Amino acid dipepetide frequency for Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.081AlaAla: 6.081 ± 0.034
1.21AlaCys: 1.21 ± 0.01
2.649AlaAsp: 2.649 ± 0.013
4.413AlaGlu: 4.413 ± 0.021
2.633AlaPhe: 2.633 ± 0.016
4.181AlaGly: 4.181 ± 0.023
1.39AlaHis: 1.39 ± 0.01
2.825AlaIle: 2.825 ± 0.014
3.399AlaLys: 3.399 ± 0.021
6.533AlaLeu: 6.533 ± 0.026
1.393AlaMet: 1.393 ± 0.008
2.019AlaAsn: 2.019 ± 0.01
3.749AlaPro: 3.749 ± 0.025
2.984AlaGln: 2.984 ± 0.016
3.216AlaArg: 3.216 ± 0.018
5.38AlaSer: 5.38 ± 0.02
3.254AlaThr: 3.254 ± 0.018
4.203AlaVal: 4.203 ± 0.018
0.696AlaTrp: 0.696 ± 0.006
1.428AlaTyr: 1.428 ± 0.01
0.0AlaXaa: 0.0 ± 0.0
Cys
1.08CysAla: 1.08 ± 0.01
0.581CysCys: 0.581 ± 0.008
0.982CysAsp: 0.982 ± 0.01
1.237CysGlu: 1.237 ± 0.01
0.822CysPhe: 0.822 ± 0.007
1.768CysGly: 1.768 ± 0.021
0.624CysHis: 0.624 ± 0.006
0.999CysIle: 0.999 ± 0.009
1.185CysLys: 1.185 ± 0.008
2.071CysLeu: 2.071 ± 0.012
0.413CysMet: 0.413 ± 0.005
1.025CysAsn: 1.025 ± 0.014
1.297CysPro: 1.297 ± 0.012
1.033CysGln: 1.033 ± 0.01
1.138CysArg: 1.138 ± 0.009
1.917CysSer: 1.917 ± 0.012
1.048CysThr: 1.048 ± 0.009
1.189CysVal: 1.189 ± 0.01
0.269CysTrp: 0.269 ± 0.004
0.563CysTyr: 0.563 ± 0.005
0.0CysXaa: 0.0 ± 0.0
Asp
2.577AspAla: 2.577 ± 0.012
1.009AspCys: 1.009 ± 0.01
2.649AspAsp: 2.649 ± 0.015
3.492AspGlu: 3.492 ± 0.016
2.162AspPhe: 2.162 ± 0.009
3.184AspGly: 3.184 ± 0.022
1.166AspHis: 1.166 ± 0.01
2.762AspIle: 2.762 ± 0.019
2.638AspLys: 2.638 ± 0.015
5.036AspLeu: 5.036 ± 0.022
1.139AspMet: 1.139 ± 0.008
1.82AspAsn: 1.82 ± 0.011
2.806AspPro: 2.806 ± 0.013
1.875AspGln: 1.875 ± 0.01
2.344AspArg: 2.344 ± 0.014
4.268AspSer: 4.268 ± 0.024
2.384AspThr: 2.384 ± 0.012
2.98AspVal: 2.98 ± 0.037
0.607AspTrp: 0.607 ± 0.006
1.507AspTyr: 1.507 ± 0.011
0.0AspXaa: 0.0 ± 0.0
Glu
4.857GluAla: 4.857 ± 0.02
1.573GluCys: 1.573 ± 0.02
4.381GluAsp: 4.381 ± 0.019
8.292GluGlu: 8.292 ± 0.045
2.087GluPhe: 2.087 ± 0.012
4.174GluGly: 4.174 ± 0.024
1.514GluHis: 1.514 ± 0.009
3.54GluIle: 3.54 ± 0.017
6.093GluLys: 6.093 ± 0.031
6.569GluLeu: 6.569 ± 0.031
1.792GluMet: 1.792 ± 0.012
3.475GluAsn: 3.475 ± 0.017
3.082GluPro: 3.082 ± 0.017
3.232GluGln: 3.232 ± 0.022
4.06GluArg: 4.06 ± 0.023
4.683GluSer: 4.683 ± 0.02
3.525GluThr: 3.525 ± 0.015
4.107GluVal: 4.107 ± 0.016
0.698GluTrp: 0.698 ± 0.007
1.624GluTyr: 1.624 ± 0.011
0.0GluXaa: 0.0 ± 0.0
Phe
1.873PheAla: 1.873 ± 0.011
0.933PheCys: 0.933 ± 0.007
1.707PheAsp: 1.707 ± 0.01
2.053PheGlu: 2.053 ± 0.013
1.71PhePhe: 1.71 ± 0.013
2.208PheGly: 2.208 ± 0.014
1.057PheHis: 1.057 ± 0.007
2.012PheIle: 2.012 ± 0.012
1.914PheLys: 1.914 ± 0.014
4.21PheLeu: 4.21 ± 0.021
0.786PheMet: 0.786 ± 0.006
1.437PheAsn: 1.437 ± 0.008
2.075PhePro: 2.075 ± 0.011
1.816PheGln: 1.816 ± 0.011
1.953PheArg: 1.953 ± 0.013
3.589PheSer: 3.589 ± 0.013
2.106PheThr: 2.106 ± 0.012
2.1PheVal: 2.1 ± 0.01
0.483PheTrp: 0.483 ± 0.006
1.208PheTyr: 1.208 ± 0.009
0.0PheXaa: 0.0 ± 0.0
Gly
4.035GlyAla: 4.035 ± 0.022
1.146GlyCys: 1.146 ± 0.009
3.046GlyAsp: 3.046 ± 0.016
4.323GlyGlu: 4.323 ± 0.025
2.389GlyPhe: 2.389 ± 0.015
5.05GlyGly: 5.05 ± 0.035
1.597GlyHis: 1.597 ± 0.01
2.886GlyIle: 2.886 ± 0.014
4.1GlyLys: 4.1 ± 0.022
5.525GlyLeu: 5.525 ± 0.021
1.278GlyMet: 1.278 ± 0.01
2.504GlyAsn: 2.504 ± 0.013
4.067GlyPro: 4.067 ± 0.046
2.642GlyGln: 2.642 ± 0.014
3.623GlyArg: 3.623 ± 0.017
5.652GlySer: 5.652 ± 0.027
3.471GlyThr: 3.471 ± 0.019
3.278GlyVal: 3.278 ± 0.017
0.738GlyTrp: 0.738 ± 0.007
1.698GlyTyr: 1.698 ± 0.013
0.0GlyXaa: 0.0 ± 0.0
His
1.196HisAla: 1.196 ± 0.007
0.688HisCys: 0.688 ± 0.006
0.888HisAsp: 0.888 ± 0.006
1.335HisGlu: 1.335 ± 0.008
1.083HisPhe: 1.083 ± 0.008
1.46HisGly: 1.46 ± 0.01
0.908HisHis: 0.908 ± 0.009
1.322HisIle: 1.322 ± 0.008
1.347HisLys: 1.347 ± 0.008
2.886HisLeu: 2.886 ± 0.013
0.567HisMet: 0.567 ± 0.005
0.916HisAsn: 0.916 ± 0.006
1.577HisPro: 1.577 ± 0.01
1.559HisGln: 1.559 ± 0.018
1.509HisArg: 1.509 ± 0.009
2.275HisSer: 2.275 ± 0.013
1.576HisThr: 1.576 ± 0.015
1.371HisVal: 1.371 ± 0.008
0.327HisTrp: 0.327 ± 0.004
0.814HisTyr: 0.814 ± 0.006
0.0HisXaa: 0.0 ± 0.0
Ile
2.616IleAla: 2.616 ± 0.013
1.131IleCys: 1.131 ± 0.009
2.179IleAsp: 2.179 ± 0.012
2.865IleGlu: 2.865 ± 0.015
2.026IlePhe: 2.026 ± 0.012
2.335IleGly: 2.335 ± 0.012
1.621IleHis: 1.621 ± 0.015
2.69IleIle: 2.69 ± 0.017
2.921IleLys: 2.921 ± 0.017
4.933IleLeu: 4.933 ± 0.02
1.071IleMet: 1.071 ± 0.008
2.024IleAsn: 2.024 ± 0.012
2.839IlePro: 2.839 ± 0.013
2.509IleGln: 2.509 ± 0.012
2.506IleArg: 2.506 ± 0.012
4.083IleSer: 4.083 ± 0.017
2.776IleThr: 2.776 ± 0.015
2.59IleVal: 2.59 ± 0.013
0.533IleTrp: 0.533 ± 0.006
1.48IleTyr: 1.48 ± 0.01
0.0IleXaa: 0.0 ± 0.0
Lys
4.069LysAla: 4.069 ± 0.019
1.221LysCys: 1.221 ± 0.011
3.343LysAsp: 3.343 ± 0.017
5.652LysGlu: 5.652 ± 0.03
1.816LysPhe: 1.816 ± 0.014
3.455LysGly: 3.455 ± 0.033
1.472LysHis: 1.472 ± 0.01
3.168LysIle: 3.168 ± 0.017
5.206LysLys: 5.206 ± 0.027
5.492LysLeu: 5.492 ± 0.022
1.588LysMet: 1.588 ± 0.015
2.723LysAsn: 2.723 ± 0.014
3.281LysPro: 3.281 ± 0.021
2.782LysGln: 2.782 ± 0.015
3.374LysArg: 3.374 ± 0.015
4.309LysSer: 4.309 ± 0.021
3.369LysThr: 3.369 ± 0.017
3.575LysVal: 3.575 ± 0.021
0.626LysTrp: 0.626 ± 0.005
1.628LysTyr: 1.628 ± 0.011
0.0LysXaa: 0.0 ± 0.0
Leu
6.244LeuAla: 6.244 ± 0.025
2.036LeuCys: 2.036 ± 0.011
4.678LeuAsp: 4.678 ± 0.021
7.334LeuGlu: 7.334 ± 0.032
3.432LeuPhe: 3.432 ± 0.018
5.667LeuGly: 5.667 ± 0.022
2.716LeuHis: 2.716 ± 0.013
4.206LeuIle: 4.206 ± 0.018
6.25LeuLys: 6.25 ± 0.03
10.441LeuLeu: 10.441 ± 0.043
2.079LeuMet: 2.079 ± 0.013
3.787LeuAsn: 3.787 ± 0.016
5.913LeuPro: 5.913 ± 0.025
5.709LeuGln: 5.709 ± 0.031
5.52LeuArg: 5.52 ± 0.023
8.241LeuSer: 8.241 ± 0.028
5.112LeuThr: 5.112 ± 0.019
5.26LeuVal: 5.26 ± 0.021
1.092LeuTrp: 1.092 ± 0.009
2.557LeuTyr: 2.557 ± 0.012
0.0LeuXaa: 0.0 ± 0.0
Met
1.789MetAla: 1.789 ± 0.01
0.394MetCys: 0.394 ± 0.004
1.288MetAsp: 1.288 ± 0.009
1.976MetGlu: 1.976 ± 0.011
0.767MetPhe: 0.767 ± 0.007
1.27MetGly: 1.27 ± 0.01
0.466MetHis: 0.466 ± 0.005
0.94MetIle: 0.94 ± 0.007
1.563MetLys: 1.563 ± 0.009
1.99MetLeu: 1.99 ± 0.011
0.592MetMet: 0.592 ± 0.006
0.991MetAsn: 0.991 ± 0.007
1.071MetPro: 1.071 ± 0.021
0.937MetGln: 0.937 ± 0.008
1.003MetArg: 1.003 ± 0.007
1.61MetSer: 1.61 ± 0.01
1.163MetThr: 1.163 ± 0.008
1.357MetVal: 1.357 ± 0.009
0.231MetTrp: 0.231 ± 0.003
0.622MetTyr: 0.622 ± 0.006
0.0MetXaa: 0.0 ± 0.0
Asn
2.035AsnAla: 2.035 ± 0.012
0.865AsnCys: 0.865 ± 0.008
1.665AsnAsp: 1.665 ± 0.01
2.594AsnGlu: 2.594 ± 0.014
1.61AsnPhe: 1.61 ± 0.009
2.559AsnGly: 2.559 ± 0.017
1.039AsnHis: 1.039 ± 0.007
2.347AsnIle: 2.347 ± 0.013
2.498AsnLys: 2.498 ± 0.013
4.079AsnLeu: 4.079 ± 0.018
0.954AsnMet: 0.954 ± 0.007
1.739AsnAsn: 1.739 ± 0.011
2.261AsnPro: 2.261 ± 0.012
1.924AsnGln: 1.924 ± 0.011
1.918AsnArg: 1.918 ± 0.01
3.447AsnSer: 3.447 ± 0.017
2.059AsnThr: 2.059 ± 0.012
2.275AsnVal: 2.275 ± 0.011
0.486AsnTrp: 0.486 ± 0.005
1.216AsnTyr: 1.216 ± 0.008
0.0AsnXaa: 0.0 ± 0.0
Pro
4.29ProAla: 4.29 ± 0.023
1.063ProCys: 1.063 ± 0.01
2.749ProAsp: 2.749 ± 0.027
4.376ProGlu: 4.376 ± 0.023
2.052ProPhe: 2.052 ± 0.012
4.912ProGly: 4.912 ± 0.048
1.382ProHis: 1.382 ± 0.009
2.049ProIle: 2.049 ± 0.011
3.021ProLys: 3.021 ± 0.044
5.171ProLeu: 5.171 ± 0.019
1.06ProMet: 1.06 ± 0.008
1.963ProAsn: 1.963 ± 0.011
6.032ProPro: 6.032 ± 0.044
2.711ProGln: 2.711 ± 0.015
3.159ProArg: 3.159 ± 0.018
5.743ProSer: 5.743 ± 0.026
3.005ProThr: 3.005 ± 0.015
3.581ProVal: 3.581 ± 0.016
0.659ProTrp: 0.659 ± 0.006
1.569ProTyr: 1.569 ± 0.014
0.0ProXaa: 0.0 ± 0.0
Gln
3.245GlnAla: 3.245 ± 0.019
1.031GlnCys: 1.031 ± 0.013
2.288GlnAsp: 2.288 ± 0.012
4.013GlnGlu: 4.013 ± 0.021
1.407GlnPhe: 1.407 ± 0.009
2.714GlnGly: 2.714 ± 0.015
1.288GlnHis: 1.288 ± 0.009
2.179GlnIle: 2.179 ± 0.01
3.194GlnLys: 3.194 ± 0.019
4.777GlnLeu: 4.777 ± 0.025
1.138GlnMet: 1.138 ± 0.008
2.033GlnAsn: 2.033 ± 0.013
2.648GlnPro: 2.648 ± 0.017
3.226GlnGln: 3.226 ± 0.029
2.947GlnArg: 2.947 ± 0.019
3.272GlnSer: 3.272 ± 0.017
2.334GlnThr: 2.334 ± 0.013
2.719GlnVal: 2.719 ± 0.011
0.529GlnTrp: 0.529 ± 0.005
1.175GlnTyr: 1.175 ± 0.008
0.0GlnXaa: 0.0 ± 0.0
Arg
3.44ArgAla: 3.44 ± 0.019
1.106ArgCys: 1.106 ± 0.01
2.646ArgAsp: 2.646 ± 0.015
3.985ArgGlu: 3.985 ± 0.022
1.832ArgPhe: 1.832 ± 0.01
3.438ArgGly: 3.438 ± 0.02
1.441ArgHis: 1.441 ± 0.009
2.657ArgIle: 2.657 ± 0.015
3.725ArgLys: 3.725 ± 0.016
5.083ArgLeu: 5.083 ± 0.021
1.147ArgMet: 1.147 ± 0.008
2.168ArgAsn: 2.168 ± 0.011
2.982ArgPro: 2.982 ± 0.015
2.544ArgGln: 2.544 ± 0.014
4.116ArgArg: 4.116 ± 0.027
4.213ArgSer: 4.213 ± 0.031
2.757ArgThr: 2.757 ± 0.016
2.832ArgVal: 2.832 ± 0.013
0.639ArgTrp: 0.639 ± 0.006
1.433ArgTyr: 1.433 ± 0.008
0.0ArgXaa: 0.0 ± 0.0
Ser
4.932SerAla: 4.932 ± 0.019
1.784SerCys: 1.784 ± 0.013
3.988SerAsp: 3.988 ± 0.021
5.339SerGlu: 5.339 ± 0.02
3.199SerPhe: 3.199 ± 0.013
5.564SerGly: 5.564 ± 0.024
2.162SerHis: 2.162 ± 0.011
3.531SerIle: 3.531 ± 0.017
4.396SerLys: 4.396 ± 0.019
8.577SerLeu: 8.577 ± 0.029
1.67SerMet: 1.67 ± 0.012
2.977SerAsn: 2.977 ± 0.016
6.14SerPro: 6.14 ± 0.034
3.993SerGln: 3.993 ± 0.02
4.443SerArg: 4.443 ± 0.032
9.992SerSer: 9.992 ± 0.056
4.61SerThr: 4.61 ± 0.023
4.79SerVal: 4.79 ± 0.018
1.048SerTrp: 1.048 ± 0.007
2.144SerTyr: 2.144 ± 0.012
0.0SerXaa: 0.0 ± 0.0
Thr
3.462ThrAla: 3.462 ± 0.014
1.253ThrCys: 1.253 ± 0.013
2.507ThrAsp: 2.507 ± 0.013
3.686ThrGlu: 3.686 ± 0.015
2.256ThrPhe: 2.256 ± 0.013
3.614ThrGly: 3.614 ± 0.022
1.234ThrHis: 1.234 ± 0.011
2.589ThrIle: 2.589 ± 0.012
2.803ThrLys: 2.803 ± 0.014
5.295ThrLeu: 5.295 ± 0.021
1.14ThrMet: 1.14 ± 0.008
1.89ThrAsn: 1.89 ± 0.01
3.44ThrPro: 3.44 ± 0.021
2.238ThrGln: 2.238 ± 0.012
2.377ThrArg: 2.377 ± 0.012
4.748ThrSer: 4.748 ± 0.023
3.008ThrThr: 3.008 ± 0.021
3.715ThrVal: 3.715 ± 0.015
0.681ThrTrp: 0.681 ± 0.006
1.433ThrTyr: 1.433 ± 0.008
0.0ThrXaa: 0.0 ± 0.0
Val
3.789ValAla: 3.789 ± 0.013
1.332ValCys: 1.332 ± 0.01
2.83ValAsp: 2.83 ± 0.029
3.785ValGlu: 3.785 ± 0.016
2.291ValPhe: 2.291 ± 0.012
3.143ValGly: 3.143 ± 0.014
1.503ValHis: 1.503 ± 0.01
3.022ValIle: 3.022 ± 0.013
3.437ValLys: 3.437 ± 0.016
5.791ValLeu: 5.791 ± 0.024
1.289ValMet: 1.289 ± 0.008
2.322ValAsn: 2.322 ± 0.011
3.474ValPro: 3.474 ± 0.017
2.651ValGln: 2.651 ± 0.011
2.759ValArg: 2.759 ± 0.013
4.737ValSer: 4.737 ± 0.022
3.675ValThr: 3.675 ± 0.018
3.623ValVal: 3.623 ± 0.017
0.665ValTrp: 0.665 ± 0.006
1.577ValTyr: 1.577 ± 0.009
0.0ValXaa: 0.0 ± 0.0
Trp
0.706TrpAla: 0.706 ± 0.006
0.216TrpCys: 0.216 ± 0.003
0.632TrpAsp: 0.632 ± 0.007
0.799TrpGlu: 0.799 ± 0.007
0.423TrpPhe: 0.423 ± 0.004
0.714TrpGly: 0.714 ± 0.008
0.272TrpHis: 0.272 ± 0.004
0.578TrpIle: 0.578 ± 0.006
0.853TrpLys: 0.853 ± 0.007
1.142TrpLeu: 1.142 ± 0.009
0.313TrpMet: 0.313 ± 0.004
0.586TrpAsn: 0.586 ± 0.005
0.489TrpPro: 0.489 ± 0.005
0.505TrpGln: 0.505 ± 0.004
0.677TrpArg: 0.677 ± 0.005
0.853TrpSer: 0.853 ± 0.008
0.638TrpThr: 0.638 ± 0.007
0.634TrpVal: 0.634 ± 0.006
0.18TrpTrp: 0.18 ± 0.003
0.327TrpTyr: 0.327 ± 0.004
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.321TyrAla: 1.321 ± 0.009
0.669TyrCys: 0.669 ± 0.006
1.31TyrAsp: 1.31 ± 0.009
1.809TyrGlu: 1.809 ± 0.013
1.233TyrPhe: 1.233 ± 0.008
1.639TyrGly: 1.639 ± 0.011
0.753TyrHis: 0.753 ± 0.005
1.426TyrIle: 1.426 ± 0.008
1.607TyrLys: 1.607 ± 0.017
2.671TyrLeu: 2.671 ± 0.014
0.61TyrMet: 0.61 ± 0.006
1.171TyrAsn: 1.171 ± 0.008
1.323TyrPro: 1.323 ± 0.009
1.286TyrGln: 1.286 ± 0.009
1.542TyrArg: 1.542 ± 0.01
2.268TyrSer: 2.268 ± 0.011
1.498TyrThr: 1.498 ± 0.01
1.518TyrVal: 1.518 ± 0.01
0.35TyrTrp: 0.35 ± 0.005
0.957TyrTyr: 0.957 ± 0.008
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 36286 proteins (23604767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski