Amino acid dipepetide frequency for Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.483AlaAla: 9.483 ± 0.09
1.159AlaCys: 1.159 ± 0.034
3.534AlaAsp: 3.534 ± 0.024
4.698AlaGlu: 4.698 ± 0.029
2.15AlaPhe: 2.15 ± 0.018
4.594AlaGly: 4.594 ± 0.031
1.773AlaHis: 1.773 ± 0.016
3.55AlaIle: 3.55 ± 0.023
4.126AlaLys: 4.126 ± 0.026
6.538AlaLeu: 6.538 ± 0.037
1.701AlaMet: 1.701 ± 0.013
3.504AlaAsn: 3.504 ± 0.024
4.16AlaPro: 4.16 ± 0.047
3.616AlaGln: 3.616 ± 0.027
3.392AlaArg: 3.392 ± 0.022
6.192AlaSer: 6.192 ± 0.041
5.434AlaThr: 5.434 ± 0.037
4.454AlaVal: 4.454 ± 0.024
0.566AlaTrp: 0.566 ± 0.009
1.792AlaTyr: 1.792 ± 0.016
0.001AlaXaa: 0.001 ± 0.0
Cys
1.224CysAla: 1.224 ± 0.021
0.471CysCys: 0.471 ± 0.009
1.037CysAsp: 1.037 ± 0.014
1.125CysGlu: 1.125 ± 0.019
0.681CysPhe: 0.681 ± 0.01
1.274CysGly: 1.274 ± 0.042
0.469CysHis: 0.469 ± 0.01
0.993CysIle: 0.993 ± 0.029
1.008CysLys: 1.008 ± 0.014
1.614CysLeu: 1.614 ± 0.028
0.395CysMet: 0.395 ± 0.007
0.918CysAsn: 0.918 ± 0.014
0.91CysPro: 0.91 ± 0.034
0.75CysGln: 0.75 ± 0.025
1.039CysArg: 1.039 ± 0.046
1.47CysSer: 1.47 ± 0.028
0.99CysThr: 0.99 ± 0.022
1.139CysVal: 1.139 ± 0.029
0.188CysTrp: 0.188 ± 0.004
0.548CysTyr: 0.548 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.84AspAla: 3.84 ± 0.024
0.951AspCys: 0.951 ± 0.02
3.987AspAsp: 3.987 ± 0.045
4.404AspGlu: 4.404 ± 0.03
2.082AspPhe: 2.082 ± 0.017
3.107AspGly: 3.107 ± 0.029
1.056AspHis: 1.056 ± 0.01
3.039AspIle: 3.039 ± 0.028
2.841AspLys: 2.841 ± 0.046
4.634AspLeu: 4.634 ± 0.029
1.302AspMet: 1.302 ± 0.011
2.458AspAsn: 2.458 ± 0.022
2.352AspPro: 2.352 ± 0.04
1.746AspGln: 1.746 ± 0.013
2.334AspArg: 2.334 ± 0.02
3.848AspSer: 3.848 ± 0.026
2.607AspThr: 2.607 ± 0.018
3.432AspVal: 3.432 ± 0.021
0.596AspTrp: 0.596 ± 0.009
1.767AspTyr: 1.767 ± 0.014
0.0AspXaa: 0.0 ± 0.0
Glu
4.547GluAla: 4.547 ± 0.03
1.16GluCys: 1.16 ± 0.042
3.736GluAsp: 3.736 ± 0.036
5.599GluGlu: 5.599 ± 0.069
2.081GluPhe: 2.081 ± 0.018
2.794GluGly: 2.794 ± 0.027
1.74GluHis: 1.74 ± 0.014
3.297GluIle: 3.297 ± 0.023
4.26GluLys: 4.26 ± 0.043
6.435GluLeu: 6.435 ± 0.043
1.512GluMet: 1.512 ± 0.015
3.033GluAsn: 3.033 ± 0.02
2.903GluPro: 2.903 ± 0.034
3.705GluGln: 3.705 ± 0.03
4.126GluArg: 4.126 ± 0.031
4.344GluSer: 4.344 ± 0.034
3.434GluThr: 3.434 ± 0.033
3.509GluVal: 3.509 ± 0.036
0.559GluTrp: 0.559 ± 0.008
1.814GluTyr: 1.814 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.142PheAla: 2.142 ± 0.017
0.694PheCys: 0.694 ± 0.009
2.014PheAsp: 2.014 ± 0.016
2.09PheGlu: 2.09 ± 0.017
1.345PhePhe: 1.345 ± 0.017
2.254PheGly: 2.254 ± 0.026
0.849PheHis: 0.849 ± 0.01
1.836PheIle: 1.836 ± 0.017
1.84PheLys: 1.84 ± 0.015
3.116PheLeu: 3.116 ± 0.027
0.83PheMet: 0.83 ± 0.011
1.725PheAsn: 1.725 ± 0.016
1.333PhePro: 1.333 ± 0.014
1.362PheGln: 1.362 ± 0.013
1.802PheArg: 1.802 ± 0.019
2.45PheSer: 2.45 ± 0.017
1.765PheThr: 1.765 ± 0.015
2.287PheVal: 2.287 ± 0.019
0.394PheTrp: 0.394 ± 0.007
1.221PheTyr: 1.221 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
4.503GlyAla: 4.503 ± 0.034
0.96GlyCys: 0.96 ± 0.019
2.94GlyAsp: 2.94 ± 0.024
3.122GlyGlu: 3.122 ± 0.028
1.995GlyPhe: 1.995 ± 0.02
6.064GlyGly: 6.064 ± 0.077
1.464GlyHis: 1.464 ± 0.015
2.828GlyIle: 2.828 ± 0.017
3.014GlyLys: 3.014 ± 0.024
4.398GlyLeu: 4.398 ± 0.026
1.23GlyMet: 1.23 ± 0.015
3.061GlyAsn: 3.061 ± 0.025
2.323GlyPro: 2.323 ± 0.025
2.243GlyGln: 2.243 ± 0.019
2.868GlyArg: 2.868 ± 0.017
5.419GlySer: 5.419 ± 0.04
3.247GlyThr: 3.247 ± 0.021
3.404GlyVal: 3.404 ± 0.021
0.571GlyTrp: 0.571 ± 0.009
1.869GlyTyr: 1.869 ± 0.021
0.001GlyXaa: 0.001 ± 0.0
His
1.698HisAla: 1.698 ± 0.014
0.549HisCys: 0.549 ± 0.01
1.128HisAsp: 1.128 ± 0.011
1.466HisGlu: 1.466 ± 0.014
1.031HisPhe: 1.031 ± 0.009
1.415HisGly: 1.415 ± 0.013
1.283HisHis: 1.283 ± 0.022
1.415HisIle: 1.415 ± 0.013
1.385HisLys: 1.385 ± 0.011
2.424HisLeu: 2.424 ± 0.017
0.732HisMet: 0.732 ± 0.009
1.323HisAsn: 1.323 ± 0.013
1.28HisPro: 1.28 ± 0.013
1.657HisGln: 1.657 ± 0.021
1.371HisArg: 1.371 ± 0.014
2.105HisSer: 2.105 ± 0.018
1.423HisThr: 1.423 ± 0.012
1.455HisVal: 1.455 ± 0.013
0.289HisTrp: 0.289 ± 0.005
0.865HisTyr: 0.865 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
3.564IleAla: 3.564 ± 0.022
1.164IleCys: 1.164 ± 0.024
2.907IleAsp: 2.907 ± 0.022
3.473IleGlu: 3.473 ± 0.031
2.014IlePhe: 2.014 ± 0.018
2.711IleGly: 2.711 ± 0.024
1.063IleHis: 1.063 ± 0.011
2.831IleIle: 2.831 ± 0.021
3.059IleLys: 3.059 ± 0.027
4.154IleLeu: 4.154 ± 0.026
1.162IleMet: 1.162 ± 0.011
2.648IleAsn: 2.648 ± 0.025
2.299IlePro: 2.299 ± 0.018
1.971IleGln: 1.971 ± 0.015
2.392IleArg: 2.392 ± 0.017
4.069IleSer: 4.069 ± 0.024
3.005IleThr: 3.005 ± 0.029
3.29IleVal: 3.29 ± 0.024
0.511IleTrp: 0.511 ± 0.007
1.664IleTyr: 1.664 ± 0.015
0.001IleXaa: 0.001 ± 0.0
Lys
3.674LysAla: 3.674 ± 0.035
1.123LysCys: 1.123 ± 0.024
2.91LysAsp: 2.91 ± 0.034
3.853LysGlu: 3.853 ± 0.033
1.898LysPhe: 1.898 ± 0.018
2.295LysGly: 2.295 ± 0.019
1.479LysHis: 1.479 ± 0.014
2.903LysIle: 2.903 ± 0.027
4.278LysLys: 4.278 ± 0.064
5.507LysLeu: 5.507 ± 0.037
1.407LysMet: 1.407 ± 0.011
2.593LysAsn: 2.593 ± 0.018
3.272LysPro: 3.272 ± 0.083
3.003LysGln: 3.003 ± 0.021
3.811LysArg: 3.811 ± 0.023
4.311LysSer: 4.311 ± 0.032
3.268LysThr: 3.268 ± 0.023
3.021LysVal: 3.021 ± 0.03
0.607LysTrp: 0.607 ± 0.012
1.819LysTyr: 1.819 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
6.427LeuAla: 6.427 ± 0.031
1.64LeuCys: 1.64 ± 0.017
4.793LeuAsp: 4.793 ± 0.029
6.123LeuGlu: 6.123 ± 0.044
2.826LeuPhe: 2.826 ± 0.024
4.509LeuGly: 4.509 ± 0.028
2.499LeuHis: 2.499 ± 0.02
4.266LeuIle: 4.266 ± 0.026
5.405LeuLys: 5.405 ± 0.032
8.87LeuLeu: 8.87 ± 0.063
1.944LeuMet: 1.944 ± 0.014
4.49LeuAsn: 4.49 ± 0.026
4.961LeuPro: 4.961 ± 0.027
5.459LeuGln: 5.459 ± 0.038
5.413LeuArg: 5.413 ± 0.034
6.904LeuSer: 6.904 ± 0.036
4.849LeuThr: 4.849 ± 0.025
4.835LeuVal: 4.835 ± 0.03
0.822LeuTrp: 0.822 ± 0.01
2.44LeuTyr: 2.44 ± 0.02
0.001LeuXaa: 0.001 ± 0.0
Met
1.784MetAla: 1.784 ± 0.013
0.416MetCys: 0.416 ± 0.007
1.338MetAsp: 1.338 ± 0.012
1.546MetGlu: 1.546 ± 0.013
0.752MetPhe: 0.752 ± 0.009
1.276MetGly: 1.276 ± 0.014
0.656MetHis: 0.656 ± 0.009
0.88MetIle: 0.88 ± 0.011
1.184MetLys: 1.184 ± 0.012
2.192MetLeu: 2.192 ± 0.02
0.564MetMet: 0.564 ± 0.008
1.015MetAsn: 1.015 ± 0.011
1.399MetPro: 1.399 ± 0.014
1.326MetGln: 1.326 ± 0.013
1.416MetArg: 1.416 ± 0.012
1.835MetSer: 1.835 ± 0.015
1.125MetThr: 1.125 ± 0.014
1.186MetVal: 1.186 ± 0.011
0.221MetTrp: 0.221 ± 0.005
0.626MetTyr: 0.626 ± 0.007
0.001MetXaa: 0.001 ± 0.0
Asn
3.976AsnAla: 3.976 ± 0.031
0.952AsnCys: 0.952 ± 0.016
2.584AsnAsp: 2.584 ± 0.021
3.199AsnGlu: 3.199 ± 0.021
1.754AsnPhe: 1.754 ± 0.015
3.387AsnGly: 3.387 ± 0.029
1.119AsnHis: 1.119 ± 0.015
2.826AsnIle: 2.826 ± 0.019
2.673AsnLys: 2.673 ± 0.018
4.137AsnLeu: 4.137 ± 0.025
1.213AsnMet: 1.213 ± 0.012
4.046AsnAsn: 4.046 ± 0.045
2.137AsnPro: 2.137 ± 0.028
1.869AsnGln: 1.869 ± 0.015
2.291AsnArg: 2.291 ± 0.018
4.58AsnSer: 4.58 ± 0.036
2.886AsnThr: 2.886 ± 0.019
3.061AsnVal: 3.061 ± 0.021
0.499AsnTrp: 0.499 ± 0.006
1.621AsnTyr: 1.621 ± 0.013
0.001AsnXaa: 0.001 ± 0.0
Pro
4.152ProAla: 4.152 ± 0.046
0.775ProCys: 0.775 ± 0.057
2.394ProAsp: 2.394 ± 0.017
3.237ProGlu: 3.237 ± 0.034
1.556ProPhe: 1.556 ± 0.015
2.747ProGly: 2.747 ± 0.029
1.455ProHis: 1.455 ± 0.015
2.54ProIle: 2.54 ± 0.033
2.999ProLys: 2.999 ± 0.03
4.402ProLeu: 4.402 ± 0.034
1.097ProMet: 1.097 ± 0.011
2.574ProAsn: 2.574 ± 0.026
5.056ProPro: 5.056 ± 0.068
2.931ProGln: 2.931 ± 0.033
2.411ProArg: 2.411 ± 0.019
4.426ProSer: 4.426 ± 0.041
3.952ProThr: 3.952 ± 0.041
3.138ProVal: 3.138 ± 0.03
0.41ProTrp: 0.41 ± 0.006
1.431ProTyr: 1.431 ± 0.013
0.001ProXaa: 0.001 ± 0.0
Gln
3.396GlnAla: 3.396 ± 0.021
0.824GlnCys: 0.824 ± 0.023
1.861GlnAsp: 1.861 ± 0.014
2.86GlnGlu: 2.86 ± 0.025
1.463GlnPhe: 1.463 ± 0.011
1.879GlnGly: 1.879 ± 0.017
2.014GlnHis: 2.014 ± 0.023
2.257GlnIle: 2.257 ± 0.016
2.753GlnLys: 2.753 ± 0.023
5.416GlnLeu: 5.416 ± 0.036
1.246GlnMet: 1.246 ± 0.011
2.18GlnAsn: 2.18 ± 0.016
2.997GlnPro: 2.997 ± 0.035
9.036GlnGln: 9.036 ± 0.15
3.432GlnArg: 3.432 ± 0.025
3.617GlnSer: 3.617 ± 0.026
2.757GlnThr: 2.757 ± 0.021
2.338GlnVal: 2.338 ± 0.016
0.451GlnTrp: 0.451 ± 0.007
1.318GlnTyr: 1.318 ± 0.014
0.002GlnXaa: 0.002 ± 0.0
Arg
3.457ArgAla: 3.457 ± 0.02
1.017ArgCys: 1.017 ± 0.019
2.795ArgAsp: 2.795 ± 0.02
3.54ArgGlu: 3.54 ± 0.031
1.884ArgPhe: 1.884 ± 0.015
2.677ArgGly: 2.677 ± 0.02
1.532ArgHis: 1.532 ± 0.014
2.76ArgIle: 2.76 ± 0.02
3.559ArgLys: 3.559 ± 0.021
4.967ArgLeu: 4.967 ± 0.033
1.182ArgMet: 1.182 ± 0.012
2.782ArgAsn: 2.782 ± 0.018
2.649ArgPro: 2.649 ± 0.03
2.898ArgGln: 2.898 ± 0.024
4.265ArgArg: 4.265 ± 0.029
4.246ArgSer: 4.246 ± 0.034
2.893ArgThr: 2.893 ± 0.017
2.822ArgVal: 2.822 ± 0.02
0.553ArgTrp: 0.553 ± 0.009
1.647ArgTyr: 1.647 ± 0.013
0.002ArgXaa: 0.002 ± 0.0
Ser
6.249SerAla: 6.249 ± 0.043
1.376SerCys: 1.376 ± 0.029
4.098SerAsp: 4.098 ± 0.037
4.496SerGlu: 4.496 ± 0.031
2.487SerPhe: 2.487 ± 0.019
5.46SerGly: 5.46 ± 0.039
1.841SerHis: 1.841 ± 0.017
3.799SerIle: 3.799 ± 0.021
4.229SerLys: 4.229 ± 0.026
6.596SerLeu: 6.596 ± 0.031
1.732SerMet: 1.732 ± 0.015
4.752SerAsn: 4.752 ± 0.037
4.575SerPro: 4.575 ± 0.042
3.425SerGln: 3.425 ± 0.025
3.802SerArg: 3.802 ± 0.028
9.98SerSer: 9.98 ± 0.093
5.866SerThr: 5.866 ± 0.05
4.487SerVal: 4.487 ± 0.025
0.696SerTrp: 0.696 ± 0.008
2.165SerTyr: 2.165 ± 0.023
0.001SerXaa: 0.001 ± 0.0
Thr
5.147ThrAla: 5.147 ± 0.034
1.014ThrCys: 1.014 ± 0.021
2.81ThrAsp: 2.81 ± 0.018
3.452ThrGlu: 3.452 ± 0.028
1.845ThrPhe: 1.845 ± 0.016
3.439ThrGly: 3.439 ± 0.023
1.485ThrHis: 1.485 ± 0.014
3.06ThrIle: 3.06 ± 0.02
3.07ThrLys: 3.07 ± 0.025
5.215ThrLeu: 5.215 ± 0.027
1.224ThrMet: 1.224 ± 0.013
2.949ThrAsn: 2.949 ± 0.018
4.226ThrPro: 4.226 ± 0.042
2.626ThrGln: 2.626 ± 0.021
2.596ThrArg: 2.596 ± 0.019
5.306ThrSer: 5.306 ± 0.035
6.006ThrThr: 6.006 ± 0.087
3.571ThrVal: 3.571 ± 0.03
0.506ThrTrp: 0.506 ± 0.008
1.506ThrTyr: 1.506 ± 0.012
0.0ThrXaa: 0.0 ± 0.0
Val
4.652ValAla: 4.652 ± 0.027
1.156ValCys: 1.156 ± 0.024
3.257ValAsp: 3.257 ± 0.024
3.9ValGlu: 3.9 ± 0.039
1.928ValPhe: 1.928 ± 0.017
3.333ValGly: 3.333 ± 0.02
1.468ValHis: 1.468 ± 0.012
2.88ValIle: 2.88 ± 0.021
3.173ValLys: 3.173 ± 0.03
5.281ValLeu: 5.281 ± 0.03
1.253ValMet: 1.253 ± 0.013
2.686ValAsn: 2.686 ± 0.019
3.248ValPro: 3.248 ± 0.027
2.662ValGln: 2.662 ± 0.018
3.088ValArg: 3.088 ± 0.02
4.217ValSer: 4.217 ± 0.026
3.355ValThr: 3.355 ± 0.028
3.783ValVal: 3.783 ± 0.027
0.547ValTrp: 0.547 ± 0.008
1.613ValTyr: 1.613 ± 0.015
0.001ValXaa: 0.001 ± 0.0
Trp
0.546TrpAla: 0.546 ± 0.008
0.181TrpCys: 0.181 ± 0.004
0.503TrpAsp: 0.503 ± 0.011
0.518TrpGlu: 0.518 ± 0.009
0.367TrpPhe: 0.367 ± 0.006
0.46TrpGly: 0.46 ± 0.007
0.274TrpHis: 0.274 ± 0.006
0.511TrpIle: 0.511 ± 0.008
0.543TrpLys: 0.543 ± 0.009
1.072TrpLeu: 1.072 ± 0.013
0.246TrpMet: 0.246 ± 0.005
0.481TrpAsn: 0.481 ± 0.008
0.368TrpPro: 0.368 ± 0.007
0.495TrpGln: 0.495 ± 0.008
0.646TrpArg: 0.646 ± 0.008
0.699TrpSer: 0.699 ± 0.01
0.568TrpThr: 0.568 ± 0.009
0.519TrpVal: 0.519 ± 0.01
0.157TrpTrp: 0.157 ± 0.004
0.32TrpTyr: 0.32 ± 0.006
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.958TyrAla: 1.958 ± 0.018
0.659TyrCys: 0.659 ± 0.011
1.76TyrAsp: 1.76 ± 0.013
1.882TyrGlu: 1.882 ± 0.015
1.211TyrPhe: 1.211 ± 0.013
1.846TyrGly: 1.846 ± 0.016
0.777TyrHis: 0.777 ± 0.009
1.481TyrIle: 1.481 ± 0.014
1.633TyrLys: 1.633 ± 0.014
2.507TyrLeu: 2.507 ± 0.019
0.764TyrMet: 0.764 ± 0.009
1.59TyrAsn: 1.59 ± 0.014
1.234TyrPro: 1.234 ± 0.014
1.316TyrGln: 1.316 ± 0.013
1.632TyrArg: 1.632 ± 0.015
2.092TyrSer: 2.092 ± 0.021
1.625TyrThr: 1.625 ± 0.014
1.748TyrVal: 1.748 ± 0.015
0.329TyrTrp: 0.329 ± 0.006
1.109TyrTyr: 1.109 ± 0.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.001XaaHis: 0.001 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.002XaaAsn: 0.002 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.0
0.001XaaArg: 0.001 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.001XaaVal: 0.001 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17832 proteins (11910080 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski