Amino acid dipepetide frequency for Nocardioides immobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.077AlaAla: 19.077 ± 0.143	1.041AlaCys: 1.041 ± 0.025	8.752AlaAsp: 8.752 ± 0.064	8.33AlaGlu: 8.33 ± 0.082	3.535AlaPhe: 3.535 ± 0.047	12.039AlaGly: 12.039 ± 0.091	2.505AlaHis: 2.505 ± 0.038	4.888AlaIle: 4.888 ± 0.052	2.581AlaLys: 2.581 ± 0.047	12.939AlaLeu: 12.939 ± 0.099	2.693AlaMet: 2.693 ± 0.039	2.134AlaAsn: 2.134 ± 0.04	5.955AlaPro: 5.955 ± 0.068	3.383AlaGln: 3.383 ± 0.049	9.237AlaArg: 9.237 ± 0.091	6.166AlaSer: 6.166 ± 0.051	7.44AlaThr: 7.44 ± 0.064	11.555AlaVal: 11.555 ± 0.093	1.863AlaTrp: 1.863 ± 0.031	2.474AlaTyr: 2.474 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.967CysAla: 0.967 ± 0.022	0.107CysCys: 0.107 ± 0.006	0.525CysAsp: 0.525 ± 0.017	0.46CysGlu: 0.46 ± 0.015	0.223CysPhe: 0.223 ± 0.011	0.908CysGly: 0.908 ± 0.023	0.198CysHis: 0.198 ± 0.011	0.235CysIle: 0.235 ± 0.012	0.109CysLys: 0.109 ± 0.007	0.71CysLeu: 0.71 ± 0.02	0.124CysMet: 0.124 ± 0.008	0.164CysAsn: 0.164 ± 0.008	0.5CysPro: 0.5 ± 0.017	0.208CysGln: 0.208 ± 0.009	0.637CysArg: 0.637 ± 0.019	0.501CysSer: 0.501 ± 0.019	0.483CysThr: 0.483 ± 0.016	0.655CysVal: 0.655 ± 0.018	0.136CysTrp: 0.136 ± 0.009	0.168CysTyr: 0.168 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.099AspAla: 8.099 ± 0.064	0.449AspCys: 0.449 ± 0.015	4.862AspAsp: 4.862 ± 0.061	4.687AspGlu: 4.687 ± 0.054	1.787AspPhe: 1.787 ± 0.033	6.582AspGly: 6.582 ± 0.071	1.62AspHis: 1.62 ± 0.03	2.206AspIle: 2.206 ± 0.04	1.137AspLys: 1.137 ± 0.027	7.538AspLeu: 7.538 ± 0.067	0.88AspMet: 0.88 ± 0.023	1.118AspAsn: 1.118 ± 0.025	4.724AspPro: 4.724 ± 0.055	1.997AspGln: 1.997 ± 0.032	5.242AspArg: 5.242 ± 0.06	2.543AspSer: 2.543 ± 0.039	2.818AspThr: 2.818 ± 0.044	6.055AspVal: 6.055 ± 0.056	1.018AspTrp: 1.018 ± 0.026	1.315AspTyr: 1.315 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.306GluAla: 7.306 ± 0.074	0.421GluCys: 0.421 ± 0.013	3.192GluAsp: 3.192 ± 0.043	3.571GluGlu: 3.571 ± 0.048	1.618GluPhe: 1.618 ± 0.027	4.337GluGly: 4.337 ± 0.051	1.67GluHis: 1.67 ± 0.032	2.823GluIle: 2.823 ± 0.038	1.31GluLys: 1.31 ± 0.028	6.746GluLeu: 6.746 ± 0.063	1.073GluMet: 1.073 ± 0.026	0.984GluAsn: 0.984 ± 0.026	3.386GluPro: 3.386 ± 0.05	2.346GluGln: 2.346 ± 0.036	5.228GluArg: 5.228 ± 0.053	2.82GluSer: 2.82 ± 0.044	3.154GluThr: 3.154 ± 0.038	5.478GluVal: 5.478 ± 0.054	0.909GluTrp: 0.909 ± 0.023	1.152GluTyr: 1.152 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.758PheAla: 3.758 ± 0.049	0.296PheCys: 0.296 ± 0.012	2.226PheAsp: 2.226 ± 0.035	1.75PheGlu: 1.75 ± 0.027	0.878PhePhe: 0.878 ± 0.023	3.15PheGly: 3.15 ± 0.039	0.613PheHis: 0.613 ± 0.016	0.84PheIle: 0.84 ± 0.025	0.529PheLys: 0.529 ± 0.018	2.607PheLeu: 2.607 ± 0.04	0.417PheMet: 0.417 ± 0.015	0.658PheAsn: 0.658 ± 0.02	1.34PhePro: 1.34 ± 0.03	0.673PheGln: 0.673 ± 0.021	1.83PheArg: 1.83 ± 0.03	1.513PheSer: 1.513 ± 0.028	1.863PheThr: 1.863 ± 0.033	2.656PheVal: 2.656 ± 0.032	0.439PheTrp: 0.439 ± 0.014	0.633PheTyr: 0.633 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.163GlyAla: 10.163 ± 0.079	0.845GlyCys: 0.845 ± 0.024	5.702GlyAsp: 5.702 ± 0.061	5.157GlyGlu: 5.157 ± 0.053	3.076GlyPhe: 3.076 ± 0.038	8.263GlyGly: 8.263 ± 0.078	2.112GlyHis: 2.112 ± 0.036	3.92GlyIle: 3.92 ± 0.049	2.118GlyLys: 2.118 ± 0.036	9.14GlyLeu: 9.14 ± 0.069	1.999GlyMet: 1.999 ± 0.037	1.845GlyAsn: 1.845 ± 0.032	4.572GlyPro: 4.572 ± 0.052	2.598GlyGln: 2.598 ± 0.036	7.158GlyArg: 7.158 ± 0.072	5.384GlySer: 5.384 ± 0.058	5.6GlyThr: 5.6 ± 0.064	7.892GlyVal: 7.892 ± 0.083	1.702GlyTrp: 1.702 ± 0.03	2.192GlyTyr: 2.192 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.549HisAla: 2.549 ± 0.037	0.215HisCys: 0.215 ± 0.01	1.478HisAsp: 1.478 ± 0.03	1.285HisGlu: 1.285 ± 0.026	0.634HisPhe: 0.634 ± 0.019	2.23HisGly: 2.23 ± 0.038	0.738HisHis: 0.738 ± 0.021	0.614HisIle: 0.614 ± 0.018	0.315HisLys: 0.315 ± 0.013	2.382HisLeu: 2.382 ± 0.037	0.314HisMet: 0.314 ± 0.014	0.388HisAsn: 0.388 ± 0.016	1.635HisPro: 1.635 ± 0.031	0.699HisGln: 0.699 ± 0.02	1.947HisArg: 1.947 ± 0.038	0.909HisSer: 0.909 ± 0.021	1.067HisThr: 1.067 ± 0.025	1.914HisVal: 1.914 ± 0.031	0.324HisTrp: 0.324 ± 0.013	0.5HisTyr: 0.5 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.514IleAla: 5.514 ± 0.06	0.329IleCys: 0.329 ± 0.013	3.094IleAsp: 3.094 ± 0.038	2.617IleGlu: 2.617 ± 0.036	0.911IlePhe: 0.911 ± 0.025	4.046IleGly: 4.046 ± 0.049	0.738IleHis: 0.738 ± 0.018	1.151IleIle: 1.151 ± 0.026	0.801IleLys: 0.801 ± 0.02	2.789IleLeu: 2.789 ± 0.047	0.509IleMet: 0.509 ± 0.018	0.948IleAsn: 0.948 ± 0.023	1.981IlePro: 1.981 ± 0.034	0.869IleGln: 0.869 ± 0.02	2.477IleArg: 2.477 ± 0.032	1.986IleSer: 1.986 ± 0.036	2.392IleThr: 2.392 ± 0.038	3.466IleVal: 3.466 ± 0.044	0.439IleTrp: 0.439 ± 0.016	0.721IleTyr: 0.721 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.513LysAla: 2.513 ± 0.041	0.125LysCys: 0.125 ± 0.009	1.147LysAsp: 1.147 ± 0.026	1.095LysGlu: 1.095 ± 0.023	0.465LysPhe: 0.465 ± 0.016	1.545LysGly: 1.545 ± 0.034	0.461LysHis: 0.461 ± 0.013	0.853LysIle: 0.853 ± 0.022	0.66LysLys: 0.66 ± 0.027	1.838LysLeu: 1.838 ± 0.032	0.403LysMet: 0.403 ± 0.016	0.449LysAsn: 0.449 ± 0.015	1.154LysPro: 1.154 ± 0.025	0.679LysGln: 0.679 ± 0.023	1.505LysArg: 1.505 ± 0.029	1.05LysSer: 1.05 ± 0.024	1.12LysThr: 1.12 ± 0.028	1.947LysVal: 1.947 ± 0.031	0.253LysTrp: 0.253 ± 0.012	0.451LysTyr: 0.451 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.683LeuAla: 14.683 ± 0.115	0.75LeuCys: 0.75 ± 0.017	7.056LeuAsp: 7.056 ± 0.067	5.573LeuGlu: 5.573 ± 0.055	2.488LeuPhe: 2.488 ± 0.038	9.463LeuGly: 9.463 ± 0.083	2.074LeuHis: 2.074 ± 0.032	3.346LeuIle: 3.346 ± 0.043	1.747LeuLys: 1.747 ± 0.031	10.064LeuLeu: 10.064 ± 0.097	1.681LeuMet: 1.681 ± 0.03	1.774LeuAsn: 1.774 ± 0.033	5.656LeuPro: 5.656 ± 0.053	2.436LeuGln: 2.436 ± 0.038	7.621LeuArg: 7.621 ± 0.075	5.147LeuSer: 5.147 ± 0.058	6.279LeuThr: 6.279 ± 0.061	9.901LeuVal: 9.901 ± 0.083	1.19LeuTrp: 1.19 ± 0.028	1.541LeuTyr: 1.541 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.292MetAla: 2.292 ± 0.037	0.157MetCys: 0.157 ± 0.009	0.918MetAsp: 0.918 ± 0.023	0.776MetGlu: 0.776 ± 0.02	0.52MetPhe: 0.52 ± 0.017	1.421MetGly: 1.421 ± 0.028	0.363MetHis: 0.363 ± 0.015	0.755MetIle: 0.755 ± 0.019	0.463MetLys: 0.463 ± 0.016	1.879MetLeu: 1.879 ± 0.031	0.328MetMet: 0.328 ± 0.016	0.425MetAsn: 0.425 ± 0.014	1.104MetPro: 1.104 ± 0.023	0.476MetGln: 0.476 ± 0.016	1.487MetArg: 1.487 ± 0.027	1.449MetSer: 1.449 ± 0.029	1.763MetThr: 1.763 ± 0.031	1.498MetVal: 1.498 ± 0.032	0.219MetTrp: 0.219 ± 0.011	0.3MetTyr: 0.3 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.302AsnAla: 2.302 ± 0.035	0.185AsnCys: 0.185 ± 0.009	1.24AsnAsp: 1.24 ± 0.029	0.975AsnGlu: 0.975 ± 0.025	0.534AsnPhe: 0.534 ± 0.017	1.903AsnGly: 1.903 ± 0.038	0.413AsnHis: 0.413 ± 0.013	0.734AsnIle: 0.734 ± 0.02	0.403AsnLys: 0.403 ± 0.015	1.946AsnLeu: 1.946 ± 0.036	0.312AsnMet: 0.312 ± 0.014	0.475AsnAsn: 0.475 ± 0.015	1.443AsnPro: 1.443 ± 0.031	0.59AsnGln: 0.59 ± 0.016	1.331AsnArg: 1.331 ± 0.03	0.865AsnSer: 0.865 ± 0.021	1.04AsnThr: 1.04 ± 0.025	1.588AsnVal: 1.588 ± 0.031	0.276AsnTrp: 0.276 ± 0.012	0.41AsnTyr: 0.41 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.085ProAla: 7.085 ± 0.073	0.305ProCys: 0.305 ± 0.014	4.584ProAsp: 4.584 ± 0.051	4.032ProGlu: 4.032 ± 0.046	1.581ProPhe: 1.581 ± 0.031	5.632ProGly: 5.632 ± 0.054	1.173ProHis: 1.173 ± 0.027	1.878ProIle: 1.878 ± 0.033	1.061ProLys: 1.061 ± 0.025	4.785ProLeu: 4.785 ± 0.055	1.051ProMet: 1.051 ± 0.022	0.923ProAsn: 0.923 ± 0.024	3.122ProPro: 3.122 ± 0.052	1.356ProGln: 1.356 ± 0.027	3.625ProArg: 3.625 ± 0.049	3.107ProSer: 3.107 ± 0.042	3.61ProThr: 3.61 ± 0.043	5.056ProVal: 5.056 ± 0.054	0.931ProTrp: 0.931 ± 0.026	1.245ProTyr: 1.245 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.454GlnAla: 3.454 ± 0.04	0.19GlnCys: 0.19 ± 0.011	1.295GlnAsp: 1.295 ± 0.028	1.449GlnGlu: 1.449 ± 0.028	0.752GlnPhe: 0.752 ± 0.019	2.081GlnGly: 2.081 ± 0.035	0.706GlnHis: 0.706 ± 0.02	1.239GlnIle: 1.239 ± 0.023	0.549GlnLys: 0.549 ± 0.017	3.132GlnLeu: 3.132 ± 0.04	0.575GlnMet: 0.575 ± 0.018	0.468GlnAsn: 0.468 ± 0.015	1.721GlnPro: 1.721 ± 0.031	1.169GlnGln: 1.169 ± 0.023	2.506GlnArg: 2.506 ± 0.041	1.233GlnSer: 1.233 ± 0.027	1.434GlnThr: 1.434 ± 0.029	2.87GlnVal: 2.87 ± 0.038	0.456GlnTrp: 0.456 ± 0.015	0.566GlnTyr: 0.566 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.898ArgAla: 8.898 ± 0.085	0.581ArgCys: 0.581 ± 0.019	4.61ArgAsp: 4.61 ± 0.054	4.481ArgGlu: 4.481 ± 0.053	2.372ArgPhe: 2.372 ± 0.036	5.638ArgGly: 5.638 ± 0.062	1.852ArgHis: 1.852 ± 0.032	3.351ArgIle: 3.351 ± 0.048	1.507ArgLys: 1.507 ± 0.034	8.081ArgLeu: 8.081 ± 0.068	1.786ArgMet: 1.786 ± 0.026	1.433ArgAsn: 1.433 ± 0.029	4.253ArgPro: 4.253 ± 0.048	2.313ArgGln: 2.313 ± 0.037	7.193ArgArg: 7.193 ± 0.076	4.307ArgSer: 4.307 ± 0.05	4.573ArgThr: 4.573 ± 0.05	6.114ArgVal: 6.114 ± 0.057	1.353ArgTrp: 1.353 ± 0.028	1.686ArgTyr: 1.686 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.227SerAla: 6.227 ± 0.065	0.423SerCys: 0.423 ± 0.013	3.196SerAsp: 3.196 ± 0.042	2.668SerGlu: 2.668 ± 0.042	1.73SerPhe: 1.73 ± 0.033	5.518SerGly: 5.518 ± 0.055	1.062SerHis: 1.062 ± 0.026	1.954SerIle: 1.954 ± 0.031	0.969SerLys: 0.969 ± 0.02	4.895SerLeu: 4.895 ± 0.057	1.25SerMet: 1.25 ± 0.027	1.001SerAsn: 1.001 ± 0.026	3.062SerPro: 3.062 ± 0.044	1.325SerGln: 1.325 ± 0.024	3.813SerArg: 3.813 ± 0.045	3.057SerSer: 3.057 ± 0.042	3.241SerThr: 3.241 ± 0.039	4.4SerVal: 4.4 ± 0.049	0.931SerTrp: 0.931 ± 0.022	1.393SerTyr: 1.393 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.409ThrAla: 7.409 ± 0.066	0.506ThrCys: 0.506 ± 0.017	3.763ThrAsp: 3.763 ± 0.046	3.153ThrGlu: 3.153 ± 0.034	1.886ThrPhe: 1.886 ± 0.029	5.958ThrGly: 5.958 ± 0.058	1.163ThrHis: 1.163 ± 0.027	2.417ThrIle: 2.417 ± 0.035	1.17ThrLys: 1.17 ± 0.025	5.502ThrLeu: 5.502 ± 0.058	1.111ThrMet: 1.111 ± 0.025	1.176ThrAsn: 1.176 ± 0.027	3.696ThrPro: 3.696 ± 0.049	1.391ThrGln: 1.391 ± 0.028	3.859ThrArg: 3.859 ± 0.052	3.532ThrSer: 3.532 ± 0.052	4.073ThrThr: 4.073 ± 0.058	5.555ThrVal: 5.555 ± 0.068	0.983ThrTrp: 0.983 ± 0.024	1.419ThrTyr: 1.419 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	12.29ValAla: 12.29 ± 0.09	0.726ValCys: 0.726 ± 0.019	6.369ValAsp: 6.369 ± 0.058	5.59ValGlu: 5.59 ± 0.055	2.416ValPhe: 2.416 ± 0.04	7.548ValGly: 7.548 ± 0.067	1.914ValHis: 1.914 ± 0.029	3.42ValIle: 3.42 ± 0.043	1.628ValLys: 1.628 ± 0.03	9.549ValLeu: 9.549 ± 0.084	1.539ValMet: 1.539 ± 0.027	1.833ValAsn: 1.833 ± 0.029	5.027ValPro: 5.027 ± 0.054	2.152ValGln: 2.152 ± 0.031	6.79ValArg: 6.79 ± 0.064	4.567ValSer: 4.567 ± 0.054	5.789ValThr: 5.789 ± 0.056	9.803ValVal: 9.803 ± 0.088	1.143ValTrp: 1.143 ± 0.025	1.472ValTyr: 1.472 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.562TrpAla: 1.562 ± 0.027	0.159TrpCys: 0.159 ± 0.01	0.865TrpAsp: 0.865 ± 0.022	0.771TrpGlu: 0.771 ± 0.02	0.546TrpPhe: 0.546 ± 0.017	1.068TrpGly: 1.068 ± 0.027	0.375TrpHis: 0.375 ± 0.014	0.629TrpIle: 0.629 ± 0.021	0.324TrpLys: 0.324 ± 0.013	1.773TrpLeu: 1.773 ± 0.032	0.326TrpMet: 0.326 ± 0.011	0.369TrpAsn: 0.369 ± 0.017	0.749TrpPro: 0.749 ± 0.019	0.588TrpGln: 0.588 ± 0.019	1.272TrpArg: 1.272 ± 0.023	1.002TrpSer: 1.002 ± 0.024	0.986TrpThr: 0.986 ± 0.024	1.222TrpVal: 1.222 ± 0.024	0.369TrpTrp: 0.369 ± 0.014	0.301TrpTyr: 0.301 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.438TyrAla: 2.438 ± 0.036	0.209TyrCys: 0.209 ± 0.011	1.802TyrAsp: 1.802 ± 0.031	1.103TyrGlu: 1.103 ± 0.026	0.718TyrPhe: 0.718 ± 0.02	2.108TyrGly: 2.108 ± 0.034	0.389TyrHis: 0.389 ± 0.015	0.526TyrIle: 0.526 ± 0.017	0.334TyrLys: 0.334 ± 0.013	2.174TyrLeu: 2.174 ± 0.037	0.221TyrMet: 0.221 ± 0.01	0.398TyrAsn: 0.398 ± 0.016	1.062TyrPro: 1.062 ± 0.024	0.596TyrGln: 0.596 ± 0.018	1.624TyrArg: 1.624 ± 0.029	0.977TyrSer: 0.977 ± 0.025	0.996TyrThr: 0.996 ± 0.023	1.941TyrVal: 1.941 ± 0.031	0.324TyrTrp: 0.324 ± 0.012	0.464TyrTyr: 0.464 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6094 proteins (1939228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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