCys: 0.365 ± 0.009
1.101MetAsp: 1.101 ± 0.014
1.194MetGlu: 1.194 ± 0.015
0.763MetPhe: 0.763 ± 0.012
0.774MetGly: 0.774 ± 0.013
0.477MetHis: 0.477 ± 0.01
1.309MetIle: 1.309 ± 0.018
1.506MetLys: 1.506 ± 0.019
1.762MetLeu: 1.762 ± 0.017
0.536MetMet: 0.536 ± 0.017
1.822MetAsn: 1.822 ± 0.024
0.826MetPro: 0.826 ± 0.012
0.723MetGln: 0.723 ± 0.011
0.903MetArg: 0.903 ± 0.013
1.698MetSer: 1.698 ± 0.018
1.156MetThr: 1.156 ± 0.013
0.969MetVal: 0.969 ± 0.015
0.171MetTrp: 0.171 ± 0.005
0.559MetTyr: 0.559 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
2.514AsnAla: 2.514 ± 0.026
1.353AsnCys: 1.353 ± 0.018
4.175AsnAsp: 4.175 ± 0.039
4.106AsnGlu: 4.106 ± 0.038
2.287AsnPhe: 2.287 ± 0.023
2.839AsnGly: 2.839 ± 0.03
2.292AsnHis: 2.292 ± 0.028
4.566AsnIle: 4.566 ± 0.04
3.91AsnLys: 3.91 ± 0.035
5.97AsnLeu: 5.97 ± 0.042
1.211AsnMet: 1.211 ± 0.019
8.531AsnAsn: 8.531 ± 0.151
2.868AsnPro: 2.868 ± 0.026
3.304AsnGln: 3.304 ± 0.029
2.915AsnArg: 2.915 ± 0.023
7.283AsnSer: 7.283 ± 0.066
4.379AsnThr: 4.379 ± 0.045
3.355AsnVal: 3.355 ± 0.027
0.633AsnTrp: 0.633 ± 0.011
2.384AsnTyr: 2.384 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
1.775ProAla: 1.775 ± 0.02
0.936ProCys: 0.936 ± 0.015
2.293ProAsp: 2.293 ± 0.029
2.406ProGlu: 2.406 ± 0.021
1.745ProPhe: 1.745 ± 0.019
2.319ProGly: 2.319 ± 0.071
1.143ProHis: 1.143 ± 0.014
3.305ProIle: 3.305 ± 0.032
2.314ProLys: 2.314 ± 0.025
4.101ProLeu: 4.101 ± 0.029
0.818ProMet: 0.818 ± 0.013
2.936ProAsn: 2.936 ± 0.027
2.958ProPro: 2.958 ± 0.043
1.637ProGln: 1.637 ± 0.018
2.029ProArg: 2.029 ± 0.021
4.88ProSer: 4.88 ± 0.037
3.207ProThr: 3.207 ± 0.03
2.951ProVal: 2.951 ± 0.028
0.41ProTrp: 0.41 ± 0.01
1.475ProTyr: 1.475 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
1.838GlnAla: 1.838 ± 0.025
0.951GlnCys: 0.951 ± 0.015
1.553GlnAsp: 1.553 ± 0.017
1.921GlnGlu: 1.921 ± 0.023
1.714GlnPhe: 1.714 ± 0.018
1.298GlnGly: 1.298 ± 0.023
1.355GlnHis: 1.355 ± 0.018
2.898GlnIle: 2.898 ± 0.022
2.307GlnLys: 2.307 ± 0.023
5.101GlnLeu: 5.101 ± 0.041
0.957GlnMet: 0.957 ± 0.015
2.743GlnAsn: 2.743 ± 0.027
1.957GlnPro: 1.957 ± 0.026
2.904GlnGln: 2.904 ± 0.05
2.186GlnArg: 2.186 ± 0.02
4.4GlnSer: 4.4 ± 0.034
2.637GlnThr: 2.637 ± 0.023
1.929GlnVal: 1.929 ± 0.018
0.534GlnTrp: 0.534 ± 0.01
1.421GlnTyr: 1.421 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
2.28ArgAla: 2.28 ± 0.024
1.123ArgCys: 1.123 ± 0.02
2.166ArgAsp: 2.166 ± 0.026
2.542ArgGlu: 2.542 ± 0.027
2.125ArgPhe: 2.125 ± 0.021
2.116ArgGly: 2.116 ± 0.031
1.55ArgHis: 1.55 ± 0.02
3.476ArgIle: 3.476 ± 0.027
3.349ArgLys: 3.349 ± 0.033
5.87ArgLeu: 5.87 ± 0.041
1.047ArgMet: 1.047 ± 0.015
2.969ArgAsn: 2.969 ± 0.026
2.201ArgPro: 2.201 ± 0.023
2.283ArgGln: 2.283 ± 0.022
3.931ArgArg: 3.931 ± 0.042
4.494ArgSer: 4.494 ± 0.039
2.751ArgThr: 2.751 ± 0.027
2.628ArgVal: 2.628 ± 0.032
0.666ArgTrp: 0.666 ± 0.012
1.633ArgTyr: 1.633 ± 0.017
0.0ArgXaa: 0.0 ± 0.0
Ser
4.079SerAla: 4.079 ± 0.03
2.083SerCys: 2.083 ± 0.025
5.15SerAsp: 5.15 ± 0.037
4.931SerGlu: 4.931 ± 0.034
3.577SerPhe: 3.577 ± 0.028
4.752SerGly: 4.752 ± 0.041
2.683SerHis: 2.683 ± 0.028
6.536SerIle: 6.536 ± 0.043
5.234SerLys: 5.234 ± 0.037
9.163SerLeu: 9.163 ± 0.049
1.948SerMet: 1.948 ± 0.021
7.612SerAsn: 7.612 ± 0.074
4.615SerPro: 4.615 ± 0.041
3.817SerGln: 3.817 ± 0.033
4.524SerArg: 4.524 ± 0.04
14.724SerSer: 14.724 ± 0.409
7.162SerThr: 7.162 ± 0.058
5.792SerVal: 5.792 ± 0.044
0.909SerTrp: 0.909 ± 0.013
2.757SerTyr: 2.757 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
2.892ThrAla: 2.892 ± 0.024
1.303ThrCys: 1.303 ± 0.017
3.375ThrAsp: 3.375 ± 0.028
3.294ThrGlu: 3.294 ± 0.026
2.233ThrPhe: 2.233 ± 0.023
2.996ThrGly: 2.996 ± 0.032
1.501ThrHis: 1.501 ± 0.02
4.242ThrIle: 4.242 ± 0.033
3.273ThrLys: 3.273 ± 0.022
5.407ThrLeu: 5.407 ± 0.032
1.242ThrMet: 1.242 ± 0.015
4.972ThrAsn: 4.972 ± 0.044
2.899ThrPro: 2.899 ± 0.025
2.081ThrGln: 2.081 ± 0.021
2.604ThrArg: 2.604 ± 0.024
6.956ThrSer: 6.956 ± 0.058
6.566ThrThr: 6.566 ± 0.122
3.623ThrVal: 3.623 ± 0.03
0.668ThrTrp: 0.668 ± 0.011
1.823ThrTyr: 1.823 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
2.674ValAla: 2.674 ± 0.027
1.323ValCys: 1.323 ± 0.018
3.175ValAsp: 3.175 ± 0.026
2.955ValGlu: 2.955 ± 0.03
2.193ValPhe: 2.193 ± 0.02
2.679ValGly: 2.679 ± 0.029
1.523ValHis: 1.523 ± 0.018
3.366ValIle: 3.366 ± 0.025
3.117ValLys: 3.117 ± 0.028
4.95ValLeu: 4.95 ± 0.035
0.997ValMet: 0.997 ± 0.013
3.63ValAsn: 3.63 ± 0.027
2.34ValPro: 2.34 ± 0.027
2.104ValGln: 2.104 ± 0.021
2.767ValArg: 2.767 ± 0.03
4.959ValSer: 4.959 ± 0.039
3.341ValThr: 3.341 ± 0.025
3.338ValVal: 3.338 ± 0.036
0.574ValTrp: 0.574 ± 0.01
1.842ValTyr: 1.842 ± 0.02
0.0ValXaa: 0.0 ± 0.0
Trp
0.437TrpAla: 0.437 ± 0.01
0.27TrpCys: 0.27 ± 0.007
0.559TrpAsp: 0.559 ± 0.01
0.5TrpGlu: 0.5 ± 0.011
0.508TrpPhe: 0.508 ± 0.011
0.387TrpGly: 0.387 ± 0.009
0.289TrpHis: 0.289 ± 0.007
0.88TrpIle: 0.88 ± 0.015
0.737TrpLys: 0.737 ± 0.012
1.212TrpLeu: 1.212 ± 0.017
0.225TrpMet: 0.225 ± 0.007
0.724TrpAsn: 0.724 ± 0.013
0.534TrpPro: 0.534 ± 0.009
0.377TrpGln: 0.377 ± 0.009
0.686TrpArg: 0.686 ± 0.012
1.002TrpSer: 1.002 ± 0.016
0.581TrpThr: 0.581 ± 0.011
0.425TrpVal: 0.425 ± 0.011
0.155TrpTrp: 0.155 ± 0.005
0.337TrpTyr: 0.337 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.476TyrAla: 1.476 ± 0.017
0.796TyrCys: 0.796 ± 0.012
1.733TyrAsp: 1.733 ± 0.02
1.822TyrGlu: 1.822 ± 0.022
1.468TyrPhe: 1.468 ± 0.019
1.705TyrGly: 1.705 ± 0.022
1.11TyrHis: 1.11 ± 0.015
2.056TyrIle: 2.056 ± 0.026
1.62TyrLys: 1.62 ± 0.019
3.422TyrLeu: 3.422 ± 0.032
0.605TyrMet: 0.605 ± 0.013
1.99TyrAsn: 1.99 ± 0.024
1.518TyrPro: 1.518 ± 0.018
1.388TyrGln: 1.388 ± 0.016
1.773TyrArg: 1.773 ± 0.019
3.032TyrSer: 3.032 ± 0.027
1.855TyrThr: 1.855 ± 0.019
1.576TyrVal: 1.576 ± 0.019
0.384TyrTrp: 0.384 ± 0.008
1.233TyrTyr: 1.233 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.001
Statistics based on 8963 proteins (5861687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski