Amino acid dipepetide frequency for Torulaspora sp. CBS 2947

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.637AlaAla: 4.637 ± 0.071	0.787AlaCys: 0.787 ± 0.019	3.136AlaAsp: 3.136 ± 0.041	3.847AlaGlu: 3.847 ± 0.048	2.477AlaPhe: 2.477 ± 0.035	3.472AlaGly: 3.472 ± 0.045	1.171AlaHis: 1.171 ± 0.022	3.825AlaIle: 3.825 ± 0.042	4.218AlaLys: 4.218 ± 0.041	6.036AlaLeu: 6.036 ± 0.059	1.394AlaMet: 1.394 ± 0.026	2.917AlaAsn: 2.917 ± 0.036	2.376AlaPro: 2.376 ± 0.053	2.503AlaGln: 2.503 ± 0.035	3.14AlaArg: 3.14 ± 0.039	5.213AlaSer: 5.213 ± 0.069	3.622AlaThr: 3.622 ± 0.042	3.925AlaVal: 3.925 ± 0.049	0.558AlaTrp: 0.558 ± 0.016	1.766AlaTyr: 1.766 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.718CysAla: 0.718 ± 0.019	0.311CysCys: 0.311 ± 0.013	0.785CysAsp: 0.785 ± 0.02	0.75CysGlu: 0.75 ± 0.017	0.67CysPhe: 0.67 ± 0.018	0.95CysGly: 0.95 ± 0.023	0.337CysHis: 0.337 ± 0.012	0.888CysIle: 0.888 ± 0.022	0.774CysLys: 0.774 ± 0.018	1.43CysLeu: 1.43 ± 0.027	0.275CysMet: 0.275 ± 0.011	0.622CysAsn: 0.622 ± 0.018	0.561CysPro: 0.561 ± 0.018	0.537CysGln: 0.537 ± 0.016	0.636CysArg: 0.636 ± 0.018	1.144CysSer: 1.144 ± 0.024	0.619CysThr: 0.619 ± 0.018	0.917CysVal: 0.917 ± 0.019	0.17CysTrp: 0.17 ± 0.008	0.54CysTyr: 0.54 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.283AspAla: 3.283 ± 0.04	0.765AspCys: 0.765 ± 0.02	4.469AspAsp: 4.469 ± 0.059	5.444AspGlu: 5.444 ± 0.055	2.61AspPhe: 2.61 ± 0.032	3.253AspGly: 3.253 ± 0.039	1.184AspHis: 1.184 ± 0.024	3.714AspIle: 3.714 ± 0.047	3.447AspLys: 3.447 ± 0.041	5.843AspLeu: 5.843 ± 0.054	1.189AspMet: 1.189 ± 0.022	2.708AspAsn: 2.708 ± 0.037	2.554AspPro: 2.554 ± 0.031	2.188AspGln: 2.188 ± 0.029	2.605AspArg: 2.605 ± 0.034	4.684AspSer: 4.684 ± 0.047	2.811AspThr: 2.811 ± 0.04	3.756AspVal: 3.756 ± 0.04	0.665AspTrp: 0.665 ± 0.016	2.079AspTyr: 2.079 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	4.051GluAla: 4.051 ± 0.052	0.746GluCys: 0.746 ± 0.018	4.376GluAsp: 4.376 ± 0.051	6.126GluGlu: 6.126 ± 0.08	2.791GluPhe: 2.791 ± 0.035	2.961GluGly: 2.961 ± 0.04	1.282GluHis: 1.282 ± 0.026	4.422GluIle: 4.422 ± 0.05	4.916GluLys: 4.916 ± 0.054	7.022GluLeu: 7.022 ± 0.066	1.55GluMet: 1.55 ± 0.026	3.673GluAsn: 3.673 ± 0.044	2.364GluPro: 2.364 ± 0.039	3.068GluGln: 3.068 ± 0.04	3.672GluArg: 3.672 ± 0.042	5.348GluSer: 5.348 ± 0.059	3.871GluThr: 3.871 ± 0.043	3.753GluVal: 3.753 ± 0.044	0.703GluTrp: 0.703 ± 0.017	2.214GluTyr: 2.214 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	2.61PheAla: 2.61 ± 0.038	0.589PheCys: 0.589 ± 0.017	2.785PheAsp: 2.785 ± 0.034	2.885PheGlu: 2.885 ± 0.038	1.897PhePhe: 1.897 ± 0.034	2.667PheGly: 2.667 ± 0.046	0.976PheHis: 0.976 ± 0.022	2.645PheIle: 2.645 ± 0.039	2.837PheLys: 2.837 ± 0.037	4.061PheLeu: 4.061 ± 0.05	0.926PheMet: 0.926 ± 0.023	2.223PheAsn: 2.223 ± 0.033	1.745PhePro: 1.745 ± 0.023	1.82PheGln: 1.82 ± 0.029	1.789PheArg: 1.789 ± 0.03	3.354PheSer: 3.354 ± 0.046	2.335PheThr: 2.335 ± 0.037	2.66PheVal: 2.66 ± 0.034	0.501PheTrp: 0.501 ± 0.017	1.544PheTyr: 1.544 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	3.175GlyAla: 3.175 ± 0.048	0.83GlyCys: 0.83 ± 0.02	3.003GlyAsp: 3.003 ± 0.037	3.134GlyGlu: 3.134 ± 0.041	2.55GlyPhe: 2.55 ± 0.042	3.594GlyGly: 3.594 ± 0.063	1.216GlyHis: 1.216 ± 0.023	3.492GlyIle: 3.492 ± 0.045	3.797GlyLys: 3.797 ± 0.045	5.021GlyLeu: 5.021 ± 0.05	1.038GlyMet: 1.038 ± 0.024	2.77GlyAsn: 2.77 ± 0.037	1.861GlyPro: 1.861 ± 0.043	1.981GlyGln: 1.981 ± 0.028	2.677GlyArg: 2.677 ± 0.037	5.392GlySer: 5.392 ± 0.067	3.18GlyThr: 3.18 ± 0.046	3.435GlyVal: 3.435 ± 0.044	0.641GlyTrp: 0.641 ± 0.017	1.907GlyTyr: 1.907 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.091HisAla: 1.091 ± 0.018	0.337HisCys: 0.337 ± 0.014	1.203HisAsp: 1.203 ± 0.021	1.316HisGlu: 1.316 ± 0.026	0.962HisPhe: 0.962 ± 0.023	1.242HisGly: 1.242 ± 0.023	0.612HisHis: 0.612 ± 0.017	1.306HisIle: 1.306 ± 0.026	1.182HisLys: 1.182 ± 0.023	2.163HisLeu: 2.163 ± 0.029	0.427HisMet: 0.427 ± 0.014	0.978HisAsn: 0.978 ± 0.022	1.041HisPro: 1.041 ± 0.022	0.851HisGln: 0.851 ± 0.019	1.163HisArg: 1.163 ± 0.021	1.769HisSer: 1.769 ± 0.029	0.971HisThr: 0.971 ± 0.02	1.21HisVal: 1.21 ± 0.019	0.268HisTrp: 0.268 ± 0.011	0.808HisTyr: 0.808 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.966IleAla: 3.966 ± 0.046	0.958IleCys: 0.958 ± 0.024	3.96IleAsp: 3.96 ± 0.041	3.999IleGlu: 3.999 ± 0.047	2.543IlePhe: 2.543 ± 0.04	3.19IleGly: 3.19 ± 0.045	1.233IleHis: 1.233 ± 0.029	3.388IleIle: 3.388 ± 0.049	3.83IleLys: 3.83 ± 0.04	5.681IleLeu: 5.681 ± 0.055	1.227IleMet: 1.227 ± 0.024	2.918IleAsn: 2.918 ± 0.035	3.046IlePro: 3.046 ± 0.038	2.229IleGln: 2.229 ± 0.033	2.888IleArg: 2.888 ± 0.037	5.217IleSer: 5.217 ± 0.055	3.241IleThr: 3.241 ± 0.042	3.765IleVal: 3.765 ± 0.05	0.681IleTrp: 0.681 ± 0.017	1.896IleTyr: 1.896 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.776LysAla: 3.776 ± 0.048	0.836LysCys: 0.836 ± 0.021	3.789LysAsp: 3.789 ± 0.044	4.718LysGlu: 4.718 ± 0.066	2.895LysPhe: 2.895 ± 0.035	2.859LysGly: 2.859 ± 0.04	1.416LysHis: 1.416 ± 0.023	4.191LysIle: 4.191 ± 0.051	5.479LysLys: 5.479 ± 0.061	6.981LysLeu: 6.981 ± 0.067	1.432LysMet: 1.432 ± 0.024	3.446LysAsn: 3.446 ± 0.041	2.834LysPro: 2.834 ± 0.04	2.76LysGln: 2.76 ± 0.037	4.199LysArg: 4.199 ± 0.049	5.007LysSer: 5.007 ± 0.049	3.48LysThr: 3.48 ± 0.039	4.076LysVal: 4.076 ± 0.049	0.765LysTrp: 0.765 ± 0.018	2.294LysTyr: 2.294 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	6.205LeuAla: 6.205 ± 0.056	1.409LeuCys: 1.409 ± 0.027	5.511LeuAsp: 5.511 ± 0.049	6.713LeuGlu: 6.713 ± 0.061	4.014LeuPhe: 4.014 ± 0.04	4.849LeuGly: 4.849 ± 0.056	2.095LeuHis: 2.095 ± 0.032	5.478LeuIle: 5.478 ± 0.059	7.275LeuLys: 7.275 ± 0.064	9.817LeuLeu: 9.817 ± 0.09	2.037LeuMet: 2.037 ± 0.031	5.037LeuAsn: 5.037 ± 0.048	4.601LeuPro: 4.601 ± 0.041	4.752LeuGln: 4.752 ± 0.051	5.347LeuArg: 5.347 ± 0.051	8.112LeuSer: 8.112 ± 0.075	5.148LeuThr: 5.148 ± 0.048	5.697LeuVal: 5.697 ± 0.055	0.973LeuTrp: 0.973 ± 0.022	3.094LeuTyr: 3.094 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.495MetAla: 1.495 ± 0.025	0.278MetCys: 0.278 ± 0.011	1.243MetAsp: 1.243 ± 0.025	1.353MetGlu: 1.353 ± 0.027	0.849MetPhe: 0.849 ± 0.018	1.24MetGly: 1.24 ± 0.027	0.332MetHis: 0.332 ± 0.013	1.263MetIle: 1.263 ± 0.022	1.406MetLys: 1.406 ± 0.023	1.935MetLeu: 1.935 ± 0.026	0.518MetMet: 0.518 ± 0.015	1.111MetAsn: 1.111 ± 0.021	0.845MetPro: 0.845 ± 0.019	0.75MetGln: 0.75 ± 0.017	1.006MetArg: 1.006 ± 0.021	2.028MetSer: 2.028 ± 0.031	1.2MetThr: 1.2 ± 0.023	1.381MetVal: 1.381 ± 0.027	0.19MetTrp: 0.19 ± 0.008	0.563MetTyr: 0.563 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.088AsnAla: 3.088 ± 0.034	0.707AsnCys: 0.707 ± 0.018	3.234AsnAsp: 3.234 ± 0.035	3.654AsnGlu: 3.654 ± 0.044	2.15AsnPhe: 2.15 ± 0.031	3.389AsnGly: 3.389 ± 0.037	1.051AsnHis: 1.051 ± 0.021	2.793AsnIle: 2.793 ± 0.035	3.043AsnLys: 3.043 ± 0.043	4.702AsnLeu: 4.702 ± 0.053	1.016AsnMet: 1.016 ± 0.021	2.551AsnAsn: 2.551 ± 0.041	2.18AsnPro: 2.18 ± 0.033	1.816AsnGln: 1.816 ± 0.029	2.406AsnArg: 2.406 ± 0.034	4.219AsnSer: 4.219 ± 0.054	2.431AsnThr: 2.431 ± 0.038	3.247AsnVal: 3.247 ± 0.039	0.586AsnTrp: 0.586 ± 0.016	1.746AsnTyr: 1.746 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	2.613ProAla: 2.613 ± 0.038	0.417ProCys: 0.417 ± 0.018	2.283ProAsp: 2.283 ± 0.031	3.125ProGlu: 3.125 ± 0.034	1.821ProPhe: 1.821 ± 0.026	2.187ProGly: 2.187 ± 0.033	0.904ProHis: 0.904 ± 0.022	2.501ProIle: 2.501 ± 0.035	2.498ProLys: 2.498 ± 0.035	4.147ProLeu: 4.147 ± 0.038	0.848ProMet: 0.848 ± 0.021	2.092ProAsn: 2.092 ± 0.029	2.314ProPro: 2.314 ± 0.058	1.884ProGln: 1.884 ± 0.033	2.057ProArg: 2.057 ± 0.03	3.988ProSer: 3.988 ± 0.078	2.565ProThr: 2.565 ± 0.046	2.907ProVal: 2.907 ± 0.037	0.482ProTrp: 0.482 ± 0.017	1.321ProTyr: 1.321 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.352GlnAla: 2.352 ± 0.036	0.473GlnCys: 0.473 ± 0.014	2.366GlnAsp: 2.366 ± 0.033	3.121GlnGlu: 3.121 ± 0.041	1.783GlnPhe: 1.783 ± 0.026	1.928GlnGly: 1.928 ± 0.032	0.879GlnHis: 0.879 ± 0.021	2.48GlnIle: 2.48 ± 0.035	2.564GlnLys: 2.564 ± 0.037	4.422GlnLeu: 4.422 ± 0.044	0.912GlnMet: 0.912 ± 0.021	2.038GlnAsn: 2.038 ± 0.028	1.717GlnPro: 1.717 ± 0.036	2.72GlnGln: 2.72 ± 0.089	2.389GlnArg: 2.389 ± 0.037	3.07GlnSer: 3.07 ± 0.043	2.12GlnThr: 2.12 ± 0.036	2.384GlnVal: 2.384 ± 0.029	0.465GlnTrp: 0.465 ± 0.014	1.34GlnTyr: 1.34 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	2.935ArgAla: 2.935 ± 0.035	0.761ArgCys: 0.761 ± 0.017	2.984ArgAsp: 2.984 ± 0.034	3.485ArgGlu: 3.485 ± 0.047	2.258ArgPhe: 2.258 ± 0.035	2.52ArgGly: 2.52 ± 0.042	1.107ArgHis: 1.107 ± 0.022	3.21ArgIle: 3.21 ± 0.039	4.006ArgLys: 4.006 ± 0.051	5.045ArgLeu: 5.045 ± 0.048	1.084ArgMet: 1.084 ± 0.023	2.75ArgAsn: 2.75 ± 0.037	2.015ArgPro: 2.015 ± 0.03	2.18ArgGln: 2.18 ± 0.031	3.598ArgArg: 3.598 ± 0.045	4.35ArgSer: 4.35 ± 0.045	2.642ArgThr: 2.642 ± 0.036	2.698ArgVal: 2.698 ± 0.028	0.594ArgTrp: 0.594 ± 0.017	1.802ArgTyr: 1.802 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	4.887SerAla: 4.887 ± 0.069	1.087SerCys: 1.087 ± 0.021	4.714SerAsp: 4.714 ± 0.052	4.98SerGlu: 4.98 ± 0.05	3.69SerPhe: 3.69 ± 0.046	5.132SerGly: 5.132 ± 0.068	1.809SerHis: 1.809 ± 0.029	4.943SerIle: 4.943 ± 0.056	5.594SerLys: 5.594 ± 0.049	8.494SerLeu: 8.494 ± 0.068	1.833SerMet: 1.833 ± 0.028	4.412SerAsn: 4.412 ± 0.048	3.651SerPro: 3.651 ± 0.052	3.507SerGln: 3.507 ± 0.042	4.356SerArg: 4.356 ± 0.048	9.762SerSer: 9.762 ± 0.172	5.233SerThr: 5.233 ± 0.1	4.973SerVal: 4.973 ± 0.048	0.88SerTrp: 0.88 ± 0.021	2.457SerTyr: 2.457 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	3.64ThrAla: 3.64 ± 0.048	0.683ThrCys: 0.683 ± 0.017	2.913ThrAsp: 2.913 ± 0.032	3.225ThrGlu: 3.225 ± 0.044	2.259ThrPhe: 2.259 ± 0.032	3.387ThrGly: 3.387 ± 0.053	1.057ThrHis: 1.057 ± 0.021	3.314ThrIle: 3.314 ± 0.037	3.518ThrLys: 3.518 ± 0.039	5.098ThrLeu: 5.098 ± 0.054	1.119ThrMet: 1.119 ± 0.022	2.649ThrAsn: 2.649 ± 0.032	2.641ThrPro: 2.641 ± 0.056	1.904ThrGln: 1.904 ± 0.031	2.682ThrArg: 2.682 ± 0.039	4.994ThrSer: 4.994 ± 0.082	3.584ThrThr: 3.584 ± 0.072	3.836ThrVal: 3.836 ± 0.051	0.563ThrTrp: 0.563 ± 0.017	1.53ThrTyr: 1.53 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	4.043ValAla: 4.043 ± 0.05	0.856ValCys: 0.856 ± 0.021	3.714ValAsp: 3.714 ± 0.044	4.269ValGlu: 4.269 ± 0.05	2.598ValPhe: 2.598 ± 0.034	3.319ValGly: 3.319 ± 0.047	1.157ValHis: 1.157 ± 0.021	3.553ValIle: 3.553 ± 0.045	4.069ValLys: 4.069 ± 0.045	5.913ValLeu: 5.913 ± 0.057	1.257ValMet: 1.257 ± 0.022	2.896ValAsn: 2.896 ± 0.033	2.985ValPro: 2.985 ± 0.039	2.216ValGln: 2.216 ± 0.029	3.063ValArg: 3.063 ± 0.042	5.28ValSer: 5.28 ± 0.056	3.391ValThr: 3.391 ± 0.054	4.316ValVal: 4.316 ± 0.064	0.631ValTrp: 0.631 ± 0.017	1.983ValTyr: 1.983 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.547TrpAla: 0.547 ± 0.017	0.256TrpCys: 0.256 ± 0.011	0.699TrpAsp: 0.699 ± 0.016	0.657TrpGlu: 0.657 ± 0.018	0.53TrpPhe: 0.53 ± 0.015	0.549TrpGly: 0.549 ± 0.017	0.257TrpHis: 0.257 ± 0.012	0.69TrpIle: 0.69 ± 0.02	0.836TrpLys: 0.836 ± 0.02	1.059TrpLeu: 1.059 ± 0.022	0.221TrpMet: 0.221 ± 0.01	0.62TrpAsn: 0.62 ± 0.017	0.336TrpPro: 0.336 ± 0.013	0.428TrpGln: 0.428 ± 0.014	0.616TrpArg: 0.616 ± 0.014	0.921TrpSer: 0.921 ± 0.02	0.559TrpThr: 0.559 ± 0.019	0.55TrpVal: 0.55 ± 0.016	0.156TrpTrp: 0.156 ± 0.009	0.396TrpTyr: 0.396 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.906TyrAla: 1.906 ± 0.028	0.549TyrCys: 0.549 ± 0.016	2.088TyrAsp: 2.088 ± 0.031	2.105TyrGlu: 2.105 ± 0.033	1.505TyrPhe: 1.505 ± 0.028	2.007TyrGly: 2.007 ± 0.034	0.825TyrHis: 0.825 ± 0.018	1.759TyrIle: 1.759 ± 0.031	1.941TyrLys: 1.941 ± 0.029	3.298TyrLeu: 3.298 ± 0.041	0.683TyrMet: 0.683 ± 0.017	1.6TyrAsn: 1.6 ± 0.027	1.287TyrPro: 1.287 ± 0.024	1.43TyrGln: 1.43 ± 0.027	1.736TyrArg: 1.736 ± 0.029	2.539TyrSer: 2.539 ± 0.037	1.592TyrThr: 1.592 ± 0.034	2.023TyrVal: 2.023 ± 0.03	0.41TyrTrp: 0.41 ± 0.013	1.331TyrTyr: 1.331 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4924 proteins (2385348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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