Amino acid dipepetide frequency for Ferroplasma acidarmanus fer1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.123AlaAla: 4.123 ± 0.096
0.414AlaCys: 0.414 ± 0.025
2.739AlaAsp: 2.739 ± 0.079
3.027AlaGlu: 3.027 ± 0.076
2.973AlaPhe: 2.973 ± 0.086
5.092AlaGly: 5.092 ± 0.108
0.842AlaHis: 0.842 ± 0.045
6.674AlaIle: 6.674 ± 0.135
3.446AlaLys: 3.446 ± 0.092
5.841AlaLeu: 5.841 ± 0.108
2.195AlaMet: 2.195 ± 0.066
2.418AlaAsn: 2.418 ± 0.067
1.644AlaPro: 1.644 ± 0.057
1.031AlaGln: 1.031 ± 0.054
2.484AlaArg: 2.484 ± 0.067
4.261AlaSer: 4.261 ± 0.103
2.916AlaThr: 2.916 ± 0.09
3.94AlaVal: 3.94 ± 0.091
0.462AlaTrp: 0.462 ± 0.031
2.766AlaTyr: 2.766 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.287CysAla: 0.287 ± 0.026
0.041CysCys: 0.041 ± 0.01
0.387CysAsp: 0.387 ± 0.024
0.301CysGlu: 0.301 ± 0.022
0.191CysPhe: 0.191 ± 0.018
0.614CysGly: 0.614 ± 0.036
0.202CysHis: 0.202 ± 0.018
0.517CysIle: 0.517 ± 0.03
0.376CysLys: 0.376 ± 0.028
0.334CysLeu: 0.334 ± 0.023
0.191CysMet: 0.191 ± 0.016
0.389CysAsn: 0.389 ± 0.025
0.417CysPro: 0.417 ± 0.031
0.098CysGln: 0.098 ± 0.014
0.291CysArg: 0.291 ± 0.024
0.48CysSer: 0.48 ± 0.03
0.337CysThr: 0.337 ± 0.025
0.325CysVal: 0.325 ± 0.024
0.029CysTrp: 0.029 ± 0.007
0.248CysTyr: 0.248 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.023AspAla: 3.023 ± 0.077
0.278AspCys: 0.278 ± 0.02
2.6AspAsp: 2.6 ± 0.076
3.437AspGlu: 3.437 ± 0.089
2.907AspPhe: 2.907 ± 0.071
2.957AspGly: 2.957 ± 0.071
0.738AspHis: 0.738 ± 0.033
6.083AspIle: 6.083 ± 0.099
3.881AspLys: 3.881 ± 0.094
4.657AspLeu: 4.657 ± 0.092
1.766AspMet: 1.766 ± 0.055
3.307AspAsn: 3.307 ± 0.092
1.964AspPro: 1.964 ± 0.065
0.91AspGln: 0.91 ± 0.048
2.365AspArg: 2.365 ± 0.065
3.856AspSer: 3.856 ± 0.081
2.702AspThr: 2.702 ± 0.074
3.282AspVal: 3.282 ± 0.084
0.369AspTrp: 0.369 ± 0.026
3.041AspTyr: 3.041 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
3.317GluAla: 3.317 ± 0.087
0.366GluCys: 0.366 ± 0.027
3.267GluAsp: 3.267 ± 0.082
4.184GluGlu: 4.184 ± 0.105
2.73GluPhe: 2.73 ± 0.076
2.857GluGly: 2.857 ± 0.078
1.063GluHis: 1.063 ± 0.045
6.565GluIle: 6.565 ± 0.117
6.044GluLys: 6.044 ± 0.13
5.259GluLeu: 5.259 ± 0.118
1.801GluMet: 1.801 ± 0.058
5.051GluAsn: 5.051 ± 0.119
1.76GluPro: 1.76 ± 0.055
1.225GluGln: 1.225 ± 0.05
2.406GluArg: 2.406 ± 0.071
3.895GluSer: 3.895 ± 0.078
2.993GluThr: 2.993 ± 0.072
3.025GluVal: 3.025 ± 0.08
0.499GluTrp: 0.499 ± 0.028
3.109GluTyr: 3.109 ± 0.071
0.002GluXaa: 0.002 ± 0.002
Phe
2.832PheAla: 2.832 ± 0.079
0.287PheCys: 0.287 ± 0.022
2.354PheAsp: 2.354 ± 0.06
2.201PheGlu: 2.201 ± 0.067
2.317PhePhe: 2.317 ± 0.078
3.105PheGly: 3.105 ± 0.078
0.954PheHis: 0.954 ± 0.04
4.942PheIle: 4.942 ± 0.115
2.809PheLys: 2.809 ± 0.07
4.4PheLeu: 4.4 ± 0.11
1.448PheMet: 1.448 ± 0.05
2.996PheAsn: 2.996 ± 0.077
1.86PhePro: 1.86 ± 0.067
1.081PheGln: 1.081 ± 0.044
1.739PheArg: 1.739 ± 0.049
4.034PheSer: 4.034 ± 0.096
2.607PheThr: 2.607 ± 0.076
2.704PheVal: 2.704 ± 0.084
0.362PheTrp: 0.362 ± 0.026
2.429PheTyr: 2.429 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
3.899GlyAla: 3.899 ± 0.096
0.351GlyCys: 0.351 ± 0.027
3.262GlyAsp: 3.262 ± 0.077
3.638GlyGlu: 3.638 ± 0.077
3.462GlyPhe: 3.462 ± 0.089
4.191GlyGly: 4.191 ± 0.117
1.181GlyHis: 1.181 ± 0.052
8.304GlyIle: 8.304 ± 0.151
6.128GlyLys: 6.128 ± 0.112
5.659GlyLeu: 5.659 ± 0.126
2.131GlyMet: 2.131 ± 0.066
4.143GlyAsn: 4.143 ± 0.092
1.619GlyPro: 1.619 ± 0.061
1.195GlyGln: 1.195 ± 0.046
2.411GlyArg: 2.411 ± 0.074
4.557GlySer: 4.557 ± 0.086
3.924GlyThr: 3.924 ± 0.096
4.082GlyVal: 4.082 ± 0.093
0.642GlyTrp: 0.642 ± 0.037
3.499GlyTyr: 3.499 ± 0.094
0.0GlyXaa: 0.0 ± 0.0
His
0.924HisAla: 0.924 ± 0.039
0.127HisCys: 0.127 ± 0.017
0.872HisAsp: 0.872 ± 0.038
0.926HisGlu: 0.926 ± 0.043
0.737HisPhe: 0.737 ± 0.035
1.423HisGly: 1.423 ± 0.049
0.26HisHis: 0.26 ± 0.023
1.575HisIle: 1.575 ± 0.059
0.911HisLys: 0.911 ± 0.043
1.232HisLeu: 1.232 ± 0.047
0.594HisMet: 0.594 ± 0.032
0.956HisAsn: 0.956 ± 0.043
0.737HisPro: 0.737 ± 0.039
0.251HisGln: 0.251 ± 0.022
0.699HisArg: 0.699 ± 0.036
1.218HisSer: 1.218 ± 0.046
0.87HisThr: 0.87 ± 0.038
0.927HisVal: 0.927 ± 0.034
0.128HisTrp: 0.128 ± 0.015
0.788HisTyr: 0.788 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.445IleAla: 6.445 ± 0.131
0.53IleCys: 0.53 ± 0.03
5.807IleAsp: 5.807 ± 0.109
6.007IleGlu: 6.007 ± 0.126
4.781IlePhe: 4.781 ± 0.12
6.515IleGly: 6.515 ± 0.126
1.459IleHis: 1.459 ± 0.051
10.057IleIle: 10.057 ± 0.192
8.159IleLys: 8.159 ± 0.142
8.598IleLeu: 8.598 ± 0.169
2.88IleMet: 2.88 ± 0.072
6.067IleAsn: 6.067 ± 0.128
4.189IlePro: 4.189 ± 0.086
1.758IleGln: 1.758 ± 0.055
3.415IleArg: 3.415 ± 0.084
8.113IleSer: 8.113 ± 0.118
5.347IleThr: 5.347 ± 0.113
5.955IleVal: 5.955 ± 0.106
0.564IleTrp: 0.564 ± 0.036
4.418IleTyr: 4.418 ± 0.108
0.0IleXaa: 0.0 ± 0.0
Lys
3.865LysAla: 3.865 ± 0.088
0.553LysCys: 0.553 ± 0.032
4.066LysAsp: 4.066 ± 0.087
5.185LysGlu: 5.185 ± 0.119
3.175LysPhe: 3.175 ± 0.074
3.865LysGly: 3.865 ± 0.09
1.131LysHis: 1.131 ± 0.053
7.73LysIle: 7.73 ± 0.132
6.479LysLys: 6.479 ± 0.116
6.387LysLeu: 6.387 ± 0.115
2.258LysMet: 2.258 ± 0.065
5.909LysAsn: 5.909 ± 0.13
2.254LysPro: 2.254 ± 0.071
1.512LysGln: 1.512 ± 0.057
2.839LysArg: 2.839 ± 0.076
5.07LysSer: 5.07 ± 0.105
3.833LysThr: 3.833 ± 0.082
3.722LysVal: 3.722 ± 0.083
0.601LysTrp: 0.601 ± 0.036
4.328LysTyr: 4.328 ± 0.099
0.0LysXaa: 0.0 ± 0.0
Leu
5.333LeuAla: 5.333 ± 0.13
0.48LeuCys: 0.48 ± 0.028
4.557LeuAsp: 4.557 ± 0.093
5.177LeuGlu: 5.177 ± 0.108
4.275LeuPhe: 4.275 ± 0.096
5.919LeuGly: 5.919 ± 0.121
1.366LeuHis: 1.366 ± 0.048
7.906LeuIle: 7.906 ± 0.152
7.373LeuLys: 7.373 ± 0.147
7.812LeuLeu: 7.812 ± 0.15
2.622LeuMet: 2.622 ± 0.073
5.217LeuAsn: 5.217 ± 0.117
3.187LeuPro: 3.187 ± 0.084
1.735LeuGln: 1.735 ± 0.057
3.166LeuArg: 3.166 ± 0.081
6.995LeuSer: 6.995 ± 0.108
4.114LeuThr: 4.114 ± 0.09
4.699LeuVal: 4.699 ± 0.111
0.608LeuTrp: 0.608 ± 0.038
4.113LeuTyr: 4.113 ± 0.092
0.0LeuXaa: 0.0 ± 0.0
Met
2.311MetAla: 2.311 ± 0.056
0.153MetCys: 0.153 ± 0.015
2.274MetAsp: 2.274 ± 0.058
2.805MetGlu: 2.805 ± 0.086
1.149MetPhe: 1.149 ± 0.053
2.217MetGly: 2.217 ± 0.069
0.551MetHis: 0.551 ± 0.033
2.354MetIle: 2.354 ± 0.063
2.549MetLys: 2.549 ± 0.07
2.413MetLeu: 2.413 ± 0.062
0.704MetMet: 0.704 ± 0.041
1.703MetAsn: 1.703 ± 0.054
1.24MetPro: 1.24 ± 0.058
0.674MetGln: 0.674 ± 0.034
1.086MetArg: 1.086 ± 0.038
1.744MetSer: 1.744 ± 0.061
1.174MetThr: 1.174 ± 0.052
2.201MetVal: 2.201 ± 0.064
0.216MetTrp: 0.216 ± 0.019
1.088MetTyr: 1.088 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.246AsnAla: 3.246 ± 0.083
0.375AsnCys: 0.375 ± 0.025
2.903AsnAsp: 2.903 ± 0.082
3.456AsnGlu: 3.456 ± 0.089
2.764AsnPhe: 2.764 ± 0.063
4.136AsnGly: 4.136 ± 0.091
0.858AsnHis: 0.858 ± 0.04
6.877AsnIle: 6.877 ± 0.123
4.232AsnLys: 4.232 ± 0.097
4.649AsnLeu: 4.649 ± 0.101
1.912AsnMet: 1.912 ± 0.049
4.17AsnAsn: 4.17 ± 0.12
2.37AsnPro: 2.37 ± 0.075
1.165AsnGln: 1.165 ± 0.049
2.557AsnArg: 2.557 ± 0.068
4.53AsnSer: 4.53 ± 0.116
3.076AsnThr: 3.076 ± 0.073
3.731AsnVal: 3.731 ± 0.093
0.351AsnTrp: 0.351 ± 0.021
3.207AsnTyr: 3.207 ± 0.087
0.0AsnXaa: 0.0 ± 0.0
Pro
2.306ProAla: 2.306 ± 0.072
0.184ProCys: 0.184 ± 0.017
2.72ProAsp: 2.72 ± 0.075
3.553ProGlu: 3.553 ± 0.086
1.785ProPhe: 1.785 ± 0.06
2.843ProGly: 2.843 ± 0.08
0.558ProHis: 0.558 ± 0.034
1.994ProIle: 1.994 ± 0.065
1.448ProLys: 1.448 ± 0.049
3.216ProLeu: 3.216 ± 0.074
0.886ProMet: 0.886 ± 0.037
1.015ProAsn: 1.015 ± 0.045
1.072ProPro: 1.072 ± 0.047
0.749ProGln: 0.749 ± 0.04
1.086ProArg: 1.086 ± 0.045
2.265ProSer: 2.265 ± 0.066
1.347ProThr: 1.347 ± 0.05
3.622ProVal: 3.622 ± 0.093
0.339ProTrp: 0.339 ± 0.024
1.853ProTyr: 1.853 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
1.168GlnAla: 1.168 ± 0.046
0.137GlnCys: 0.137 ± 0.015
0.963GlnAsp: 0.963 ± 0.04
1.277GlnGlu: 1.277 ± 0.053
0.952GlnPhe: 0.952 ± 0.04
1.145GlnGly: 1.145 ± 0.046
0.309GlnHis: 0.309 ± 0.025
1.76GlnIle: 1.76 ± 0.054
1.63GlnLys: 1.63 ± 0.059
1.801GlnLeu: 1.801 ± 0.052
0.622GlnMet: 0.622 ± 0.032
1.17GlnAsn: 1.17 ± 0.049
0.521GlnPro: 0.521 ± 0.03
0.48GlnGln: 0.48 ± 0.03
0.847GlnArg: 0.847 ± 0.04
1.188GlnSer: 1.188 ± 0.048
0.797GlnThr: 0.797 ± 0.04
1.018GlnVal: 1.018 ± 0.045
0.234GlnTrp: 0.234 ± 0.021
1.045GlnTyr: 1.045 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.106ArgAla: 2.106 ± 0.063
0.244ArgCys: 0.244 ± 0.021
2.322ArgAsp: 2.322 ± 0.072
3.112ArgGlu: 3.112 ± 0.087
1.612ArgPhe: 1.612 ± 0.054
2.308ArgGly: 2.308 ± 0.069
0.672ArgHis: 0.672 ± 0.037
3.936ArgIle: 3.936 ± 0.083
3.797ArgLys: 3.797 ± 0.088
2.964ArgLeu: 2.964 ± 0.076
1.163ArgMet: 1.163 ± 0.05
2.582ArgAsn: 2.582 ± 0.065
1.065ArgPro: 1.065 ± 0.046
0.803ArgGln: 0.803 ± 0.035
1.842ArgArg: 1.842 ± 0.065
2.442ArgSer: 2.442 ± 0.071
1.751ArgThr: 1.751 ± 0.054
2.071ArgVal: 2.071 ± 0.058
0.303ArgTrp: 0.303 ± 0.023
1.956ArgTyr: 1.956 ± 0.066
0.002ArgXaa: 0.002 ± 0.002
Ser
3.982SerAla: 3.982 ± 0.088
0.424SerCys: 0.424 ± 0.029
3.697SerAsp: 3.697 ± 0.094
4.016SerGlu: 4.016 ± 0.087
3.394SerPhe: 3.394 ± 0.093
6.249SerGly: 6.249 ± 0.109
1.2SerHis: 1.2 ± 0.051
7.688SerIle: 7.688 ± 0.133
4.462SerLys: 4.462 ± 0.094
6.69SerLeu: 6.69 ± 0.115
2.495SerMet: 2.495 ± 0.066
3.685SerAsn: 3.685 ± 0.097
2.409SerPro: 2.409 ± 0.072
1.427SerGln: 1.427 ± 0.054
3.417SerArg: 3.417 ± 0.084
5.602SerSer: 5.602 ± 0.122
3.9SerThr: 3.9 ± 0.091
4.239SerVal: 4.239 ± 0.09
0.565SerTrp: 0.565 ± 0.032
3.392SerTyr: 3.392 ± 0.097
0.002SerXaa: 0.002 ± 0.002
Thr
3.289ThrAla: 3.289 ± 0.075
0.282ThrCys: 0.282 ± 0.022
2.845ThrAsp: 2.845 ± 0.068
2.845ThrGlu: 2.845 ± 0.077
2.318ThrPhe: 2.318 ± 0.068
5.311ThrGly: 5.311 ± 0.114
0.833ThrHis: 0.833 ± 0.035
4.785ThrIle: 4.785 ± 0.1
2.768ThrLys: 2.768 ± 0.072
4.468ThrLeu: 4.468 ± 0.078
1.536ThrMet: 1.536 ± 0.052
2.144ThrAsn: 2.144 ± 0.076
2.092ThrPro: 2.092 ± 0.063
0.895ThrGln: 0.895 ± 0.041
1.855ThrArg: 1.855 ± 0.067
3.26ThrSer: 3.26 ± 0.086
2.554ThrThr: 2.554 ± 0.072
3.654ThrVal: 3.654 ± 0.095
0.371ThrTrp: 0.371 ± 0.024
2.297ThrTyr: 2.297 ± 0.077
0.002ThrXaa: 0.002 ± 0.002
Val
3.66ValAla: 3.66 ± 0.084
0.433ValCys: 0.433 ± 0.03
3.408ValAsp: 3.408 ± 0.078
3.378ValGlu: 3.378 ± 0.081
3.112ValPhe: 3.112 ± 0.092
3.408ValGly: 3.408 ± 0.094
0.979ValHis: 0.979 ± 0.044
5.955ValIle: 5.955 ± 0.103
4.459ValLys: 4.459 ± 0.094
5.288ValLeu: 5.288 ± 0.099
1.725ValMet: 1.725 ± 0.061
3.717ValAsn: 3.717 ± 0.09
2.49ValPro: 2.49 ± 0.066
1.07ValGln: 1.07 ± 0.044
2.03ValArg: 2.03 ± 0.061
4.714ValSer: 4.714 ± 0.088
3.159ValThr: 3.159 ± 0.087
3.706ValVal: 3.706 ± 0.098
0.417ValTrp: 0.417 ± 0.031
2.952ValTyr: 2.952 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.455TrpAla: 0.455 ± 0.032
0.052TrpCys: 0.052 ± 0.01
0.403TrpAsp: 0.403 ± 0.027
0.439TrpGlu: 0.439 ± 0.029
0.412TrpPhe: 0.412 ± 0.029
0.465TrpGly: 0.465 ± 0.028
0.198TrpHis: 0.198 ± 0.021
0.672TrpIle: 0.672 ± 0.036
0.61TrpLys: 0.61 ± 0.033
0.706TrpLeu: 0.706 ± 0.031
0.228TrpMet: 0.228 ± 0.021
0.476TrpAsn: 0.476 ± 0.032
0.198TrpPro: 0.198 ± 0.02
0.187TrpGln: 0.187 ± 0.017
0.335TrpArg: 0.335 ± 0.022
0.49TrpSer: 0.49 ± 0.031
0.3TrpThr: 0.3 ± 0.021
0.414TrpVal: 0.414 ± 0.028
0.114TrpTrp: 0.114 ± 0.014
0.378TrpTyr: 0.378 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.716TyrAla: 2.716 ± 0.078
0.341TyrCys: 0.341 ± 0.026
2.673TyrAsp: 2.673 ± 0.067
2.456TyrGlu: 2.456 ± 0.07
2.415TyrPhe: 2.415 ± 0.074
3.656TyrGly: 3.656 ± 0.088
0.803TyrHis: 0.803 ± 0.035
4.692TyrIle: 4.692 ± 0.099
3.2TyrLys: 3.2 ± 0.086
4.28TyrLeu: 4.28 ± 0.091
1.446TyrMet: 1.446 ± 0.049
3.453TyrAsn: 3.453 ± 0.101
1.751TyrPro: 1.751 ± 0.063
0.819TyrGln: 0.819 ± 0.043
2.181TyrArg: 2.181 ± 0.065
4.223TyrSer: 4.223 ± 0.109
2.702TyrThr: 2.702 ± 0.084
2.741TyrVal: 2.741 ± 0.067
0.358TyrTrp: 0.358 ± 0.029
2.768TyrTyr: 2.768 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.002XaaCys: 0.002 ± 0.002
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.002XaaArg: 0.002 ± 0.002
0.002XaaSer: 0.002 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1927 proteins (560709 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski