Amino acid dipepetide frequency for Thorsellia anophelis DSM 18579

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.815AlaAla: 5.815 ± 0.115
0.755AlaCys: 0.755 ± 0.03
3.746AlaAsp: 3.746 ± 0.068
4.549AlaGlu: 4.549 ± 0.093
3.237AlaPhe: 3.237 ± 0.059
4.948AlaGly: 4.948 ± 0.091
1.455AlaHis: 1.455 ± 0.042
6.448AlaIle: 6.448 ± 0.093
5.264AlaLys: 5.264 ± 0.091
8.661AlaLeu: 8.661 ± 0.119
1.958AlaMet: 1.958 ± 0.047
3.911AlaAsn: 3.911 ± 0.067
2.492AlaPro: 2.492 ± 0.064
3.179AlaGln: 3.179 ± 0.062
3.074AlaArg: 3.074 ± 0.067
4.754AlaSer: 4.754 ± 0.07
3.915AlaThr: 3.915 ± 0.083
4.528AlaVal: 4.528 ± 0.084
0.762AlaTrp: 0.762 ± 0.029
2.276AlaTyr: 2.276 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.665CysAla: 0.665 ± 0.029
0.111CysCys: 0.111 ± 0.011
0.552CysAsp: 0.552 ± 0.025
0.586CysGlu: 0.586 ± 0.023
0.512CysPhe: 0.512 ± 0.026
0.615CysGly: 0.615 ± 0.024
0.26CysHis: 0.26 ± 0.017
0.69CysIle: 0.69 ± 0.027
0.436CysLys: 0.436 ± 0.022
0.938CysLeu: 0.938 ± 0.038
0.169CysMet: 0.169 ± 0.013
0.339CysAsn: 0.339 ± 0.021
0.354CysPro: 0.354 ± 0.023
0.389CysGln: 0.389 ± 0.024
0.356CysArg: 0.356 ± 0.021
0.539CysSer: 0.539 ± 0.024
0.406CysThr: 0.406 ± 0.022
0.556CysVal: 0.556 ± 0.026
0.102CysTrp: 0.102 ± 0.01
0.324CysTyr: 0.324 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.081AspAla: 4.081 ± 0.075
0.405AspCys: 0.405 ± 0.02
2.833AspAsp: 2.833 ± 0.071
4.119AspGlu: 4.119 ± 0.078
2.476AspPhe: 2.476 ± 0.055
3.379AspGly: 3.379 ± 0.105
0.845AspHis: 0.845 ± 0.031
4.59AspIle: 4.59 ± 0.066
3.863AspLys: 3.863 ± 0.08
4.938AspLeu: 4.938 ± 0.068
1.245AspMet: 1.245 ± 0.035
2.962AspAsn: 2.962 ± 0.068
2.023AspPro: 2.023 ± 0.055
1.353AspGln: 1.353 ± 0.037
2.045AspArg: 2.045 ± 0.058
3.339AspSer: 3.339 ± 0.061
2.719AspThr: 2.719 ± 0.063
3.258AspVal: 3.258 ± 0.06
0.743AspTrp: 0.743 ± 0.029
2.12AspTyr: 2.12 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
4.681GluAla: 4.681 ± 0.09
0.478GluCys: 0.478 ± 0.026
2.7GluAsp: 2.7 ± 0.066
3.475GluGlu: 3.475 ± 0.076
2.525GluPhe: 2.525 ± 0.055
3.336GluGly: 3.336 ± 0.061
1.404GluHis: 1.404 ± 0.04
5.248GluIle: 5.248 ± 0.083
3.918GluLys: 3.918 ± 0.08
6.901GluLeu: 6.901 ± 0.107
1.604GluMet: 1.604 ± 0.04
3.383GluAsn: 3.383 ± 0.058
1.999GluPro: 1.999 ± 0.047
3.345GluGln: 3.345 ± 0.072
2.725GluArg: 2.725 ± 0.063
4.004GluSer: 4.004 ± 0.07
3.379GluThr: 3.379 ± 0.06
3.739GluVal: 3.739 ± 0.071
0.681GluTrp: 0.681 ± 0.027
1.948GluTyr: 1.948 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.327PheAla: 3.327 ± 0.059
0.468PheCys: 0.468 ± 0.022
2.924PheAsp: 2.924 ± 0.061
2.697PheGlu: 2.697 ± 0.054
2.16PhePhe: 2.16 ± 0.054
2.953PheGly: 2.953 ± 0.059
0.802PheHis: 0.802 ± 0.032
3.703PheIle: 3.703 ± 0.087
2.701PheLys: 2.701 ± 0.053
3.869PheLeu: 3.869 ± 0.076
1.076PheMet: 1.076 ± 0.037
2.683PheAsn: 2.683 ± 0.061
1.472PhePro: 1.472 ± 0.042
1.219PheGln: 1.219 ± 0.038
1.5PheArg: 1.5 ± 0.042
3.427PheSer: 3.427 ± 0.062
2.626PheThr: 2.626 ± 0.053
2.501PheVal: 2.501 ± 0.052
0.554PheTrp: 0.554 ± 0.027
1.606PheTyr: 1.606 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.418GlyAla: 4.418 ± 0.083
0.673GlyCys: 0.673 ± 0.027
3.097GlyAsp: 3.097 ± 0.079
3.769GlyGlu: 3.769 ± 0.077
3.154GlyPhe: 3.154 ± 0.062
4.028GlyGly: 4.028 ± 0.105
1.28GlyHis: 1.28 ± 0.037
5.239GlyIle: 5.239 ± 0.09
3.97GlyLys: 3.97 ± 0.083
6.54GlyLeu: 6.54 ± 0.095
1.664GlyMet: 1.664 ± 0.045
2.97GlyAsn: 2.97 ± 0.1
1.471GlyPro: 1.471 ± 0.041
2.541GlyGln: 2.541 ± 0.058
2.553GlyArg: 2.553 ± 0.058
3.702GlySer: 3.702 ± 0.073
3.435GlyThr: 3.435 ± 0.074
4.291GlyVal: 4.291 ± 0.074
0.753GlyTrp: 0.753 ± 0.025
2.343GlyTyr: 2.343 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.608HisAla: 1.608 ± 0.045
0.245HisCys: 0.245 ± 0.014
1.039HisAsp: 1.039 ± 0.033
1.122HisGlu: 1.122 ± 0.031
1.123HisPhe: 1.123 ± 0.036
1.172HisGly: 1.172 ± 0.041
0.583HisHis: 0.583 ± 0.027
1.595HisIle: 1.595 ± 0.042
1.135HisLys: 1.135 ± 0.037
2.227HisLeu: 2.227 ± 0.059
0.386HisMet: 0.386 ± 0.02
1.031HisAsn: 1.031 ± 0.037
1.168HisPro: 1.168 ± 0.036
0.973HisGln: 0.973 ± 0.033
0.852HisArg: 0.852 ± 0.025
1.406HisSer: 1.406 ± 0.043
1.075HisThr: 1.075 ± 0.036
1.092HisVal: 1.092 ± 0.036
0.302HisTrp: 0.302 ± 0.02
0.886HisTyr: 0.886 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.785IleAla: 6.785 ± 0.099
0.764IleCys: 0.764 ± 0.031
5.26IleAsp: 5.26 ± 0.081
6.007IleGlu: 6.007 ± 0.093
3.154IlePhe: 3.154 ± 0.068
5.251IleGly: 5.251 ± 0.082
1.518IleHis: 1.518 ± 0.044
5.881IleIle: 5.881 ± 0.093
5.177IleLys: 5.177 ± 0.081
7.361IleLeu: 7.361 ± 0.116
1.531IleMet: 1.531 ± 0.043
4.596IleAsn: 4.596 ± 0.084
3.231IlePro: 3.231 ± 0.066
2.731IleGln: 2.731 ± 0.052
3.037IleArg: 3.037 ± 0.057
5.648IleSer: 5.648 ± 0.077
4.987IleThr: 4.987 ± 0.08
4.545IleVal: 4.545 ± 0.071
0.789IleTrp: 0.789 ± 0.031
2.342IleTyr: 2.342 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.599LysAla: 4.599 ± 0.088
0.372LysCys: 0.372 ± 0.02
2.877LysAsp: 2.877 ± 0.06
3.659LysGlu: 3.659 ± 0.067
2.102LysPhe: 2.102 ± 0.05
3.387LysGly: 3.387 ± 0.065
1.392LysHis: 1.392 ± 0.047
4.714LysIle: 4.714 ± 0.074
3.769LysLys: 3.769 ± 0.075
6.459LysLeu: 6.459 ± 0.093
1.532LysMet: 1.532 ± 0.046
3.376LysAsn: 3.376 ± 0.066
2.519LysPro: 2.519 ± 0.059
3.119LysGln: 3.119 ± 0.062
2.871LysArg: 2.871 ± 0.065
3.923LysSer: 3.923 ± 0.07
3.678LysThr: 3.678 ± 0.068
3.538LysVal: 3.538 ± 0.073
0.777LysTrp: 0.777 ± 0.032
1.765LysTyr: 1.765 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
8.578LeuAla: 8.578 ± 0.108
0.968LeuCys: 0.968 ± 0.031
5.6LeuAsp: 5.6 ± 0.083
6.022LeuGlu: 6.022 ± 0.102
4.544LeuPhe: 4.544 ± 0.081
6.585LeuGly: 6.585 ± 0.098
1.896LeuHis: 1.896 ± 0.048
8.441LeuIle: 8.441 ± 0.135
6.16LeuLys: 6.16 ± 0.086
10.404LeuLeu: 10.404 ± 0.146
2.555LeuMet: 2.555 ± 0.056
6.006LeuAsn: 6.006 ± 0.092
4.75LeuPro: 4.75 ± 0.071
3.397LeuGln: 3.397 ± 0.063
4.019LeuArg: 4.019 ± 0.08
8.649LeuSer: 8.649 ± 0.112
6.666LeuThr: 6.666 ± 0.094
6.092LeuVal: 6.092 ± 0.087
0.977LeuTrp: 0.977 ± 0.032
2.804LeuTyr: 2.804 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.82MetAla: 1.82 ± 0.043
0.185MetCys: 0.185 ± 0.016
1.035MetAsp: 1.035 ± 0.029
0.925MetGlu: 0.925 ± 0.033
0.824MetPhe: 0.824 ± 0.033
1.363MetGly: 1.363 ± 0.041
0.555MetHis: 0.555 ± 0.026
1.815MetIle: 1.815 ± 0.043
1.515MetLys: 1.515 ± 0.038
2.559MetLeu: 2.559 ± 0.053
0.675MetMet: 0.675 ± 0.029
1.311MetAsn: 1.311 ± 0.035
1.159MetPro: 1.159 ± 0.036
1.215MetGln: 1.215 ± 0.038
1.082MetArg: 1.082 ± 0.038
1.659MetSer: 1.659 ± 0.048
1.555MetThr: 1.555 ± 0.035
1.369MetVal: 1.369 ± 0.038
0.157MetTrp: 0.157 ± 0.012
0.517MetTyr: 0.517 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.797AsnAla: 3.797 ± 0.073
0.441AsnCys: 0.441 ± 0.023
2.785AsnAsp: 2.785 ± 0.056
3.456AsnGlu: 3.456 ± 0.067
2.088AsnPhe: 2.088 ± 0.058
3.149AsnGly: 3.149 ± 0.086
1.267AsnHis: 1.267 ± 0.042
3.979AsnIle: 3.979 ± 0.065
3.09AsnLys: 3.09 ± 0.067
5.346AsnLeu: 5.346 ± 0.09
1.108AsnMet: 1.108 ± 0.032
2.958AsnAsn: 2.958 ± 0.075
2.57AsnPro: 2.57 ± 0.064
3.101AsnGln: 3.101 ± 0.068
2.235AsnArg: 2.235 ± 0.05
3.564AsnSer: 3.564 ± 0.07
3.124AsnThr: 3.124 ± 0.075
2.771AsnVal: 2.771 ± 0.063
0.798AsnTrp: 0.798 ± 0.032
1.752AsnTyr: 1.752 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.579ProAla: 2.579 ± 0.058
0.251ProCys: 0.251 ± 0.015
2.277ProAsp: 2.277 ± 0.055
2.894ProGlu: 2.894 ± 0.065
1.898ProPhe: 1.898 ± 0.047
2.059ProGly: 2.059 ± 0.064
0.763ProHis: 0.763 ± 0.028
3.49ProIle: 3.49 ± 0.073
2.41ProLys: 2.41 ± 0.054
3.992ProLeu: 3.992 ± 0.066
0.821ProMet: 0.821 ± 0.033
2.393ProAsn: 2.393 ± 0.054
1.301ProPro: 1.301 ± 0.053
1.215ProGln: 1.215 ± 0.04
1.169ProArg: 1.169 ± 0.041
2.649ProSer: 2.649 ± 0.053
2.443ProThr: 2.443 ± 0.063
2.58ProVal: 2.58 ± 0.062
0.473ProTrp: 0.473 ± 0.027
1.404ProTyr: 1.404 ± 0.037
0.002ProXaa: 0.002 ± 0.001
Gln
3.528GlnAla: 3.528 ± 0.071
0.301GlnCys: 0.301 ± 0.017
1.862GlnAsp: 1.862 ± 0.047
2.041GlnGlu: 2.041 ± 0.051
1.932GlnPhe: 1.932 ± 0.044
2.39GlnGly: 2.39 ± 0.049
0.898GlnHis: 0.898 ± 0.034
3.307GlnIle: 3.307 ± 0.065
2.431GlnLys: 2.431 ± 0.057
4.694GlnLeu: 4.694 ± 0.096
0.977GlnMet: 0.977 ± 0.031
2.252GlnAsn: 2.252 ± 0.054
1.483GlnPro: 1.483 ± 0.046
1.931GlnGln: 1.931 ± 0.061
1.65GlnArg: 1.65 ± 0.044
3.234GlnSer: 3.234 ± 0.069
2.578GlnThr: 2.578 ± 0.055
2.575GlnVal: 2.575 ± 0.052
0.455GlnTrp: 0.455 ± 0.019
1.411GlnTyr: 1.411 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.925ArgAla: 2.925 ± 0.065
0.319ArgCys: 0.319 ± 0.018
2.134ArgAsp: 2.134 ± 0.049
2.492ArgGlu: 2.492 ± 0.061
2.167ArgPhe: 2.167 ± 0.043
2.153ArgGly: 2.153 ± 0.052
0.957ArgHis: 0.957 ± 0.036
3.201ArgIle: 3.201 ± 0.063
2.179ArgLys: 2.179 ± 0.052
4.628ArgLeu: 4.628 ± 0.083
0.954ArgMet: 0.954 ± 0.033
1.846ArgAsn: 1.846 ± 0.05
1.393ArgPro: 1.393 ± 0.038
1.793ArgGln: 1.793 ± 0.046
1.787ArgArg: 1.787 ± 0.05
2.282ArgSer: 2.282 ± 0.055
2.031ArgThr: 2.031 ± 0.044
2.607ArgVal: 2.607 ± 0.063
0.481ArgTrp: 0.481 ± 0.022
1.765ArgTyr: 1.765 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.846SerAla: 4.846 ± 0.079
0.572SerCys: 0.572 ± 0.027
3.64SerAsp: 3.64 ± 0.067
4.147SerGlu: 4.147 ± 0.065
3.063SerPhe: 3.063 ± 0.059
4.583SerGly: 4.583 ± 0.091
1.548SerHis: 1.548 ± 0.046
5.612SerIle: 5.612 ± 0.081
3.847SerLys: 3.847 ± 0.062
7.506SerLeu: 7.506 ± 0.115
1.525SerMet: 1.525 ± 0.042
3.534SerAsn: 3.534 ± 0.064
2.587SerPro: 2.587 ± 0.06
2.962SerGln: 2.962 ± 0.067
2.538SerArg: 2.538 ± 0.056
4.596SerSer: 4.596 ± 0.069
3.719SerThr: 3.719 ± 0.075
4.259SerVal: 4.259 ± 0.069
0.749SerTrp: 0.749 ± 0.031
2.082SerTyr: 2.082 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.169ThrAla: 4.169 ± 0.07
0.446ThrCys: 0.446 ± 0.023
3.064ThrAsp: 3.064 ± 0.066
3.347ThrGlu: 3.347 ± 0.056
2.396ThrPhe: 2.396 ± 0.06
3.936ThrGly: 3.936 ± 0.075
1.45ThrHis: 1.45 ± 0.039
4.374ThrIle: 4.374 ± 0.086
2.961ThrLys: 2.961 ± 0.065
6.884ThrLeu: 6.884 ± 0.103
1.048ThrMet: 1.048 ± 0.037
2.731ThrAsn: 2.731 ± 0.063
2.941ThrPro: 2.941 ± 0.072
2.762ThrGln: 2.762 ± 0.059
2.202ThrArg: 2.202 ± 0.056
3.494ThrSer: 3.494 ± 0.065
3.131ThrThr: 3.131 ± 0.07
3.586ThrVal: 3.586 ± 0.074
0.652ThrTrp: 0.652 ± 0.029
1.801ThrTyr: 1.801 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.468ValAla: 4.468 ± 0.084
0.597ValCys: 0.597 ± 0.026
3.452ValAsp: 3.452 ± 0.074
3.675ValGlu: 3.675 ± 0.07
2.608ValPhe: 2.608 ± 0.052
3.992ValGly: 3.992 ± 0.079
0.993ValHis: 0.993 ± 0.031
5.305ValIle: 5.305 ± 0.09
3.601ValLys: 3.601 ± 0.073
6.019ValLeu: 6.019 ± 0.105
1.569ValMet: 1.569 ± 0.041
3.294ValAsn: 3.294 ± 0.071
2.295ValPro: 2.295 ± 0.057
1.919ValGln: 1.919 ± 0.046
2.265ValArg: 2.265 ± 0.059
4.196ValSer: 4.196 ± 0.066
3.697ValThr: 3.697 ± 0.069
3.958ValVal: 3.958 ± 0.078
0.597ValTrp: 0.597 ± 0.027
1.724ValTyr: 1.724 ± 0.042
0.001ValXaa: 0.001 ± 0.001
Trp
0.696TrpAla: 0.696 ± 0.027
0.134TrpCys: 0.134 ± 0.012
0.596TrpAsp: 0.596 ± 0.025
0.567TrpGlu: 0.567 ± 0.023
0.561TrpPhe: 0.561 ± 0.028
0.677TrpGly: 0.677 ± 0.028
0.331TrpHis: 0.331 ± 0.02
0.8TrpIle: 0.8 ± 0.032
0.468TrpLys: 0.468 ± 0.025
1.54TrpLeu: 1.54 ± 0.045
0.298TrpMet: 0.298 ± 0.017
0.478TrpAsn: 0.478 ± 0.025
0.387TrpPro: 0.387 ± 0.021
0.835TrpGln: 0.835 ± 0.032
0.588TrpArg: 0.588 ± 0.023
0.727TrpSer: 0.727 ± 0.036
0.472TrpThr: 0.472 ± 0.022
0.719TrpVal: 0.719 ± 0.03
0.167TrpTrp: 0.167 ± 0.014
0.408TrpTyr: 0.408 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.341TyrAla: 2.341 ± 0.051
0.414TyrCys: 0.414 ± 0.021
1.86TyrAsp: 1.86 ± 0.053
1.923TyrGlu: 1.923 ± 0.045
1.743TyrPhe: 1.743 ± 0.046
1.934TyrGly: 1.934 ± 0.048
0.824TyrHis: 0.824 ± 0.033
2.159TyrIle: 2.159 ± 0.043
1.535TyrLys: 1.535 ± 0.048
3.648TyrLeu: 3.648 ± 0.078
0.6TyrMet: 0.6 ± 0.026
1.326TyrAsn: 1.326 ± 0.042
1.466TyrPro: 1.466 ± 0.037
1.949TyrGln: 1.949 ± 0.043
1.548TyrArg: 1.548 ± 0.043
2.124TyrSer: 2.124 ± 0.048
1.739TyrThr: 1.739 ± 0.053
1.663TyrVal: 1.663 ± 0.038
0.478TyrTrp: 0.478 ± 0.023
1.239TyrTyr: 1.239 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.007XaaXaa: 0.007 ± 0.004
Statistics based on 2885 proteins (965995 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski