Amino acid dipepetide frequency for Nitrospira defluvii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.293AlaAla: 11.293 ± 0.139	1.17AlaCys: 1.17 ± 0.031	5.056AlaAsp: 5.056 ± 0.072	6.095AlaGlu: 6.095 ± 0.076	3.31AlaPhe: 3.31 ± 0.054	8.572AlaGly: 8.572 ± 0.095	2.196AlaHis: 2.196 ± 0.045	5.068AlaIle: 5.068 ± 0.069	4.164AlaLys: 4.164 ± 0.065	11.128AlaLeu: 11.128 ± 0.12	2.784AlaMet: 2.784 ± 0.051	2.352AlaAsn: 2.352 ± 0.056	4.478AlaPro: 4.478 ± 0.073	4.278AlaGln: 4.278 ± 0.066	6.607AlaArg: 6.607 ± 0.082	5.428AlaSer: 5.428 ± 0.067	5.49AlaThr: 5.49 ± 0.071	7.931AlaVal: 7.931 ± 0.09	1.356AlaTrp: 1.356 ± 0.036	2.465AlaTyr: 2.465 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.029	0.166CysCys: 0.166 ± 0.012	0.465CysAsp: 0.465 ± 0.021	0.542CysGlu: 0.542 ± 0.022	0.351CysPhe: 0.351 ± 0.019	0.958CysGly: 0.958 ± 0.026	0.357CysHis: 0.357 ± 0.021	0.375CysIle: 0.375 ± 0.015	0.298CysLys: 0.298 ± 0.013	1.182CysLeu: 1.182 ± 0.032	0.223CysMet: 0.223 ± 0.013	0.226CysAsn: 0.226 ± 0.014	0.605CysPro: 0.605 ± 0.024	0.375CysGln: 0.375 ± 0.018	0.816CysArg: 0.816 ± 0.025	0.632CysSer: 0.632 ± 0.02	0.511CysThr: 0.511 ± 0.023	0.703CysVal: 0.703 ± 0.024	0.146CysTrp: 0.146 ± 0.01	0.279CysTyr: 0.279 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.967AspAla: 4.967 ± 0.066	0.543AspCys: 0.543 ± 0.022	2.416AspAsp: 2.416 ± 0.055	3.176AspGlu: 3.176 ± 0.046	1.774AspPhe: 1.774 ± 0.036	4.053AspGly: 4.053 ± 0.062	1.365AspHis: 1.365 ± 0.031	2.565AspIle: 2.565 ± 0.046	1.549AspLys: 1.549 ± 0.039	5.946AspLeu: 5.946 ± 0.079	1.005AspMet: 1.005 ± 0.03	1.112AspAsn: 1.112 ± 0.031	3.11AspPro: 3.11 ± 0.05	2.191AspGln: 2.191 ± 0.041	4.299AspArg: 4.299 ± 0.06	2.525AspSer: 2.525 ± 0.046	2.454AspThr: 2.454 ± 0.045	3.98AspVal: 3.98 ± 0.067	0.774AspTrp: 0.774 ± 0.029	1.383AspTyr: 1.383 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.493GluAla: 6.493 ± 0.076	0.479GluCys: 0.479 ± 0.019	2.59GluAsp: 2.59 ± 0.046	3.797GluGlu: 3.797 ± 0.08	2.064GluPhe: 2.064 ± 0.042	4.211GluGly: 4.211 ± 0.057	1.452GluHis: 1.452 ± 0.033	3.067GluIle: 3.067 ± 0.05	2.419GluLys: 2.419 ± 0.056	5.997GluLeu: 5.997 ± 0.077	1.39GluMet: 1.39 ± 0.031	1.251GluAsn: 1.251 ± 0.03	2.655GluPro: 2.655 ± 0.05	3.403GluGln: 3.403 ± 0.062	5.17GluArg: 5.17 ± 0.077	3.432GluSer: 3.432 ± 0.056	3.181GluThr: 3.181 ± 0.052	4.317GluVal: 4.317 ± 0.068	0.893GluTrp: 0.893 ± 0.03	1.357GluTyr: 1.357 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.26PheAla: 3.26 ± 0.048	0.45PheCys: 0.45 ± 0.022	2.127PheAsp: 2.127 ± 0.04	2.045PheGlu: 2.045 ± 0.043	1.416PhePhe: 1.416 ± 0.038	3.106PheGly: 3.106 ± 0.059	0.938PheHis: 0.938 ± 0.028	1.501PheIle: 1.501 ± 0.035	1.131PheLys: 1.131 ± 0.033	3.746PheLeu: 3.746 ± 0.067	0.784PheMet: 0.784 ± 0.029	1.064PheAsn: 1.064 ± 0.027	1.728PhePro: 1.728 ± 0.035	1.303PheGln: 1.303 ± 0.033	2.339PheArg: 2.339 ± 0.043	2.356PheSer: 2.356 ± 0.042	2.113PheThr: 2.113 ± 0.037	2.709PheVal: 2.709 ± 0.05	0.528PheTrp: 0.528 ± 0.021	0.973PheTyr: 0.973 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.916GlyAla: 6.916 ± 0.096	0.984GlyCys: 0.984 ± 0.028	3.688GlyAsp: 3.688 ± 0.07	4.443GlyGlu: 4.443 ± 0.058	3.106GlyPhe: 3.106 ± 0.055	6.33GlyGly: 6.33 ± 0.107	1.975GlyHis: 1.975 ± 0.043	4.259GlyIle: 4.259 ± 0.06	3.47GlyLys: 3.47 ± 0.054	8.538GlyLeu: 8.538 ± 0.089	2.17GlyMet: 2.17 ± 0.039	2.168GlyAsn: 2.168 ± 0.068	3.11GlyPro: 3.11 ± 0.052	3.229GlyGln: 3.229 ± 0.055	5.543GlyArg: 5.543 ± 0.071	4.693GlySer: 4.693 ± 0.072	4.998GlyThr: 4.998 ± 0.083	5.853GlyVal: 5.853 ± 0.075	1.244GlyTrp: 1.244 ± 0.03	2.318GlyTyr: 2.318 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.319HisAla: 2.319 ± 0.048	0.31HisCys: 0.31 ± 0.017	1.241HisAsp: 1.241 ± 0.032	1.384HisGlu: 1.384 ± 0.03	0.865HisPhe: 0.865 ± 0.028	1.874HisGly: 1.874 ± 0.039	0.799HisHis: 0.799 ± 0.026	1.14HisIle: 1.14 ± 0.027	0.672HisLys: 0.672 ± 0.021	2.569HisLeu: 2.569 ± 0.048	0.492HisMet: 0.492 ± 0.018	0.562HisAsn: 0.562 ± 0.023	1.663HisPro: 1.663 ± 0.041	0.938HisGln: 0.938 ± 0.026	1.921HisArg: 1.921 ± 0.04	1.239HisSer: 1.239 ± 0.028	1.145HisThr: 1.145 ± 0.032	1.724HisVal: 1.724 ± 0.039	0.336HisTrp: 0.336 ± 0.016	0.661HisTyr: 0.661 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.117IleAla: 5.117 ± 0.059	0.467IleCys: 0.467 ± 0.022	2.869IleAsp: 2.869 ± 0.048	3.458IleGlu: 3.458 ± 0.064	1.45IlePhe: 1.45 ± 0.035	4.451IleGly: 4.451 ± 0.07	1.22IleHis: 1.22 ± 0.032	1.994IleIle: 1.994 ± 0.045	1.862IleLys: 1.862 ± 0.046	4.813IleLeu: 4.813 ± 0.069	0.864IleMet: 0.864 ± 0.025	1.31IleAsn: 1.31 ± 0.038	2.858IlePro: 2.858 ± 0.046	1.949IleGln: 1.949 ± 0.036	3.513IleArg: 3.513 ± 0.058	2.617IleSer: 2.617 ± 0.046	2.892IleThr: 2.892 ± 0.05	4.111IleVal: 4.111 ± 0.059	0.505IleTrp: 0.505 ± 0.02	1.096IleTyr: 1.096 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.988LysAla: 3.988 ± 0.066	0.245LysCys: 0.245 ± 0.015	2.177LysAsp: 2.177 ± 0.047	2.573LysGlu: 2.573 ± 0.052	1.019LysPhe: 1.019 ± 0.034	2.976LysGly: 2.976 ± 0.06	0.789LysHis: 0.789 ± 0.025	1.904LysIle: 1.904 ± 0.051	1.92LysLys: 1.92 ± 0.052	3.39LysLeu: 3.39 ± 0.053	0.903LysMet: 0.903 ± 0.027	1.064LysAsn: 1.064 ± 0.026	2.113LysPro: 2.113 ± 0.043	1.784LysGln: 1.784 ± 0.041	2.632LysArg: 2.632 ± 0.052	2.096LysSer: 2.096 ± 0.041	2.353LysThr: 2.353 ± 0.046	2.77LysVal: 2.77 ± 0.058	0.372LysTrp: 0.372 ± 0.02	0.795LysTyr: 0.795 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.416LeuAla: 11.416 ± 0.136	1.215LeuCys: 1.215 ± 0.031	5.694LeuAsp: 5.694 ± 0.067	5.826LeuGlu: 5.826 ± 0.07	3.923LeuPhe: 3.923 ± 0.073	7.713LeuGly: 7.713 ± 0.085	2.391LeuHis: 2.391 ± 0.05	5.009LeuIle: 5.009 ± 0.078	4.187LeuLys: 4.187 ± 0.068	11.536LeuLeu: 11.536 ± 0.126	2.295LeuMet: 2.295 ± 0.046	2.929LeuAsn: 2.929 ± 0.047	5.572LeuPro: 5.572 ± 0.065	4.003LeuGln: 4.003 ± 0.063	7.47LeuArg: 7.47 ± 0.089	6.973LeuSer: 6.973 ± 0.079	6.698LeuThr: 6.698 ± 0.084	7.806LeuVal: 7.806 ± 0.086	1.266LeuTrp: 1.266 ± 0.036	2.584LeuTyr: 2.584 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.647MetAla: 2.647 ± 0.046	0.177MetCys: 0.177 ± 0.012	1.143MetAsp: 1.143 ± 0.032	1.3MetGlu: 1.3 ± 0.034	0.693MetPhe: 0.693 ± 0.022	1.791MetGly: 1.791 ± 0.045	0.466MetHis: 0.466 ± 0.019	1.175MetIle: 1.175 ± 0.033	1.214MetLys: 1.214 ± 0.033	2.249MetLeu: 2.249 ± 0.042	0.615MetMet: 0.615 ± 0.024	0.815MetAsn: 0.815 ± 0.024	1.373MetPro: 1.373 ± 0.031	0.896MetGln: 0.896 ± 0.028	1.577MetArg: 1.577 ± 0.033	1.4MetSer: 1.4 ± 0.033	1.699MetThr: 1.699 ± 0.04	1.842MetVal: 1.842 ± 0.041	0.23MetTrp: 0.23 ± 0.014	0.404MetTyr: 0.404 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.381AsnAla: 2.381 ± 0.044	0.248AsnCys: 0.248 ± 0.012	1.247AsnAsp: 1.247 ± 0.04	1.38AsnGlu: 1.38 ± 0.032	0.918AsnPhe: 0.918 ± 0.027	2.157AsnGly: 2.157 ± 0.046	0.647AsnHis: 0.647 ± 0.021	1.272AsnIle: 1.272 ± 0.033	0.835AsnLys: 0.835 ± 0.028	2.86AsnLeu: 2.86 ± 0.053	0.552AsnMet: 0.552 ± 0.019	0.756AsnAsn: 0.756 ± 0.028	1.899AsnPro: 1.899 ± 0.044	1.106AsnGln: 1.106 ± 0.033	1.977AsnArg: 1.977 ± 0.04	1.324AsnSer: 1.324 ± 0.038	1.292AsnThr: 1.292 ± 0.034	2.026AsnVal: 2.026 ± 0.047	0.356AsnTrp: 0.356 ± 0.017	0.681AsnTyr: 0.681 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.487ProAla: 5.487 ± 0.083	0.463ProCys: 0.463 ± 0.019	3.265ProAsp: 3.265 ± 0.057	3.406ProGlu: 3.406 ± 0.054	2.005ProPhe: 2.005 ± 0.037	4.146ProGly: 4.146 ± 0.054	1.185ProHis: 1.185 ± 0.03	2.457ProIle: 2.457 ± 0.049	1.833ProLys: 1.833 ± 0.043	5.168ProLeu: 5.168 ± 0.068	1.237ProMet: 1.237 ± 0.034	1.381ProAsn: 1.381 ± 0.034	2.875ProPro: 2.875 ± 0.084	1.922ProGln: 1.922 ± 0.045	2.775ProArg: 2.775 ± 0.051	3.317ProSer: 3.317 ± 0.056	2.977ProThr: 2.977 ± 0.054	4.352ProVal: 4.352 ± 0.056	0.687ProTrp: 0.687 ± 0.021	1.238ProTyr: 1.238 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.078GlnAla: 5.078 ± 0.075	0.324GlnCys: 0.324 ± 0.016	2.073GlnAsp: 2.073 ± 0.042	2.612GlnGlu: 2.612 ± 0.052	1.447GlnPhe: 1.447 ± 0.036	3.095GlnGly: 3.095 ± 0.052	0.954GlnHis: 0.954 ± 0.027	1.953GlnIle: 1.953 ± 0.037	1.358GlnLys: 1.358 ± 0.031	4.017GlnLeu: 4.017 ± 0.065	0.83GlnMet: 0.83 ± 0.024	0.905GlnAsn: 0.905 ± 0.025	2.205GlnPro: 2.205 ± 0.044	2.111GlnGln: 2.111 ± 0.043	3.05GlnArg: 3.05 ± 0.05	2.331GlnSer: 2.331 ± 0.046	2.216GlnThr: 2.216 ± 0.041	3.294GlnVal: 3.294 ± 0.05	0.584GlnTrp: 0.584 ± 0.022	0.993GlnTyr: 0.993 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.518ArgAla: 6.518 ± 0.086	0.702ArgCys: 0.702 ± 0.023	3.58ArgAsp: 3.58 ± 0.054	4.615ArgGlu: 4.615 ± 0.071	2.816ArgPhe: 2.816 ± 0.043	4.445ArgGly: 4.445 ± 0.064	1.889ArgHis: 1.889 ± 0.039	3.895ArgIle: 3.895 ± 0.053	2.566ArgLys: 2.566 ± 0.05	8.21ArgLeu: 8.21 ± 0.09	1.973ArgMet: 1.973 ± 0.047	1.812ArgAsn: 1.812 ± 0.041	3.438ArgPro: 3.438 ± 0.052	3.136ArgGln: 3.136 ± 0.049	5.408ArgArg: 5.408 ± 0.08	3.815ArgSer: 3.815 ± 0.056	3.927ArgThr: 3.927 ± 0.059	5.287ArgVal: 5.287 ± 0.067	1.109ArgTrp: 1.109 ± 0.03	2.126ArgTyr: 2.126 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.591SerAla: 5.591 ± 0.067	0.552SerCys: 0.552 ± 0.021	2.766SerAsp: 2.766 ± 0.048	3.006SerGlu: 3.006 ± 0.056	2.2SerPhe: 2.2 ± 0.045	5.255SerGly: 5.255 ± 0.077	1.373SerHis: 1.373 ± 0.034	2.83SerIle: 2.83 ± 0.054	1.979SerLys: 1.979 ± 0.042	6.505SerLeu: 6.505 ± 0.08	1.482SerMet: 1.482 ± 0.034	1.441SerAsn: 1.441 ± 0.038	3.329SerPro: 3.329 ± 0.058	2.156SerGln: 2.156 ± 0.046	4.089SerArg: 4.089 ± 0.069	3.706SerSer: 3.706 ± 0.074	3.212SerThr: 3.212 ± 0.052	4.187SerVal: 4.187 ± 0.054	0.799SerTrp: 0.799 ± 0.025	1.44SerTyr: 1.44 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.617ThrAla: 5.617 ± 0.078	0.538ThrCys: 0.538 ± 0.022	2.809ThrAsp: 2.809 ± 0.055	3.009ThrGlu: 3.009 ± 0.054	2.151ThrPhe: 2.151 ± 0.043	5.051ThrGly: 5.051 ± 0.076	1.326ThrHis: 1.326 ± 0.033	3.387ThrIle: 3.387 ± 0.053	2.079ThrLys: 2.079 ± 0.042	6.189ThrLeu: 6.189 ± 0.08	1.345ThrMet: 1.345 ± 0.026	1.515ThrAsn: 1.515 ± 0.037	3.408ThrPro: 3.408 ± 0.059	2.11ThrGln: 2.11 ± 0.037	3.347ThrArg: 3.347 ± 0.052	3.126ThrSer: 3.126 ± 0.049	3.467ThrThr: 3.467 ± 0.069	5.028ThrVal: 5.028 ± 0.076	0.674ThrTrp: 0.674 ± 0.025	1.405ThrTyr: 1.405 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.707ValAla: 7.707 ± 0.085	0.755ValCys: 0.755 ± 0.025	3.843ValAsp: 3.843 ± 0.057	4.752ValGlu: 4.752 ± 0.071	2.581ValPhe: 2.581 ± 0.047	5.853ValGly: 5.853 ± 0.078	1.549ValHis: 1.549 ± 0.035	3.879ValIle: 3.879 ± 0.057	2.993ValLys: 2.993 ± 0.063	8.112ValLeu: 8.112 ± 0.073	1.909ValMet: 1.909 ± 0.037	2.122ValAsn: 2.122 ± 0.047	3.929ValPro: 3.929 ± 0.057	2.856ValGln: 2.856 ± 0.055	5.489ValArg: 5.489 ± 0.081	4.678ValSer: 4.678 ± 0.075	5.063ValThr: 5.063 ± 0.069	6.407ValVal: 6.407 ± 0.097	0.868ValTrp: 0.868 ± 0.028	1.682ValTyr: 1.682 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.109TrpAla: 1.109 ± 0.032	0.153TrpCys: 0.153 ± 0.012	0.652TrpAsp: 0.652 ± 0.023	0.723TrpGlu: 0.723 ± 0.026	0.539TrpPhe: 0.539 ± 0.021	0.892TrpGly: 0.892 ± 0.028	0.329TrpHis: 0.329 ± 0.016	0.694TrpIle: 0.694 ± 0.023	0.567TrpLys: 0.567 ± 0.021	1.556TrpLeu: 1.556 ± 0.033	0.404TrpMet: 0.404 ± 0.017	0.479TrpAsn: 0.479 ± 0.018	0.597TrpPro: 0.597 ± 0.022	0.603TrpGln: 0.603 ± 0.024	0.951TrpArg: 0.951 ± 0.034	0.844TrpSer: 0.844 ± 0.029	0.742TrpThr: 0.742 ± 0.027	0.898TrpVal: 0.898 ± 0.026	0.252TrpTrp: 0.252 ± 0.014	0.389TrpTyr: 0.389 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.286TyrAla: 2.286 ± 0.042	0.299TyrCys: 0.299 ± 0.015	1.487TyrAsp: 1.487 ± 0.04	1.475TyrGlu: 1.475 ± 0.036	0.987TyrPhe: 0.987 ± 0.031	2.107TyrGly: 2.107 ± 0.041	0.654TyrHis: 0.654 ± 0.025	0.991TyrIle: 0.991 ± 0.029	0.766TyrLys: 0.766 ± 0.026	2.794TyrLeu: 2.794 ± 0.046	0.449TyrMet: 0.449 ± 0.019	0.651TyrAsn: 0.651 ± 0.026	1.231TyrPro: 1.231 ± 0.031	1.082TyrGln: 1.082 ± 0.029	2.296TyrArg: 2.296 ± 0.044	1.366TyrSer: 1.366 ± 0.03	1.149TyrThr: 1.149 ± 0.032	1.803TyrVal: 1.803 ± 0.038	0.396TyrTrp: 0.396 ± 0.018	0.79TyrTyr: 0.79 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4263 proteins (1285082 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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