Human papillomavirus 120

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus; Betapapillomavirus 2

Average proteome isoelectric point is 5.89

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|D7P169|D7P169_9PAPI Regulatory protein E2 OS=Human papillomavirus 120 OX=765052 GN=E2 PE=3 SV=1
MM1 pKa = 7.54IGKK4 pKa = 8.59QATLRR9 pKa = 11.84DD10 pKa = 3.69IVLEE14 pKa = 4.01EE15 pKa = 4.08LVQPIDD21 pKa = 3.57LHH23 pKa = 6.18CHH25 pKa = 5.48EE26 pKa = 5.19EE27 pKa = 3.89LLEE30 pKa = 4.19EE31 pKa = 4.18VEE33 pKa = 4.19EE34 pKa = 4.2AVVEE38 pKa = 4.18EE39 pKa = 4.3EE40 pKa = 5.26PEE42 pKa = 3.92YY43 pKa = 10.56TPYY46 pKa = 10.77KK47 pKa = 10.31IIVNCGGCDD56 pKa = 3.18TKK58 pKa = 11.4LKK60 pKa = 10.72LFVLATDD67 pKa = 3.87FGIRR71 pKa = 11.84AFQASLLEE79 pKa = 4.13NVRR82 pKa = 11.84LVCPSCRR89 pKa = 11.84EE90 pKa = 4.15DD91 pKa = 3.16IRR93 pKa = 11.84DD94 pKa = 3.4GRR96 pKa = 11.84RR97 pKa = 2.97

Molecular weight: 11.07 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|D7P170|D7P170_9PAPI E4 OS=Human papillomavirus 120 OX=765052 GN=E4 PE=4 SV=1
MM1 pKa = 7.43EE2 pKa = 5.41ALSEE6 pKa = 4.17RR7 pKa = 11.84FSALQEE13 pKa = 4.13KK14 pKa = 10.62LMDD17 pKa = 4.39LYY19 pKa = 11.33EE20 pKa = 5.54SGLEE24 pKa = 3.93DD25 pKa = 5.27LEE27 pKa = 4.38TQILHH32 pKa = 6.0WKK34 pKa = 9.93LLRR37 pKa = 11.84QEE39 pKa = 4.47QIIFYY44 pKa = 8.08YY45 pKa = 10.09AKK47 pKa = 10.23KK48 pKa = 10.42RR49 pKa = 11.84GITRR53 pKa = 11.84LGYY56 pKa = 10.29QPVPSLASSEE66 pKa = 4.31TKK68 pKa = 10.71AKK70 pKa = 10.48DD71 pKa = 3.41AIAIGLLLEE80 pKa = 4.52SLQKK84 pKa = 10.35SQYY87 pKa = 11.21ANEE90 pKa = 3.95PWTLVEE96 pKa = 4.59TSLEE100 pKa = 4.5TIKK103 pKa = 10.95SPPVDD108 pKa = 3.9CFKK111 pKa = 10.9KK112 pKa = 10.17GPKK115 pKa = 8.36TVEE118 pKa = 4.01VYY120 pKa = 10.76FDD122 pKa = 3.87GNPANVMPYY131 pKa = 8.82TVWSYY136 pKa = 11.23IYY138 pKa = 10.22YY139 pKa = 8.39QTDD142 pKa = 2.95EE143 pKa = 4.38DD144 pKa = 3.6TWEE147 pKa = 4.14KK148 pKa = 11.38VEE150 pKa = 4.12GQVDD154 pKa = 3.59YY155 pKa = 10.8TGAYY159 pKa = 9.48FFEE162 pKa = 5.24GNFKK166 pKa = 10.59NYY168 pKa = 9.99YY169 pKa = 9.78IKK171 pKa = 10.8FEE173 pKa = 4.37NDD175 pKa = 2.48AKK177 pKa = 10.83RR178 pKa = 11.84YY179 pKa = 5.43GTTGIWEE186 pKa = 4.09VHH188 pKa = 4.93VDD190 pKa = 3.26KK191 pKa = 10.63DD192 pKa = 4.18TVFTPVTSSTPPVGDD207 pKa = 3.52ASNNTVPEE215 pKa = 4.14AVSASVSSPQRR226 pKa = 11.84SPSTNRR232 pKa = 11.84RR233 pKa = 11.84YY234 pKa = 9.89GRR236 pKa = 11.84KK237 pKa = 9.3ASSPTTTSRR246 pKa = 11.84RR247 pKa = 11.84QKK249 pKa = 9.81RR250 pKa = 11.84QRR252 pKa = 11.84EE253 pKa = 3.87EE254 pKa = 3.38TRR256 pKa = 11.84RR257 pKa = 11.84RR258 pKa = 11.84KK259 pKa = 7.63TRR261 pKa = 11.84SRR263 pKa = 11.84SRR265 pKa = 11.84SRR267 pKa = 11.84EE268 pKa = 3.58QRR270 pKa = 11.84GGRR273 pKa = 11.84EE274 pKa = 3.96TRR276 pKa = 11.84RR277 pKa = 11.84SSSRR281 pKa = 11.84GSSKK285 pKa = 10.51SPRR288 pKa = 11.84RR289 pKa = 11.84GGNGGGGPLTRR300 pKa = 11.84SRR302 pKa = 11.84SRR304 pKa = 11.84SRR306 pKa = 11.84TRR308 pKa = 11.84KK309 pKa = 8.73EE310 pKa = 3.89SVGGGGVAPSEE321 pKa = 4.16VGATVRR327 pKa = 11.84SLSRR331 pKa = 11.84HH332 pKa = 4.35NSGRR336 pKa = 11.84LAQLLDD342 pKa = 3.62AAKK345 pKa = 9.99DD346 pKa = 3.57PPVILLRR353 pKa = 11.84GNANTLKK360 pKa = 10.22CYY362 pKa = 9.81RR363 pKa = 11.84WRR365 pKa = 11.84FRR367 pKa = 11.84KK368 pKa = 9.42KK369 pKa = 8.94HH370 pKa = 5.52AGNFRR375 pKa = 11.84FVSTTWSWVGGNSNDD390 pKa = 3.73RR391 pKa = 11.84IGRR394 pKa = 11.84ARR396 pKa = 11.84MLIAFDD402 pKa = 3.85TDD404 pKa = 3.78LEE406 pKa = 4.21RR407 pKa = 11.84DD408 pKa = 3.28KK409 pKa = 11.25CIQQMKK415 pKa = 10.18LPLGVDD421 pKa = 3.33WSYY424 pKa = 11.93GQFDD428 pKa = 4.23DD429 pKa = 5.18LL430 pKa = 5.54

Molecular weight: 48.71 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2472

97

604

353.1

39.97

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.583 ± 0.414

2.144 ± 0.719

6.472 ± 0.443

6.877 ± 0.719

4.207 ± 0.305

6.23 ± 0.608

1.739 ± 0.191

5.299 ± 0.883

5.421 ± 0.87

8.455 ± 0.649

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.578 ± 0.375

4.086 ± 0.506

6.553 ± 1.155

5.016 ± 0.67

6.432 ± 1.019

6.998 ± 0.84

5.785 ± 0.942

6.23 ± 0.72

1.294 ± 0.355

3.6 ± 0.427
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski