Amino acid dipepetide frequency for Trichinella britovi (Parasitic roundworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.594AlaAla: 5.594 ± 0.044
1.497AlaCys: 1.497 ± 0.015
3.569AlaAsp: 3.569 ± 0.023
4.521AlaGlu: 4.521 ± 0.028
2.771AlaPhe: 2.771 ± 0.02
3.363AlaGly: 3.363 ± 0.026
1.3AlaHis: 1.3 ± 0.012
3.426AlaIle: 3.426 ± 0.023
3.606AlaLys: 3.606 ± 0.025
6.244AlaLeu: 6.244 ± 0.032
1.586AlaMet: 1.586 ± 0.013
2.931AlaAsn: 2.931 ± 0.019
2.364AlaPro: 2.364 ± 0.019
2.299AlaGln: 2.299 ± 0.017
2.985AlaArg: 2.985 ± 0.023
5.238AlaSer: 5.238 ± 0.032
3.53AlaThr: 3.53 ± 0.028
5.119AlaVal: 5.119 ± 0.028
0.685AlaTrp: 0.685 ± 0.009
1.866AlaTyr: 1.866 ± 0.016
0.001AlaXaa: 0.001 ± 0.0
Cys
1.463CysAla: 1.463 ± 0.014
0.895CysCys: 0.895 ± 0.014
1.378CysAsp: 1.378 ± 0.02
1.477CysGlu: 1.477 ± 0.019
1.294CysPhe: 1.294 ± 0.014
1.432CysGly: 1.432 ± 0.015
0.682CysHis: 0.682 ± 0.01
1.551CysIle: 1.551 ± 0.018
1.469CysLys: 1.469 ± 0.018
2.572CysLeu: 2.572 ± 0.021
0.574CysMet: 0.574 ± 0.008
1.21CysAsn: 1.21 ± 0.012
1.248CysPro: 1.248 ± 0.022
1.12CysGln: 1.12 ± 0.015
1.628CysArg: 1.628 ± 0.018
2.462CysSer: 2.462 ± 0.021
1.388CysThr: 1.388 ± 0.015
1.508CysVal: 1.508 ± 0.017
0.354CysTrp: 0.354 ± 0.007
0.791CysTyr: 0.791 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.291AspAla: 3.291 ± 0.024
1.405AspCys: 1.405 ± 0.02
3.988AspAsp: 3.988 ± 0.039
4.269AspGlu: 4.269 ± 0.026
2.377AspPhe: 2.377 ± 0.015
3.208AspGly: 3.208 ± 0.038
1.231AspHis: 1.231 ± 0.012
2.79AspIle: 2.79 ± 0.02
2.52AspLys: 2.52 ± 0.017
4.666AspLeu: 4.666 ± 0.025
1.13AspMet: 1.13 ± 0.012
2.353AspAsn: 2.353 ± 0.015
2.073AspPro: 2.073 ± 0.017
2.069AspGln: 2.069 ± 0.018
2.788AspArg: 2.788 ± 0.019
4.165AspSer: 4.165 ± 0.026
2.186AspThr: 2.186 ± 0.017
3.687AspVal: 3.687 ± 0.021
0.68AspTrp: 0.68 ± 0.011
1.644AspTyr: 1.644 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
3.96GluAla: 3.96 ± 0.03
1.348GluCys: 1.348 ± 0.018
3.18GluAsp: 3.18 ± 0.027
5.444GluGlu: 5.444 ± 0.043
2.462GluPhe: 2.462 ± 0.018
2.315GluGly: 2.315 ± 0.023
1.43GluHis: 1.43 ± 0.013
3.963GluIle: 3.963 ± 0.028
4.984GluLys: 4.984 ± 0.032
5.815GluLeu: 5.815 ± 0.032
1.944GluMet: 1.944 ± 0.015
4.024GluAsn: 4.024 ± 0.025
2.17GluPro: 2.17 ± 0.019
3.051GluGln: 3.051 ± 0.023
3.578GluArg: 3.578 ± 0.026
4.5GluSer: 4.5 ± 0.03
3.332GluThr: 3.332 ± 0.024
3.501GluVal: 3.501 ± 0.028
0.723GluTrp: 0.723 ± 0.01
1.728GluTyr: 1.728 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
2.808PheAla: 2.808 ± 0.019
1.408PheCys: 1.408 ± 0.013
2.612PheAsp: 2.612 ± 0.019
2.641PheGlu: 2.641 ± 0.017
2.165PhePhe: 2.165 ± 0.022
2.596PheGly: 2.596 ± 0.017
1.301PheHis: 1.301 ± 0.012
2.544PheIle: 2.544 ± 0.02
2.19PheLys: 2.19 ± 0.016
4.352PheLeu: 4.352 ± 0.03
0.901PheMet: 0.901 ± 0.01
2.078PheAsn: 2.078 ± 0.016
1.987PhePro: 1.987 ± 0.015
1.935PheGln: 1.935 ± 0.014
2.329PheArg: 2.329 ± 0.018
3.903PheSer: 3.903 ± 0.024
2.398PheThr: 2.398 ± 0.019
3.074PheVal: 3.074 ± 0.021
0.625PheTrp: 0.625 ± 0.009
1.7PheTyr: 1.7 ± 0.017
0.001PheXaa: 0.001 ± 0.0
Gly
2.727GlyAla: 2.727 ± 0.022
1.295GlyCys: 1.295 ± 0.016
2.612GlyAsp: 2.612 ± 0.021
2.928GlyGlu: 2.928 ± 0.027
2.231GlyPhe: 2.231 ± 0.018
3.293GlyGly: 3.293 ± 0.031
1.289GlyHis: 1.289 ± 0.012
2.885GlyIle: 2.885 ± 0.023
3.33GlyLys: 3.33 ± 0.024
4.057GlyLeu: 4.057 ± 0.03
1.233GlyMet: 1.233 ± 0.014
2.499GlyAsn: 2.499 ± 0.019
1.806GlyPro: 1.806 ± 0.025
2.076GlyGln: 2.076 ± 0.02
3.315GlyArg: 3.315 ± 0.026
4.287GlySer: 4.287 ± 0.03
2.621GlyThr: 2.621 ± 0.021
3.07GlyVal: 3.07 ± 0.019
0.636GlyTrp: 0.636 ± 0.008
1.704GlyTyr: 1.704 ± 0.02
0.001GlyXaa: 0.001 ± 0.0
His
1.431HisAla: 1.431 ± 0.012
0.889HisCys: 0.889 ± 0.013
1.019HisAsp: 1.019 ± 0.013
1.247HisGlu: 1.247 ± 0.011
1.391HisPhe: 1.391 ± 0.013
1.322HisGly: 1.322 ± 0.012
0.966HisHis: 0.966 ± 0.017
1.265HisIle: 1.265 ± 0.01
0.979HisLys: 0.979 ± 0.01
2.705HisLeu: 2.705 ± 0.019
0.528HisMet: 0.528 ± 0.009
0.977HisAsn: 0.977 ± 0.011
1.227HisPro: 1.227 ± 0.01
1.104HisGln: 1.104 ± 0.013
1.548HisArg: 1.548 ± 0.013
2.059HisSer: 2.059 ± 0.015
1.101HisThr: 1.101 ± 0.01
1.596HisVal: 1.596 ± 0.014
0.354HisTrp: 0.354 ± 0.006
0.865HisTyr: 0.865 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
3.703IleAla: 3.703 ± 0.026
1.69IleCys: 1.69 ± 0.02
2.974IleAsp: 2.974 ± 0.021
3.315IleGlu: 3.315 ± 0.023
2.816IlePhe: 2.816 ± 0.024
2.881IleGly: 2.881 ± 0.019
1.323IleHis: 1.323 ± 0.012
3.082IleIle: 3.082 ± 0.024
2.822IleLys: 2.822 ± 0.02
5.335IleLeu: 5.335 ± 0.031
1.197IleMet: 1.197 ± 0.012
2.434IleAsn: 2.434 ± 0.018
2.587IlePro: 2.587 ± 0.018
2.195IleGln: 2.195 ± 0.019
3.195IleArg: 3.195 ± 0.023
4.716IleSer: 4.716 ± 0.028
2.865IleThr: 2.865 ± 0.025
3.661IleVal: 3.661 ± 0.024
0.657IleTrp: 0.657 ± 0.009
1.906IleTyr: 1.906 ± 0.016
0.001IleXaa: 0.001 ± 0.0
Lys
3.552LysAla: 3.552 ± 0.025
1.489LysCys: 1.489 ± 0.016
2.651LysAsp: 2.651 ± 0.02
3.912LysGlu: 3.912 ± 0.026
2.509LysPhe: 2.509 ± 0.021
2.292LysGly: 2.292 ± 0.023
1.496LysHis: 1.496 ± 0.014
3.62LysIle: 3.62 ± 0.022
4.61LysLys: 4.61 ± 0.042
6.162LysLeu: 6.162 ± 0.035
1.722LysMet: 1.722 ± 0.014
3.13LysAsn: 3.13 ± 0.021
2.458LysPro: 2.458 ± 0.023
2.825LysGln: 2.825 ± 0.019
3.832LysArg: 3.832 ± 0.023
4.636LysSer: 4.636 ± 0.025
3.02LysThr: 3.02 ± 0.02
3.31LysVal: 3.31 ± 0.021
0.756LysTrp: 0.756 ± 0.01
1.869LysTyr: 1.869 ± 0.014
0.001LysXaa: 0.001 ± 0.0
Leu
6.117LeuAla: 6.117 ± 0.03
2.502LeuCys: 2.502 ± 0.018
4.581LeuAsp: 4.581 ± 0.025
5.782LeuGlu: 5.782 ± 0.037
4.582LeuPhe: 4.582 ± 0.032
3.858LeuGly: 3.858 ± 0.026
2.704LeuHis: 2.704 ± 0.019
5.417LeuIle: 5.417 ± 0.029
6.575LeuLys: 6.575 ± 0.034
10.806LeuLeu: 10.806 ± 0.055
2.265LeuMet: 2.265 ± 0.018
4.964LeuAsn: 4.964 ± 0.027
4.825LeuPro: 4.825 ± 0.029
4.535LeuGln: 4.535 ± 0.026
5.528LeuArg: 5.528 ± 0.033
7.65LeuSer: 7.65 ± 0.033
5.031LeuThr: 5.031 ± 0.028
5.533LeuVal: 5.533 ± 0.031
1.07LeuTrp: 1.07 ± 0.014
2.893LeuTyr: 2.893 ± 0.024
0.001LeuXaa: 0.001 ± 0.0
Met
1.613MetAla: 1.613 ± 0.012
0.493MetCys: 0.493 ± 0.008
1.306MetAsp: 1.306 ± 0.014
1.649MetGlu: 1.649 ± 0.015
1.02MetPhe: 1.02 ± 0.011
0.916MetGly: 0.916 ± 0.011
0.647MetHis: 0.647 ± 0.009
1.324MetIle: 1.324 ± 0.014
1.763MetLys: 1.763 ± 0.015
2.457MetLeu: 2.457 ± 0.017
0.691MetMet: 0.691 ± 0.009
1.347MetAsn: 1.347 ± 0.012
1.163MetPro: 1.163 ± 0.014
1.158MetGln: 1.158 ± 0.013
1.254MetArg: 1.254 ± 0.013
1.695MetSer: 1.695 ± 0.014
1.26MetThr: 1.26 ± 0.012
1.376MetVal: 1.376 ± 0.012
0.231MetTrp: 0.231 ± 0.005
0.681MetTyr: 0.681 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.246AsnAla: 3.246 ± 0.021
1.441AsnCys: 1.441 ± 0.016
2.783AsnAsp: 2.783 ± 0.019
3.266AsnGlu: 3.266 ± 0.021
2.494AsnPhe: 2.494 ± 0.019
2.986AsnGly: 2.986 ± 0.024
1.045AsnHis: 1.045 ± 0.011
2.686AsnIle: 2.686 ± 0.02
2.494AsnLys: 2.494 ± 0.019
4.532AsnLeu: 4.532 ± 0.027
1.142AsnMet: 1.142 ± 0.011
2.94AsnAsn: 2.94 ± 0.03
1.918AsnPro: 1.918 ± 0.016
1.787AsnGln: 1.787 ± 0.017
2.645AsnArg: 2.645 ± 0.02
4.231AsnSer: 4.231 ± 0.029
2.23AsnThr: 2.23 ± 0.016
3.445AsnVal: 3.445 ± 0.019
0.592AsnTrp: 0.592 ± 0.009
1.693AsnTyr: 1.693 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
2.869ProAla: 2.869 ± 0.021
0.962ProCys: 0.962 ± 0.012
2.283ProAsp: 2.283 ± 0.016
2.651ProGlu: 2.651 ± 0.022
1.954ProPhe: 1.954 ± 0.016
2.32ProGly: 2.32 ± 0.048
0.924ProHis: 0.924 ± 0.011
2.195ProIle: 2.195 ± 0.016
2.389ProLys: 2.389 ± 0.018
4.087ProLeu: 4.087 ± 0.028
0.952ProMet: 0.952 ± 0.013
2.081ProAsn: 2.081 ± 0.016
3.027ProPro: 3.027 ± 0.04
1.508ProGln: 1.508 ± 0.015
2.005ProArg: 2.005 ± 0.016
3.816ProSer: 3.816 ± 0.026
2.637ProThr: 2.637 ± 0.022
3.161ProVal: 3.161 ± 0.023
0.478ProTrp: 0.478 ± 0.008
1.356ProTyr: 1.356 ± 0.013
0.001ProXaa: 0.001 ± 0.0
Gln
2.607GlnAla: 2.607 ± 0.019
1.161GlnCys: 1.161 ± 0.016
1.474GlnAsp: 1.474 ± 0.013
2.18GlnGlu: 2.18 ± 0.017
1.955GlnPhe: 1.955 ± 0.013
1.484GlnGly: 1.484 ± 0.015
1.188GlnHis: 1.188 ± 0.012
2.414GlnIle: 2.414 ± 0.017
2.504GlnLys: 2.504 ± 0.02
4.889GlnLeu: 4.889 ± 0.028
1.209GlnMet: 1.209 ± 0.012
2.094GlnAsn: 2.094 ± 0.016
1.907GlnPro: 1.907 ± 0.019
3.583GlnGln: 3.583 ± 0.061
2.703GlnArg: 2.703 ± 0.022
3.305GlnSer: 3.305 ± 0.025
2.111GlnThr: 2.111 ± 0.018
2.096GlnVal: 2.096 ± 0.016
0.605GlnTrp: 0.605 ± 0.009
1.278GlnTyr: 1.278 ± 0.013
0.0GlnXaa: 0.0 ± 0.0
Arg
3.074ArgAla: 3.074 ± 0.019
1.608ArgCys: 1.608 ± 0.02
2.47ArgAsp: 2.47 ± 0.02
3.069ArgGlu: 3.069 ± 0.025
2.616ArgPhe: 2.616 ± 0.018
2.53ArgGly: 2.53 ± 0.022
1.568ArgHis: 1.568 ± 0.014
3.27ArgIle: 3.27 ± 0.02
3.745ArgLys: 3.745 ± 0.026
5.941ArgLeu: 5.941 ± 0.034
1.444ArgMet: 1.444 ± 0.014
2.711ArgAsn: 2.711 ± 0.019
2.386ArgPro: 2.386 ± 0.02
2.644ArgGln: 2.644 ± 0.022
4.819ArgArg: 4.819 ± 0.042
4.498ArgSer: 4.498 ± 0.027
2.82ArgThr: 2.82 ± 0.021
3.037ArgVal: 3.037 ± 0.023
0.812ArgTrp: 0.812 ± 0.012
1.708ArgTyr: 1.708 ± 0.014
0.001ArgXaa: 0.001 ± 0.0
Ser
5.537SerAla: 5.537 ± 0.029
2.102SerCys: 2.102 ± 0.019
4.54SerAsp: 4.54 ± 0.028
4.88SerGlu: 4.88 ± 0.026
3.592SerPhe: 3.592 ± 0.021
4.595SerGly: 4.595 ± 0.028
1.625SerHis: 1.625 ± 0.013
4.177SerIle: 4.177 ± 0.026
4.734SerLys: 4.734 ± 0.028
7.465SerLeu: 7.465 ± 0.033
1.827SerMet: 1.827 ± 0.016
4.116SerAsn: 4.116 ± 0.025
3.564SerPro: 3.564 ± 0.029
2.83SerGln: 2.83 ± 0.02
4.384SerArg: 4.384 ± 0.027
9.549SerSer: 9.549 ± 0.062
5.21SerThr: 5.21 ± 0.032
5.68SerVal: 5.68 ± 0.027
0.916SerTrp: 0.916 ± 0.01
2.206SerTyr: 2.206 ± 0.017
0.002SerXaa: 0.002 ± 0.0
Thr
4.154ThrAla: 4.154 ± 0.028
1.34ThrCys: 1.34 ± 0.018
2.797ThrAsp: 2.797 ± 0.019
3.144ThrGlu: 3.144 ± 0.021
2.379ThrPhe: 2.379 ± 0.017
2.922ThrGly: 2.922 ± 0.022
0.935ThrHis: 0.935 ± 0.011
2.856ThrIle: 2.856 ± 0.018
2.771ThrLys: 2.771 ± 0.02
5.012ThrLeu: 5.012 ± 0.027
1.259ThrMet: 1.259 ± 0.013
2.448ThrAsn: 2.448 ± 0.016
2.389ThrPro: 2.389 ± 0.019
1.524ThrGln: 1.524 ± 0.013
2.302ThrArg: 2.302 ± 0.018
4.517ThrSer: 4.517 ± 0.028
3.801ThrThr: 3.801 ± 0.035
4.462ThrVal: 4.462 ± 0.024
0.574ThrTrp: 0.574 ± 0.009
1.404ThrTyr: 1.404 ± 0.013
0.001ThrXaa: 0.001 ± 0.0
Val
4.273ValAla: 4.273 ± 0.024
1.683ValCys: 1.683 ± 0.018
4.127ValAsp: 4.127 ± 0.027
4.688ValGlu: 4.688 ± 0.029
2.625ValPhe: 2.625 ± 0.019
3.427ValGly: 3.427 ± 0.022
1.779ValHis: 1.779 ± 0.013
3.488ValIle: 3.488 ± 0.021
3.773ValLys: 3.773 ± 0.023
5.811ValLeu: 5.811 ± 0.026
1.399ValMet: 1.399 ± 0.012
3.029ValAsn: 3.029 ± 0.02
2.756ValPro: 2.756 ± 0.018
2.794ValGln: 2.794 ± 0.02
3.4ValArg: 3.4 ± 0.022
4.798ValSer: 4.798 ± 0.03
3.308ValThr: 3.308 ± 0.022
4.599ValVal: 4.599 ± 0.026
0.726ValTrp: 0.726 ± 0.008
1.843ValTyr: 1.843 ± 0.016
0.001ValXaa: 0.001 ± 0.0
Trp
0.618TrpAla: 0.618 ± 0.01
0.287TrpCys: 0.287 ± 0.006
0.549TrpAsp: 0.549 ± 0.009
0.563TrpGlu: 0.563 ± 0.009
0.556TrpPhe: 0.556 ± 0.01
0.398TrpGly: 0.398 ± 0.006
0.331TrpHis: 0.331 ± 0.007
0.804TrpIle: 0.804 ± 0.012
0.949TrpLys: 0.949 ± 0.011
1.308TrpLeu: 1.308 ± 0.014
0.346TrpMet: 0.346 ± 0.007
0.76TrpAsn: 0.76 ± 0.009
0.502TrpPro: 0.502 ± 0.008
0.536TrpGln: 0.536 ± 0.008
0.743TrpArg: 0.743 ± 0.01
1.029TrpSer: 1.029 ± 0.012
0.704TrpThr: 0.704 ± 0.01
0.518TrpVal: 0.518 ± 0.008
0.186TrpTrp: 0.186 ± 0.005
0.426TrpTyr: 0.426 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.856TyrAla: 1.856 ± 0.014
0.998TyrCys: 0.998 ± 0.012
1.623TyrAsp: 1.623 ± 0.016
1.824TyrGlu: 1.824 ± 0.017
1.76TyrPhe: 1.76 ± 0.017
1.757TyrGly: 1.757 ± 0.018
0.808TyrHis: 0.808 ± 0.011
1.596TyrIle: 1.596 ± 0.016
1.646TyrLys: 1.646 ± 0.015
3.002TyrLeu: 3.002 ± 0.021
0.695TyrMet: 0.695 ± 0.009
1.474TyrAsn: 1.474 ± 0.013
1.299TyrPro: 1.299 ± 0.014
1.171TyrGln: 1.171 ± 0.01
1.788TyrArg: 1.788 ± 0.014
2.475TyrSer: 2.475 ± 0.018
1.44TyrThr: 1.44 ± 0.015
1.896TyrVal: 1.896 ± 0.014
0.453TyrTrp: 0.453 ± 0.01
1.21TyrTyr: 1.21 ± 0.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.001XaaCys: 0.001 ± 0.0
0.001XaaAsp: 0.001 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.001XaaHis: 0.001 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.0
0.001XaaArg: 0.001 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.001XaaThr: 0.001 ± 0.0
0.001XaaVal: 0.001 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.029XaaXaa: 0.029 ± 0.006
Statistics based on 19931 proteins (9386352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski