Amino acid dipepetide frequency for uncultured archaeon A07HR67

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.196AlaAla: 18.196 ± 0.276	0.832AlaCys: 0.832 ± 0.036	12.122AlaAsp: 12.122 ± 0.16	9.226AlaGlu: 9.226 ± 0.132	4.484AlaPhe: 4.484 ± 0.083	11.74AlaGly: 11.74 ± 0.15	1.914AlaHis: 1.914 ± 0.053	4.696AlaIle: 4.696 ± 0.085	1.553AlaLys: 1.553 ± 0.05	10.295AlaLeu: 10.295 ± 0.151	2.163AlaMet: 2.163 ± 0.062	2.322AlaAsn: 2.322 ± 0.053	4.447AlaPro: 4.447 ± 0.087	1.802AlaGln: 1.802 ± 0.042	6.936AlaArg: 6.936 ± 0.112	5.685AlaSer: 5.685 ± 0.088	7.745AlaThr: 7.745 ± 0.118	13.184AlaVal: 13.184 ± 0.19	1.172AlaTrp: 1.172 ± 0.04	2.975AlaTyr: 2.975 ± 0.067	0.022AlaXaa: 0.022 ± 0.006
Cys	0.687CysAla: 0.687 ± 0.032	0.081CysCys: 0.081 ± 0.011	0.573CysAsp: 0.573 ± 0.027	0.538CysGlu: 0.538 ± 0.024	0.199CysPhe: 0.199 ± 0.014	0.848CysGly: 0.848 ± 0.036	0.178CysHis: 0.178 ± 0.015	0.179CysIle: 0.179 ± 0.013	0.074CysLys: 0.074 ± 0.009	0.554CysLeu: 0.554 ± 0.023	0.108CysMet: 0.108 ± 0.012	0.164CysAsn: 0.164 ± 0.015	0.538CysPro: 0.538 ± 0.03	0.134CysGln: 0.134 ± 0.013	0.572CysArg: 0.572 ± 0.026	0.424CysSer: 0.424 ± 0.026	0.352CysThr: 0.352 ± 0.022	0.583CysVal: 0.583 ± 0.026	0.073CysTrp: 0.073 ± 0.01	0.146CysTyr: 0.146 ± 0.014	0.001CysXaa: 0.001 ± 0.001
Asp	12.497AspAla: 12.497 ± 0.179	0.514AspCys: 0.514 ± 0.029	8.247AspAsp: 8.247 ± 0.145	7.311AspGlu: 7.311 ± 0.129	1.609AspPhe: 1.609 ± 0.045	8.811AspGly: 8.811 ± 0.113	2.018AspHis: 2.018 ± 0.054	2.674AspIle: 2.674 ± 0.065	0.739AspLys: 0.739 ± 0.032	6.815AspLeu: 6.815 ± 0.11	1.095AspMet: 1.095 ± 0.039	1.113AspAsn: 1.113 ± 0.042	5.567AspPro: 5.567 ± 0.094	1.506AspGln: 1.506 ± 0.043	8.06AspArg: 8.06 ± 0.117	3.074AspSer: 3.074 ± 0.069	4.281AspThr: 4.281 ± 0.078	7.608AspVal: 7.608 ± 0.114	0.888AspTrp: 0.888 ± 0.042	1.326AspTyr: 1.326 ± 0.039	0.01AspXaa: 0.01 ± 0.003
Glu	9.156GluAla: 9.156 ± 0.136	0.486GluCys: 0.486 ± 0.028	4.269GluAsp: 4.269 ± 0.093	5.384GluGlu: 5.384 ± 0.133	2.67GluPhe: 2.67 ± 0.056	4.745GluGly: 4.745 ± 0.085	1.654GluHis: 1.654 ± 0.049	3.125GluIle: 3.125 ± 0.081	1.421GluLys: 1.421 ± 0.054	6.999GluLeu: 6.999 ± 0.098	1.753GluMet: 1.753 ± 0.048	2.092GluAsn: 2.092 ± 0.058	4.45GluPro: 4.45 ± 0.089	1.935GluGln: 1.935 ± 0.053	7.563GluArg: 7.563 ± 0.115	4.415GluSer: 4.415 ± 0.084	7.092GluThr: 7.092 ± 0.103	5.416GluVal: 5.416 ± 0.094	1.056GluTrp: 1.056 ± 0.039	2.339GluTyr: 2.339 ± 0.061	0.005GluXaa: 0.005 ± 0.003
Phe	3.867PheAla: 3.867 ± 0.085	0.246PheCys: 0.246 ± 0.017	3.2PheAsp: 3.2 ± 0.062	2.867PheGlu: 2.867 ± 0.065	0.953PhePhe: 0.953 ± 0.046	3.295PheGly: 3.295 ± 0.086	0.599PheHis: 0.599 ± 0.028	0.956PheIle: 0.956 ± 0.034	0.403PheLys: 0.403 ± 0.021	2.662PheLeu: 2.662 ± 0.068	0.466PheMet: 0.466 ± 0.027	0.618PheAsn: 0.618 ± 0.026	1.335PhePro: 1.335 ± 0.044	0.657PheGln: 0.657 ± 0.027	1.883PheArg: 1.883 ± 0.048	1.653PheSer: 1.653 ± 0.045	1.774PheThr: 1.774 ± 0.052	3.122PheVal: 3.122 ± 0.069	0.365PheTrp: 0.365 ± 0.022	0.779PheTyr: 0.779 ± 0.033	0.001PheXaa: 0.001 ± 0.001
Gly	9.123GlyAla: 9.123 ± 0.127	0.741GlyCys: 0.741 ± 0.035	7.472GlyAsp: 7.472 ± 0.117	6.752GlyGlu: 6.752 ± 0.101	3.238GlyPhe: 3.238 ± 0.081	8.161GlyGly: 8.161 ± 0.127	1.753GlyHis: 1.753 ± 0.054	4.203GlyIle: 4.203 ± 0.073	1.507GlyLys: 1.507 ± 0.048	7.571GlyLeu: 7.571 ± 0.126	1.644GlyMet: 1.644 ± 0.049	1.646GlyAsn: 1.646 ± 0.052	3.748GlyPro: 3.748 ± 0.085	1.702GlyGln: 1.702 ± 0.054	5.93GlyArg: 5.93 ± 0.108	5.391GlySer: 5.391 ± 0.079	5.702GlyThr: 5.702 ± 0.072	8.889GlyVal: 8.889 ± 0.127	1.101GlyTrp: 1.101 ± 0.041	2.659GlyTyr: 2.659 ± 0.052	0.021GlyXaa: 0.021 ± 0.005
His	2.215HisAla: 2.215 ± 0.054	0.181HisCys: 0.181 ± 0.015	1.889HisAsp: 1.889 ± 0.053	1.655HisGlu: 1.655 ± 0.053	0.425HisPhe: 0.425 ± 0.026	1.905HisGly: 1.905 ± 0.054	0.475HisHis: 0.475 ± 0.027	0.536HisIle: 0.536 ± 0.031	0.248HisLys: 0.248 ± 0.02	1.54HisLeu: 1.54 ± 0.056	0.293HisMet: 0.293 ± 0.019	0.437HisAsn: 0.437 ± 0.025	1.22HisPro: 1.22 ± 0.037	0.386HisGln: 0.386 ± 0.02	1.308HisArg: 1.308 ± 0.046	0.783HisSer: 0.783 ± 0.035	1.108HisThr: 1.108 ± 0.044	1.841HisVal: 1.841 ± 0.059	0.213HisTrp: 0.213 ± 0.017	0.488HisTyr: 0.488 ± 0.026	0.003HisXaa: 0.003 ± 0.002
Ile	4.807IleAla: 4.807 ± 0.088	0.244IleCys: 0.244 ± 0.018	3.921IleAsp: 3.921 ± 0.069	3.804IleGlu: 3.804 ± 0.074	0.654IlePhe: 0.654 ± 0.031	3.755IleGly: 3.755 ± 0.089	0.778IleHis: 0.778 ± 0.031	0.993IleIle: 0.993 ± 0.042	0.549IleLys: 0.549 ± 0.03	2.386IleLeu: 2.386 ± 0.067	0.415IleMet: 0.415 ± 0.026	0.883IleAsn: 0.883 ± 0.041	1.884IlePro: 1.884 ± 0.051	0.936IleGln: 0.936 ± 0.034	2.649IleArg: 2.649 ± 0.059	1.702IleSer: 1.702 ± 0.061	2.276IleThr: 2.276 ± 0.066	3.51IleVal: 3.51 ± 0.072	0.252IleTrp: 0.252 ± 0.017	0.661IleTyr: 0.661 ± 0.028	0.004IleXaa: 0.004 ± 0.002
Lys	1.49LysAla: 1.49 ± 0.043	0.091LysCys: 0.091 ± 0.012	0.723LysAsp: 0.723 ± 0.034	0.934LysGlu: 0.934 ± 0.041	0.399LysPhe: 0.399 ± 0.024	1.144LysGly: 1.144 ± 0.042	0.385LysHis: 0.385 ± 0.023	0.536LysIle: 0.536 ± 0.032	0.386LysLys: 0.386 ± 0.025	1.338LysLeu: 1.338 ± 0.04	0.293LysMet: 0.293 ± 0.019	0.443LysAsn: 0.443 ± 0.028	0.804LysPro: 0.804 ± 0.035	0.547LysGln: 0.547 ± 0.027	1.649LysArg: 1.649 ± 0.05	0.871LysSer: 0.871 ± 0.039	1.182LysThr: 1.182 ± 0.039	0.917LysVal: 0.917 ± 0.036	0.169LysTrp: 0.169 ± 0.013	0.419LysTyr: 0.419 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	11.675LeuAla: 11.675 ± 0.149	0.567LeuCys: 0.567 ± 0.026	7.181LeuAsp: 7.181 ± 0.109	5.683LeuGlu: 5.683 ± 0.107	2.802LeuPhe: 2.802 ± 0.069	7.541LeuGly: 7.541 ± 0.121	1.3LeuHis: 1.3 ± 0.039	2.856LeuIle: 2.856 ± 0.065	1.254LeuLys: 1.254 ± 0.041	7.809LeuLeu: 7.809 ± 0.142	1.205LeuMet: 1.205 ± 0.04	1.67LeuAsn: 1.67 ± 0.051	4.142LeuPro: 4.142 ± 0.076	1.541LeuGln: 1.541 ± 0.047	5.979LeuArg: 5.979 ± 0.09	5.121LeuSer: 5.121 ± 0.076	5.104LeuThr: 5.104 ± 0.097	8.495LeuVal: 8.495 ± 0.113	0.746LeuTrp: 0.746 ± 0.031	1.966LeuTyr: 1.966 ± 0.049	0.009LeuXaa: 0.009 ± 0.003
Met	1.742MetAla: 1.742 ± 0.044	0.147MetCys: 0.147 ± 0.016	1.226MetAsp: 1.226 ± 0.041	0.977MetGlu: 0.977 ± 0.039	0.485MetPhe: 0.485 ± 0.029	1.29MetGly: 1.29 ± 0.041	0.243MetHis: 0.243 ± 0.017	0.692MetIle: 0.692 ± 0.031	0.343MetLys: 0.343 ± 0.019	1.304MetLeu: 1.304 ± 0.046	0.281MetMet: 0.281 ± 0.019	0.558MetAsn: 0.558 ± 0.027	0.802MetPro: 0.802 ± 0.027	0.309MetGln: 0.309 ± 0.023	1.15MetArg: 1.15 ± 0.043	1.601MetSer: 1.601 ± 0.052	1.593MetThr: 1.593 ± 0.048	1.213MetVal: 1.213 ± 0.044	0.156MetTrp: 0.156 ± 0.017	0.463MetTyr: 0.463 ± 0.03	0.004MetXaa: 0.004 ± 0.002
Asn	2.711AsnAla: 2.711 ± 0.058	0.178AsnCys: 0.178 ± 0.016	1.564AsnAsp: 1.564 ± 0.043	1.55AsnGlu: 1.55 ± 0.052	0.577AsnPhe: 0.577 ± 0.026	1.913AsnGly: 1.913 ± 0.047	0.417AsnHis: 0.417 ± 0.02	0.69AsnIle: 0.69 ± 0.034	0.355AsnLys: 0.355 ± 0.021	1.607AsnLeu: 1.607 ± 0.053	0.341AsnMet: 0.341 ± 0.02	0.52AsnAsn: 0.52 ± 0.031	1.44AsnPro: 1.44 ± 0.051	0.45AsnGln: 0.45 ± 0.025	1.544AsnArg: 1.544 ± 0.042	0.774AsnSer: 0.774 ± 0.034	1.231AsnThr: 1.231 ± 0.04	2.199AsnVal: 2.199 ± 0.057	0.263AsnTrp: 0.263 ± 0.021	0.534AsnTyr: 0.534 ± 0.027	0.004AsnXaa: 0.004 ± 0.002
Pro	5.995ProAla: 5.995 ± 0.104	0.255ProCys: 0.255 ± 0.019	5.317ProAsp: 5.317 ± 0.092	4.283ProGlu: 4.283 ± 0.079	1.642ProPhe: 1.642 ± 0.046	4.278ProGly: 4.278 ± 0.073	0.908ProHis: 0.908 ± 0.033	1.822ProIle: 1.822 ± 0.051	0.702ProLys: 0.702 ± 0.027	3.698ProLeu: 3.698 ± 0.07	0.904ProMet: 0.904 ± 0.035	1.066ProAsn: 1.066 ± 0.037	2.519ProPro: 2.519 ± 0.064	0.874ProGln: 0.874 ± 0.036	2.688ProArg: 2.688 ± 0.063	2.661ProSer: 2.661 ± 0.062	3.688ProThr: 3.688 ± 0.073	4.72ProVal: 4.72 ± 0.084	0.454ProTrp: 0.454 ± 0.023	1.079ProTyr: 1.079 ± 0.035	0.007ProXaa: 0.007 ± 0.003
Gln	2.055GlnAla: 2.055 ± 0.055	0.127GlnCys: 0.127 ± 0.014	0.982GlnAsp: 0.982 ± 0.035	1.315GlnGlu: 1.315 ± 0.047	0.837GlnPhe: 0.837 ± 0.033	1.42GlnGly: 1.42 ± 0.046	0.432GlnHis: 0.432 ± 0.025	1.008GlnIle: 1.008 ± 0.039	0.427GlnLys: 0.427 ± 0.025	1.908GlnLeu: 1.908 ± 0.051	0.436GlnMet: 0.436 ± 0.024	0.618GlnAsn: 0.618 ± 0.025	1.017GlnPro: 1.017 ± 0.039	0.756GlnGln: 0.756 ± 0.04	1.719GlnArg: 1.719 ± 0.044	1.205GlnSer: 1.205 ± 0.04	1.454GlnThr: 1.454 ± 0.05	1.466GlnVal: 1.466 ± 0.05	0.27GlnTrp: 0.27 ± 0.021	0.644GlnTyr: 0.644 ± 0.028	0.003GlnXaa: 0.003 ± 0.002
Arg	7.551ArgAla: 7.551 ± 0.125	0.514ArgCys: 0.514 ± 0.028	5.465ArgAsp: 5.465 ± 0.086	6.723ArgGlu: 6.723 ± 0.116	2.537ArgPhe: 2.537 ± 0.055	5.143ArgGly: 5.143 ± 0.093	1.35ArgHis: 1.35 ± 0.044	3.173ArgIle: 3.173 ± 0.062	1.178ArgLys: 1.178 ± 0.041	6.992ArgLeu: 6.992 ± 0.11	1.38ArgMet: 1.38 ± 0.038	1.506ArgAsn: 1.506 ± 0.044	3.276ArgPro: 3.276 ± 0.086	1.69ArgGln: 1.69 ± 0.041	6.56ArgArg: 6.56 ± 0.203	4.065ArgSer: 4.065 ± 0.073	4.556ArgThr: 4.556 ± 0.09	6.473ArgVal: 6.473 ± 0.109	0.818ArgTrp: 0.818 ± 0.033	1.995ArgTyr: 1.995 ± 0.054	0.007ArgXaa: 0.007 ± 0.003
Ser	5.814SerAla: 5.814 ± 0.088	0.319SerCys: 0.319 ± 0.022	4.11SerAsp: 4.11 ± 0.088	3.684SerGlu: 3.684 ± 0.072	1.784SerPhe: 1.784 ± 0.05	5.182SerGly: 5.182 ± 0.091	0.887SerHis: 0.887 ± 0.033	2.097SerIle: 2.097 ± 0.052	0.922SerLys: 0.922 ± 0.036	4.421SerLeu: 4.421 ± 0.082	0.964SerMet: 0.964 ± 0.038	1.086SerAsn: 1.086 ± 0.037	2.664SerPro: 2.664 ± 0.059	1.117SerGln: 1.117 ± 0.042	3.666SerArg: 3.666 ± 0.075	2.71SerSer: 2.71 ± 0.071	3.39SerThr: 3.39 ± 0.07	5.147SerVal: 5.147 ± 0.087	0.563SerTrp: 0.563 ± 0.024	1.283SerTyr: 1.283 ± 0.044	0.012SerXaa: 0.012 ± 0.004
Thr	8.038ThrAla: 8.038 ± 0.116	0.388ThrCys: 0.388 ± 0.022	5.901ThrAsp: 5.901 ± 0.094	4.744ThrGlu: 4.744 ± 0.089	2.095ThrPhe: 2.095 ± 0.045	6.034ThrGly: 6.034 ± 0.094	1.337ThrHis: 1.337 ± 0.043	2.525ThrIle: 2.525 ± 0.06	0.902ThrLys: 0.902 ± 0.038	5.663ThrLeu: 5.663 ± 0.099	1.025ThrMet: 1.025 ± 0.039	1.381ThrAsn: 1.381 ± 0.039	3.615ThrPro: 3.615 ± 0.072	1.269ThrGln: 1.269 ± 0.046	4.008ThrArg: 4.008 ± 0.078	2.651ThrSer: 2.651 ± 0.061	4.732ThrThr: 4.732 ± 0.097	7.302ThrVal: 7.302 ± 0.099	0.581ThrTrp: 0.581 ± 0.028	1.631ThrTyr: 1.631 ± 0.05	0.013ThrXaa: 0.013 ± 0.005
Val	12.011ValAla: 12.011 ± 0.175	0.788ValCys: 0.788 ± 0.03	8.615ValAsp: 8.615 ± 0.137	7.69ValGlu: 7.69 ± 0.119	3.205ValPhe: 3.205 ± 0.072	8.69ValGly: 8.69 ± 0.136	1.757ValHis: 1.757 ± 0.05	3.204ValIle: 3.204 ± 0.068	1.187ValLys: 1.187 ± 0.042	7.731ValLeu: 7.731 ± 0.119	1.287ValMet: 1.287 ± 0.045	1.878ValAsn: 1.878 ± 0.048	4.432ValPro: 4.432 ± 0.075	1.553ValGln: 1.553 ± 0.04	6.3ValArg: 6.3 ± 0.098	5.455ValSer: 5.455 ± 0.094	6.446ValThr: 6.446 ± 0.091	10.567ValVal: 10.567 ± 0.156	0.821ValTrp: 0.821 ± 0.032	2.13ValTyr: 2.13 ± 0.057	0.016ValXaa: 0.016 ± 0.005
Trp	0.921TrpAla: 0.921 ± 0.035	0.105TrpCys: 0.105 ± 0.012	0.61TrpAsp: 0.61 ± 0.029	0.785TrpGlu: 0.785 ± 0.032	0.397TrpPhe: 0.397 ± 0.024	0.784TrpGly: 0.784 ± 0.029	0.225TrpHis: 0.225 ± 0.016	0.492TrpIle: 0.492 ± 0.024	0.224TrpLys: 0.224 ± 0.018	1.094TrpLeu: 1.094 ± 0.041	0.2TrpMet: 0.2 ± 0.017	0.286TrpAsn: 0.286 ± 0.019	0.44TrpPro: 0.44 ± 0.026	0.333TrpGln: 0.333 ± 0.019	0.891TrpArg: 0.891 ± 0.032	0.575TrpSer: 0.575 ± 0.026	0.727TrpThr: 0.727 ± 0.031	0.809TrpVal: 0.809 ± 0.036	0.16TrpTrp: 0.16 ± 0.015	0.343TrpTyr: 0.343 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.944TyrAla: 2.944 ± 0.056	0.2TyrCys: 0.2 ± 0.016	2.363TyrAsp: 2.363 ± 0.061	2.117TyrGlu: 2.117 ± 0.063	0.706TyrPhe: 0.706 ± 0.033	2.264TyrGly: 2.264 ± 0.048	0.536TyrHis: 0.536 ± 0.027	0.605TyrIle: 0.605 ± 0.03	0.346TyrLys: 0.346 ± 0.02	2.254TyrLeu: 2.254 ± 0.06	0.326TyrMet: 0.326 ± 0.02	0.576TyrAsn: 0.576 ± 0.03	1.212TyrPro: 1.212 ± 0.041	0.59TyrGln: 0.59 ± 0.028	1.874TyrArg: 1.874 ± 0.055	0.993TyrSer: 0.993 ± 0.037	1.391TyrThr: 1.391 ± 0.04	2.286TyrVal: 2.286 ± 0.057	0.277TyrTrp: 0.277 ± 0.019	0.687TyrTyr: 0.687 ± 0.029	0.003TyrXaa: 0.003 ± 0.002
Xaa	0.017XaaAla: 0.017 ± 0.005	0.003XaaCys: 0.003 ± 0.002	0.01XaaAsp: 0.01 ± 0.003	0.005XaaGlu: 0.005 ± 0.003	0.003XaaPhe: 0.003 ± 0.002	0.01XaaGly: 0.01 ± 0.003	0.003XaaHis: 0.003 ± 0.002	0.003XaaIle: 0.003 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.005XaaLeu: 0.005 ± 0.003	0.003XaaMet: 0.003 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.009XaaPro: 0.009 ± 0.003	0.008XaaGln: 0.008 ± 0.003	0.025XaaArg: 0.025 ± 0.005	0.013XaaSer: 0.013 ± 0.004	0.009XaaThr: 0.009 ± 0.003	0.016XaaVal: 0.016 ± 0.004	0.0XaaTrp: 0.0 ± 0.0	0.003XaaTyr: 0.003 ± 0.002	0.904XaaXaa: 0.904 ± 0.089

Statistics based on 2887 proteins (769015 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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