Amino acid dipepetide frequency for Tuhoko virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.675AlaAla: 5.675 ± 1.789
0.811AlaCys: 0.811 ± 0.266
3.04AlaAsp: 3.04 ± 0.628
2.837AlaGlu: 2.837 ± 0.626
2.837AlaPhe: 2.837 ± 0.781
2.027AlaGly: 2.027 ± 0.557
1.621AlaHis: 1.621 ± 0.738
2.635AlaIle: 2.635 ± 0.806
3.04AlaLys: 3.04 ± 0.647
5.878AlaLeu: 5.878 ± 1.072
1.621AlaMet: 1.621 ± 0.801
2.432AlaAsn: 2.432 ± 0.823
3.648AlaPro: 3.648 ± 0.902
2.837AlaGln: 2.837 ± 1.168
3.243AlaArg: 3.243 ± 1.181
3.648AlaSer: 3.648 ± 0.558
4.256AlaThr: 4.256 ± 1.475
3.851AlaVal: 3.851 ± 1.172
1.013AlaTrp: 1.013 ± 0.457
1.621AlaTyr: 1.621 ± 0.457
0.0AlaXaa: 0.0 ± 0.0
Cys
0.608CysAla: 0.608 ± 0.218
0.203CysCys: 0.203 ± 0.13
1.013CysAsp: 1.013 ± 0.218
1.419CysGlu: 1.419 ± 0.349
0.405CysPhe: 0.405 ± 0.186
0.811CysGly: 0.811 ± 0.341
0.203CysHis: 0.203 ± 0.26
1.216CysIle: 1.216 ± 0.329
2.027CysLys: 2.027 ± 0.427
2.027CysLeu: 2.027 ± 0.634
0.203CysMet: 0.203 ± 0.22
1.824CysAsn: 1.824 ± 0.788
1.013CysPro: 1.013 ± 0.415
0.405CysGln: 0.405 ± 0.26
0.811CysArg: 0.811 ± 0.538
1.824CysSer: 1.824 ± 0.605
1.216CysThr: 1.216 ± 0.347
1.621CysVal: 1.621 ± 0.418
0.0CysTrp: 0.0 ± 0.0
1.216CysTyr: 1.216 ± 0.62
0.0CysXaa: 0.0 ± 0.0
Asp
2.432AspAla: 2.432 ± 0.503
1.013AspCys: 1.013 ± 0.34
3.04AspAsp: 3.04 ± 0.71
3.851AspGlu: 3.851 ± 0.59
2.229AspPhe: 2.229 ± 0.769
2.027AspGly: 2.027 ± 0.424
1.216AspHis: 1.216 ± 0.423
3.445AspIle: 3.445 ± 1.013
3.243AspLys: 3.243 ± 0.664
6.283AspLeu: 6.283 ± 0.917
0.405AspMet: 0.405 ± 0.235
2.837AspAsn: 2.837 ± 0.49
3.851AspPro: 3.851 ± 0.866
3.243AspGln: 3.243 ± 0.987
2.837AspArg: 2.837 ± 0.809
3.445AspSer: 3.445 ± 0.582
2.635AspThr: 2.635 ± 0.658
1.216AspVal: 1.216 ± 0.383
0.405AspTrp: 0.405 ± 0.26
2.229AspTyr: 2.229 ± 0.639
0.0AspXaa: 0.0 ± 0.0
Glu
1.419GluAla: 1.419 ± 0.393
0.811GluCys: 0.811 ± 0.354
2.432GluAsp: 2.432 ± 0.701
5.472GluGlu: 5.472 ± 2.484
1.621GluPhe: 1.621 ± 0.548
2.635GluGly: 2.635 ± 0.548
0.608GluHis: 0.608 ± 0.538
4.256GluIle: 4.256 ± 0.767
4.256GluLys: 4.256 ± 1.163
5.27GluLeu: 5.27 ± 0.931
2.229GluMet: 2.229 ± 1.234
2.837GluAsn: 2.837 ± 0.716
2.027GluPro: 2.027 ± 0.827
2.635GluGln: 2.635 ± 0.656
3.243GluArg: 3.243 ± 0.816
5.27GluSer: 5.27 ± 1.259
3.648GluThr: 3.648 ± 1.373
4.256GluVal: 4.256 ± 1.462
0.405GluTrp: 0.405 ± 0.311
0.405GluTyr: 0.405 ± 0.207
0.203GluXaa: 0.203 ± 0.228
Phe
1.621PheAla: 1.621 ± 0.635
1.013PheCys: 1.013 ± 0.432
1.621PheAsp: 1.621 ± 0.4
2.432PheGlu: 2.432 ± 0.804
2.027PhePhe: 2.027 ± 0.674
1.419PheGly: 1.419 ± 0.482
0.405PheHis: 0.405 ± 0.235
3.04PheIle: 3.04 ± 0.317
1.419PheLys: 1.419 ± 0.838
3.851PheLeu: 3.851 ± 0.883
0.405PheMet: 0.405 ± 0.186
1.621PheAsn: 1.621 ± 0.607
2.027PhePro: 2.027 ± 0.554
2.229PheGln: 2.229 ± 0.627
1.621PheArg: 1.621 ± 0.8
3.04PheSer: 3.04 ± 1.033
2.432PheThr: 2.432 ± 0.587
1.013PheVal: 1.013 ± 0.651
0.0PheTrp: 0.0 ± 0.0
1.419PheTyr: 1.419 ± 0.523
0.0PheXaa: 0.0 ± 0.0
Gly
2.635GlyAla: 2.635 ± 0.831
1.013GlyCys: 1.013 ± 0.655
3.648GlyAsp: 3.648 ± 0.564
1.621GlyGlu: 1.621 ± 1.066
1.013GlyPhe: 1.013 ± 0.516
3.04GlyGly: 3.04 ± 0.543
0.811GlyHis: 0.811 ± 0.313
4.256GlyIle: 4.256 ± 0.757
2.635GlyLys: 2.635 ± 0.822
6.891GlyLeu: 6.891 ± 1.24
1.824GlyMet: 1.824 ± 1.073
3.648GlyAsn: 3.648 ± 0.843
2.027GlyPro: 2.027 ± 1.138
1.419GlyGln: 1.419 ± 0.554
2.837GlyArg: 2.837 ± 0.619
4.662GlySer: 4.662 ± 0.844
1.216GlyThr: 1.216 ± 0.639
3.243GlyVal: 3.243 ± 0.808
0.203GlyTrp: 0.203 ± 0.26
1.824GlyTyr: 1.824 ± 0.749
0.0GlyXaa: 0.0 ± 0.0
His
0.608HisAla: 0.608 ± 0.273
0.203HisCys: 0.203 ± 0.22
1.419HisAsp: 1.419 ± 0.497
0.608HisGlu: 0.608 ± 0.269
0.608HisPhe: 0.608 ± 0.441
1.419HisGly: 1.419 ± 0.482
0.811HisHis: 0.811 ± 0.364
1.824HisIle: 1.824 ± 0.763
0.811HisLys: 0.811 ± 0.424
2.432HisLeu: 2.432 ± 0.778
0.405HisMet: 0.405 ± 0.207
0.405HisAsn: 0.405 ± 0.26
1.621HisPro: 1.621 ± 0.548
1.216HisGln: 1.216 ± 0.403
1.013HisArg: 1.013 ± 0.363
0.608HisSer: 0.608 ± 0.273
0.608HisThr: 0.608 ± 0.273
1.013HisVal: 1.013 ± 0.506
0.203HisTrp: 0.203 ± 0.13
0.203HisTyr: 0.203 ± 0.26
0.0HisXaa: 0.0 ± 0.0
Ile
5.675IleAla: 5.675 ± 1.319
1.419IleCys: 1.419 ± 0.478
4.256IleAsp: 4.256 ± 0.841
6.891IleGlu: 6.891 ± 1.326
3.243IlePhe: 3.243 ± 0.848
4.256IleGly: 4.256 ± 1.188
0.811IleHis: 0.811 ± 0.256
5.472IleIle: 5.472 ± 1.357
4.864IleLys: 4.864 ± 1.501
8.107IleLeu: 8.107 ± 1.204
1.824IleMet: 1.824 ± 0.682
4.256IleAsn: 4.256 ± 1.185
3.851IlePro: 3.851 ± 0.891
3.648IleGln: 3.648 ± 1.419
3.851IleArg: 3.851 ± 1.275
7.904IleSer: 7.904 ± 1.627
3.648IleThr: 3.648 ± 0.988
4.256IleVal: 4.256 ± 1.045
0.405IleTrp: 0.405 ± 0.26
1.419IleTyr: 1.419 ± 0.425
0.0IleXaa: 0.0 ± 0.0
Lys
3.243LysAla: 3.243 ± 0.717
0.811LysCys: 0.811 ± 0.364
2.027LysAsp: 2.027 ± 0.724
3.851LysGlu: 3.851 ± 0.837
2.229LysPhe: 2.229 ± 0.528
2.432LysGly: 2.432 ± 0.721
1.216LysHis: 1.216 ± 0.29
5.27LysIle: 5.27 ± 2.259
4.256LysLys: 4.256 ± 1.67
6.486LysLeu: 6.486 ± 1.746
1.216LysMet: 1.216 ± 0.554
2.229LysAsn: 2.229 ± 0.552
1.824LysPro: 1.824 ± 0.514
2.635LysGln: 2.635 ± 0.473
2.027LysArg: 2.027 ± 0.863
4.459LysSer: 4.459 ± 1.199
3.445LysThr: 3.445 ± 0.471
2.635LysVal: 2.635 ± 0.768
0.203LysTrp: 0.203 ± 0.13
2.229LysTyr: 2.229 ± 0.952
0.0LysXaa: 0.0 ± 0.0
Leu
6.08LeuAla: 6.08 ± 0.827
1.621LeuCys: 1.621 ± 0.409
6.891LeuAsp: 6.891 ± 2.369
5.067LeuGlu: 5.067 ± 0.78
3.445LeuPhe: 3.445 ± 0.921
6.688LeuGly: 6.688 ± 0.976
1.419LeuHis: 1.419 ± 0.492
9.526LeuIle: 9.526 ± 1.53
5.27LeuLys: 5.27 ± 0.915
9.728LeuLeu: 9.728 ± 2.222
2.432LeuMet: 2.432 ± 0.473
6.486LeuAsn: 6.486 ± 1.681
4.459LeuPro: 4.459 ± 1.012
4.864LeuGln: 4.864 ± 1.135
4.256LeuArg: 4.256 ± 0.675
9.931LeuSer: 9.931 ± 2.139
10.134LeuThr: 10.134 ± 1.403
5.675LeuVal: 5.675 ± 0.905
1.216LeuTrp: 1.216 ± 0.587
3.851LeuTyr: 3.851 ± 1.155
0.0LeuXaa: 0.0 ± 0.0
Met
2.229MetAla: 2.229 ± 1.178
0.608MetCys: 0.608 ± 0.339
2.635MetAsp: 2.635 ± 1.091
1.216MetGlu: 1.216 ± 0.423
0.203MetPhe: 0.203 ± 0.13
0.608MetGly: 0.608 ± 0.518
0.0MetHis: 0.0 ± 0.0
1.621MetIle: 1.621 ± 0.495
1.419MetLys: 1.419 ± 0.393
1.621MetLeu: 1.621 ± 0.217
0.203MetMet: 0.203 ± 0.228
0.405MetAsn: 0.405 ± 0.235
1.013MetPro: 1.013 ± 0.489
1.419MetGln: 1.419 ± 0.861
2.635MetArg: 2.635 ± 0.882
2.432MetSer: 2.432 ± 0.612
1.824MetThr: 1.824 ± 0.598
1.621MetVal: 1.621 ± 0.412
0.811MetTrp: 0.811 ± 0.364
0.405MetTyr: 0.405 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
2.432AsnAla: 2.432 ± 0.553
1.013AsnCys: 1.013 ± 0.608
2.027AsnAsp: 2.027 ± 0.609
1.621AsnGlu: 1.621 ± 0.33
1.419AsnPhe: 1.419 ± 0.325
1.621AsnGly: 1.621 ± 0.748
2.027AsnHis: 2.027 ± 0.531
5.067AsnIle: 5.067 ± 0.983
2.432AsnLys: 2.432 ± 0.778
6.891AsnLeu: 6.891 ± 1.427
0.811AsnMet: 0.811 ± 0.438
2.027AsnAsn: 2.027 ± 0.854
3.445AsnPro: 3.445 ± 0.622
3.04AsnGln: 3.04 ± 0.799
2.837AsnArg: 2.837 ± 0.632
3.445AsnSer: 3.445 ± 0.642
2.635AsnThr: 2.635 ± 1.14
3.04AsnVal: 3.04 ± 0.768
1.216AsnTrp: 1.216 ± 0.61
0.811AsnTyr: 0.811 ± 0.39
0.0AsnXaa: 0.0 ± 0.0
Pro
3.445ProAla: 3.445 ± 1.386
0.608ProCys: 0.608 ± 0.54
2.635ProAsp: 2.635 ± 0.3
1.824ProGlu: 1.824 ± 0.697
1.824ProPhe: 1.824 ± 0.838
4.054ProGly: 4.054 ± 1.419
0.405ProHis: 0.405 ± 0.186
4.054ProIle: 4.054 ± 0.724
3.243ProLys: 3.243 ± 0.665
5.067ProLeu: 5.067 ± 0.967
2.229ProMet: 2.229 ± 0.474
1.621ProAsn: 1.621 ± 0.752
4.459ProPro: 4.459 ± 1.063
2.837ProGln: 2.837 ± 1.196
2.027ProArg: 2.027 ± 1.087
4.459ProSer: 4.459 ± 1.119
4.054ProThr: 4.054 ± 0.824
3.445ProVal: 3.445 ± 1.213
0.405ProTrp: 0.405 ± 0.425
1.621ProTyr: 1.621 ± 0.735
0.0ProXaa: 0.0 ± 0.0
Gln
3.648GlnAla: 3.648 ± 0.881
1.419GlnCys: 1.419 ± 0.354
2.229GlnAsp: 2.229 ± 1.179
2.635GlnGlu: 2.635 ± 1.302
2.432GlnPhe: 2.432 ± 0.68
3.243GlnGly: 3.243 ± 1.122
0.608GlnHis: 0.608 ± 0.54
3.851GlnIle: 3.851 ± 0.721
2.432GlnLys: 2.432 ± 0.372
6.891GlnLeu: 6.891 ± 1.373
2.027GlnMet: 2.027 ± 0.734
3.04GlnAsn: 3.04 ± 0.811
2.635GlnPro: 2.635 ± 0.893
4.864GlnGln: 4.864 ± 2.409
1.621GlnArg: 1.621 ± 0.504
3.04GlnSer: 3.04 ± 0.934
2.027GlnThr: 2.027 ± 0.466
2.432GlnVal: 2.432 ± 0.908
0.203GlnTrp: 0.203 ± 0.13
0.608GlnTyr: 0.608 ± 0.391
0.0GlnXaa: 0.0 ± 0.0
Arg
1.824ArgAla: 1.824 ± 0.771
0.203ArgCys: 0.203 ± 0.212
1.621ArgAsp: 1.621 ± 0.62
3.04ArgGlu: 3.04 ± 1.173
1.216ArgPhe: 1.216 ± 0.263
2.229ArgGly: 2.229 ± 0.325
0.811ArgHis: 0.811 ± 0.325
3.851ArgIle: 3.851 ± 0.988
3.243ArgLys: 3.243 ± 0.526
6.891ArgLeu: 6.891 ± 1.518
1.013ArgMet: 1.013 ± 0.279
2.229ArgAsn: 2.229 ± 0.671
4.054ArgPro: 4.054 ± 2.048
2.229ArgGln: 2.229 ± 1.113
4.054ArgArg: 4.054 ± 1.264
3.243ArgSer: 3.243 ± 0.348
2.229ArgThr: 2.229 ± 0.501
3.243ArgVal: 3.243 ± 0.765
0.608ArgTrp: 0.608 ± 0.507
1.824ArgTyr: 1.824 ± 0.435
0.0ArgXaa: 0.0 ± 0.0
Ser
5.675SerAla: 5.675 ± 1.481
2.229SerCys: 2.229 ± 0.964
5.27SerAsp: 5.27 ± 0.768
3.851SerGlu: 3.851 ± 0.597
2.837SerPhe: 2.837 ± 0.989
3.243SerGly: 3.243 ± 0.638
1.419SerHis: 1.419 ± 0.438
6.891SerIle: 6.891 ± 1.497
4.054SerLys: 4.054 ± 0.563
7.702SerLeu: 7.702 ± 1.159
1.419SerMet: 1.419 ± 0.478
3.243SerAsn: 3.243 ± 0.734
4.459SerPro: 4.459 ± 0.86
3.04SerGln: 3.04 ± 0.715
3.648SerArg: 3.648 ± 0.743
6.688SerSer: 6.688 ± 0.877
4.864SerThr: 4.864 ± 1.283
6.08SerVal: 6.08 ± 2.026
0.608SerTrp: 0.608 ± 0.273
3.445SerTyr: 3.445 ± 1.096
0.0SerXaa: 0.0 ± 0.0
Thr
3.851ThrAla: 3.851 ± 1.297
1.419ThrCys: 1.419 ± 0.851
2.432ThrAsp: 2.432 ± 0.983
4.256ThrGlu: 4.256 ± 0.577
1.216ThrPhe: 1.216 ± 0.578
3.851ThrGly: 3.851 ± 0.439
1.013ThrHis: 1.013 ± 0.466
5.472ThrIle: 5.472 ± 0.881
2.027ThrLys: 2.027 ± 0.768
6.688ThrLeu: 6.688 ± 1.82
1.013ThrMet: 1.013 ± 0.305
2.027ThrAsn: 2.027 ± 0.668
3.04ThrPro: 3.04 ± 0.651
4.054ThrGln: 4.054 ± 0.679
2.837ThrArg: 2.837 ± 1.064
5.878ThrSer: 5.878 ± 1.008
3.243ThrThr: 3.243 ± 1.024
1.824ThrVal: 1.824 ± 0.441
0.811ThrTrp: 0.811 ± 0.364
1.824ThrTyr: 1.824 ± 0.329
0.0ThrXaa: 0.0 ± 0.0
Val
3.243ValAla: 3.243 ± 0.792
2.432ValCys: 2.432 ± 0.826
1.824ValAsp: 1.824 ± 0.365
2.229ValGlu: 2.229 ± 0.522
2.229ValPhe: 2.229 ± 0.905
2.432ValGly: 2.432 ± 0.618
1.419ValHis: 1.419 ± 0.397
5.27ValIle: 5.27 ± 1.051
2.432ValLys: 2.432 ± 0.872
5.472ValLeu: 5.472 ± 0.762
1.824ValMet: 1.824 ± 0.547
3.445ValAsn: 3.445 ± 1.414
2.635ValPro: 2.635 ± 0.547
2.635ValGln: 2.635 ± 0.421
3.04ValArg: 3.04 ± 0.703
3.445ValSer: 3.445 ± 0.57
3.04ValThr: 3.04 ± 0.934
2.635ValVal: 2.635 ± 1.228
0.608ValTrp: 0.608 ± 0.424
2.837ValTyr: 2.837 ± 0.618
0.0ValXaa: 0.0 ± 0.0
Trp
0.405TrpAla: 0.405 ± 0.207
0.405TrpCys: 0.405 ± 0.391
0.405TrpAsp: 0.405 ± 0.26
0.0TrpGlu: 0.0 ± 0.0
0.608TrpPhe: 0.608 ± 0.277
0.608TrpGly: 0.608 ± 0.277
0.0TrpHis: 0.0 ± 0.0
1.419TrpIle: 1.419 ± 0.465
0.608TrpLys: 0.608 ± 0.391
0.405TrpLeu: 0.405 ± 0.26
0.0TrpMet: 0.0 ± 0.0
0.608TrpAsn: 0.608 ± 0.277
0.811TrpPro: 0.811 ± 0.256
0.203TrpGln: 0.203 ± 0.228
0.405TrpArg: 0.405 ± 0.235
1.216TrpSer: 1.216 ± 0.466
0.405TrpThr: 0.405 ± 0.26
0.405TrpVal: 0.405 ± 0.324
0.203TrpTrp: 0.203 ± 0.212
0.405TrpTyr: 0.405 ± 0.311
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.824TyrAla: 1.824 ± 0.565
0.811TyrCys: 0.811 ± 0.315
1.419TyrAsp: 1.419 ± 0.548
1.216TyrGlu: 1.216 ± 0.684
1.013TyrPhe: 1.013 ± 0.459
1.824TyrGly: 1.824 ± 0.348
1.216TyrHis: 1.216 ± 0.583
1.824TyrIle: 1.824 ± 0.573
1.013TyrLys: 1.013 ± 0.252
4.459TyrLeu: 4.459 ± 1.481
1.419TyrMet: 1.419 ± 0.325
2.635TyrAsn: 2.635 ± 1.22
1.419TyrPro: 1.419 ± 0.581
2.432TyrGln: 2.432 ± 0.63
0.811TyrArg: 0.811 ± 0.444
2.027TyrSer: 2.027 ± 0.543
1.216TyrThr: 1.216 ± 0.624
1.621TyrVal: 1.621 ± 0.617
0.0TyrTrp: 0.0 ± 0.0
1.419TyrTyr: 1.419 ± 0.478
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.203XaaMet: 0.203 ± 0.228
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4935 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski