Amino acid dipepetide frequency for Thiohalomonas denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.479AlaAla: 11.479 ± 0.153	1.055AlaCys: 1.055 ± 0.039	5.616AlaAsp: 5.616 ± 0.081	7.639AlaGlu: 7.639 ± 0.098	3.618AlaPhe: 3.618 ± 0.058	8.878AlaGly: 8.878 ± 0.094	2.145AlaHis: 2.145 ± 0.05	5.36AlaIle: 5.36 ± 0.08	2.927AlaLys: 2.927 ± 0.06	11.295AlaLeu: 11.295 ± 0.115	2.642AlaMet: 2.642 ± 0.057	2.537AlaAsn: 2.537 ± 0.047	4.037AlaPro: 4.037 ± 0.058	3.061AlaGln: 3.061 ± 0.058	7.372AlaArg: 7.372 ± 0.101	5.065AlaSer: 5.065 ± 0.083	4.637AlaThr: 4.637 ± 0.084	7.97AlaVal: 7.97 ± 0.099	1.443AlaTrp: 1.443 ± 0.044	2.405AlaTyr: 2.405 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.824CysAla: 0.824 ± 0.032	0.137CysCys: 0.137 ± 0.012	0.523CysAsp: 0.523 ± 0.023	0.533CysGlu: 0.533 ± 0.023	0.296CysPhe: 0.296 ± 0.015	0.981CysGly: 0.981 ± 0.031	0.41CysHis: 0.41 ± 0.035	0.441CysIle: 0.441 ± 0.023	0.229CysLys: 0.229 ± 0.015	0.819CysLeu: 0.819 ± 0.028	0.174CysMet: 0.174 ± 0.012	0.254CysAsn: 0.254 ± 0.017	0.576CysPro: 0.576 ± 0.025	0.248CysGln: 0.248 ± 0.018	0.794CysArg: 0.794 ± 0.029	0.588CysSer: 0.588 ± 0.026	0.461CysThr: 0.461 ± 0.026	0.603CysVal: 0.603 ± 0.028	0.084CysTrp: 0.084 ± 0.01	0.235CysTyr: 0.235 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.507AspAla: 5.507 ± 0.076	0.465AspCys: 0.465 ± 0.024	3.177AspAsp: 3.177 ± 0.069	4.302AspGlu: 4.302 ± 0.071	2.244AspPhe: 2.244 ± 0.05	4.528AspGly: 4.528 ± 0.081	1.265AspHis: 1.265 ± 0.042	2.933AspIle: 2.933 ± 0.059	1.659AspLys: 1.659 ± 0.044	5.772AspLeu: 5.772 ± 0.076	1.185AspMet: 1.185 ± 0.036	1.547AspAsn: 1.547 ± 0.038	3.229AspPro: 3.229 ± 0.063	1.728AspGln: 1.728 ± 0.041	4.318AspArg: 4.318 ± 0.071	2.954AspSer: 2.954 ± 0.062	2.787AspThr: 2.787 ± 0.058	3.778AspVal: 3.778 ± 0.067	0.932AspTrp: 0.932 ± 0.03	1.795AspTyr: 1.795 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.733GluAla: 7.733 ± 0.103	0.54GluCys: 0.54 ± 0.025	3.13GluAsp: 3.13 ± 0.053	5.262GluGlu: 5.262 ± 0.098	2.24GluPhe: 2.24 ± 0.048	5.305GluGly: 5.305 ± 0.091	1.867GluHis: 1.867 ± 0.04	3.361GluIle: 3.361 ± 0.062	2.852GluLys: 2.852 ± 0.057	7.581GluLeu: 7.581 ± 0.105	1.802GluMet: 1.802 ± 0.04	2.0GluAsn: 2.0 ± 0.046	3.454GluPro: 3.454 ± 0.062	3.633GluGln: 3.633 ± 0.063	6.48GluArg: 6.48 ± 0.105	3.844GluSer: 3.844 ± 0.062	3.631GluThr: 3.631 ± 0.068	5.242GluVal: 5.242 ± 0.078	0.987GluTrp: 0.987 ± 0.039	1.734GluTyr: 1.734 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.643PheAla: 3.643 ± 0.072	0.385PheCys: 0.385 ± 0.022	2.482PheAsp: 2.482 ± 0.057	2.562PheGlu: 2.562 ± 0.052	1.509PhePhe: 1.509 ± 0.049	3.378PheGly: 3.378 ± 0.065	0.853PheHis: 0.853 ± 0.031	1.767PheIle: 1.767 ± 0.044	0.969PheLys: 0.969 ± 0.031	3.577PheLeu: 3.577 ± 0.068	0.818PheMet: 0.818 ± 0.027	1.088PheAsn: 1.088 ± 0.035	1.674PhePro: 1.674 ± 0.044	1.057PheGln: 1.057 ± 0.034	2.566PheArg: 2.566 ± 0.056	2.334PheSer: 2.334 ± 0.054	1.961PheThr: 1.961 ± 0.044	2.608PheVal: 2.608 ± 0.048	0.59PheTrp: 0.59 ± 0.027	1.051PheTyr: 1.051 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.333GlyAla: 7.333 ± 0.092	0.997GlyCys: 0.997 ± 0.037	4.415GlyAsp: 4.415 ± 0.074	5.987GlyGlu: 5.987 ± 0.08	3.365GlyPhe: 3.365 ± 0.059	6.552GlyGly: 6.552 ± 0.1	1.953GlyHis: 1.953 ± 0.05	4.63GlyIle: 4.63 ± 0.069	3.26GlyLys: 3.26 ± 0.07	8.41GlyLeu: 8.41 ± 0.112	2.339GlyMet: 2.339 ± 0.055	2.276GlyAsn: 2.276 ± 0.052	3.078GlyPro: 3.078 ± 0.061	2.764GlyGln: 2.764 ± 0.062	6.09GlyArg: 6.09 ± 0.093	4.501GlySer: 4.501 ± 0.074	4.238GlyThr: 4.238 ± 0.077	6.03GlyVal: 6.03 ± 0.087	1.317GlyTrp: 1.317 ± 0.041	2.574GlyTyr: 2.574 ± 0.052	0.001GlyXaa: 0.001 ± 0.001
His	2.141HisAla: 2.141 ± 0.044	0.295HisCys: 0.295 ± 0.018	1.338HisAsp: 1.338 ± 0.038	1.398HisGlu: 1.398 ± 0.038	1.074HisPhe: 1.074 ± 0.037	1.994HisGly: 1.994 ± 0.047	0.771HisHis: 0.771 ± 0.03	1.109HisIle: 1.109 ± 0.037	0.63HisLys: 0.63 ± 0.027	2.685HisLeu: 2.685 ± 0.054	0.549HisMet: 0.549 ± 0.022	0.616HisAsn: 0.616 ± 0.024	1.632HisPro: 1.632 ± 0.042	0.887HisGln: 0.887 ± 0.031	1.875HisArg: 1.875 ± 0.036	1.213HisSer: 1.213 ± 0.038	1.119HisThr: 1.119 ± 0.029	1.418HisVal: 1.418 ± 0.039	0.455HisTrp: 0.455 ± 0.021	0.771HisTyr: 0.771 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.473IleAla: 5.473 ± 0.085	0.455IleCys: 0.455 ± 0.022	3.549IleAsp: 3.549 ± 0.069	3.841IleGlu: 3.841 ± 0.069	1.548IlePhe: 1.548 ± 0.039	4.46IleGly: 4.46 ± 0.07	1.171IleHis: 1.171 ± 0.033	2.283IleIle: 2.283 ± 0.059	1.48IleLys: 1.48 ± 0.043	4.443IleLeu: 4.443 ± 0.071	0.863IleMet: 0.863 ± 0.031	1.521IleAsn: 1.521 ± 0.043	2.567IlePro: 2.567 ± 0.057	1.432IleGln: 1.432 ± 0.045	3.582IleArg: 3.582 ± 0.061	2.769IleSer: 2.769 ± 0.056	2.889IleThr: 2.889 ± 0.059	3.212IleVal: 3.212 ± 0.064	0.531IleTrp: 0.531 ± 0.021	1.252IleTyr: 1.252 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.397LysAla: 3.397 ± 0.069	0.224LysCys: 0.224 ± 0.017	1.541LysAsp: 1.541 ± 0.044	2.228LysGlu: 2.228 ± 0.054	0.824LysPhe: 0.824 ± 0.031	2.643LysGly: 2.643 ± 0.057	0.74LysHis: 0.74 ± 0.029	1.401LysIle: 1.401 ± 0.038	1.531LysLys: 1.531 ± 0.053	3.101LysLeu: 3.101 ± 0.067	0.812LysMet: 0.812 ± 0.034	0.909LysAsn: 0.909 ± 0.03	1.849LysPro: 1.849 ± 0.044	1.308LysGln: 1.308 ± 0.036	2.73LysArg: 2.73 ± 0.059	1.821LysSer: 1.821 ± 0.042	1.796LysThr: 1.796 ± 0.049	2.425LysVal: 2.425 ± 0.057	0.395LysTrp: 0.395 ± 0.021	0.751LysTyr: 0.751 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.457LeuAla: 11.457 ± 0.144	0.824LeuCys: 0.824 ± 0.028	5.996LeuAsp: 5.996 ± 0.09	7.86LeuGlu: 7.86 ± 0.109	4.146LeuPhe: 4.146 ± 0.079	8.157LeuGly: 8.157 ± 0.101	2.381LeuHis: 2.381 ± 0.056	4.893LeuIle: 4.893 ± 0.075	3.714LeuLys: 3.714 ± 0.064	11.703LeuLeu: 11.703 ± 0.146	2.425LeuMet: 2.425 ± 0.052	2.902LeuAsn: 2.902 ± 0.056	5.635LeuPro: 5.635 ± 0.083	3.67LeuGln: 3.67 ± 0.061	7.53LeuArg: 7.53 ± 0.098	6.406LeuSer: 6.406 ± 0.1	5.355LeuThr: 5.355 ± 0.085	7.784LeuVal: 7.784 ± 0.09	1.31LeuTrp: 1.31 ± 0.042	2.491LeuTyr: 2.491 ± 0.056	0.001LeuXaa: 0.001 ± 0.001
Met	2.85MetAla: 2.85 ± 0.057	0.152MetCys: 0.152 ± 0.012	1.336MetAsp: 1.336 ± 0.041	1.734MetGlu: 1.734 ± 0.038	0.646MetPhe: 0.646 ± 0.023	1.835MetGly: 1.835 ± 0.056	0.577MetHis: 0.577 ± 0.028	0.965MetIle: 0.965 ± 0.034	1.022MetLys: 1.022 ± 0.032	2.375MetLeu: 2.375 ± 0.049	0.608MetMet: 0.608 ± 0.03	0.837MetAsn: 0.837 ± 0.031	1.278MetPro: 1.278 ± 0.034	0.865MetGln: 0.865 ± 0.028	1.632MetArg: 1.632 ± 0.035	1.383MetSer: 1.383 ± 0.04	1.329MetThr: 1.329 ± 0.036	1.798MetVal: 1.798 ± 0.044	0.208MetTrp: 0.208 ± 0.014	0.386MetTyr: 0.386 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.65AsnAla: 2.65 ± 0.056	0.273AsnCys: 0.273 ± 0.017	1.408AsnAsp: 1.408 ± 0.038	1.664AsnGlu: 1.664 ± 0.042	0.966AsnPhe: 0.966 ± 0.03	2.391AsnGly: 2.391 ± 0.053	0.609AsnHis: 0.609 ± 0.024	1.505AsnIle: 1.505 ± 0.037	0.772AsnLys: 0.772 ± 0.032	2.905AsnLeu: 2.905 ± 0.051	0.567AsnMet: 0.567 ± 0.023	0.796AsnAsn: 0.796 ± 0.031	1.85AsnPro: 1.85 ± 0.052	0.898AsnGln: 0.898 ± 0.03	2.273AsnArg: 2.273 ± 0.046	1.385AsnSer: 1.385 ± 0.045	1.445AsnThr: 1.445 ± 0.048	1.824AsnVal: 1.824 ± 0.041	0.434AsnTrp: 0.434 ± 0.022	0.774AsnTyr: 0.774 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.688ProAla: 4.688 ± 0.077	0.347ProCys: 0.347 ± 0.021	3.557ProAsp: 3.557 ± 0.07	4.837ProGlu: 4.837 ± 0.08	1.885ProPhe: 1.885 ± 0.043	4.479ProGly: 4.479 ± 0.073	1.066ProHis: 1.066 ± 0.031	2.109ProIle: 2.109 ± 0.05	1.512ProLys: 1.512 ± 0.04	5.083ProLeu: 5.083 ± 0.07	1.176ProMet: 1.176 ± 0.036	1.203ProAsn: 1.203 ± 0.037	2.358ProPro: 2.358 ± 0.058	1.479ProGln: 1.479 ± 0.039	2.838ProArg: 2.838 ± 0.054	2.416ProSer: 2.416 ± 0.052	2.211ProThr: 2.211 ± 0.05	4.285ProVal: 4.285 ± 0.073	0.67ProTrp: 0.67 ± 0.025	1.264ProTyr: 1.264 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.805GlnAla: 3.805 ± 0.07	0.271GlnCys: 0.271 ± 0.017	1.363GlnAsp: 1.363 ± 0.042	2.243GlnGlu: 2.243 ± 0.045	1.14GlnPhe: 1.14 ± 0.035	2.559GlnGly: 2.559 ± 0.048	0.909GlnHis: 0.909 ± 0.031	1.6GlnIle: 1.6 ± 0.037	1.145GlnLys: 1.145 ± 0.037	3.852GlnLeu: 3.852 ± 0.064	0.86GlnMet: 0.86 ± 0.034	0.834GlnAsn: 0.834 ± 0.03	1.784GlnPro: 1.784 ± 0.046	1.702GlnGln: 1.702 ± 0.05	3.007GlnArg: 3.007 ± 0.061	1.811GlnSer: 1.811 ± 0.043	1.606GlnThr: 1.606 ± 0.039	2.8GlnVal: 2.8 ± 0.059	0.528GlnTrp: 0.528 ± 0.023	0.811GlnTyr: 0.811 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.458ArgAla: 6.458 ± 0.092	0.689ArgCys: 0.689 ± 0.029	4.038ArgAsp: 4.038 ± 0.065	5.853ArgGlu: 5.853 ± 0.093	3.28ArgPhe: 3.28 ± 0.06	4.91ArgGly: 4.91 ± 0.074	2.129ArgHis: 2.129 ± 0.046	4.239ArgIle: 4.239 ± 0.061	2.57ArgLys: 2.57 ± 0.054	8.91ArgLeu: 8.91 ± 0.13	1.984ArgMet: 1.984 ± 0.047	2.123ArgAsn: 2.123 ± 0.045	3.378ArgPro: 3.378 ± 0.069	3.1ArgGln: 3.1 ± 0.061	6.167ArgArg: 6.167 ± 0.096	3.778ArgSer: 3.778 ± 0.06	3.379ArgThr: 3.379 ± 0.058	5.357ArgVal: 5.357 ± 0.084	1.129ArgTrp: 1.129 ± 0.035	2.361ArgTyr: 2.361 ± 0.05	0.001ArgXaa: 0.001 ± 0.001
Ser	5.341SerAla: 5.341 ± 0.08	0.54SerCys: 0.54 ± 0.024	3.183SerAsp: 3.183 ± 0.056	3.86SerGlu: 3.86 ± 0.059	1.909SerPhe: 1.909 ± 0.048	5.44SerGly: 5.44 ± 0.08	1.275SerHis: 1.275 ± 0.039	2.532SerIle: 2.532 ± 0.049	1.479SerLys: 1.479 ± 0.049	5.661SerLeu: 5.661 ± 0.082	1.35SerMet: 1.35 ± 0.036	1.475SerAsn: 1.475 ± 0.039	2.751SerPro: 2.751 ± 0.052	1.667SerGln: 1.667 ± 0.044	4.208SerArg: 4.208 ± 0.057	2.868SerSer: 2.868 ± 0.068	2.534SerThr: 2.534 ± 0.06	4.052SerVal: 4.052 ± 0.077	0.721SerTrp: 0.721 ± 0.026	1.368SerTyr: 1.368 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.236ThrAla: 5.236 ± 0.088	0.471ThrCys: 0.471 ± 0.021	2.928ThrAsp: 2.928 ± 0.062	3.112ThrGlu: 3.112 ± 0.056	1.822ThrPhe: 1.822 ± 0.049	4.878ThrGly: 4.878 ± 0.076	1.094ThrHis: 1.094 ± 0.038	2.563ThrIle: 2.563 ± 0.054	1.175ThrLys: 1.175 ± 0.035	5.983ThrLeu: 5.983 ± 0.092	0.989ThrMet: 0.989 ± 0.031	1.214ThrAsn: 1.214 ± 0.037	2.912ThrPro: 2.912 ± 0.058	1.249ThrGln: 1.249 ± 0.038	3.439ThrArg: 3.439 ± 0.059	2.535ThrSer: 2.535 ± 0.063	2.638ThrThr: 2.638 ± 0.076	4.075ThrVal: 4.075 ± 0.075	0.566ThrTrp: 0.566 ± 0.025	1.213ThrTyr: 1.213 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.799ValAla: 7.799 ± 0.106	0.669ValCys: 0.669 ± 0.025	4.365ValAsp: 4.365 ± 0.076	5.36ValGlu: 5.36 ± 0.073	2.713ValPhe: 2.713 ± 0.052	5.536ValGly: 5.536 ± 0.076	1.678ValHis: 1.678 ± 0.044	3.979ValIle: 3.979 ± 0.071	2.313ValLys: 2.313 ± 0.063	7.67ValLeu: 7.67 ± 0.097	1.803ValMet: 1.803 ± 0.045	2.113ValAsn: 2.113 ± 0.048	3.509ValPro: 3.509 ± 0.065	2.139ValGln: 2.139 ± 0.047	5.205ValArg: 5.205 ± 0.079	4.264ValSer: 4.264 ± 0.074	4.213ValThr: 4.213 ± 0.073	6.152ValVal: 6.152 ± 0.113	0.916ValTrp: 0.916 ± 0.034	1.689ValTyr: 1.689 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.073TrpAla: 1.073 ± 0.033	0.149TrpCys: 0.149 ± 0.012	0.748TrpAsp: 0.748 ± 0.027	0.895TrpGlu: 0.895 ± 0.027	0.603TrpPhe: 0.603 ± 0.026	0.95TrpGly: 0.95 ± 0.033	0.403TrpHis: 0.403 ± 0.02	0.602TrpIle: 0.602 ± 0.024	0.455TrpLys: 0.455 ± 0.02	1.816TrpLeu: 1.816 ± 0.048	0.358TrpMet: 0.358 ± 0.02	0.425TrpAsn: 0.425 ± 0.023	0.648TrpPro: 0.648 ± 0.028	0.631TrpGln: 0.631 ± 0.024	1.172TrpArg: 1.172 ± 0.04	0.814TrpSer: 0.814 ± 0.031	0.559TrpThr: 0.559 ± 0.028	0.976TrpVal: 0.976 ± 0.032	0.253TrpTrp: 0.253 ± 0.017	0.36TrpTyr: 0.36 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.042	0.273TyrCys: 0.273 ± 0.016	1.411TyrAsp: 1.411 ± 0.045	1.509TyrGlu: 1.509 ± 0.042	1.045TyrPhe: 1.045 ± 0.036	2.254TyrGly: 2.254 ± 0.05	0.674TyrHis: 0.674 ± 0.026	1.047TyrIle: 1.047 ± 0.032	0.731TyrLys: 0.731 ± 0.032	2.997TyrLeu: 2.997 ± 0.05	0.514TyrMet: 0.514 ± 0.023	0.717TyrAsn: 0.717 ± 0.025	1.263TyrPro: 1.263 ± 0.034	1.111TyrGln: 1.111 ± 0.036	2.556TyrArg: 2.556 ± 0.051	1.466TyrSer: 1.466 ± 0.043	1.304TyrThr: 1.304 ± 0.043	1.696TyrVal: 1.696 ± 0.044	0.423TyrTrp: 0.423 ± 0.02	0.766TyrTyr: 0.766 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.021XaaXaa: 0.021 ± 0.016

Statistics based on 3255 proteins (1022376 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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