Amino acid dipepetide frequency for Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.045AlaAla: 9.045 ± 0.065	1.182AlaCys: 1.182 ± 0.017	4.184AlaAsp: 4.184 ± 0.028	5.069AlaGlu: 5.069 ± 0.047	3.059AlaPhe: 3.059 ± 0.024	5.702AlaGly: 5.702 ± 0.04	2.126AlaHis: 2.126 ± 0.024	4.175AlaIle: 4.175 ± 0.033	4.29AlaLys: 4.29 ± 0.037	7.713AlaLeu: 7.713 ± 0.048	2.106AlaMet: 2.106 ± 0.021	3.204AlaAsn: 3.204 ± 0.026	5.365AlaPro: 5.365 ± 0.044	3.736AlaGln: 3.736 ± 0.031	5.323AlaArg: 5.323 ± 0.032	7.592AlaSer: 7.592 ± 0.048	5.571AlaThr: 5.571 ± 0.037	5.269AlaVal: 5.269 ± 0.041	1.205AlaTrp: 1.205 ± 0.014	2.203AlaTyr: 2.203 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.016	0.321CysCys: 0.321 ± 0.009	0.674CysAsp: 0.674 ± 0.013	0.632CysGlu: 0.632 ± 0.012	0.521CysPhe: 0.521 ± 0.012	1.014CysGly: 1.014 ± 0.016	0.389CysHis: 0.389 ± 0.01	0.739CysIle: 0.739 ± 0.012	0.556CysLys: 0.556 ± 0.011	1.254CysLeu: 1.254 ± 0.018	0.316CysMet: 0.316 ± 0.008	0.472CysAsn: 0.472 ± 0.011	0.757CysPro: 0.757 ± 0.013	0.484CysGln: 0.484 ± 0.009	0.855CysArg: 0.855 ± 0.015	1.02CysSer: 1.02 ± 0.017	0.877CysThr: 0.877 ± 0.013	0.828CysVal: 0.828 ± 0.013	0.212CysTrp: 0.212 ± 0.006	0.349CysTyr: 0.349 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.909AspAla: 4.909 ± 0.034	0.661AspCys: 0.661 ± 0.013	4.063AspAsp: 4.063 ± 0.04	4.241AspGlu: 4.241 ± 0.037	2.106AspPhe: 2.106 ± 0.023	3.822AspGly: 3.822 ± 0.03	1.284AspHis: 1.284 ± 0.016	2.75AspIle: 2.75 ± 0.023	2.348AspLys: 2.348 ± 0.023	4.581AspLeu: 4.581 ± 0.032	1.351AspMet: 1.351 ± 0.016	1.752AspAsn: 1.752 ± 0.02	3.085AspPro: 3.085 ± 0.026	1.814AspGln: 1.814 ± 0.019	2.996AspArg: 2.996 ± 0.029	3.931AspSer: 3.931 ± 0.027	2.939AspThr: 2.939 ± 0.024	3.543AspVal: 3.543 ± 0.027	0.873AspTrp: 0.873 ± 0.012	1.544AspTyr: 1.544 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.378GluAla: 5.378 ± 0.045	0.621GluCys: 0.621 ± 0.011	4.154GluAsp: 4.154 ± 0.041	5.392GluGlu: 5.392 ± 0.056	1.78GluPhe: 1.78 ± 0.021	3.763GluGly: 3.763 ± 0.032	1.439GluHis: 1.439 ± 0.017	2.768GluIle: 2.768 ± 0.025	3.571GluLys: 3.571 ± 0.037	4.821GluLeu: 4.821 ± 0.036	1.448GluMet: 1.448 ± 0.017	2.072GluAsn: 2.072 ± 0.018	2.732GluPro: 2.732 ± 0.047	2.612GluGln: 2.612 ± 0.027	4.005GluArg: 4.005 ± 0.034	4.05GluSer: 4.05 ± 0.032	3.283GluThr: 3.283 ± 0.029	3.389GluVal: 3.389 ± 0.027	0.837GluTrp: 0.837 ± 0.012	1.59GluTyr: 1.59 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.096PheAla: 3.096 ± 0.029	0.542PheCys: 0.542 ± 0.01	2.119PheAsp: 2.119 ± 0.021	2.025PheGlu: 2.025 ± 0.02	1.499PhePhe: 1.499 ± 0.022	2.679PheGly: 2.679 ± 0.024	0.906PheHis: 0.906 ± 0.014	1.651PheIle: 1.651 ± 0.021	1.482PheLys: 1.482 ± 0.016	3.223PheLeu: 3.223 ± 0.03	0.705PheMet: 0.705 ± 0.011	1.346PheAsn: 1.346 ± 0.016	1.943PhePro: 1.943 ± 0.021	1.33PheGln: 1.33 ± 0.016	1.845PheArg: 1.845 ± 0.021	2.872PheSer: 2.872 ± 0.025	2.152PheThr: 2.152 ± 0.019	2.217PheVal: 2.217 ± 0.023	0.6PheTrp: 0.6 ± 0.013	0.993PheTyr: 0.993 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.28GlyAla: 5.28 ± 0.033	0.914GlyCys: 0.914 ± 0.015	3.383GlyAsp: 3.383 ± 0.031	3.67GlyGlu: 3.67 ± 0.031	2.588GlyPhe: 2.588 ± 0.024	5.824GlyGly: 5.824 ± 0.063	1.697GlyHis: 1.697 ± 0.02	3.233GlyIle: 3.233 ± 0.028	3.45GlyLys: 3.45 ± 0.034	5.75GlyLeu: 5.75 ± 0.038	1.672GlyMet: 1.672 ± 0.02	2.438GlyAsn: 2.438 ± 0.027	3.338GlyPro: 3.338 ± 0.03	2.566GlyGln: 2.566 ± 0.027	4.271GlyArg: 4.271 ± 0.036	5.367GlySer: 5.367 ± 0.039	3.982GlyThr: 3.982 ± 0.034	4.19GlyVal: 4.19 ± 0.035	1.169GlyTrp: 1.169 ± 0.017	2.002GlyTyr: 2.002 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	2.219HisAla: 2.219 ± 0.025	0.411HisCys: 0.411 ± 0.009	1.412HisAsp: 1.412 ± 0.016	1.396HisGlu: 1.396 ± 0.016	0.955HisPhe: 0.955 ± 0.015	1.833HisGly: 1.833 ± 0.02	1.036HisHis: 1.036 ± 0.023	1.274HisIle: 1.274 ± 0.017	0.977HisLys: 0.977 ± 0.013	2.367HisLeu: 2.367 ± 0.023	0.552HisMet: 0.552 ± 0.011	0.959HisAsn: 0.959 ± 0.013	1.828HisPro: 1.828 ± 0.021	1.118HisGln: 1.118 ± 0.018	1.67HisArg: 1.67 ± 0.018	2.094HisSer: 2.094 ± 0.023	1.599HisThr: 1.599 ± 0.019	1.657HisVal: 1.657 ± 0.021	0.373HisTrp: 0.373 ± 0.008	0.728HisTyr: 0.728 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.254IleAla: 4.254 ± 0.034	0.757IleCys: 0.757 ± 0.014	2.68IleAsp: 2.68 ± 0.024	2.725IleGlu: 2.725 ± 0.025	1.816IlePhe: 1.816 ± 0.022	2.916IleGly: 2.916 ± 0.026	1.236IleHis: 1.236 ± 0.017	2.38IleIle: 2.38 ± 0.027	2.127IleLys: 2.127 ± 0.021	4.266IleLeu: 4.266 ± 0.035	1.025IleMet: 1.025 ± 0.015	1.705IleAsn: 1.705 ± 0.018	3.032IlePro: 3.032 ± 0.025	1.833IleGln: 1.833 ± 0.02	2.723IleArg: 2.723 ± 0.025	3.634IleSer: 3.634 ± 0.031	2.904IleThr: 2.904 ± 0.026	3.006IleVal: 3.006 ± 0.028	0.681IleTrp: 0.681 ± 0.012	1.324IleTyr: 1.324 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.32LysAla: 4.32 ± 0.033	0.523LysCys: 0.523 ± 0.01	2.711LysAsp: 2.711 ± 0.026	3.41LysGlu: 3.41 ± 0.031	1.359LysPhe: 1.359 ± 0.019	2.99LysGly: 2.99 ± 0.028	1.215LysHis: 1.215 ± 0.016	2.229LysIle: 2.229 ± 0.021	3.596LysLys: 3.596 ± 0.057	3.883LysLeu: 3.883 ± 0.03	1.088LysMet: 1.088 ± 0.015	1.701LysAsn: 1.701 ± 0.021	2.829LysPro: 2.829 ± 0.026	1.983LysGln: 1.983 ± 0.019	3.548LysArg: 3.548 ± 0.031	3.547LysSer: 3.547 ± 0.03	2.916LysThr: 2.916 ± 0.028	2.706LysVal: 2.706 ± 0.025	0.652LysTrp: 0.652 ± 0.011	1.278LysTyr: 1.278 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.748LeuAla: 7.748 ± 0.041	1.27LeuCys: 1.27 ± 0.017	4.877LeuAsp: 4.877 ± 0.033	5.149LeuGlu: 5.149 ± 0.04	3.169LeuPhe: 3.169 ± 0.031	5.597LeuGly: 5.597 ± 0.038	2.456LeuHis: 2.456 ± 0.022	3.692LeuIle: 3.692 ± 0.031	3.978LeuLys: 3.978 ± 0.03	8.077LeuLeu: 8.077 ± 0.057	1.692LeuMet: 1.692 ± 0.019	2.991LeuAsn: 2.991 ± 0.024	5.849LeuPro: 5.849 ± 0.04	3.877LeuGln: 3.877 ± 0.032	5.664LeuArg: 5.664 ± 0.04	7.182LeuSer: 7.182 ± 0.045	4.807LeuThr: 4.807 ± 0.032	5.15LeuVal: 5.15 ± 0.038	1.13LeuTrp: 1.13 ± 0.016	2.259LeuTyr: 2.259 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.286MetAla: 2.286 ± 0.02	0.289MetCys: 0.289 ± 0.008	1.272MetAsp: 1.272 ± 0.015	1.272MetGlu: 1.272 ± 0.015	0.731MetPhe: 0.731 ± 0.012	1.519MetGly: 1.519 ± 0.021	0.569MetHis: 0.569 ± 0.011	0.966MetIle: 0.966 ± 0.014	1.031MetLys: 1.031 ± 0.014	1.908MetLeu: 1.908 ± 0.02	0.609MetMet: 0.609 ± 0.013	0.824MetAsn: 0.824 ± 0.013	1.409MetPro: 1.409 ± 0.017	0.987MetGln: 0.987 ± 0.015	1.405MetArg: 1.405 ± 0.017	1.993MetSer: 1.993 ± 0.021	1.305MetThr: 1.305 ± 0.016	1.29MetVal: 1.29 ± 0.017	0.277MetTrp: 0.277 ± 0.008	0.591MetTyr: 0.591 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.177AsnAla: 3.177 ± 0.024	0.445AsnCys: 0.445 ± 0.009	1.887AsnAsp: 1.887 ± 0.023	1.961AsnGlu: 1.961 ± 0.019	1.319AsnPhe: 1.319 ± 0.017	2.872AsnGly: 2.872 ± 0.031	0.913AsnHis: 0.913 ± 0.014	1.952AsnIle: 1.952 ± 0.019	1.593AsnLys: 1.593 ± 0.018	3.136AsnLeu: 3.136 ± 0.027	0.911AsnMet: 0.911 ± 0.013	1.539AsnAsn: 1.539 ± 0.024	2.45AsnPro: 2.45 ± 0.022	1.327AsnGln: 1.327 ± 0.017	1.91AsnArg: 1.91 ± 0.019	2.773AsnSer: 2.773 ± 0.026	2.374AsnThr: 2.374 ± 0.025	2.257AsnVal: 2.257 ± 0.022	0.525AsnTrp: 0.525 ± 0.01	0.989AsnTyr: 0.989 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.73ProAla: 5.73 ± 0.044	0.675ProCys: 0.675 ± 0.013	3.035ProAsp: 3.035 ± 0.026	3.532ProGlu: 3.532 ± 0.043	2.088ProPhe: 2.088 ± 0.02	3.768ProGly: 3.768 ± 0.035	1.681ProHis: 1.681 ± 0.021	2.635ProIle: 2.635 ± 0.023	2.765ProLys: 2.765 ± 0.025	4.969ProLeu: 4.969 ± 0.032	1.214ProMet: 1.214 ± 0.016	2.319ProAsn: 2.319 ± 0.025	5.927ProPro: 5.927 ± 0.071	2.676ProGln: 2.676 ± 0.033	3.799ProArg: 3.799 ± 0.038	6.519ProSer: 6.519 ± 0.049	4.662ProThr: 4.662 ± 0.041	3.592ProVal: 3.592 ± 0.03	0.754ProTrp: 0.754 ± 0.013	1.563ProTyr: 1.563 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.633GlnAla: 3.633 ± 0.031	0.504GlnCys: 0.504 ± 0.011	2.183GlnAsp: 2.183 ± 0.026	2.378GlnGlu: 2.378 ± 0.028	1.233GlnPhe: 1.233 ± 0.015	2.457GlnGly: 2.457 ± 0.021	1.374GlnHis: 1.374 ± 0.023	1.879GlnIle: 1.879 ± 0.02	1.998GlnLys: 1.998 ± 0.021	3.444GlnLeu: 3.444 ± 0.027	0.899GlnMet: 0.899 ± 0.014	1.583GlnAsn: 1.583 ± 0.018	2.795GlnPro: 2.795 ± 0.032	2.924GlnGln: 2.924 ± 0.073	2.88GlnArg: 2.88 ± 0.029	3.399GlnSer: 3.399 ± 0.034	2.491GlnThr: 2.491 ± 0.021	2.149GlnVal: 2.149 ± 0.019	0.566GlnTrp: 0.566 ± 0.01	1.201GlnTyr: 1.201 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.98ArgAla: 4.98 ± 0.036	0.832ArgCys: 0.832 ± 0.013	3.239ArgAsp: 3.239 ± 0.03	3.828ArgGlu: 3.828 ± 0.035	2.117ArgPhe: 2.117 ± 0.021	3.857ArgGly: 3.857 ± 0.039	1.719ArgHis: 1.719 ± 0.021	2.998ArgIle: 2.998 ± 0.028	3.588ArgLys: 3.588 ± 0.026	5.549ArgLeu: 5.549 ± 0.036	1.45ArgMet: 1.45 ± 0.019	2.37ArgAsn: 2.37 ± 0.022	3.859ArgPro: 3.859 ± 0.034	2.762ArgGln: 2.762 ± 0.029	5.351ArgArg: 5.351 ± 0.052	4.996ArgSer: 4.996 ± 0.039	3.642ArgThr: 3.642 ± 0.03	3.345ArgVal: 3.345 ± 0.027	0.919ArgTrp: 0.919 ± 0.014	1.673ArgTyr: 1.673 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.863SerAla: 6.863 ± 0.044	0.998SerCys: 0.998 ± 0.015	3.984SerAsp: 3.984 ± 0.033	3.913SerGlu: 3.913 ± 0.029	2.88SerPhe: 2.88 ± 0.025	5.252SerGly: 5.252 ± 0.039	2.23SerHis: 2.23 ± 0.02	3.913SerIle: 3.913 ± 0.033	3.744SerLys: 3.744 ± 0.037	7.16SerLeu: 7.16 ± 0.039	1.798SerMet: 1.798 ± 0.019	3.067SerAsn: 3.067 ± 0.027	6.027SerPro: 6.027 ± 0.052	3.413SerGln: 3.413 ± 0.03	5.253SerArg: 5.253 ± 0.042	8.949SerSer: 8.949 ± 0.087	6.117SerThr: 6.117 ± 0.05	4.436SerVal: 4.436 ± 0.032	1.074SerTrp: 1.074 ± 0.017	2.017SerTyr: 2.017 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.596ThrAla: 5.596 ± 0.037	0.897ThrCys: 0.897 ± 0.014	2.797ThrAsp: 2.797 ± 0.024	3.019ThrGlu: 3.019 ± 0.026	2.194ThrPhe: 2.194 ± 0.022	4.066ThrGly: 4.066 ± 0.034	1.548ThrHis: 1.548 ± 0.018	3.084ThrIle: 3.084 ± 0.026	2.709ThrLys: 2.709 ± 0.026	5.425ThrLeu: 5.425 ± 0.04	1.322ThrMet: 1.322 ± 0.016	2.202ThrAsn: 2.202 ± 0.025	4.94ThrPro: 4.94 ± 0.043	2.333ThrGln: 2.333 ± 0.024	3.48ThrArg: 3.48 ± 0.025	5.77ThrSer: 5.77 ± 0.046	4.859ThrThr: 4.859 ± 0.044	3.739ThrVal: 3.739 ± 0.029	0.851ThrTrp: 0.851 ± 0.014	1.635ThrTyr: 1.635 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.258ValAla: 5.258 ± 0.038	0.862ValCys: 0.862 ± 0.015	3.492ValAsp: 3.492 ± 0.03	3.772ValGlu: 3.772 ± 0.029	2.214ValPhe: 2.214 ± 0.025	4.02ValGly: 4.02 ± 0.033	1.489ValHis: 1.489 ± 0.019	2.654ValIle: 2.654 ± 0.023	2.815ValLys: 2.815 ± 0.026	5.313ValLeu: 5.313 ± 0.034	1.334ValMet: 1.334 ± 0.016	2.049ValAsn: 2.049 ± 0.019	3.565ValPro: 3.565 ± 0.027	2.498ValGln: 2.498 ± 0.021	3.486ValArg: 3.486 ± 0.029	4.37ValSer: 4.37 ± 0.032	3.356ValThr: 3.356 ± 0.028	4.088ValVal: 4.088 ± 0.036	0.867ValTrp: 0.867 ± 0.012	1.656ValTyr: 1.656 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.09TrpAla: 1.09 ± 0.015	0.225TrpCys: 0.225 ± 0.008	0.852TrpAsp: 0.852 ± 0.014	0.814TrpGlu: 0.814 ± 0.012	0.49TrpPhe: 0.49 ± 0.01	0.896TrpGly: 0.896 ± 0.015	0.377TrpHis: 0.377 ± 0.01	0.731TrpIle: 0.731 ± 0.013	0.763TrpLys: 0.763 ± 0.012	1.303TrpLeu: 1.303 ± 0.016	0.377TrpMet: 0.377 ± 0.009	0.609TrpAsn: 0.609 ± 0.011	0.651TrpPro: 0.651 ± 0.012	0.61TrpGln: 0.61 ± 0.012	0.985TrpArg: 0.985 ± 0.015	1.055TrpSer: 1.055 ± 0.016	0.921TrpThr: 0.921 ± 0.014	0.82TrpVal: 0.82 ± 0.013	0.272TrpTrp: 0.272 ± 0.008	0.408TrpTyr: 0.408 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.176TyrAla: 2.176 ± 0.023	0.424TyrCys: 0.424 ± 0.01	1.594TyrAsp: 1.594 ± 0.019	1.506TyrGlu: 1.506 ± 0.02	1.104TyrPhe: 1.104 ± 0.017	1.935TyrGly: 1.935 ± 0.024	0.773TyrHis: 0.773 ± 0.013	1.321TyrIle: 1.321 ± 0.015	1.101TyrLys: 1.101 ± 0.014	2.471TyrLeu: 2.471 ± 0.024	0.664TyrMet: 0.664 ± 0.011	1.108TyrAsn: 1.108 ± 0.014	1.52TyrPro: 1.52 ± 0.018	1.089TyrGln: 1.089 ± 0.015	1.625TyrArg: 1.625 ± 0.016	1.974TyrSer: 1.974 ± 0.021	1.711TyrThr: 1.711 ± 0.021	1.488TyrVal: 1.488 ± 0.016	0.415TyrTrp: 0.415 ± 0.009	0.893TyrTyr: 0.893 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12608 proteins (5283209 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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