Amino acid dipepetide frequency for uncultured archaeon A07HB70

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.362AlaAla: 20.362 ± 0.293	0.87AlaCys: 0.87 ± 0.041	11.451AlaAsp: 11.451 ± 0.17	8.794AlaGlu: 8.794 ± 0.143	4.027AlaPhe: 4.027 ± 0.084	12.78AlaGly: 12.78 ± 0.154	1.987AlaHis: 1.987 ± 0.06	2.694AlaIle: 2.694 ± 0.078	1.303AlaLys: 1.303 ± 0.046	13.005AlaLeu: 13.005 ± 0.203	1.995AlaMet: 1.995 ± 0.059	2.104AlaAsn: 2.104 ± 0.062	5.484AlaPro: 5.484 ± 0.104	1.957AlaGln: 1.957 ± 0.054	9.317AlaArg: 9.317 ± 0.164	5.594AlaSer: 5.594 ± 0.101	7.763AlaThr: 7.763 ± 0.118	14.861AlaVal: 14.861 ± 0.208	1.289AlaTrp: 1.289 ± 0.05	2.698AlaTyr: 2.698 ± 0.062	0.027AlaXaa: 0.027 ± 0.006
Cys	0.758CysAla: 0.758 ± 0.033	0.103CysCys: 0.103 ± 0.012	0.619CysAsp: 0.619 ± 0.029	0.544CysGlu: 0.544 ± 0.028	0.184CysPhe: 0.184 ± 0.017	0.923CysGly: 0.923 ± 0.042	0.2CysHis: 0.2 ± 0.017	0.161CysIle: 0.161 ± 0.017	0.072CysLys: 0.072 ± 0.011	0.595CysLeu: 0.595 ± 0.033	0.089CysMet: 0.089 ± 0.013	0.172CysAsn: 0.172 ± 0.018	0.587CysPro: 0.587 ± 0.034	0.147CysGln: 0.147 ± 0.016	0.694CysArg: 0.694 ± 0.032	0.472CysSer: 0.472 ± 0.031	0.355CysThr: 0.355 ± 0.024	0.551CysVal: 0.551 ± 0.027	0.094CysTrp: 0.094 ± 0.013	0.175CysTyr: 0.175 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	11.384AspAla: 11.384 ± 0.185	0.709AspCys: 0.709 ± 0.039	8.263AspAsp: 8.263 ± 0.153	7.484AspGlu: 7.484 ± 0.12	1.321AspPhe: 1.321 ± 0.042	8.86AspGly: 8.86 ± 0.144	2.009AspHis: 2.009 ± 0.063	1.701AspIle: 1.701 ± 0.057	0.57AspLys: 0.57 ± 0.029	7.226AspLeu: 7.226 ± 0.135	0.993AspMet: 0.993 ± 0.039	0.775AspAsn: 0.775 ± 0.04	5.775AspPro: 5.775 ± 0.109	1.331AspGln: 1.331 ± 0.044	8.238AspArg: 8.238 ± 0.135	2.716AspSer: 2.716 ± 0.061	3.463AspThr: 3.463 ± 0.082	7.854AspVal: 7.854 ± 0.141	0.922AspTrp: 0.922 ± 0.049	1.74AspTyr: 1.74 ± 0.059	0.009AspXaa: 0.009 ± 0.003
Glu	9.224GluAla: 9.224 ± 0.148	0.412GluCys: 0.412 ± 0.027	3.957GluAsp: 3.957 ± 0.084	4.688GluGlu: 4.688 ± 0.095	2.566GluPhe: 2.566 ± 0.066	4.961GluGly: 4.961 ± 0.093	1.6GluHis: 1.6 ± 0.058	2.263GluIle: 2.263 ± 0.072	1.109GluLys: 1.109 ± 0.049	5.864GluLeu: 5.864 ± 0.121	1.479GluMet: 1.479 ± 0.054	1.67GluAsn: 1.67 ± 0.054	3.593GluPro: 3.593 ± 0.076	2.059GluGln: 2.059 ± 0.063	9.258GluArg: 9.258 ± 0.159	4.313GluSer: 4.313 ± 0.091	6.417GluThr: 6.417 ± 0.128	5.534GluVal: 5.534 ± 0.096	0.843GluTrp: 0.843 ± 0.037	1.809GluTyr: 1.809 ± 0.062	0.003GluXaa: 0.003 ± 0.002
Phe	3.747PheAla: 3.747 ± 0.075	0.226PheCys: 0.226 ± 0.019	3.171PheAsp: 3.171 ± 0.075	2.39PheGlu: 2.39 ± 0.055	0.794PhePhe: 0.794 ± 0.042	3.165PheGly: 3.165 ± 0.08	0.547PheHis: 0.547 ± 0.026	0.506PheIle: 0.506 ± 0.029	0.325PheLys: 0.325 ± 0.023	2.423PheLeu: 2.423 ± 0.067	0.38PheMet: 0.38 ± 0.027	0.465PheAsn: 0.465 ± 0.034	1.29PhePro: 1.29 ± 0.043	0.594PheGln: 0.594 ± 0.038	1.834PheArg: 1.834 ± 0.058	1.311PheSer: 1.311 ± 0.048	1.481PheThr: 1.481 ± 0.049	3.336PheVal: 3.336 ± 0.073	0.303PheTrp: 0.303 ± 0.023	0.719PheTyr: 0.719 ± 0.034	0.002PheXaa: 0.002 ± 0.002
Gly	10.873GlyAla: 10.873 ± 0.151	0.795GlyCys: 0.795 ± 0.039	7.242GlyAsp: 7.242 ± 0.128	6.86GlyGlu: 6.86 ± 0.121	2.918GlyPhe: 2.918 ± 0.069	8.704GlyGly: 8.704 ± 0.161	1.89GlyHis: 1.89 ± 0.055	2.768GlyIle: 2.768 ± 0.07	1.286GlyLys: 1.286 ± 0.041	8.227GlyLeu: 8.227 ± 0.142	1.654GlyMet: 1.654 ± 0.046	1.37GlyAsn: 1.37 ± 0.056	4.411GlyPro: 4.411 ± 0.084	2.063GlyGln: 2.063 ± 0.052	6.576GlyArg: 6.576 ± 0.109	5.301GlySer: 5.301 ± 0.102	5.608GlyThr: 5.608 ± 0.088	9.989GlyVal: 9.989 ± 0.143	1.115GlyTrp: 1.115 ± 0.038	2.449GlyTyr: 2.449 ± 0.061	0.016GlyXaa: 0.016 ± 0.005
His	2.332HisAla: 2.332 ± 0.06	0.161HisCys: 0.161 ± 0.018	1.878HisAsp: 1.878 ± 0.059	1.578HisGlu: 1.578 ± 0.047	0.389HisPhe: 0.389 ± 0.025	2.043HisGly: 2.043 ± 0.055	0.54HisHis: 0.54 ± 0.031	0.348HisIle: 0.348 ± 0.03	0.192HisLys: 0.192 ± 0.017	1.74HisLeu: 1.74 ± 0.055	0.225HisMet: 0.225 ± 0.018	0.358HisAsn: 0.358 ± 0.022	1.246HisPro: 1.246 ± 0.057	0.409HisGln: 0.409 ± 0.027	1.353HisArg: 1.353 ± 0.051	0.687HisSer: 0.687 ± 0.033	0.954HisThr: 0.954 ± 0.048	2.056HisVal: 2.056 ± 0.056	0.203HisTrp: 0.203 ± 0.018	0.475HisTyr: 0.475 ± 0.029	0.003HisXaa: 0.003 ± 0.002
Ile	3.057IleAla: 3.057 ± 0.086	0.17IleCys: 0.17 ± 0.014	2.316IleAsp: 2.316 ± 0.076	2.31IleGlu: 2.31 ± 0.075	0.505IlePhe: 0.505 ± 0.037	2.455IleGly: 2.455 ± 0.078	0.58IleHis: 0.58 ± 0.029	0.605IleIle: 0.605 ± 0.037	0.362IleLys: 0.362 ± 0.024	1.82IleLeu: 1.82 ± 0.066	0.301IleMet: 0.301 ± 0.022	0.615IleAsn: 0.615 ± 0.033	1.275IlePro: 1.275 ± 0.043	0.704IleGln: 0.704 ± 0.041	1.856IleArg: 1.856 ± 0.057	1.197IleSer: 1.197 ± 0.043	1.482IleThr: 1.482 ± 0.056	2.293IleVal: 2.293 ± 0.072	0.162IleTrp: 0.162 ± 0.018	0.537IleTyr: 0.537 ± 0.033	0.005IleXaa: 0.005 ± 0.003
Lys	1.123LysAla: 1.123 ± 0.048	0.077LysCys: 0.077 ± 0.01	0.592LysAsp: 0.592 ± 0.033	0.742LysGlu: 0.742 ± 0.039	0.401LysPhe: 0.401 ± 0.022	0.995LysGly: 0.995 ± 0.045	0.272LysHis: 0.272 ± 0.021	0.464LysIle: 0.464 ± 0.029	0.273LysLys: 0.273 ± 0.024	1.129LysLeu: 1.129 ± 0.044	0.225LysMet: 0.225 ± 0.017	0.333LysAsn: 0.333 ± 0.025	0.664LysPro: 0.664 ± 0.03	0.495LysGln: 0.495 ± 0.031	1.348LysArg: 1.348 ± 0.048	0.737LysSer: 0.737 ± 0.041	0.967LysThr: 0.967 ± 0.043	0.817LysVal: 0.817 ± 0.036	0.152LysTrp: 0.152 ± 0.017	0.342LysTyr: 0.342 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.098LeuAla: 13.098 ± 0.186	0.726LeuCys: 0.726 ± 0.034	7.923LeuAsp: 7.923 ± 0.134	4.97LeuGlu: 4.97 ± 0.119	2.851LeuPhe: 2.851 ± 0.083	7.993LeuGly: 7.993 ± 0.12	1.417LeuHis: 1.417 ± 0.051	1.935LeuIle: 1.935 ± 0.065	1.098LeuLys: 1.098 ± 0.044	8.366LeuLeu: 8.366 ± 0.166	1.161LeuMet: 1.161 ± 0.041	1.432LeuAsn: 1.432 ± 0.049	4.711LeuPro: 4.711 ± 0.082	1.56LeuGln: 1.56 ± 0.054	6.995LeuArg: 6.995 ± 0.097	5.298LeuSer: 5.298 ± 0.086	5.162LeuThr: 5.162 ± 0.091	10.123LeuVal: 10.123 ± 0.169	0.772LeuTrp: 0.772 ± 0.03	1.998LeuTyr: 1.998 ± 0.057	0.014LeuXaa: 0.014 ± 0.004
Met	1.701MetAla: 1.701 ± 0.056	0.112MetCys: 0.112 ± 0.013	1.078MetAsp: 1.078 ± 0.043	0.859MetGlu: 0.859 ± 0.035	0.425MetPhe: 0.425 ± 0.026	1.234MetGly: 1.234 ± 0.046	0.226MetHis: 0.226 ± 0.021	0.505MetIle: 0.505 ± 0.034	0.3MetLys: 0.3 ± 0.022	1.42MetLeu: 1.42 ± 0.047	0.223MetMet: 0.223 ± 0.02	0.487MetAsn: 0.487 ± 0.024	0.708MetPro: 0.708 ± 0.037	0.314MetGln: 0.314 ± 0.022	1.209MetArg: 1.209 ± 0.044	1.348MetSer: 1.348 ± 0.046	1.431MetThr: 1.431 ± 0.046	1.139MetVal: 1.139 ± 0.044	0.128MetTrp: 0.128 ± 0.015	0.323MetTyr: 0.323 ± 0.021	0.002MetXaa: 0.002 ± 0.002
Asn	2.115AsnAla: 2.115 ± 0.055	0.158AsnCys: 0.158 ± 0.016	1.217AsnAsp: 1.217 ± 0.044	1.24AsnGlu: 1.24 ± 0.053	0.505AsnPhe: 0.505 ± 0.031	1.556AsnGly: 1.556 ± 0.055	0.353AsnHis: 0.353 ± 0.024	0.492AsnIle: 0.492 ± 0.031	0.287AsnLys: 0.287 ± 0.027	1.517AsnLeu: 1.517 ± 0.056	0.262AsnMet: 0.262 ± 0.021	0.376AsnAsn: 0.376 ± 0.025	1.203AsnPro: 1.203 ± 0.046	0.383AsnGln: 0.383 ± 0.026	1.401AsnArg: 1.401 ± 0.045	0.753AsnSer: 0.753 ± 0.036	0.948AsnThr: 0.948 ± 0.042	2.037AsnVal: 2.037 ± 0.052	0.209AsnTrp: 0.209 ± 0.018	0.53AsnTyr: 0.53 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.629ProAla: 6.629 ± 0.11	0.311ProCys: 0.311 ± 0.025	5.431ProAsp: 5.431 ± 0.112	4.249ProGlu: 4.249 ± 0.082	1.546ProPhe: 1.546 ± 0.05	4.956ProGly: 4.956 ± 0.081	0.872ProHis: 0.872 ± 0.034	1.139ProIle: 1.139 ± 0.045	0.595ProLys: 0.595 ± 0.031	4.049ProLeu: 4.049 ± 0.087	0.812ProMet: 0.812 ± 0.034	0.887ProAsn: 0.887 ± 0.037	2.824ProPro: 2.824 ± 0.078	0.89ProGln: 0.89 ± 0.04	3.138ProArg: 3.138 ± 0.074	2.61ProSer: 2.61 ± 0.051	3.705ProThr: 3.705 ± 0.086	5.508ProVal: 5.508 ± 0.091	0.511ProTrp: 0.511 ± 0.029	1.103ProTyr: 1.103 ± 0.042	0.009ProXaa: 0.009 ± 0.003
Gln	2.151GlnAla: 2.151 ± 0.066	0.12GlnCys: 0.12 ± 0.015	0.934GlnAsp: 0.934 ± 0.04	1.164GlnGlu: 1.164 ± 0.055	0.915GlnPhe: 0.915 ± 0.038	1.442GlnGly: 1.442 ± 0.049	0.419GlnHis: 0.419 ± 0.027	0.859GlnIle: 0.859 ± 0.044	0.43GlnLys: 0.43 ± 0.026	1.626GlnLeu: 1.626 ± 0.052	0.492GlnMet: 0.492 ± 0.027	0.584GlnAsn: 0.584 ± 0.029	1.228GlnPro: 1.228 ± 0.049	0.769GlnGln: 0.769 ± 0.043	1.626GlnArg: 1.626 ± 0.046	1.256GlnSer: 1.256 ± 0.049	1.639GlnThr: 1.639 ± 0.055	1.86GlnVal: 1.86 ± 0.055	0.223GlnTrp: 0.223 ± 0.021	0.592GlnTyr: 0.592 ± 0.031	0.002GlnXaa: 0.002 ± 0.002
Arg	9.981ArgAla: 9.981 ± 0.151	0.631ArgCys: 0.631 ± 0.033	6.039ArgAsp: 6.039 ± 0.106	7.146ArgGlu: 7.146 ± 0.118	2.421ArgPhe: 2.421 ± 0.065	6.0ArgGly: 6.0 ± 0.12	1.545ArgHis: 1.545 ± 0.059	2.351ArgIle: 2.351 ± 0.058	1.011ArgLys: 1.011 ± 0.039	8.29ArgLeu: 8.29 ± 0.124	1.362ArgMet: 1.362 ± 0.045	1.423ArgAsn: 1.423 ± 0.048	3.644ArgPro: 3.644 ± 0.079	1.89ArgGln: 1.89 ± 0.058	8.069ArgArg: 8.069 ± 0.182	4.21ArgSer: 4.21 ± 0.09	4.847ArgThr: 4.847 ± 0.089	8.168ArgVal: 8.168 ± 0.116	0.851ArgTrp: 0.851 ± 0.035	2.076ArgTyr: 2.076 ± 0.056	0.017ArgXaa: 0.017 ± 0.005
Ser	5.601SerAla: 5.601 ± 0.104	0.281SerCys: 0.281 ± 0.021	3.411SerAsp: 3.411 ± 0.077	3.166SerGlu: 3.166 ± 0.071	1.668SerPhe: 1.668 ± 0.049	5.017SerGly: 5.017 ± 0.096	0.897SerHis: 0.897 ± 0.037	1.462SerIle: 1.462 ± 0.046	0.772SerLys: 0.772 ± 0.039	4.633SerLeu: 4.633 ± 0.088	0.965SerMet: 0.965 ± 0.042	0.906SerAsn: 0.906 ± 0.035	2.673SerPro: 2.673 ± 0.068	0.975SerGln: 0.975 ± 0.044	4.08SerArg: 4.08 ± 0.087	2.555SerSer: 2.555 ± 0.071	3.326SerThr: 3.326 ± 0.08	5.289SerVal: 5.289 ± 0.091	0.581SerTrp: 0.581 ± 0.032	1.198SerTyr: 1.198 ± 0.041	0.012SerXaa: 0.012 ± 0.005
Thr	8.038ThrAla: 8.038 ± 0.123	0.395ThrCys: 0.395 ± 0.026	5.052ThrAsp: 5.052 ± 0.1	3.869ThrGlu: 3.869 ± 0.083	1.904ThrPhe: 1.904 ± 0.055	6.181ThrGly: 6.181 ± 0.099	1.134ThrHis: 1.134 ± 0.039	1.609ThrIle: 1.609 ± 0.05	0.665ThrLys: 0.665 ± 0.035	5.656ThrLeu: 5.656 ± 0.101	0.879ThrMet: 0.879 ± 0.041	1.156ThrAsn: 1.156 ± 0.044	3.724ThrPro: 3.724 ± 0.091	1.182ThrGln: 1.182 ± 0.043	4.08ThrArg: 4.08 ± 0.084	2.568ThrSer: 2.568 ± 0.076	4.402ThrThr: 4.402 ± 0.095	7.748ThrVal: 7.748 ± 0.128	0.534ThrTrp: 0.534 ± 0.03	1.557ThrTyr: 1.557 ± 0.045	0.009ThrXaa: 0.009 ± 0.004
Val	14.486ValAla: 14.486 ± 0.154	0.912ValCys: 0.912 ± 0.043	9.769ValAsp: 9.769 ± 0.15	9.0ValGlu: 9.0 ± 0.136	2.759ValPhe: 2.759 ± 0.077	9.82ValGly: 9.82 ± 0.167	1.899ValHis: 1.899 ± 0.062	1.996ValIle: 1.996 ± 0.069	1.048ValLys: 1.048 ± 0.039	8.61ValLeu: 8.61 ± 0.134	1.176ValMet: 1.176 ± 0.042	1.714ValAsn: 1.714 ± 0.058	5.095ValPro: 5.095 ± 0.101	1.734ValGln: 1.734 ± 0.064	7.794ValArg: 7.794 ± 0.133	5.061ValSer: 5.061 ± 0.114	6.334ValThr: 6.334 ± 0.102	13.033ValVal: 13.033 ± 0.186	0.784ValTrp: 0.784 ± 0.036	2.251ValTyr: 2.251 ± 0.065	0.016ValXaa: 0.016 ± 0.004
Trp	0.992TrpAla: 0.992 ± 0.04	0.077TrpCys: 0.077 ± 0.011	0.611TrpAsp: 0.611 ± 0.03	0.609TrpGlu: 0.609 ± 0.03	0.316TrpPhe: 0.316 ± 0.024	0.778TrpGly: 0.778 ± 0.038	0.245TrpHis: 0.245 ± 0.019	0.342TrpIle: 0.342 ± 0.027	0.164TrpLys: 0.164 ± 0.015	1.098TrpLeu: 1.098 ± 0.038	0.169TrpMet: 0.169 ± 0.015	0.237TrpAsn: 0.237 ± 0.019	0.486TrpPro: 0.486 ± 0.027	0.3TrpGln: 0.3 ± 0.024	1.008TrpArg: 1.008 ± 0.044	0.506TrpSer: 0.506 ± 0.033	0.833TrpThr: 0.833 ± 0.036	0.867TrpVal: 0.867 ± 0.037	0.161TrpTrp: 0.161 ± 0.015	0.303TrpTyr: 0.303 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.694TyrAla: 2.694 ± 0.074	0.241TyrCys: 0.241 ± 0.02	2.379TyrAsp: 2.379 ± 0.054	1.956TyrGlu: 1.956 ± 0.064	0.592TyrPhe: 0.592 ± 0.037	2.237TyrGly: 2.237 ± 0.063	0.534TyrHis: 0.534 ± 0.032	0.405TyrIle: 0.405 ± 0.027	0.284TyrLys: 0.284 ± 0.019	2.306TyrLeu: 2.306 ± 0.055	0.323TyrMet: 0.323 ± 0.023	0.475TyrAsn: 0.475 ± 0.028	1.143TyrPro: 1.143 ± 0.047	0.573TyrGln: 0.573 ± 0.029	2.074TyrArg: 2.074 ± 0.062	0.967TyrSer: 0.967 ± 0.037	1.217TyrThr: 1.217 ± 0.044	2.215TyrVal: 2.215 ± 0.059	0.259TyrTrp: 0.259 ± 0.021	0.629TyrTyr: 0.629 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.016XaaAla: 0.016 ± 0.005	0.005XaaCys: 0.005 ± 0.003	0.012XaaAsp: 0.012 ± 0.004	0.003XaaGlu: 0.003 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.017XaaGly: 0.017 ± 0.005	0.006XaaHis: 0.006 ± 0.003	0.003XaaIle: 0.003 ± 0.002	0.002XaaLys: 0.002 ± 0.002	0.005XaaLeu: 0.005 ± 0.003	0.003XaaMet: 0.003 ± 0.002	0.002XaaAsn: 0.002 ± 0.002	0.011XaaPro: 0.011 ± 0.004	0.0XaaGln: 0.0 ± 0.0	0.023XaaArg: 0.023 ± 0.006	0.009XaaSer: 0.009 ± 0.004	0.011XaaThr: 0.011 ± 0.004	0.014XaaVal: 0.014 ± 0.004	0.003XaaTrp: 0.003 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.884XaaXaa: 0.884 ± 0.087

Statistics based on 2513 proteins (640198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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