Amino acid dipepetide frequency for Rhodotorula sp. CCFEE 5036

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.461AlaAla: 17.461 ± 0.115	1.022AlaCys: 1.022 ± 0.02	5.578AlaAsp: 5.578 ± 0.042	6.421AlaGlu: 6.421 ± 0.051	3.444AlaPhe: 3.444 ± 0.037	7.968AlaGly: 7.968 ± 0.053	2.309AlaHis: 2.309 ± 0.028	3.859AlaIle: 3.859 ± 0.036	4.378AlaLys: 4.378 ± 0.046	9.663AlaLeu: 9.663 ± 0.071	1.916AlaMet: 1.916 ± 0.02	2.985AlaAsn: 2.985 ± 0.028	7.849AlaPro: 7.849 ± 0.075	4.259AlaGln: 4.259 ± 0.041	7.008AlaArg: 7.008 ± 0.05	10.597AlaSer: 10.597 ± 0.081	7.182AlaThr: 7.182 ± 0.049	6.473AlaVal: 6.473 ± 0.047	1.182AlaTrp: 1.182 ± 0.02	2.281AlaTyr: 2.281 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.863CysAla: 0.863 ± 0.019	0.172CysCys: 0.172 ± 0.008	0.535CysAsp: 0.535 ± 0.012	0.484CysGlu: 0.484 ± 0.013	0.385CysPhe: 0.385 ± 0.012	0.777CysGly: 0.777 ± 0.019	0.212CysHis: 0.212 ± 0.008	0.442CysIle: 0.442 ± 0.012	0.369CysLys: 0.369 ± 0.01	0.971CysLeu: 0.971 ± 0.019	0.177CysMet: 0.177 ± 0.008	0.235CysAsn: 0.235 ± 0.009	0.553CysPro: 0.553 ± 0.015	0.304CysGln: 0.304 ± 0.01	0.597CysArg: 0.597 ± 0.014	0.723CysSer: 0.723 ± 0.017	0.541CysThr: 0.541 ± 0.014	0.606CysVal: 0.606 ± 0.014	0.146CysTrp: 0.146 ± 0.007	0.253CysTyr: 0.253 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.103AspAla: 6.103 ± 0.047	0.482AspCys: 0.482 ± 0.013	5.515AspAsp: 5.515 ± 0.072	5.381AspGlu: 5.381 ± 0.054	1.968AspPhe: 1.968 ± 0.026	4.249AspGly: 4.249 ± 0.036	1.171AspHis: 1.171 ± 0.019	1.831AspIle: 1.831 ± 0.025	2.154AspLys: 2.154 ± 0.029	5.437AspLeu: 5.437 ± 0.036	0.909AspMet: 0.909 ± 0.015	1.285AspAsn: 1.285 ± 0.019	3.78AspPro: 3.78 ± 0.035	1.808AspGln: 1.808 ± 0.022	3.371AspArg: 3.371 ± 0.04	4.241AspSer: 4.241 ± 0.038	2.251AspThr: 2.251 ± 0.025	3.521AspVal: 3.521 ± 0.035	0.831AspTrp: 0.831 ± 0.015	1.363AspTyr: 1.363 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.554GluAla: 6.554 ± 0.05	0.501GluCys: 0.501 ± 0.013	4.182GluAsp: 4.182 ± 0.039	6.274GluGlu: 6.274 ± 0.09	1.529GluPhe: 1.529 ± 0.022	4.182GluGly: 4.182 ± 0.042	1.406GluHis: 1.406 ± 0.021	2.408GluIle: 2.408 ± 0.027	2.919GluLys: 2.919 ± 0.037	5.434GluLeu: 5.434 ± 0.051	1.303GluMet: 1.303 ± 0.018	1.508GluAsn: 1.508 ± 0.021	3.031GluPro: 3.031 ± 0.034	2.853GluGln: 2.853 ± 0.033	4.806GluArg: 4.806 ± 0.044	3.819GluSer: 3.819 ± 0.033	3.421GluThr: 3.421 ± 0.033	3.599GluVal: 3.599 ± 0.038	0.881GluTrp: 0.881 ± 0.015	1.367GluTyr: 1.367 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.576PheAla: 3.576 ± 0.035	0.429PheCys: 0.429 ± 0.011	2.195PheAsp: 2.195 ± 0.026	1.939PheGlu: 1.939 ± 0.023	1.299PhePhe: 1.299 ± 0.023	2.66PheGly: 2.66 ± 0.036	0.699PheHis: 0.699 ± 0.013	1.159PheIle: 1.159 ± 0.021	1.135PheLys: 1.135 ± 0.019	3.031PheLeu: 3.031 ± 0.037	0.493PheMet: 0.493 ± 0.012	0.877PheAsn: 0.877 ± 0.015	1.741PhePro: 1.741 ± 0.024	0.997PheGln: 0.997 ± 0.018	1.837PheArg: 1.837 ± 0.024	2.635PheSer: 2.635 ± 0.031	1.63PheThr: 1.63 ± 0.023	2.295PheVal: 2.295 ± 0.031	0.428PheTrp: 0.428 ± 0.01	0.824PheTyr: 0.824 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	7.352GlyAla: 7.352 ± 0.061	0.641GlyCys: 0.641 ± 0.015	3.904GlyAsp: 3.904 ± 0.038	4.069GlyGlu: 4.069 ± 0.038	2.408GlyPhe: 2.408 ± 0.03	9.405GlyGly: 9.405 ± 0.113	1.581GlyHis: 1.581 ± 0.024	2.676GlyIle: 2.676 ± 0.036	3.436GlyLys: 3.436 ± 0.041	5.728GlyLeu: 5.728 ± 0.05	1.395GlyMet: 1.395 ± 0.02	1.916GlyAsn: 1.916 ± 0.025	3.863GlyPro: 3.863 ± 0.039	2.571GlyGln: 2.571 ± 0.03	4.492GlyArg: 4.492 ± 0.041	6.231GlySer: 6.231 ± 0.05	4.113GlyThr: 4.113 ± 0.036	4.221GlyVal: 4.221 ± 0.042	1.048GlyTrp: 1.048 ± 0.02	1.777GlyTyr: 1.777 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	2.43HisAla: 2.43 ± 0.03	0.219HisCys: 0.219 ± 0.008	1.331HisAsp: 1.331 ± 0.021	1.27HisGlu: 1.27 ± 0.019	0.839HisPhe: 0.839 ± 0.014	1.596HisGly: 1.596 ± 0.022	0.983HisHis: 0.983 ± 0.026	0.77HisIle: 0.77 ± 0.016	0.702HisLys: 0.702 ± 0.017	2.472HisLeu: 2.472 ± 0.031	0.314HisMet: 0.314 ± 0.01	0.556HisAsn: 0.556 ± 0.013	1.757HisPro: 1.757 ± 0.028	0.876HisGln: 0.876 ± 0.021	1.546HisArg: 1.546 ± 0.021	1.731HisSer: 1.731 ± 0.023	1.012HisThr: 1.012 ± 0.017	1.444HisVal: 1.444 ± 0.023	0.27HisTrp: 0.27 ± 0.008	0.591HisTyr: 0.591 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.922IleAla: 3.922 ± 0.04	0.471IleCys: 0.471 ± 0.012	2.333IleAsp: 2.333 ± 0.027	2.364IleGlu: 2.364 ± 0.027	1.261IlePhe: 1.261 ± 0.021	2.533IleGly: 2.533 ± 0.033	0.76IleHis: 0.76 ± 0.014	1.358IleIle: 1.358 ± 0.028	1.616IleLys: 1.616 ± 0.024	3.415IleLeu: 3.415 ± 0.042	0.619IleMet: 0.619 ± 0.015	1.065IleAsn: 1.065 ± 0.019	2.269IlePro: 2.269 ± 0.026	1.185IleGln: 1.185 ± 0.02	2.34IleArg: 2.34 ± 0.026	2.701IleSer: 2.701 ± 0.03	1.813IleThr: 1.813 ± 0.025	2.632IleVal: 2.632 ± 0.03	0.454IleTrp: 0.454 ± 0.012	0.863IleTyr: 0.863 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.356LysAla: 4.356 ± 0.047	0.331LysCys: 0.331 ± 0.008	2.129LysAsp: 2.129 ± 0.026	2.842LysGlu: 2.842 ± 0.037	1.019LysPhe: 1.019 ± 0.018	2.85LysGly: 2.85 ± 0.036	0.908LysHis: 0.908 ± 0.017	1.532LysIle: 1.532 ± 0.02	2.914LysLys: 2.914 ± 0.053	3.498LysLeu: 3.498 ± 0.038	0.774LysMet: 0.774 ± 0.014	1.095LysAsn: 1.095 ± 0.018	2.415LysPro: 2.415 ± 0.03	1.696LysGln: 1.696 ± 0.023	3.596LysArg: 3.596 ± 0.045	2.823LysSer: 2.823 ± 0.029	2.253LysThr: 2.253 ± 0.028	2.566LysVal: 2.566 ± 0.032	0.508LysTrp: 0.508 ± 0.012	0.915LysTyr: 0.915 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	10.588LeuAla: 10.588 ± 0.073	0.989LeuCys: 0.989 ± 0.019	5.58LeuAsp: 5.58 ± 0.05	5.792LeuGlu: 5.792 ± 0.051	3.012LeuPhe: 3.012 ± 0.034	5.856LeuGly: 5.856 ± 0.045	2.137LeuHis: 2.137 ± 0.027	3.011LeuIle: 3.011 ± 0.035	3.412LeuLys: 3.412 ± 0.035	8.656LeuLeu: 8.656 ± 0.073	1.345LeuMet: 1.345 ± 0.019	2.418LeuAsn: 2.418 ± 0.025	6.49LeuPro: 6.49 ± 0.048	3.415LeuGln: 3.415 ± 0.032	6.353LeuArg: 6.353 ± 0.051	7.509LeuSer: 7.509 ± 0.049	4.537LeuThr: 4.537 ± 0.037	6.285LeuVal: 6.285 ± 0.061	0.989LeuTrp: 0.989 ± 0.018	2.039LeuTyr: 2.039 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.846MetAla: 1.846 ± 0.022	0.167MetCys: 0.167 ± 0.006	0.899MetAsp: 0.899 ± 0.014	0.837MetGlu: 0.837 ± 0.015	0.479MetPhe: 0.479 ± 0.011	1.095MetGly: 1.095 ± 0.02	0.406MetHis: 0.406 ± 0.011	0.64MetIle: 0.64 ± 0.016	0.587MetLys: 0.587 ± 0.015	1.588MetLeu: 1.588 ± 0.022	0.403MetMet: 0.403 ± 0.011	0.47MetAsn: 0.47 ± 0.012	1.182MetPro: 1.182 ± 0.021	0.758MetGln: 0.758 ± 0.014	1.164MetArg: 1.164 ± 0.018	1.578MetSer: 1.578 ± 0.023	1.051MetThr: 1.051 ± 0.017	0.932MetVal: 0.932 ± 0.015	0.19MetTrp: 0.19 ± 0.008	0.406MetTyr: 0.406 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.991AsnAla: 2.991 ± 0.029	0.262AsnCys: 0.262 ± 0.01	1.482AsnAsp: 1.482 ± 0.018	1.549AsnGlu: 1.549 ± 0.021	0.866AsnPhe: 0.866 ± 0.017	2.614AsnGly: 2.614 ± 0.035	0.543AsnHis: 0.543 ± 0.013	0.988AsnIle: 0.988 ± 0.018	1.134AsnLys: 1.134 ± 0.019	2.567AsnLeu: 2.567 ± 0.029	0.441AsnMet: 0.441 ± 0.011	0.918AsnAsn: 0.918 ± 0.02	1.921AsnPro: 1.921 ± 0.022	0.849AsnGln: 0.849 ± 0.018	1.586AsnArg: 1.586 ± 0.019	2.021AsnSer: 2.021 ± 0.027	1.252AsnThr: 1.252 ± 0.019	1.724AsnVal: 1.724 ± 0.023	0.369AsnTrp: 0.369 ± 0.009	0.624AsnTyr: 0.624 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.441ProAla: 8.441 ± 0.072	0.398ProCys: 0.398 ± 0.013	3.246ProAsp: 3.246 ± 0.029	3.506ProGlu: 3.506 ± 0.039	2.106ProPhe: 2.106 ± 0.025	3.846ProGly: 3.846 ± 0.035	1.53ProHis: 1.53 ± 0.025	2.275ProIle: 2.275 ± 0.027	2.31ProLys: 2.31 ± 0.03	5.718ProLeu: 5.718 ± 0.043	0.905ProMet: 0.905 ± 0.018	1.888ProAsn: 1.888 ± 0.025	8.77ProPro: 8.77 ± 0.119	2.359ProGln: 2.359 ± 0.032	4.15ProArg: 4.15 ± 0.043	7.696ProSer: 7.696 ± 0.068	4.977ProThr: 4.977 ± 0.047	4.084ProVal: 4.084 ± 0.038	0.589ProTrp: 0.589 ± 0.014	1.44ProTyr: 1.44 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.091GlnAla: 4.091 ± 0.046	0.294GlnCys: 0.294 ± 0.009	1.896GlnAsp: 1.896 ± 0.024	2.147GlnGlu: 2.147 ± 0.027	0.988GlnPhe: 0.988 ± 0.017	2.224GlnGly: 2.224 ± 0.027	1.172GlnHis: 1.172 ± 0.022	1.434GlnIle: 1.434 ± 0.021	1.505GlnLys: 1.505 ± 0.025	3.617GlnLeu: 3.617 ± 0.033	0.673GlnMet: 0.673 ± 0.013	1.003GlnAsn: 1.003 ± 0.018	2.684GlnPro: 2.684 ± 0.039	3.602GlnGln: 3.602 ± 0.096	2.839GlnArg: 2.839 ± 0.035	2.664GlnSer: 2.664 ± 0.027	1.972GlnThr: 1.972 ± 0.023	2.219GlnVal: 2.219 ± 0.026	0.416GlnTrp: 0.416 ± 0.01	0.858GlnTyr: 0.858 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	6.673ArgAla: 6.673 ± 0.049	0.603ArgCys: 0.603 ± 0.015	3.691ArgAsp: 3.691 ± 0.032	4.211ArgGlu: 4.211 ± 0.044	2.14ArgPhe: 2.14 ± 0.025	4.142ArgGly: 4.142 ± 0.047	1.565ArgHis: 1.565 ± 0.022	2.672ArgIle: 2.672 ± 0.033	3.426ArgLys: 3.426 ± 0.037	6.272ArgLeu: 6.272 ± 0.043	1.177ArgMet: 1.177 ± 0.018	1.905ArgAsn: 1.905 ± 0.026	4.279ArgPro: 4.279 ± 0.045	2.784ArgGln: 2.784 ± 0.029	6.314ArgArg: 6.314 ± 0.067	5.561ArgSer: 5.561 ± 0.054	3.878ArgThr: 3.878 ± 0.034	3.73ArgVal: 3.73 ± 0.031	0.882ArgTrp: 0.882 ± 0.015	1.502ArgTyr: 1.502 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	9.772SerAla: 9.772 ± 0.065	0.67SerCys: 0.67 ± 0.017	4.38SerAsp: 4.38 ± 0.037	3.922SerGlu: 3.922 ± 0.039	2.734SerPhe: 2.734 ± 0.032	6.03SerGly: 6.03 ± 0.052	1.97SerHis: 1.97 ± 0.024	2.918SerIle: 2.918 ± 0.03	2.939SerLys: 2.939 ± 0.034	7.766SerLeu: 7.766 ± 0.053	1.353SerMet: 1.353 ± 0.019	2.318SerAsn: 2.318 ± 0.028	7.009SerPro: 7.009 ± 0.083	2.693SerGln: 2.693 ± 0.032	5.559SerArg: 5.559 ± 0.052	12.745SerSer: 12.745 ± 0.152	6.659SerThr: 6.659 ± 0.069	4.472SerVal: 4.472 ± 0.032	0.887SerTrp: 0.887 ± 0.015	1.719SerTyr: 1.719 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	7.027ThrAla: 7.027 ± 0.047	0.58ThrCys: 0.58 ± 0.016	2.688ThrAsp: 2.688 ± 0.03	2.763ThrGlu: 2.763 ± 0.029	1.985ThrPhe: 1.985 ± 0.022	4.18ThrGly: 4.18 ± 0.038	1.129ThrHis: 1.129 ± 0.02	2.237ThrIle: 2.237 ± 0.028	2.026ThrLys: 2.026 ± 0.024	5.418ThrLeu: 5.418 ± 0.042	0.869ThrMet: 0.869 ± 0.016	1.505ThrAsn: 1.505 ± 0.019	4.759ThrPro: 4.759 ± 0.041	1.693ThrGln: 1.693 ± 0.022	3.518ThrArg: 3.518 ± 0.039	6.114ThrSer: 6.114 ± 0.063	5.169ThrThr: 5.169 ± 0.069	3.485ThrVal: 3.485 ± 0.037	0.676ThrTrp: 0.676 ± 0.013	1.28ThrTyr: 1.28 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	6.497ValAla: 6.497 ± 0.051	0.676ValCys: 0.676 ± 0.015	3.847ValAsp: 3.847 ± 0.032	4.222ValGlu: 4.222 ± 0.047	2.108ValPhe: 2.108 ± 0.025	4.082ValGly: 4.082 ± 0.043	1.364ValHis: 1.364 ± 0.022	2.29ValIle: 2.29 ± 0.025	2.694ValLys: 2.694 ± 0.029	5.678ValLeu: 5.678 ± 0.046	0.994ValMet: 0.994 ± 0.017	1.624ValAsn: 1.624 ± 0.021	4.084ValPro: 4.084 ± 0.041	2.309ValGln: 2.309 ± 0.023	3.904ValArg: 3.904 ± 0.037	4.444ValSer: 4.444 ± 0.036	3.267ValThr: 3.267 ± 0.036	4.555ValVal: 4.555 ± 0.044	0.792ValTrp: 0.792 ± 0.019	1.416ValTyr: 1.416 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.04TrpAla: 1.04 ± 0.02	0.15TrpCys: 0.15 ± 0.007	0.773TrpAsp: 0.773 ± 0.017	0.691TrpGlu: 0.691 ± 0.014	0.429TrpPhe: 0.429 ± 0.012	0.683TrpGly: 0.683 ± 0.016	0.293TrpHis: 0.293 ± 0.01	0.61TrpIle: 0.61 ± 0.016	0.556TrpLys: 0.556 ± 0.014	1.163TrpLeu: 1.163 ± 0.019	0.253TrpMet: 0.253 ± 0.008	0.427TrpAsn: 0.427 ± 0.013	0.513TrpPro: 0.513 ± 0.014	0.494TrpGln: 0.494 ± 0.011	0.932TrpArg: 0.932 ± 0.018	0.978TrpSer: 0.978 ± 0.017	0.869TrpThr: 0.869 ± 0.017	0.686TrpVal: 0.686 ± 0.015	0.226TrpTrp: 0.226 ± 0.009	0.313TrpTyr: 0.313 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.251TyrAla: 2.251 ± 0.026	0.284TyrCys: 0.284 ± 0.01	1.467TyrAsp: 1.467 ± 0.019	1.295TyrGlu: 1.295 ± 0.02	0.88TyrPhe: 0.88 ± 0.016	1.852TyrGly: 1.852 ± 0.026	0.572TyrHis: 0.572 ± 0.012	0.864TyrIle: 0.864 ± 0.018	0.811TyrLys: 0.811 ± 0.016	2.323TyrLeu: 2.323 ± 0.032	0.362TyrMet: 0.362 ± 0.011	0.701TyrAsn: 0.701 ± 0.015	1.287TyrPro: 1.287 ± 0.021	0.794TyrGln: 0.794 ± 0.017	1.494TyrArg: 1.494 ± 0.023	1.706TyrSer: 1.706 ± 0.024	1.254TyrThr: 1.254 ± 0.019	1.318TyrVal: 1.318 ± 0.02	0.314TyrTrp: 0.314 ± 0.01	0.676TyrTyr: 0.676 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6416 proteins (3727238 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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