Amino acid dipepetide frequency for Kwoniella heveanensis BCC8398

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.554AlaAla: 9.554 ± 0.076	0.852AlaCys: 0.852 ± 0.016	4.279AlaAsp: 4.279 ± 0.035	5.562AlaGlu: 5.562 ± 0.046	2.892AlaPhe: 2.892 ± 0.031	7.017AlaGly: 7.017 ± 0.056	1.919AlaHis: 1.919 ± 0.023	4.059AlaIle: 4.059 ± 0.033	4.282AlaLys: 4.282 ± 0.043	7.756AlaLeu: 7.756 ± 0.055	1.919AlaMet: 1.919 ± 0.021	2.869AlaAsn: 2.869 ± 0.028	5.542AlaPro: 5.542 ± 0.059	3.76AlaGln: 3.76 ± 0.04	5.01AlaArg: 5.01 ± 0.039	9.137AlaSer: 9.137 ± 0.066	5.291AlaThr: 5.291 ± 0.04	5.147AlaVal: 5.147 ± 0.038	1.057AlaTrp: 1.057 ± 0.016	2.078AlaTyr: 2.078 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.719CysAla: 0.719 ± 0.015	0.166CysCys: 0.166 ± 0.008	0.481CysAsp: 0.481 ± 0.011	0.498CysGlu: 0.498 ± 0.012	0.401CysPhe: 0.401 ± 0.01	0.772CysGly: 0.772 ± 0.016	0.239CysHis: 0.239 ± 0.009	0.508CysIle: 0.508 ± 0.011	0.395CysLys: 0.395 ± 0.01	0.997CysLeu: 0.997 ± 0.017	0.204CysMet: 0.204 ± 0.007	0.283CysAsn: 0.283 ± 0.009	0.542CysPro: 0.542 ± 0.014	0.355CysGln: 0.355 ± 0.01	0.521CysArg: 0.521 ± 0.012	0.691CysSer: 0.691 ± 0.013	0.551CysThr: 0.551 ± 0.013	0.622CysVal: 0.622 ± 0.013	0.158CysTrp: 0.158 ± 0.006	0.267CysTyr: 0.267 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.482AspAla: 4.482 ± 0.033	0.479AspCys: 0.479 ± 0.013	4.551AspAsp: 4.551 ± 0.048	5.019AspGlu: 5.019 ± 0.055	1.787AspPhe: 1.787 ± 0.021	4.411AspGly: 4.411 ± 0.039	1.33AspHis: 1.33 ± 0.02	2.639AspIle: 2.639 ± 0.024	2.432AspLys: 2.432 ± 0.031	4.996AspLeu: 4.996 ± 0.041	1.15AspMet: 1.15 ± 0.017	1.683AspAsn: 1.683 ± 0.021	3.437AspPro: 3.437 ± 0.031	2.043AspGln: 2.043 ± 0.024	3.262AspArg: 3.262 ± 0.039	3.914AspSer: 3.914 ± 0.032	2.687AspThr: 2.687 ± 0.025	3.622AspVal: 3.622 ± 0.032	0.844AspTrp: 0.844 ± 0.015	1.341AspTyr: 1.341 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.474GluAla: 5.474 ± 0.045	0.501GluCys: 0.501 ± 0.013	4.521GluAsp: 4.521 ± 0.048	6.154GluGlu: 6.154 ± 0.075	1.536GluPhe: 1.536 ± 0.019	4.883GluGly: 4.883 ± 0.041	1.295GluHis: 1.295 ± 0.017	2.858GluIle: 2.858 ± 0.031	3.711GluLys: 3.711 ± 0.043	4.835GluLeu: 4.835 ± 0.041	1.504GluMet: 1.504 ± 0.02	1.924GluAsn: 1.924 ± 0.022	2.654GluPro: 2.654 ± 0.031	2.35GluGln: 2.35 ± 0.028	4.279GluArg: 4.279 ± 0.044	4.184GluSer: 4.184 ± 0.037	3.131GluThr: 3.131 ± 0.027	3.845GluVal: 3.845 ± 0.036	0.901GluTrp: 0.901 ± 0.015	1.488GluTyr: 1.488 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.816PheAla: 2.816 ± 0.031	0.409PheCys: 0.409 ± 0.01	2.057PheAsp: 2.057 ± 0.023	1.836PheGlu: 1.836 ± 0.023	1.345PhePhe: 1.345 ± 0.022	2.767PheGly: 2.767 ± 0.039	0.76PheHis: 0.76 ± 0.013	1.487PheIle: 1.487 ± 0.021	1.339PheLys: 1.339 ± 0.018	2.801PheLeu: 2.801 ± 0.034	0.642PheMet: 0.642 ± 0.013	1.147PheAsn: 1.147 ± 0.016	1.81PhePro: 1.81 ± 0.023	1.037PheGln: 1.037 ± 0.016	1.619PheArg: 1.619 ± 0.02	2.679PheSer: 2.679 ± 0.029	1.906PheThr: 1.906 ± 0.02	2.064PheVal: 2.064 ± 0.025	0.507PheTrp: 0.507 ± 0.012	0.852PheTyr: 0.852 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	6.025GlyAla: 6.025 ± 0.05	0.734GlyCys: 0.734 ± 0.014	4.067GlyAsp: 4.067 ± 0.034	4.504GlyGlu: 4.504 ± 0.036	2.508GlyPhe: 2.508 ± 0.026	8.138GlyGly: 8.138 ± 0.078	1.832GlyHis: 1.832 ± 0.023	3.293GlyIle: 3.293 ± 0.031	4.129GlyLys: 4.129 ± 0.04	6.412GlyLeu: 6.412 ± 0.047	1.839GlyMet: 1.839 ± 0.025	2.592GlyAsn: 2.592 ± 0.029	3.78GlyPro: 3.78 ± 0.041	2.992GlyGln: 2.992 ± 0.041	4.512GlyArg: 4.512 ± 0.04	7.207GlySer: 7.207 ± 0.059	4.218GlyThr: 4.218 ± 0.037	4.779GlyVal: 4.779 ± 0.038	1.36GlyTrp: 1.36 ± 0.021	2.123GlyTyr: 2.123 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.918HisAla: 1.918 ± 0.027	0.226HisCys: 0.226 ± 0.007	1.248HisAsp: 1.248 ± 0.021	1.213HisGlu: 1.213 ± 0.018	0.79HisPhe: 0.79 ± 0.015	1.744HisGly: 1.744 ± 0.024	0.974HisHis: 0.974 ± 0.02	1.068HisIle: 1.068 ± 0.015	0.826HisLys: 0.826 ± 0.015	2.339HisLeu: 2.339 ± 0.025	0.43HisMet: 0.43 ± 0.01	0.756HisAsn: 0.756 ± 0.014	1.958HisPro: 1.958 ± 0.023	1.056HisGln: 1.056 ± 0.017	1.501HisArg: 1.501 ± 0.022	2.059HisSer: 2.059 ± 0.031	1.359HisThr: 1.359 ± 0.018	1.349HisVal: 1.349 ± 0.017	0.284HisTrp: 0.284 ± 0.009	0.592HisTyr: 0.592 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.081IleAla: 4.081 ± 0.032	0.557IleCys: 0.557 ± 0.014	2.754IleAsp: 2.754 ± 0.026	2.693IleGlu: 2.693 ± 0.028	1.597IlePhe: 1.597 ± 0.024	3.232IleGly: 3.232 ± 0.033	1.092IleHis: 1.092 ± 0.016	2.247IleIle: 2.247 ± 0.033	2.145IleLys: 2.145 ± 0.025	3.975IleLeu: 3.975 ± 0.037	0.859IleMet: 0.859 ± 0.014	1.585IleAsn: 1.585 ± 0.02	3.245IlePro: 3.245 ± 0.031	1.593IleGln: 1.593 ± 0.021	2.581IleArg: 2.581 ± 0.028	3.848IleSer: 3.848 ± 0.032	2.674IleThr: 2.674 ± 0.027	2.929IleVal: 2.929 ± 0.029	0.634IleTrp: 0.634 ± 0.013	1.115IleTyr: 1.115 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.482LysAla: 4.482 ± 0.048	0.383LysCys: 0.383 ± 0.011	2.676LysAsp: 2.676 ± 0.032	3.582LysGlu: 3.582 ± 0.04	1.167LysPhe: 1.167 ± 0.02	3.728LysGly: 3.728 ± 0.037	0.999LysHis: 0.999 ± 0.016	2.087LysIle: 2.087 ± 0.023	3.535LysLys: 3.535 ± 0.052	3.715LysLeu: 3.715 ± 0.033	0.975LysMet: 0.975 ± 0.015	1.48LysAsn: 1.48 ± 0.021	2.686LysPro: 2.686 ± 0.036	1.64LysGln: 1.64 ± 0.023	3.54LysArg: 3.54 ± 0.035	3.475LysSer: 3.475 ± 0.038	2.62LysThr: 2.62 ± 0.03	2.855LysVal: 2.855 ± 0.03	0.65LysTrp: 0.65 ± 0.013	1.108LysTyr: 1.108 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.78LeuAla: 7.78 ± 0.052	0.915LeuCys: 0.915 ± 0.016	4.828LeuAsp: 4.828 ± 0.037	5.007LeuGlu: 5.007 ± 0.042	2.924LeuPhe: 2.924 ± 0.034	6.097LeuGly: 6.097 ± 0.045	2.065LeuHis: 2.065 ± 0.027	3.842LeuIle: 3.842 ± 0.037	3.9LeuLys: 3.9 ± 0.034	7.969LeuLeu: 7.969 ± 0.068	1.556LeuMet: 1.556 ± 0.022	2.968LeuAsn: 2.968 ± 0.028	6.335LeuPro: 6.335 ± 0.05	3.125LeuGln: 3.125 ± 0.033	5.217LeuArg: 5.217 ± 0.042	8.004LeuSer: 8.004 ± 0.048	4.87LeuThr: 4.87 ± 0.039	5.014LeuVal: 5.014 ± 0.041	0.984LeuTrp: 0.984 ± 0.016	1.996LeuTyr: 1.996 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.848MetAla: 1.848 ± 0.023	0.193MetCys: 0.193 ± 0.006	1.194MetAsp: 1.194 ± 0.02	1.14MetGlu: 1.14 ± 0.016	0.646MetPhe: 0.646 ± 0.015	1.591MetGly: 1.591 ± 0.025	0.367MetHis: 0.367 ± 0.01	0.966MetIle: 0.966 ± 0.017	0.878MetLys: 0.878 ± 0.015	1.598MetLeu: 1.598 ± 0.021	0.556MetMet: 0.556 ± 0.011	0.703MetAsn: 0.703 ± 0.013	1.304MetPro: 1.304 ± 0.021	0.684MetGln: 0.684 ± 0.016	1.216MetArg: 1.216 ± 0.019	2.151MetSer: 2.151 ± 0.022	1.317MetThr: 1.317 ± 0.016	1.147MetVal: 1.147 ± 0.016	0.231MetTrp: 0.231 ± 0.008	0.459MetTyr: 0.459 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.11AsnAla: 3.11 ± 0.027	0.279AsnCys: 0.279 ± 0.008	1.853AsnAsp: 1.853 ± 0.023	1.873AsnGlu: 1.873 ± 0.022	1.014AsnPhe: 1.014 ± 0.016	3.22AsnGly: 3.22 ± 0.034	0.772AsnHis: 0.772 ± 0.013	1.57AsnIle: 1.57 ± 0.022	1.46AsnLys: 1.46 ± 0.019	2.903AsnLeu: 2.903 ± 0.029	0.652AsnMet: 0.652 ± 0.012	1.305AsnAsn: 1.305 ± 0.022	2.391AsnPro: 2.391 ± 0.023	1.252AsnGln: 1.252 ± 0.019	1.768AsnArg: 1.768 ± 0.019	2.562AsnSer: 2.562 ± 0.028	1.963AsnThr: 1.963 ± 0.022	2.087AsnVal: 2.087 ± 0.023	0.415AsnTrp: 0.415 ± 0.009	0.803AsnTyr: 0.803 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.146ProAla: 6.146 ± 0.062	0.397ProCys: 0.397 ± 0.011	3.04ProAsp: 3.04 ± 0.029	3.536ProGlu: 3.536 ± 0.034	2.066ProPhe: 2.066 ± 0.023	4.102ProGly: 4.102 ± 0.043	1.599ProHis: 1.599 ± 0.019	2.943ProIle: 2.943 ± 0.034	2.601ProLys: 2.601 ± 0.03	5.434ProLeu: 5.434 ± 0.042	1.068ProMet: 1.068 ± 0.019	2.195ProAsn: 2.195 ± 0.023	6.916ProPro: 6.916 ± 0.098	2.481ProGln: 2.481 ± 0.036	3.479ProArg: 3.479 ± 0.035	8.633ProSer: 8.633 ± 0.069	4.964ProThr: 4.964 ± 0.048	3.747ProVal: 3.747 ± 0.039	0.624ProTrp: 0.624 ± 0.013	1.528ProTyr: 1.528 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.977GlnAla: 3.977 ± 0.046	0.349GlnCys: 0.349 ± 0.009	1.835GlnAsp: 1.835 ± 0.018	2.109GlnGlu: 2.109 ± 0.026	0.983GlnPhe: 0.983 ± 0.015	2.67GlnGly: 2.67 ± 0.031	1.019GlnHis: 1.019 ± 0.017	1.66GlnIle: 1.66 ± 0.021	1.566GlnLys: 1.566 ± 0.021	3.143GlnLeu: 3.143 ± 0.031	0.829GlnMet: 0.829 ± 0.016	1.305GlnAsn: 1.305 ± 0.018	2.827GlnPro: 2.827 ± 0.042	2.549GlnGln: 2.549 ± 0.091	2.398GlnArg: 2.398 ± 0.023	3.368GlnSer: 3.368 ± 0.036	2.289GlnThr: 2.289 ± 0.022	2.155GlnVal: 2.155 ± 0.025	0.478GlnTrp: 0.478 ± 0.011	0.985GlnTyr: 0.985 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.004ArgAla: 5.004 ± 0.041	0.545ArgCys: 0.545 ± 0.01	3.333ArgAsp: 3.333 ± 0.044	3.868ArgGlu: 3.868 ± 0.039	1.829ArgPhe: 1.829 ± 0.023	4.087ArgGly: 4.087 ± 0.04	1.452ArgHis: 1.452 ± 0.02	2.613ArgIle: 2.613 ± 0.025	3.283ArgLys: 3.283 ± 0.028	5.109ArgLeu: 5.109 ± 0.039	1.298ArgMet: 1.298 ± 0.018	1.892ArgAsn: 1.892 ± 0.021	3.869ArgPro: 3.869 ± 0.037	2.43ArgGln: 2.43 ± 0.023	5.145ArgArg: 5.145 ± 0.053	5.543ArgSer: 5.543 ± 0.048	3.262ArgThr: 3.262 ± 0.029	3.198ArgVal: 3.198 ± 0.029	0.858ArgTrp: 0.858 ± 0.016	1.534ArgTyr: 1.534 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	8.933SerAla: 8.933 ± 0.067	0.674SerCys: 0.674 ± 0.014	4.47SerAsp: 4.47 ± 0.038	4.321SerGlu: 4.321 ± 0.037	2.904SerPhe: 2.904 ± 0.03	6.967SerGly: 6.967 ± 0.054	2.242SerHis: 2.242 ± 0.027	4.015SerIle: 4.015 ± 0.033	3.785SerLys: 3.785 ± 0.037	7.595SerLeu: 7.595 ± 0.046	1.665SerMet: 1.665 ± 0.019	3.13SerAsn: 3.13 ± 0.027	7.044SerPro: 7.044 ± 0.068	3.433SerGln: 3.433 ± 0.035	5.433SerArg: 5.433 ± 0.045	13.192SerSer: 13.192 ± 0.127	7.309SerThr: 7.309 ± 0.062	4.832SerVal: 4.832 ± 0.035	0.978SerTrp: 0.978 ± 0.015	2.055SerTyr: 2.055 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.654ThrAla: 5.654 ± 0.046	0.584ThrCys: 0.584 ± 0.011	2.809ThrAsp: 2.809 ± 0.029	2.87ThrGlu: 2.87 ± 0.027	2.074ThrPhe: 2.074 ± 0.023	4.379ThrGly: 4.379 ± 0.043	1.394ThrHis: 1.394 ± 0.018	2.892ThrIle: 2.892 ± 0.028	2.396ThrLys: 2.396 ± 0.027	5.183ThrLeu: 5.183 ± 0.044	1.035ThrMet: 1.035 ± 0.017	1.916ThrAsn: 1.916 ± 0.021	5.278ThrPro: 5.278 ± 0.05	2.042ThrGln: 2.042 ± 0.024	3.074ThrArg: 3.074 ± 0.028	6.8ThrSer: 6.8 ± 0.061	4.409ThrThr: 4.409 ± 0.043	3.429ThrVal: 3.429 ± 0.033	0.72ThrTrp: 0.72 ± 0.014	1.525ThrTyr: 1.525 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.876ValAla: 4.876 ± 0.036	0.652ValCys: 0.652 ± 0.014	3.721ValAsp: 3.721 ± 0.031	3.962ValGlu: 3.962 ± 0.043	2.025ValPhe: 2.025 ± 0.024	4.35ValGly: 4.35 ± 0.036	1.348ValHis: 1.348 ± 0.016	2.89ValIle: 2.89 ± 0.029	3.006ValLys: 3.006 ± 0.033	5.161ValLeu: 5.161 ± 0.039	1.209ValMet: 1.209 ± 0.018	2.096ValAsn: 2.096 ± 0.024	3.875ValPro: 3.875 ± 0.033	2.268ValGln: 2.268 ± 0.022	3.331ValArg: 3.331 ± 0.026	4.665ValSer: 4.665 ± 0.036	3.278ValThr: 3.278 ± 0.028	4.015ValVal: 4.015 ± 0.032	0.847ValTrp: 0.847 ± 0.014	1.503ValTyr: 1.503 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.039TrpAla: 1.039 ± 0.017	0.166TrpCys: 0.166 ± 0.006	0.857TrpAsp: 0.857 ± 0.016	0.863TrpGlu: 0.863 ± 0.014	0.457TrpPhe: 0.457 ± 0.011	0.936TrpGly: 0.936 ± 0.017	0.282TrpHis: 0.282 ± 0.009	0.642TrpIle: 0.642 ± 0.012	0.719TrpLys: 0.719 ± 0.014	1.14TrpLeu: 1.14 ± 0.019	0.332TrpMet: 0.332 ± 0.01	0.514TrpAsn: 0.514 ± 0.012	0.515TrpPro: 0.515 ± 0.01	0.465TrpGln: 0.465 ± 0.011	0.884TrpArg: 0.884 ± 0.017	1.038TrpSer: 1.038 ± 0.014	0.842TrpThr: 0.842 ± 0.014	0.823TrpVal: 0.823 ± 0.015	0.294TrpTrp: 0.294 ± 0.008	0.355TrpTyr: 0.355 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.063TyrAla: 2.063 ± 0.026	0.307TyrCys: 0.307 ± 0.011	1.537TyrAsp: 1.537 ± 0.022	1.416TyrGlu: 1.416 ± 0.02	0.934TyrPhe: 0.934 ± 0.017	1.955TyrGly: 1.955 ± 0.028	0.708TyrHis: 0.708 ± 0.013	1.162TyrIle: 1.162 ± 0.019	0.994TyrLys: 0.994 ± 0.016	2.338TyrLeu: 2.338 ± 0.023	0.467TyrMet: 0.467 ± 0.011	0.908TyrAsn: 0.908 ± 0.016	1.493TyrPro: 1.493 ± 0.019	0.938TyrGln: 0.938 ± 0.014	1.378TyrArg: 1.378 ± 0.021	1.825TyrSer: 1.825 ± 0.023	1.524TyrThr: 1.524 ± 0.02	1.417TyrVal: 1.417 ± 0.016	0.344TyrTrp: 0.344 ± 0.01	0.716TyrTyr: 0.716 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7924 proteins (4255186 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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