Amino acid dipepetide frequency for Tokyovirus A1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.509AlaAla: 3.509 ± 0.326
1.448AlaCys: 1.448 ± 0.139
2.283AlaAsp: 2.283 ± 0.132
4.307AlaGlu: 4.307 ± 0.211
3.221AlaPhe: 3.221 ± 0.182
2.432AlaGly: 2.432 ± 0.184
0.789AlaHis: 0.789 ± 0.093
2.627AlaIle: 2.627 ± 0.187
4.604AlaLys: 4.604 ± 0.272
5.486AlaLeu: 5.486 ± 0.247
1.439AlaMet: 1.439 ± 0.125
1.912AlaAsn: 1.912 ± 0.144
2.107AlaPro: 2.107 ± 0.143
1.754AlaGln: 1.754 ± 0.142
2.942AlaArg: 2.942 ± 0.197
4.65AlaSer: 4.65 ± 0.285
3.277AlaThr: 3.277 ± 0.279
3.239AlaVal: 3.239 ± 0.215
0.631AlaTrp: 0.631 ± 0.074
1.392AlaTyr: 1.392 ± 0.122
0.0AlaXaa: 0.0 ± 0.0
Cys
1.522CysAla: 1.522 ± 0.129
0.77CysCys: 0.77 ± 0.091
1.29CysAsp: 1.29 ± 0.099
2.024CysGlu: 2.024 ± 0.156
1.671CysPhe: 1.671 ± 0.139
2.191CysGly: 2.191 ± 0.168
0.455CysHis: 0.455 ± 0.052
0.975CysIle: 0.975 ± 0.099
1.847CysLys: 1.847 ± 0.171
2.246CysLeu: 2.246 ± 0.157
0.455CysMet: 0.455 ± 0.057
0.845CysAsn: 0.845 ± 0.089
1.374CysPro: 1.374 ± 0.138
0.668CysGln: 0.668 ± 0.073
1.281CysArg: 1.281 ± 0.122
2.478CysSer: 2.478 ± 0.215
0.9CysThr: 0.9 ± 0.094
1.587CysVal: 1.587 ± 0.106
0.362CysTrp: 0.362 ± 0.058
0.705CysTyr: 0.705 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
2.915AspAla: 2.915 ± 0.171
1.17AspCys: 1.17 ± 0.121
2.469AspAsp: 2.469 ± 0.173
4.335AspGlu: 4.335 ± 0.251
3.156AspPhe: 3.156 ± 0.177
3.871AspGly: 3.871 ± 0.203
0.473AspHis: 0.473 ± 0.06
3.685AspIle: 3.685 ± 0.213
3.444AspLys: 3.444 ± 0.215
3.369AspLeu: 3.369 ± 0.159
1.049AspMet: 1.049 ± 0.097
1.513AspAsn: 1.513 ± 0.115
1.717AspPro: 1.717 ± 0.145
0.9AspGln: 0.9 ± 0.085
2.228AspArg: 2.228 ± 0.136
3.128AspSer: 3.128 ± 0.194
2.07AspThr: 2.07 ± 0.116
3.759AspVal: 3.759 ± 0.202
0.733AspTrp: 0.733 ± 0.068
1.318AspTyr: 1.318 ± 0.124
0.0AspXaa: 0.0 ± 0.0
Glu
4.01GluAla: 4.01 ± 0.219
1.801GluCys: 1.801 ± 0.158
3.694GluAsp: 3.694 ± 0.19
9.728GluGlu: 9.728 ± 0.659
4.855GluPhe: 4.855 ± 0.234
4.91GluGly: 4.91 ± 0.21
1.782GluHis: 1.782 ± 0.134
4.39GluIle: 4.39 ± 0.194
10.08GluLys: 10.08 ± 0.389
6.757GluLeu: 6.757 ± 0.261
2.098GluMet: 2.098 ± 0.172
4.056GluAsn: 4.056 ± 0.196
1.903GluPro: 1.903 ± 0.144
3.379GluGln: 3.379 ± 0.191
6.08GluArg: 6.08 ± 0.29
4.001GluSer: 4.001 ± 0.237
5.829GluThr: 5.829 ± 0.222
4.26GluVal: 4.26 ± 0.221
1.077GluTrp: 1.077 ± 0.093
2.45GluTyr: 2.45 ± 0.162
0.0GluXaa: 0.0 ± 0.0
Phe
3.592PheAla: 3.592 ± 0.184
2.348PheCys: 2.348 ± 0.184
2.97PheAsp: 2.97 ± 0.182
5.022PheGlu: 5.022 ± 0.256
3.119PhePhe: 3.119 ± 0.191
4.084PheGly: 4.084 ± 0.248
0.891PheHis: 0.891 ± 0.097
1.921PheIle: 1.921 ± 0.121
2.228PheLys: 2.228 ± 0.133
6.451PheLeu: 6.451 ± 0.302
1.049PheMet: 1.049 ± 0.107
0.956PheAsn: 0.956 ± 0.123
2.321PhePro: 2.321 ± 0.175
1.485PheGln: 1.485 ± 0.121
2.673PheArg: 2.673 ± 0.172
5.736PheSer: 5.736 ± 0.257
1.949PheThr: 1.949 ± 0.151
4.808PheVal: 4.808 ± 0.215
1.337PheTrp: 1.337 ± 0.139
1.68PheTyr: 1.68 ± 0.134
0.0PheXaa: 0.0 ± 0.0
Gly
3.239GlyAla: 3.239 ± 0.222
1.606GlyCys: 1.606 ± 0.164
2.72GlyAsp: 2.72 ± 0.156
5.486GlyGlu: 5.486 ± 0.283
2.775GlyPhe: 2.775 ± 0.171
3.36GlyGly: 3.36 ± 0.241
1.077GlyHis: 1.077 ± 0.103
3.666GlyIle: 3.666 ± 0.194
6.795GlyLys: 6.795 ± 0.307
4.214GlyLeu: 4.214 ± 0.213
1.355GlyMet: 1.355 ± 0.112
2.692GlyAsn: 2.692 ± 0.168
1.717GlyPro: 1.717 ± 0.148
1.819GlyGln: 1.819 ± 0.167
3.323GlyArg: 3.323 ± 0.173
4.455GlySer: 4.455 ± 0.285
3.834GlyThr: 3.834 ± 0.247
4.242GlyVal: 4.242 ± 0.219
0.984GlyTrp: 0.984 ± 0.102
2.172GlyTyr: 2.172 ± 0.155
0.0GlyXaa: 0.0 ± 0.0
His
0.882HisAla: 0.882 ± 0.096
0.511HisCys: 0.511 ± 0.076
0.492HisAsp: 0.492 ± 0.065
1.058HisGlu: 1.058 ± 0.104
0.956HisPhe: 0.956 ± 0.095
1.597HisGly: 1.597 ± 0.159
0.39HisHis: 0.39 ± 0.058
1.29HisIle: 1.29 ± 0.123
1.838HisLys: 1.838 ± 0.166
1.634HisLeu: 1.634 ± 0.14
0.241HisMet: 0.241 ± 0.057
0.613HisAsn: 0.613 ± 0.078
0.863HisPro: 0.863 ± 0.092
0.687HisGln: 0.687 ± 0.076
0.854HisArg: 0.854 ± 0.087
1.364HisSer: 1.364 ± 0.122
0.622HisThr: 0.622 ± 0.08
1.142HisVal: 1.142 ± 0.101
0.26HisTrp: 0.26 ± 0.048
0.455HisTyr: 0.455 ± 0.065
0.0HisXaa: 0.0 ± 0.0
Ile
2.775IleAla: 2.775 ± 0.211
1.272IleCys: 1.272 ± 0.088
2.144IleAsp: 2.144 ± 0.147
2.924IleGlu: 2.924 ± 0.159
2.877IlePhe: 2.877 ± 0.146
2.655IleGly: 2.655 ± 0.181
0.928IleHis: 0.928 ± 0.086
2.2IleIle: 2.2 ± 0.148
3.007IleLys: 3.007 ± 0.187
5.161IleLeu: 5.161 ± 0.21
0.798IleMet: 0.798 ± 0.085
1.132IleAsn: 1.132 ± 0.112
2.887IlePro: 2.887 ± 0.214
1.847IleGln: 1.847 ± 0.139
2.432IleArg: 2.432 ± 0.155
4.892IleSer: 4.892 ± 0.199
1.968IleThr: 1.968 ± 0.151
3.462IleVal: 3.462 ± 0.206
0.78IleTrp: 0.78 ± 0.099
1.151IleTyr: 1.151 ± 0.096
0.0IleXaa: 0.0 ± 0.0
Lys
4.084LysAla: 4.084 ± 0.191
1.355LysCys: 1.355 ± 0.135
4.131LysAsp: 4.131 ± 0.209
8.521LysGlu: 8.521 ± 0.325
4.158LysPhe: 4.158 ± 0.208
5.152LysGly: 5.152 ± 0.244
1.894LysHis: 1.894 ± 0.144
4.437LysIle: 4.437 ± 0.235
10.953LysLys: 10.953 ± 0.589
6.72LysLeu: 6.72 ± 0.269
1.726LysMet: 1.726 ± 0.133
4.66LysAsn: 4.66 ± 0.271
2.348LysPro: 2.348 ± 0.218
2.877LysGln: 2.877 ± 0.185
5.968LysArg: 5.968 ± 0.258
4.353LysSer: 4.353 ± 0.238
5.059LysThr: 5.059 ± 0.218
4.493LysVal: 4.493 ± 0.215
0.947LysTrp: 0.947 ± 0.093
2.757LysTyr: 2.757 ± 0.167
0.0LysXaa: 0.0 ± 0.0
Leu
5.226LeuAla: 5.226 ± 0.22
2.97LeuCys: 2.97 ± 0.176
4.483LeuAsp: 4.483 ± 0.219
7.769LeuGlu: 7.769 ± 0.27
5.235LeuPhe: 5.235 ± 0.239
5.161LeuGly: 5.161 ± 0.246
1.522LeuHis: 1.522 ± 0.123
2.673LeuIle: 2.673 ± 0.168
5.523LeuLys: 5.523 ± 0.241
8.558LeuLeu: 8.558 ± 0.306
1.847LeuMet: 1.847 ± 0.141
2.664LeuAsn: 2.664 ± 0.144
4.298LeuPro: 4.298 ± 0.202
3.472LeuGln: 3.472 ± 0.28
4.799LeuArg: 4.799 ± 0.235
8.892LeuSer: 8.892 ± 0.371
3.434LeuThr: 3.434 ± 0.208
6.043LeuVal: 6.043 ± 0.283
1.764LeuTrp: 1.764 ± 0.131
2.358LeuTyr: 2.358 ± 0.135
0.0LeuXaa: 0.0 ± 0.0
Met
1.29MetAla: 1.29 ± 0.128
0.529MetCys: 0.529 ± 0.068
1.253MetAsp: 1.253 ± 0.122
2.07MetGlu: 2.07 ± 0.124
1.095MetPhe: 1.095 ± 0.101
1.262MetGly: 1.262 ± 0.118
0.306MetHis: 0.306 ± 0.048
0.455MetIle: 0.455 ± 0.067
1.606MetLys: 1.606 ± 0.114
1.392MetLeu: 1.392 ± 0.102
0.566MetMet: 0.566 ± 0.081
1.105MetAsn: 1.105 ± 0.112
0.631MetPro: 0.631 ± 0.078
0.854MetGln: 0.854 ± 0.096
1.086MetArg: 1.086 ± 0.106
2.2MetSer: 2.2 ± 0.124
1.327MetThr: 1.327 ± 0.101
1.114MetVal: 1.114 ± 0.117
0.232MetTrp: 0.232 ± 0.046
0.575MetTyr: 0.575 ± 0.067
0.0MetXaa: 0.0 ± 0.0
Asn
2.209AsnAla: 2.209 ± 0.136
0.743AsnCys: 0.743 ± 0.083
1.392AsnAsp: 1.392 ± 0.111
2.358AsnGlu: 2.358 ± 0.144
2.515AsnPhe: 2.515 ± 0.155
3.007AsnGly: 3.007 ± 0.205
0.492AsnHis: 0.492 ± 0.055
3.007AsnIle: 3.007 ± 0.21
3.026AsnLys: 3.026 ± 0.189
3.212AsnLeu: 3.212 ± 0.16
0.826AsnMet: 0.826 ± 0.089
1.476AsnAsn: 1.476 ± 0.125
2.088AsnPro: 2.088 ± 0.184
0.873AsnGln: 0.873 ± 0.087
1.652AsnArg: 1.652 ± 0.14
3.063AsnSer: 3.063 ± 0.206
2.228AsnThr: 2.228 ± 0.259
2.859AsnVal: 2.859 ± 0.165
0.511AsnTrp: 0.511 ± 0.073
1.235AsnTyr: 1.235 ± 0.111
0.0AsnXaa: 0.0 ± 0.0
Pro
1.541ProAla: 1.541 ± 0.133
0.808ProCys: 0.808 ± 0.086
2.024ProAsp: 2.024 ± 0.133
3.954ProGlu: 3.954 ± 0.184
2.191ProPhe: 2.191 ± 0.178
2.209ProGly: 2.209 ± 0.147
0.798ProHis: 0.798 ± 0.082
1.522ProIle: 1.522 ± 0.121
3.379ProLys: 3.379 ± 0.213
3.639ProLeu: 3.639 ± 0.205
0.64ProMet: 0.64 ± 0.068
1.717ProAsn: 1.717 ± 0.139
1.94ProPro: 1.94 ± 0.189
1.476ProGln: 1.476 ± 0.131
2.163ProArg: 2.163 ± 0.154
3.685ProSer: 3.685 ± 0.43
2.265ProThr: 2.265 ± 0.184
1.977ProVal: 1.977 ± 0.143
0.52ProTrp: 0.52 ± 0.082
1.216ProTyr: 1.216 ± 0.128
0.0ProXaa: 0.0 ± 0.0
Gln
1.661GlnAla: 1.661 ± 0.165
0.548GlnCys: 0.548 ± 0.083
1.402GlnAsp: 1.402 ± 0.114
3.342GlnGlu: 3.342 ± 0.195
1.002GlnPhe: 1.002 ± 0.086
1.764GlnGly: 1.764 ± 0.17
0.77GlnHis: 0.77 ± 0.08
1.504GlnIle: 1.504 ± 0.111
4.298GlnLys: 4.298 ± 0.228
2.061GlnLeu: 2.061 ± 0.132
1.012GlnMet: 1.012 ± 0.088
1.931GlnAsn: 1.931 ± 0.139
0.826GlnPro: 0.826 ± 0.104
1.624GlnGln: 1.624 ± 0.159
2.432GlnArg: 2.432 ± 0.163
1.661GlnSer: 1.661 ± 0.131
2.209GlnThr: 2.209 ± 0.177
2.061GlnVal: 2.061 ± 0.198
0.427GlnTrp: 0.427 ± 0.055
0.798GlnTyr: 0.798 ± 0.088
0.0GlnXaa: 0.0 ± 0.0
Arg
2.664ArgAla: 2.664 ± 0.171
1.095ArgCys: 1.095 ± 0.11
3.063ArgAsp: 3.063 ± 0.167
6.312ArgGlu: 6.312 ± 0.301
2.302ArgPhe: 2.302 ± 0.134
3.119ArgGly: 3.119 ± 0.178
1.123ArgHis: 1.123 ± 0.106
2.868ArgIle: 2.868 ± 0.173
5.746ArgLys: 5.746 ± 0.244
4.845ArgLeu: 4.845 ± 0.229
1.29ArgMet: 1.29 ± 0.098
2.618ArgAsn: 2.618 ± 0.181
1.624ArgPro: 1.624 ± 0.137
1.968ArgGln: 1.968 ± 0.149
2.896ArgArg: 2.896 ± 0.168
3.267ArgSer: 3.267 ± 0.19
2.757ArgThr: 2.757 ± 0.187
3.639ArgVal: 3.639 ± 0.223
0.724ArgTrp: 0.724 ± 0.085
1.754ArgTyr: 1.754 ± 0.114
0.0ArgXaa: 0.0 ± 0.0
Ser
4.26SerAla: 4.26 ± 0.257
2.172SerCys: 2.172 ± 0.147
3.601SerAsp: 3.601 ± 0.179
5.792SerGlu: 5.792 ± 0.304
5.449SerPhe: 5.449 ± 0.251
5.402SerGly: 5.402 ± 0.29
1.429SerHis: 1.429 ± 0.15
2.729SerIle: 2.729 ± 0.171
5.616SerLys: 5.616 ± 0.234
7.834SerLeu: 7.834 ± 0.301
1.309SerMet: 1.309 ± 0.111
2.859SerAsn: 2.859 ± 0.221
3.704SerPro: 3.704 ± 0.397
2.627SerGln: 2.627 ± 0.165
4.038SerArg: 4.038 ± 0.2
7.054SerSer: 7.054 ± 0.33
3.499SerThr: 3.499 ± 0.22
5.244SerVal: 5.244 ± 0.219
1.578SerTrp: 1.578 ± 0.118
2.024SerTyr: 2.024 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
2.692ThrAla: 2.692 ± 0.19
1.281ThrCys: 1.281 ± 0.117
2.014ThrAsp: 2.014 ± 0.142
3.648ThrGlu: 3.648 ± 0.163
3.054ThrPhe: 3.054 ± 0.179
3.045ThrGly: 3.045 ± 0.24
0.743ThrHis: 0.743 ± 0.07
2.488ThrIle: 2.488 ± 0.178
4.65ThrLys: 4.65 ± 0.246
4.585ThrLeu: 4.585 ± 0.27
1.179ThrMet: 1.179 ± 0.091
2.367ThrAsn: 2.367 ± 0.366
2.58ThrPro: 2.58 ± 0.22
1.866ThrGln: 1.866 ± 0.15
2.896ThrArg: 2.896 ± 0.179
3.704ThrSer: 3.704 ± 0.202
3.704ThrThr: 3.704 ± 0.299
2.868ThrVal: 2.868 ± 0.162
0.743ThrTrp: 0.743 ± 0.095
1.513ThrTyr: 1.513 ± 0.127
0.0ThrXaa: 0.0 ± 0.0
Val
3.601ValAla: 3.601 ± 0.228
1.847ValCys: 1.847 ± 0.15
3.342ValAsp: 3.342 ± 0.193
5.012ValGlu: 5.012 ± 0.255
4.121ValPhe: 4.121 ± 0.219
3.49ValGly: 3.49 ± 0.213
1.216ValHis: 1.216 ± 0.113
2.627ValIle: 2.627 ± 0.167
4.242ValLys: 4.242 ± 0.235
6.683ValLeu: 6.683 ± 0.256
1.17ValMet: 1.17 ± 0.115
1.847ValAsn: 1.847 ± 0.12
3.23ValPro: 3.23 ± 0.167
2.051ValGln: 2.051 ± 0.144
3.239ValArg: 3.239 ± 0.172
5.978ValSer: 5.978 ± 0.286
2.413ValThr: 2.413 ± 0.179
5.254ValVal: 5.254 ± 0.258
1.244ValTrp: 1.244 ± 0.106
2.088ValTyr: 2.088 ± 0.152
0.0ValXaa: 0.0 ± 0.0
Trp
0.65TrpAla: 0.65 ± 0.086
0.603TrpCys: 0.603 ± 0.103
0.752TrpAsp: 0.752 ± 0.094
1.16TrpGlu: 1.16 ± 0.115
1.327TrpPhe: 1.327 ± 0.127
0.64TrpGly: 0.64 ± 0.087
0.213TrpHis: 0.213 ± 0.049
0.724TrpIle: 0.724 ± 0.088
1.504TrpLys: 1.504 ± 0.117
1.597TrpLeu: 1.597 ± 0.133
0.362TrpMet: 0.362 ± 0.062
0.696TrpAsn: 0.696 ± 0.079
0.26TrpPro: 0.26 ± 0.051
0.288TrpGln: 0.288 ± 0.048
1.002TrpArg: 1.002 ± 0.109
1.411TrpSer: 1.411 ± 0.123
0.789TrpThr: 0.789 ± 0.084
0.752TrpVal: 0.752 ± 0.088
0.306TrpTrp: 0.306 ± 0.058
0.575TrpTyr: 0.575 ± 0.072
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.726TyrAla: 1.726 ± 0.129
0.77TyrCys: 0.77 ± 0.098
1.782TyrAsp: 1.782 ± 0.134
2.321TyrGlu: 2.321 ± 0.132
1.541TyrPhe: 1.541 ± 0.13
2.181TyrGly: 2.181 ± 0.137
0.455TyrHis: 0.455 ± 0.059
1.504TyrIle: 1.504 ± 0.126
2.209TyrLys: 2.209 ± 0.152
2.246TyrLeu: 2.246 ± 0.15
0.529TyrMet: 0.529 ± 0.068
1.114TyrAsn: 1.114 ± 0.109
1.244TyrPro: 1.244 ± 0.105
0.817TyrGln: 0.817 ± 0.098
1.689TyrArg: 1.689 ± 0.109
2.246TyrSer: 2.246 ± 0.148
1.485TyrThr: 1.485 ± 0.111
1.903TyrVal: 1.903 ± 0.123
0.455TyrTrp: 0.455 ± 0.064
0.631TyrTyr: 0.631 ± 0.082
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 470 proteins (107735 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski