Amino acid dipepetide frequency for Nocardioides sp. (strain ATCC BAA-499 / JS614)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.272AlaAla: 20.272 ± 0.191	1.034AlaCys: 1.034 ± 0.026	8.644AlaAsp: 8.644 ± 0.093	8.376AlaGlu: 8.376 ± 0.088	3.489AlaPhe: 3.489 ± 0.059	12.921AlaGly: 12.921 ± 0.114	2.682AlaHis: 2.682 ± 0.043	4.637AlaIle: 4.637 ± 0.054	2.48AlaLys: 2.48 ± 0.047	13.442AlaLeu: 13.442 ± 0.121	2.738AlaMet: 2.738 ± 0.04	2.074AlaAsn: 2.074 ± 0.039	6.185AlaPro: 6.185 ± 0.071	3.552AlaGln: 3.552 ± 0.049	9.982AlaArg: 9.982 ± 0.095	6.145AlaSer: 6.145 ± 0.067	7.739AlaThr: 7.739 ± 0.076	11.724AlaVal: 11.724 ± 0.11	1.999AlaTrp: 1.999 ± 0.04	2.603AlaTyr: 2.603 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.916CysAla: 0.916 ± 0.025	0.102CysCys: 0.102 ± 0.008	0.481CysAsp: 0.481 ± 0.017	0.398CysGlu: 0.398 ± 0.017	0.222CysPhe: 0.222 ± 0.013	0.875CysGly: 0.875 ± 0.026	0.209CysHis: 0.209 ± 0.011	0.198CysIle: 0.198 ± 0.013	0.106CysLys: 0.106 ± 0.008	0.689CysLeu: 0.689 ± 0.022	0.112CysMet: 0.112 ± 0.008	0.132CysAsn: 0.132 ± 0.008	0.483CysPro: 0.483 ± 0.021	0.192CysGln: 0.192 ± 0.011	0.603CysArg: 0.603 ± 0.02	0.447CysSer: 0.447 ± 0.018	0.489CysThr: 0.489 ± 0.022	0.628CysVal: 0.628 ± 0.019	0.119CysTrp: 0.119 ± 0.01	0.163CysTyr: 0.163 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.9AspAla: 7.9 ± 0.075	0.376AspCys: 0.376 ± 0.016	4.184AspAsp: 4.184 ± 0.056	4.334AspGlu: 4.334 ± 0.059	1.631AspPhe: 1.631 ± 0.036	6.302AspGly: 6.302 ± 0.083	1.565AspHis: 1.565 ± 0.037	1.864AspIle: 1.864 ± 0.04	1.0AspLys: 1.0 ± 0.029	7.526AspLeu: 7.526 ± 0.078	0.782AspMet: 0.782 ± 0.023	0.98AspAsn: 0.98 ± 0.031	4.784AspPro: 4.784 ± 0.058	2.009AspGln: 2.009 ± 0.033	5.343AspArg: 5.343 ± 0.062	2.445AspSer: 2.445 ± 0.042	2.873AspThr: 2.873 ± 0.043	5.84AspVal: 5.84 ± 0.07	1.032AspTrp: 1.032 ± 0.027	1.206AspTyr: 1.206 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.103GluAla: 7.103 ± 0.076	0.348GluCys: 0.348 ± 0.014	3.104GluAsp: 3.104 ± 0.048	3.37GluGlu: 3.37 ± 0.057	1.459GluPhe: 1.459 ± 0.03	4.202GluGly: 4.202 ± 0.058	1.827GluHis: 1.827 ± 0.035	2.498GluIle: 2.498 ± 0.042	1.153GluLys: 1.153 ± 0.03	6.727GluLeu: 6.727 ± 0.072	1.017GluMet: 1.017 ± 0.029	0.974GluAsn: 0.974 ± 0.028	3.269GluPro: 3.269 ± 0.056	2.324GluGln: 2.324 ± 0.044	5.392GluArg: 5.392 ± 0.073	2.661GluSer: 2.661 ± 0.038	2.994GluThr: 2.994 ± 0.046	5.508GluVal: 5.508 ± 0.054	0.808GluTrp: 0.808 ± 0.025	1.063GluTyr: 1.063 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.615PheAla: 3.615 ± 0.055	0.285PheCys: 0.285 ± 0.015	2.068PheAsp: 2.068 ± 0.038	1.694PheGlu: 1.694 ± 0.029	0.896PhePhe: 0.896 ± 0.029	2.99PheGly: 2.99 ± 0.047	0.606PheHis: 0.606 ± 0.021	0.775PheIle: 0.775 ± 0.024	0.474PheLys: 0.474 ± 0.019	2.64PheLeu: 2.64 ± 0.049	0.403PheMet: 0.403 ± 0.013	0.586PheAsn: 0.586 ± 0.021	1.296PhePro: 1.296 ± 0.03	0.645PheGln: 0.645 ± 0.023	1.791PheArg: 1.791 ± 0.031	1.381PheSer: 1.381 ± 0.033	1.846PheThr: 1.846 ± 0.04	2.663PheVal: 2.663 ± 0.042	0.414PheTrp: 0.414 ± 0.015	0.608PheTyr: 0.608 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.767GlyAla: 10.767 ± 0.102	0.882GlyCys: 0.882 ± 0.027	5.299GlyAsp: 5.299 ± 0.07	4.935GlyGlu: 4.935 ± 0.058	2.993GlyPhe: 2.993 ± 0.049	8.159GlyGly: 8.159 ± 0.099	2.239GlyHis: 2.239 ± 0.04	3.751GlyIle: 3.751 ± 0.057	2.023GlyLys: 2.023 ± 0.041	9.813GlyLeu: 9.813 ± 0.086	2.061GlyMet: 2.061 ± 0.036	1.628GlyAsn: 1.628 ± 0.042	4.762GlyPro: 4.762 ± 0.063	2.618GlyGln: 2.618 ± 0.046	7.581GlyArg: 7.581 ± 0.082	5.414GlySer: 5.414 ± 0.065	5.648GlyThr: 5.648 ± 0.06	8.072GlyVal: 8.072 ± 0.082	1.714GlyTrp: 1.714 ± 0.038	2.256GlyTyr: 2.256 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.731HisAla: 2.731 ± 0.049	0.195HisCys: 0.195 ± 0.011	1.546HisAsp: 1.546 ± 0.034	1.372HisGlu: 1.372 ± 0.031	0.572HisPhe: 0.572 ± 0.019	2.341HisGly: 2.341 ± 0.048	0.695HisHis: 0.695 ± 0.024	0.557HisIle: 0.557 ± 0.019	0.323HisLys: 0.323 ± 0.012	2.473HisLeu: 2.473 ± 0.042	0.33HisMet: 0.33 ± 0.015	0.371HisAsn: 0.371 ± 0.018	1.7HisPro: 1.7 ± 0.031	0.721HisGln: 0.721 ± 0.021	2.03HisArg: 2.03 ± 0.04	0.879HisSer: 0.879 ± 0.024	1.165HisThr: 1.165 ± 0.025	1.965HisVal: 1.965 ± 0.035	0.362HisTrp: 0.362 ± 0.016	0.46HisTyr: 0.46 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.132IleAla: 5.132 ± 0.065	0.309IleCys: 0.309 ± 0.014	2.58IleAsp: 2.58 ± 0.043	2.383IleGlu: 2.383 ± 0.049	0.844IlePhe: 0.844 ± 0.028	3.834IleGly: 3.834 ± 0.062	0.685IleHis: 0.685 ± 0.019	1.032IleIle: 1.032 ± 0.031	0.737IleLys: 0.737 ± 0.022	2.673IleLeu: 2.673 ± 0.05	0.456IleMet: 0.456 ± 0.018	0.753IleAsn: 0.753 ± 0.025	1.803IlePro: 1.803 ± 0.035	0.796IleGln: 0.796 ± 0.025	2.415IleArg: 2.415 ± 0.042	1.828IleSer: 1.828 ± 0.038	2.238IleThr: 2.238 ± 0.039	3.245IleVal: 3.245 ± 0.048	0.408IleTrp: 0.408 ± 0.017	0.61IleTyr: 0.61 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.478LysAla: 2.478 ± 0.046	0.09LysCys: 0.09 ± 0.008	1.036LysAsp: 1.036 ± 0.028	0.942LysGlu: 0.942 ± 0.026	0.466LysPhe: 0.466 ± 0.017	1.483LysGly: 1.483 ± 0.034	0.413LysHis: 0.413 ± 0.017	0.784LysIle: 0.784 ± 0.025	0.636LysLys: 0.636 ± 0.029	1.609LysLeu: 1.609 ± 0.037	0.372LysMet: 0.372 ± 0.017	0.41LysAsn: 0.41 ± 0.019	1.131LysPro: 1.131 ± 0.033	0.631LysGln: 0.631 ± 0.02	1.369LysArg: 1.369 ± 0.037	1.031LysSer: 1.031 ± 0.031	1.147LysThr: 1.147 ± 0.034	1.823LysVal: 1.823 ± 0.04	0.221LysTrp: 0.221 ± 0.01	0.402LysTyr: 0.402 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.47LeuAla: 15.47 ± 0.126	0.723LeuCys: 0.723 ± 0.023	7.268LeuAsp: 7.268 ± 0.082	5.59LeuGlu: 5.59 ± 0.068	2.426LeuPhe: 2.426 ± 0.045	9.896LeuGly: 9.896 ± 0.09	2.175LeuHis: 2.175 ± 0.044	2.956LeuIle: 2.956 ± 0.054	1.587LeuLys: 1.587 ± 0.04	10.728LeuLeu: 10.728 ± 0.113	1.658LeuMet: 1.658 ± 0.031	1.615LeuAsn: 1.615 ± 0.035	5.805LeuPro: 5.805 ± 0.064	2.37LeuGln: 2.37 ± 0.041	8.034LeuArg: 8.034 ± 0.09	5.186LeuSer: 5.186 ± 0.055	6.335LeuThr: 6.335 ± 0.059	10.481LeuVal: 10.481 ± 0.095	1.24LeuTrp: 1.24 ± 0.029	1.501LeuTyr: 1.501 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.335MetAla: 2.335 ± 0.043	0.128MetCys: 0.128 ± 0.009	0.885MetAsp: 0.885 ± 0.026	0.726MetGlu: 0.726 ± 0.021	0.503MetPhe: 0.503 ± 0.021	1.374MetGly: 1.374 ± 0.031	0.366MetHis: 0.366 ± 0.016	0.684MetIle: 0.684 ± 0.02	0.401MetLys: 0.401 ± 0.016	1.864MetLeu: 1.864 ± 0.036	0.362MetMet: 0.362 ± 0.017	0.439MetAsn: 0.439 ± 0.017	1.092MetPro: 1.092 ± 0.029	0.457MetGln: 0.457 ± 0.016	1.531MetArg: 1.531 ± 0.029	1.522MetSer: 1.522 ± 0.028	1.719MetThr: 1.719 ± 0.032	1.504MetVal: 1.504 ± 0.032	0.207MetTrp: 0.207 ± 0.009	0.298MetTyr: 0.298 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.193AsnAla: 2.193 ± 0.041	0.151AsnCys: 0.151 ± 0.009	1.07AsnAsp: 1.07 ± 0.027	0.848AsnGlu: 0.848 ± 0.023	0.478AsnPhe: 0.478 ± 0.018	1.672AsnGly: 1.672 ± 0.035	0.393AsnHis: 0.393 ± 0.014	0.644AsnIle: 0.644 ± 0.023	0.364AsnLys: 0.364 ± 0.018	1.843AsnLeu: 1.843 ± 0.034	0.295AsnMet: 0.295 ± 0.013	0.381AsnAsn: 0.381 ± 0.017	1.374AsnPro: 1.374 ± 0.031	0.574AsnGln: 0.574 ± 0.019	1.273AsnArg: 1.273 ± 0.028	0.779AsnSer: 0.779 ± 0.023	0.951AsnThr: 0.951 ± 0.027	1.514AsnVal: 1.514 ± 0.031	0.273AsnTrp: 0.273 ± 0.014	0.376AsnTyr: 0.376 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.646ProAla: 7.646 ± 0.081	0.317ProCys: 0.317 ± 0.013	4.528ProAsp: 4.528 ± 0.061	4.007ProGlu: 4.007 ± 0.057	1.563ProPhe: 1.563 ± 0.031	5.844ProGly: 5.844 ± 0.063	1.224ProHis: 1.224 ± 0.031	1.73ProIle: 1.73 ± 0.039	0.967ProLys: 0.967 ± 0.029	4.767ProLeu: 4.767 ± 0.057	1.101ProMet: 1.101 ± 0.027	0.856ProAsn: 0.856 ± 0.024	2.944ProPro: 2.944 ± 0.05	1.418ProGln: 1.418 ± 0.031	3.747ProArg: 3.747 ± 0.054	3.025ProSer: 3.025 ± 0.043	3.492ProThr: 3.492 ± 0.053	5.269ProVal: 5.269 ± 0.061	0.912ProTrp: 0.912 ± 0.023	1.179ProTyr: 1.179 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.754GlnAla: 3.754 ± 0.054	0.153GlnCys: 0.153 ± 0.01	1.358GlnAsp: 1.358 ± 0.026	1.379GlnGlu: 1.379 ± 0.03	0.709GlnPhe: 0.709 ± 0.021	2.145GlnGly: 2.145 ± 0.039	0.706GlnHis: 0.706 ± 0.022	1.108GlnIle: 1.108 ± 0.027	0.515GlnLys: 0.515 ± 0.02	3.164GlnLeu: 3.164 ± 0.045	0.545GlnMet: 0.545 ± 0.019	0.456GlnAsn: 0.456 ± 0.02	1.656GlnPro: 1.656 ± 0.034	1.182GlnGln: 1.182 ± 0.033	2.469GlnArg: 2.469 ± 0.039	1.186GlnSer: 1.186 ± 0.028	1.342GlnThr: 1.342 ± 0.033	2.973GlnVal: 2.973 ± 0.052	0.402GlnTrp: 0.402 ± 0.014	0.524GlnTyr: 0.524 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.515ArgAla: 9.515 ± 0.102	0.567ArgCys: 0.567 ± 0.021	4.653ArgAsp: 4.653 ± 0.056	4.533ArgGlu: 4.533 ± 0.063	2.364ArgPhe: 2.364 ± 0.035	5.846ArgGly: 5.846 ± 0.069	1.997ArgHis: 1.997 ± 0.038	3.274ArgIle: 3.274 ± 0.043	1.461ArgLys: 1.461 ± 0.036	8.625ArgLeu: 8.625 ± 0.087	1.785ArgMet: 1.785 ± 0.032	1.336ArgAsn: 1.336 ± 0.029	4.618ArgPro: 4.618 ± 0.054	2.253ArgGln: 2.253 ± 0.044	7.659ArgArg: 7.659 ± 0.084	4.331ArgSer: 4.331 ± 0.06	4.792ArgThr: 4.792 ± 0.06	6.527ArgVal: 6.527 ± 0.067	1.367ArgTrp: 1.367 ± 0.033	1.628ArgTyr: 1.628 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.236SerAla: 6.236 ± 0.068	0.419SerCys: 0.419 ± 0.018	2.884SerAsp: 2.884 ± 0.049	2.537SerGlu: 2.537 ± 0.038	1.651SerPhe: 1.651 ± 0.033	5.594SerGly: 5.594 ± 0.072	0.997SerHis: 0.997 ± 0.025	1.845SerIle: 1.845 ± 0.037	0.919SerLys: 0.919 ± 0.023	4.874SerLeu: 4.874 ± 0.062	1.249SerMet: 1.249 ± 0.03	0.936SerAsn: 0.936 ± 0.023	2.87SerPro: 2.87 ± 0.042	1.277SerGln: 1.277 ± 0.03	3.832SerArg: 3.832 ± 0.052	3.068SerSer: 3.068 ± 0.053	3.323SerThr: 3.323 ± 0.047	4.418SerVal: 4.418 ± 0.049	0.915SerTrp: 0.915 ± 0.025	1.296SerTyr: 1.296 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.567ThrAla: 7.567 ± 0.075	0.451ThrCys: 0.451 ± 0.019	3.602ThrAsp: 3.602 ± 0.051	3.046ThrGlu: 3.046 ± 0.045	1.825ThrPhe: 1.825 ± 0.038	6.259ThrGly: 6.259 ± 0.076	1.242ThrHis: 1.242 ± 0.029	2.305ThrIle: 2.305 ± 0.04	1.096ThrLys: 1.096 ± 0.031	5.563ThrLeu: 5.563 ± 0.066	1.156ThrMet: 1.156 ± 0.029	1.081ThrAsn: 1.081 ± 0.028	3.826ThrPro: 3.826 ± 0.048	1.46ThrGln: 1.46 ± 0.032	4.108ThrArg: 4.108 ± 0.05	3.329ThrSer: 3.329 ± 0.049	4.028ThrThr: 4.028 ± 0.058	5.584ThrVal: 5.584 ± 0.06	1.027ThrTrp: 1.027 ± 0.026	1.429ThrTyr: 1.429 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	12.753ValAla: 12.753 ± 0.107	0.702ValCys: 0.702 ± 0.021	6.291ValAsp: 6.291 ± 0.062	5.572ValGlu: 5.572 ± 0.066	2.452ValPhe: 2.452 ± 0.039	7.828ValGly: 7.828 ± 0.093	2.021ValHis: 2.021 ± 0.035	3.129ValIle: 3.129 ± 0.046	1.602ValLys: 1.602 ± 0.033	9.983ValLeu: 9.983 ± 0.1	1.48ValMet: 1.48 ± 0.029	1.7ValAsn: 1.7 ± 0.04	5.123ValPro: 5.123 ± 0.057	2.17ValGln: 2.17 ± 0.034	7.088ValArg: 7.088 ± 0.071	4.556ValSer: 4.556 ± 0.062	5.871ValThr: 5.871 ± 0.062	10.246ValVal: 10.246 ± 0.106	1.11ValTrp: 1.11 ± 0.027	1.503ValTyr: 1.503 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.68TrpAla: 1.68 ± 0.035	0.155TrpCys: 0.155 ± 0.009	0.836TrpAsp: 0.836 ± 0.023	0.715TrpGlu: 0.715 ± 0.021	0.496TrpPhe: 0.496 ± 0.019	1.054TrpGly: 1.054 ± 0.028	0.365TrpHis: 0.365 ± 0.014	0.566TrpIle: 0.566 ± 0.019	0.299TrpLys: 0.299 ± 0.015	1.845TrpLeu: 1.845 ± 0.038	0.297TrpMet: 0.297 ± 0.015	0.364TrpAsn: 0.364 ± 0.014	0.802TrpPro: 0.802 ± 0.026	0.503TrpGln: 0.503 ± 0.018	1.303TrpArg: 1.303 ± 0.029	0.984TrpSer: 0.984 ± 0.027	0.953TrpThr: 0.953 ± 0.026	1.314TrpVal: 1.314 ± 0.03	0.374TrpTrp: 0.374 ± 0.016	0.299TrpTyr: 0.299 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.655TyrAla: 2.655 ± 0.038	0.176TyrCys: 0.176 ± 0.012	1.661TyrAsp: 1.661 ± 0.033	1.042TyrGlu: 1.042 ± 0.022	0.638TyrPhe: 0.638 ± 0.021	1.997TyrGly: 1.997 ± 0.04	0.383TyrHis: 0.383 ± 0.014	0.428TyrIle: 0.428 ± 0.016	0.331TyrLys: 0.331 ± 0.014	2.193TyrLeu: 2.193 ± 0.043	0.197TyrMet: 0.197 ± 0.011	0.376TyrAsn: 0.376 ± 0.015	1.012TyrPro: 1.012 ± 0.025	0.571TyrGln: 0.571 ± 0.02	1.583TyrArg: 1.583 ± 0.035	0.942TyrSer: 0.942 ± 0.024	1.041TyrThr: 1.041 ± 0.022	1.881TyrVal: 1.881 ± 0.037	0.297TyrTrp: 0.297 ± 0.013	0.429TyrTyr: 0.429 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4888 proteins (1591492 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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