Amino acid dipepetide frequency for Phytophthora infestans (strain T30-4) (Potato late blight fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.595AlaAla: 9.595 ± 0.059	1.325AlaCys: 1.325 ± 0.016	4.358AlaAsp: 4.358 ± 0.028	5.125AlaGlu: 5.125 ± 0.034	3.286AlaPhe: 3.286 ± 0.025	5.136AlaGly: 5.136 ± 0.065	1.805AlaHis: 1.805 ± 0.015	3.837AlaIle: 3.837 ± 0.025	4.665AlaLys: 4.665 ± 0.033	8.759AlaLeu: 8.759 ± 0.044	2.299AlaMet: 2.299 ± 0.02	3.013AlaAsn: 3.013 ± 0.027	3.963AlaPro: 3.963 ± 0.036	3.534AlaGln: 3.534 ± 0.027	5.028AlaArg: 5.028 ± 0.034	7.521AlaSer: 7.521 ± 0.043	5.774AlaThr: 5.774 ± 0.037	6.254AlaVal: 6.254 ± 0.039	0.932AlaTrp: 0.932 ± 0.011	1.984AlaTyr: 1.984 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.348CysAla: 1.348 ± 0.016	0.429CysCys: 0.429 ± 0.009	0.872CysAsp: 0.872 ± 0.012	0.926CysGlu: 0.926 ± 0.012	0.715CysPhe: 0.715 ± 0.011	1.261CysGly: 1.261 ± 0.018	0.399CysHis: 0.399 ± 0.008	0.785CysIle: 0.785 ± 0.011	0.735CysLys: 0.735 ± 0.011	1.452CysLeu: 1.452 ± 0.016	0.411CysMet: 0.411 ± 0.007	0.542CysAsn: 0.542 ± 0.009	0.809CysPro: 0.809 ± 0.022	0.582CysGln: 0.582 ± 0.012	1.026CysArg: 1.026 ± 0.015	1.466CysSer: 1.466 ± 0.017	0.986CysThr: 0.986 ± 0.012	1.305CysVal: 1.305 ± 0.015	0.248CysTrp: 0.248 ± 0.007	0.479CysTyr: 0.479 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.287AspAla: 5.287 ± 0.03	0.844AspCys: 0.844 ± 0.013	4.283AspAsp: 4.283 ± 0.034	4.802AspGlu: 4.802 ± 0.032	2.254AspPhe: 2.254 ± 0.017	3.892AspGly: 3.892 ± 0.032	1.131AspHis: 1.131 ± 0.012	2.51AspIle: 2.51 ± 0.022	2.602AspLys: 2.602 ± 0.023	4.757AspLeu: 4.757 ± 0.025	1.295AspMet: 1.295 ± 0.014	1.865AspAsn: 1.865 ± 0.019	2.481AspPro: 2.481 ± 0.019	1.839AspGln: 1.839 ± 0.015	2.782AspArg: 2.782 ± 0.021	4.053AspSer: 4.053 ± 0.029	2.982AspThr: 2.982 ± 0.022	4.474AspVal: 4.474 ± 0.024	0.649AspTrp: 0.649 ± 0.01	1.517AspTyr: 1.517 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.688GluAla: 5.688 ± 0.041	0.909GluCys: 0.909 ± 0.011	4.161GluAsp: 4.161 ± 0.028	5.701GluGlu: 5.701 ± 0.055	2.24GluPhe: 2.24 ± 0.02	3.19GluGly: 3.19 ± 0.023	1.496GluHis: 1.496 ± 0.018	2.921GluIle: 2.921 ± 0.025	3.856GluLys: 3.856 ± 0.033	6.694GluLeu: 6.694 ± 0.042	1.786GluMet: 1.786 ± 0.019	2.409GluAsn: 2.409 ± 0.021	2.201GluPro: 2.201 ± 0.02	2.948GluGln: 2.948 ± 0.025	4.272GluArg: 4.272 ± 0.03	4.247GluSer: 4.247 ± 0.028	3.572GluThr: 3.572 ± 0.025	4.048GluVal: 4.048 ± 0.024	0.766GluTrp: 0.766 ± 0.011	1.656GluTyr: 1.656 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.185PheAla: 3.185 ± 0.025	0.749PheCys: 0.749 ± 0.011	2.293PheAsp: 2.293 ± 0.018	2.299PheGlu: 2.299 ± 0.02	1.712PhePhe: 1.712 ± 0.018	2.791PheGly: 2.791 ± 0.024	0.964PheHis: 0.964 ± 0.012	1.593PheIle: 1.593 ± 0.017	1.622PheLys: 1.622 ± 0.014	3.683PheLeu: 3.683 ± 0.027	0.961PheMet: 0.961 ± 0.012	1.371PheAsn: 1.371 ± 0.014	1.676PhePro: 1.676 ± 0.018	1.534PheGln: 1.534 ± 0.014	2.151PheArg: 2.151 ± 0.019	3.048PheSer: 3.048 ± 0.021	2.109PheThr: 2.109 ± 0.017	2.971PheVal: 2.971 ± 0.024	0.48PheTrp: 0.48 ± 0.008	1.215PheTyr: 1.215 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.19GlyAla: 5.19 ± 0.045	1.096GlyCys: 1.096 ± 0.017	3.743GlyAsp: 3.743 ± 0.029	3.524GlyGlu: 3.524 ± 0.024	2.481GlyPhe: 2.481 ± 0.022	5.012GlyGly: 5.012 ± 0.059	1.486GlyHis: 1.486 ± 0.017	2.789GlyIle: 2.789 ± 0.023	3.251GlyLys: 3.251 ± 0.025	5.082GlyLeu: 5.082 ± 0.041	1.471GlyMet: 1.471 ± 0.018	2.441GlyAsn: 2.441 ± 0.021	2.0GlyPro: 2.0 ± 0.022	1.998GlyGln: 1.998 ± 0.018	3.499GlyArg: 3.499 ± 0.027	5.312GlySer: 5.312 ± 0.044	3.471GlyThr: 3.471 ± 0.028	4.693GlyVal: 4.693 ± 0.04	0.759GlyTrp: 0.759 ± 0.011	1.901GlyTyr: 1.901 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.906HisAla: 1.906 ± 0.017	0.45HisCys: 0.45 ± 0.007	1.262HisAsp: 1.262 ± 0.015	1.475HisGlu: 1.475 ± 0.016	1.023HisPhe: 1.023 ± 0.012	1.584HisGly: 1.584 ± 0.016	0.73HisHis: 0.73 ± 0.012	0.966HisIle: 0.966 ± 0.013	1.025HisLys: 1.025 ± 0.012	2.278HisLeu: 2.278 ± 0.018	0.507HisMet: 0.507 ± 0.009	0.775HisAsn: 0.775 ± 0.011	1.245HisPro: 1.245 ± 0.013	0.981HisGln: 0.981 ± 0.012	1.577HisArg: 1.577 ± 0.017	1.742HisSer: 1.742 ± 0.015	1.185HisThr: 1.185 ± 0.014	1.81HisVal: 1.81 ± 0.016	0.323HisTrp: 0.323 ± 0.008	0.709HisTyr: 0.709 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.772IleAla: 3.772 ± 0.026	0.829IleCys: 0.829 ± 0.012	2.472IleAsp: 2.472 ± 0.02	2.617IleGlu: 2.617 ± 0.019	1.688IlePhe: 1.688 ± 0.018	2.545IleGly: 2.545 ± 0.02	0.988IleHis: 0.988 ± 0.012	1.765IleIle: 1.765 ± 0.016	2.089IleLys: 2.089 ± 0.017	3.7IleLeu: 3.7 ± 0.025	0.983IleMet: 0.983 ± 0.011	1.526IleAsn: 1.526 ± 0.017	2.099IlePro: 2.099 ± 0.017	1.743IleGln: 1.743 ± 0.017	2.495IleArg: 2.495 ± 0.018	3.255IleSer: 3.255 ± 0.023	2.362IleThr: 2.362 ± 0.022	3.217IleVal: 3.217 ± 0.025	0.501IleTrp: 0.501 ± 0.008	1.168IleTyr: 1.168 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.2LysAla: 4.2 ± 0.031	0.796LysCys: 0.796 ± 0.014	2.578LysAsp: 2.578 ± 0.022	3.485LysGlu: 3.485 ± 0.027	1.707LysPhe: 1.707 ± 0.017	2.444LysGly: 2.444 ± 0.021	1.285LysHis: 1.285 ± 0.014	2.161LysIle: 2.161 ± 0.021	4.112LysLys: 4.112 ± 0.039	5.249LysLeu: 5.249 ± 0.032	1.415LysMet: 1.415 ± 0.013	1.972LysAsn: 1.972 ± 0.017	2.189LysPro: 2.189 ± 0.017	2.415LysGln: 2.415 ± 0.022	3.89LysArg: 3.89 ± 0.029	3.572LysSer: 3.572 ± 0.023	3.286LysThr: 3.286 ± 0.025	3.11LysVal: 3.11 ± 0.025	0.746LysTrp: 0.746 ± 0.011	1.514LysTyr: 1.514 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.182LeuAla: 8.182 ± 0.04	1.659LeuCys: 1.659 ± 0.018	5.188LeuAsp: 5.188 ± 0.028	6.427LeuGlu: 6.427 ± 0.041	3.574LeuPhe: 3.574 ± 0.023	5.164LeuGly: 5.164 ± 0.028	2.603LeuHis: 2.603 ± 0.021	3.287LeuIle: 3.287 ± 0.024	4.815LeuLys: 4.815 ± 0.031	10.145LeuLeu: 10.145 ± 0.059	2.196LeuMet: 2.196 ± 0.018	3.312LeuAsn: 3.312 ± 0.029	4.627LeuPro: 4.627 ± 0.03	4.836LeuGln: 4.836 ± 0.034	6.522LeuArg: 6.522 ± 0.043	7.445LeuSer: 7.445 ± 0.034	5.098LeuThr: 5.098 ± 0.027	6.733LeuVal: 6.733 ± 0.038	1.101LeuTrp: 1.101 ± 0.013	2.422LeuTyr: 2.422 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	2.278MetAla: 2.278 ± 0.017	0.367MetCys: 0.367 ± 0.007	1.468MetAsp: 1.468 ± 0.015	1.733MetGlu: 1.733 ± 0.016	0.824MetPhe: 0.824 ± 0.012	1.43MetGly: 1.43 ± 0.017	0.573MetHis: 0.573 ± 0.009	0.962MetIle: 0.962 ± 0.012	1.41MetLys: 1.41 ± 0.014	2.489MetLeu: 2.489 ± 0.021	0.717MetMet: 0.717 ± 0.011	0.918MetAsn: 0.918 ± 0.013	1.102MetPro: 1.102 ± 0.011	1.133MetGln: 1.133 ± 0.013	1.518MetArg: 1.518 ± 0.015	1.826MetSer: 1.826 ± 0.017	1.494MetThr: 1.494 ± 0.013	1.528MetVal: 1.528 ± 0.013	0.3MetTrp: 0.3 ± 0.006	0.658MetTyr: 0.658 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.475AsnAla: 3.475 ± 0.031	0.621AsnCys: 0.621 ± 0.01	2.017AsnAsp: 2.017 ± 0.017	2.289AsnGlu: 2.289 ± 0.02	1.35AsnPhe: 1.35 ± 0.014	2.789AsnGly: 2.789 ± 0.022	0.741AsnHis: 0.741 ± 0.01	1.567AsnIle: 1.567 ± 0.015	1.709AsnLys: 1.709 ± 0.017	3.0AsnLeu: 3.0 ± 0.023	0.886AsnMet: 0.886 ± 0.012	1.361AsnAsn: 1.361 ± 0.017	1.792AsnPro: 1.792 ± 0.015	1.327AsnGln: 1.327 ± 0.014	1.899AsnArg: 1.899 ± 0.018	2.715AsnSer: 2.715 ± 0.02	2.027AsnThr: 2.027 ± 0.022	2.779AsnVal: 2.779 ± 0.019	0.44AsnTrp: 0.44 ± 0.008	0.979AsnTyr: 0.979 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	3.873ProAla: 3.873 ± 0.031	0.575ProCys: 0.575 ± 0.013	2.346ProAsp: 2.346 ± 0.019	2.884ProGlu: 2.884 ± 0.02	1.673ProPhe: 1.673 ± 0.016	2.542ProGly: 2.542 ± 0.024	1.031ProHis: 1.031 ± 0.013	1.771ProIle: 1.771 ± 0.015	2.198ProLys: 2.198 ± 0.02	4.037ProLeu: 4.037 ± 0.031	1.052ProMet: 1.052 ± 0.011	1.588ProAsn: 1.588 ± 0.013	3.079ProPro: 3.079 ± 0.035	1.79ProGln: 1.79 ± 0.017	2.759ProArg: 2.759 ± 0.022	4.346ProSer: 4.346 ± 0.028	3.334ProThr: 3.334 ± 0.033	3.315ProVal: 3.315 ± 0.026	0.5ProTrp: 0.5 ± 0.008	1.049ProTyr: 1.049 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.267GlnAla: 3.267 ± 0.026	0.648GlnCys: 0.648 ± 0.012	1.944GlnAsp: 1.944 ± 0.017	2.78GlnGlu: 2.78 ± 0.022	1.46GlnPhe: 1.46 ± 0.013	1.856GlnGly: 1.856 ± 0.02	1.201GlnHis: 1.201 ± 0.013	1.731GlnIle: 1.731 ± 0.016	2.118GlnLys: 2.118 ± 0.018	4.748GlnLeu: 4.748 ± 0.034	1.091GlnMet: 1.091 ± 0.014	1.39GlnAsn: 1.39 ± 0.015	1.785GlnPro: 1.785 ± 0.016	2.982GlnGln: 2.982 ± 0.046	3.243GlnArg: 3.243 ± 0.028	2.874GlnSer: 2.874 ± 0.025	2.296GlnThr: 2.296 ± 0.017	2.712GlnVal: 2.712 ± 0.019	0.593GlnTrp: 0.593 ± 0.011	1.104GlnTyr: 1.104 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	5.076ArgAla: 5.076 ± 0.034	1.037ArgCys: 1.037 ± 0.014	3.202ArgAsp: 3.202 ± 0.022	4.045ArgGlu: 4.045 ± 0.034	2.442ArgPhe: 2.442 ± 0.019	3.588ArgGly: 3.588 ± 0.028	1.663ArgHis: 1.663 ± 0.018	2.559ArgIle: 2.559 ± 0.022	3.572ArgLys: 3.572 ± 0.023	5.942ArgLeu: 5.942 ± 0.034	1.556ArgMet: 1.556 ± 0.016	2.196ArgAsn: 2.196 ± 0.021	2.479ArgPro: 2.479 ± 0.018	2.896ArgGln: 2.896 ± 0.025	5.488ArgArg: 5.488 ± 0.043	4.896ArgSer: 4.896 ± 0.034	3.107ArgThr: 3.107 ± 0.024	4.412ArgVal: 4.412 ± 0.028	0.886ArgTrp: 0.886 ± 0.013	1.647ArgTyr: 1.647 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	6.824SerAla: 6.824 ± 0.04	1.347SerCys: 1.347 ± 0.016	4.548SerAsp: 4.548 ± 0.029	4.331SerGlu: 4.331 ± 0.027	3.173SerPhe: 3.173 ± 0.028	5.44SerGly: 5.44 ± 0.041	1.632SerHis: 1.632 ± 0.016	3.441SerIle: 3.441 ± 0.022	3.913SerLys: 3.913 ± 0.03	6.955SerLeu: 6.955 ± 0.035	1.945SerMet: 1.945 ± 0.018	2.959SerAsn: 2.959 ± 0.024	3.99SerPro: 3.99 ± 0.03	2.669SerGln: 2.669 ± 0.02	4.675SerArg: 4.675 ± 0.032	9.302SerSer: 9.302 ± 0.066	5.622SerThr: 5.622 ± 0.041	5.448SerVal: 5.448 ± 0.032	0.991SerTrp: 0.991 ± 0.012	2.033SerTyr: 2.033 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.368ThrAla: 5.368 ± 0.036	1.024ThrCys: 1.024 ± 0.014	2.923ThrAsp: 2.923 ± 0.022	3.385ThrGlu: 3.385 ± 0.028	2.199ThrPhe: 2.199 ± 0.019	3.763ThrGly: 3.763 ± 0.034	1.246ThrHis: 1.246 ± 0.012	2.625ThrIle: 2.625 ± 0.023	2.953ThrLys: 2.953 ± 0.025	5.522ThrLeu: 5.522 ± 0.029	1.388ThrMet: 1.388 ± 0.014	2.053ThrAsn: 2.053 ± 0.02	3.491ThrPro: 3.491 ± 0.035	2.299ThrGln: 2.299 ± 0.018	3.375ThrArg: 3.375 ± 0.021	5.379ThrSer: 5.379 ± 0.034	4.253ThrThr: 4.253 ± 0.043	3.891ThrVal: 3.891 ± 0.032	0.728ThrTrp: 0.728 ± 0.01	1.46ThrTyr: 1.46 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	6.721ValAla: 6.721 ± 0.036	1.297ValCys: 1.297 ± 0.016	4.369ValAsp: 4.369 ± 0.028	4.61ValGlu: 4.61 ± 0.03	2.899ValPhe: 2.899 ± 0.022	4.18ValGly: 4.18 ± 0.035	1.623ValHis: 1.623 ± 0.014	2.87ValIle: 2.87 ± 0.021	3.51ValLys: 3.51 ± 0.023	7.007ValLeu: 7.007 ± 0.037	1.673ValMet: 1.673 ± 0.014	2.492ValAsn: 2.492 ± 0.017	3.166ValPro: 3.166 ± 0.023	2.78ValGln: 2.78 ± 0.019	3.958ValArg: 3.958 ± 0.028	5.343ValSer: 5.343 ± 0.033	4.117ValThr: 4.117 ± 0.031	5.735ValVal: 5.735 ± 0.037	0.829ValTrp: 0.829 ± 0.012	1.955ValTyr: 1.955 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.754TrpAla: 0.754 ± 0.012	0.216TrpCys: 0.216 ± 0.005	0.671TrpAsp: 0.671 ± 0.011	0.69TrpGlu: 0.69 ± 0.011	0.49TrpPhe: 0.49 ± 0.009	0.682TrpGly: 0.682 ± 0.011	0.288TrpHis: 0.288 ± 0.006	0.601TrpIle: 0.601 ± 0.008	0.812TrpLys: 0.812 ± 0.012	1.3TrpLeu: 1.3 ± 0.015	0.412TrpMet: 0.412 ± 0.008	0.543TrpAsn: 0.543 ± 0.009	0.412TrpPro: 0.412 ± 0.008	0.51TrpGln: 0.51 ± 0.01	0.89TrpArg: 0.89 ± 0.011	0.952TrpSer: 0.952 ± 0.013	0.801TrpThr: 0.801 ± 0.013	0.744TrpVal: 0.744 ± 0.011	0.2TrpTrp: 0.2 ± 0.005	0.383TrpTyr: 0.383 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.207TyrAla: 2.207 ± 0.02	0.555TyrCys: 0.555 ± 0.013	1.599TyrAsp: 1.599 ± 0.013	1.632TyrGlu: 1.632 ± 0.017	1.215TyrPhe: 1.215 ± 0.015	1.913TyrGly: 1.913 ± 0.023	0.666TyrHis: 0.666 ± 0.009	1.073TyrIle: 1.073 ± 0.013	1.158TyrLys: 1.158 ± 0.017	2.539TyrLeu: 2.539 ± 0.021	0.687TyrMet: 0.687 ± 0.01	1.036TyrAsn: 1.036 ± 0.011	1.155TyrPro: 1.155 ± 0.013	1.028TyrGln: 1.028 ± 0.011	1.643TyrArg: 1.643 ± 0.016	1.944TyrSer: 1.944 ± 0.019	1.45TyrThr: 1.45 ± 0.015	1.954TyrVal: 1.954 ± 0.017	0.378TyrTrp: 0.378 ± 0.008	0.909TyrTyr: 0.909 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 17610 proteins (7440462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---