Amino acid dipepetide frequency for Heterobasidion irregulare (strain TC 32-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.572AlaAla: 9.572 ± 0.079	1.278AlaCys: 1.278 ± 0.02	4.419AlaAsp: 4.419 ± 0.038	4.882AlaGlu: 4.882 ± 0.046	3.366AlaPhe: 3.366 ± 0.03	5.861AlaGly: 5.861 ± 0.045	2.585AlaHis: 2.585 ± 0.028	4.057AlaIle: 4.057 ± 0.032	3.59AlaLys: 3.59 ± 0.034	9.253AlaLeu: 9.253 ± 0.052	1.969AlaMet: 1.969 ± 0.019	2.677AlaAsn: 2.677 ± 0.026	5.931AlaPro: 5.931 ± 0.053	3.47AlaGln: 3.47 ± 0.028	6.579AlaArg: 6.579 ± 0.054	8.252AlaSer: 8.252 ± 0.054	5.099AlaThr: 5.099 ± 0.033	5.617AlaVal: 5.617 ± 0.044	1.263AlaTrp: 1.263 ± 0.018	2.213AlaTyr: 2.213 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.017	0.272CysCys: 0.272 ± 0.008	0.631CysAsp: 0.631 ± 0.012	0.573CysGlu: 0.573 ± 0.012	0.508CysPhe: 0.508 ± 0.01	0.924CysGly: 0.924 ± 0.017	0.381CysHis: 0.381 ± 0.009	0.663CysIle: 0.663 ± 0.012	0.469CysLys: 0.469 ± 0.011	1.291CysLeu: 1.291 ± 0.018	0.292CysMet: 0.292 ± 0.008	0.357CysAsn: 0.357 ± 0.009	0.812CysPro: 0.812 ± 0.014	0.438CysGln: 0.438 ± 0.01	0.831CysArg: 0.831 ± 0.012	1.03CysSer: 1.03 ± 0.018	0.763CysThr: 0.763 ± 0.013	0.855CysVal: 0.855 ± 0.014	0.193CysTrp: 0.193 ± 0.006	0.321CysTyr: 0.321 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.374AspAla: 5.374 ± 0.035	0.572AspCys: 0.572 ± 0.013	4.174AspAsp: 4.174 ± 0.041	4.132AspGlu: 4.132 ± 0.035	1.979AspPhe: 1.979 ± 0.02	4.011AspGly: 4.011 ± 0.035	1.274AspHis: 1.274 ± 0.019	2.925AspIle: 2.925 ± 0.027	2.052AspLys: 2.052 ± 0.022	4.97AspLeu: 4.97 ± 0.037	1.195AspMet: 1.195 ± 0.017	1.586AspAsn: 1.586 ± 0.022	3.551AspPro: 3.551 ± 0.029	1.565AspGln: 1.565 ± 0.015	3.119AspArg: 3.119 ± 0.03	3.879AspSer: 3.879 ± 0.029	2.908AspThr: 2.908 ± 0.024	3.966AspVal: 3.966 ± 0.032	0.882AspTrp: 0.882 ± 0.014	1.391AspTyr: 1.391 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.959GluAla: 4.959 ± 0.042	0.593GluCys: 0.593 ± 0.01	3.871GluAsp: 3.871 ± 0.034	4.792GluGlu: 4.792 ± 0.054	1.756GluPhe: 1.756 ± 0.02	3.875GluGly: 3.875 ± 0.034	1.479GluHis: 1.479 ± 0.018	2.598GluIle: 2.598 ± 0.025	2.779GluLys: 2.779 ± 0.032	4.948GluLeu: 4.948 ± 0.042	1.284GluMet: 1.284 ± 0.016	1.741GluAsn: 1.741 ± 0.022	2.549GluPro: 2.549 ± 0.027	2.119GluGln: 2.119 ± 0.022	4.312GluArg: 4.312 ± 0.041	3.783GluSer: 3.783 ± 0.03	2.888GluThr: 2.888 ± 0.026	3.44GluVal: 3.44 ± 0.033	0.883GluTrp: 0.883 ± 0.012	1.447GluTyr: 1.447 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.195PheAla: 3.195 ± 0.026	0.547PheCys: 0.547 ± 0.01	2.27PheAsp: 2.27 ± 0.024	1.931PheGlu: 1.931 ± 0.024	1.608PhePhe: 1.608 ± 0.02	2.576PheGly: 2.576 ± 0.027	0.981PheHis: 0.981 ± 0.013	1.771PheIle: 1.771 ± 0.021	1.415PheLys: 1.415 ± 0.017	3.53PheLeu: 3.53 ± 0.03	0.742PheMet: 0.742 ± 0.011	1.258PheAsn: 1.258 ± 0.017	2.116PhePro: 2.116 ± 0.025	1.201PheGln: 1.201 ± 0.016	2.004PheArg: 2.004 ± 0.02	3.134PheSer: 3.134 ± 0.03	2.087PheThr: 2.087 ± 0.022	2.592PheVal: 2.592 ± 0.024	0.561PheTrp: 0.561 ± 0.011	1.02PheTyr: 1.02 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.829GlyAla: 5.829 ± 0.05	0.825GlyCys: 0.825 ± 0.014	3.463GlyAsp: 3.463 ± 0.026	3.52GlyGlu: 3.52 ± 0.031	2.511GlyPhe: 2.511 ± 0.025	5.661GlyGly: 5.661 ± 0.058	1.772GlyHis: 1.772 ± 0.024	3.144GlyIle: 3.144 ± 0.026	3.184GlyLys: 3.184 ± 0.03	5.646GlyLeu: 5.646 ± 0.041	1.493GlyMet: 1.493 ± 0.021	2.115GlyAsn: 2.115 ± 0.024	3.459GlyPro: 3.459 ± 0.032	2.297GlyGln: 2.297 ± 0.027	4.522GlyArg: 4.522 ± 0.039	5.422GlySer: 5.422 ± 0.042	3.982GlyThr: 3.982 ± 0.029	4.327GlyVal: 4.327 ± 0.036	1.118GlyTrp: 1.118 ± 0.017	1.732GlyTyr: 1.732 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.563HisAla: 2.563 ± 0.025	0.375HisCys: 0.375 ± 0.009	1.45HisAsp: 1.45 ± 0.017	1.317HisGlu: 1.317 ± 0.018	1.021HisPhe: 1.021 ± 0.016	1.727HisGly: 1.727 ± 0.024	0.936HisHis: 0.936 ± 0.02	1.376HisIle: 1.376 ± 0.016	0.877HisLys: 0.877 ± 0.013	2.607HisLeu: 2.607 ± 0.026	0.514HisMet: 0.514 ± 0.011	0.822HisAsn: 0.822 ± 0.012	2.273HisPro: 2.273 ± 0.025	0.933HisGln: 0.933 ± 0.016	1.932HisArg: 1.932 ± 0.022	2.292HisSer: 2.292 ± 0.024	1.625HisThr: 1.625 ± 0.021	1.714HisVal: 1.714 ± 0.017	0.356HisTrp: 0.356 ± 0.008	0.674HisTyr: 0.674 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.188IleAla: 4.188 ± 0.037	0.705IleCys: 0.705 ± 0.013	2.748IleAsp: 2.748 ± 0.025	2.589IleGlu: 2.589 ± 0.024	1.834IlePhe: 1.834 ± 0.022	2.874IleGly: 2.874 ± 0.027	1.284IleHis: 1.284 ± 0.015	2.356IleIle: 2.356 ± 0.028	1.883IleLys: 1.883 ± 0.021	4.511IleLeu: 4.511 ± 0.04	0.93IleMet: 0.93 ± 0.014	1.53IleAsn: 1.53 ± 0.019	3.182IlePro: 3.182 ± 0.026	1.728IleGln: 1.728 ± 0.02	2.876IleArg: 2.876 ± 0.026	3.856IleSer: 3.856 ± 0.031	2.646IleThr: 2.646 ± 0.025	3.363IleVal: 3.363 ± 0.031	0.698IleTrp: 0.698 ± 0.012	1.343IleTyr: 1.343 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.879LysAla: 3.879 ± 0.03	0.46LysCys: 0.46 ± 0.01	2.334LysAsp: 2.334 ± 0.021	2.782LysGlu: 2.782 ± 0.03	1.27LysPhe: 1.27 ± 0.017	2.763LysGly: 2.763 ± 0.026	1.075LysHis: 1.075 ± 0.014	1.931LysIle: 1.931 ± 0.02	2.554LysLys: 2.554 ± 0.034	3.584LysLeu: 3.584 ± 0.031	0.869LysMet: 0.869 ± 0.015	1.3LysAsn: 1.3 ± 0.017	2.272LysPro: 2.272 ± 0.026	1.485LysGln: 1.485 ± 0.02	3.23LysArg: 3.23 ± 0.028	2.884LysSer: 2.884 ± 0.029	2.357LysThr: 2.357 ± 0.021	2.494LysVal: 2.494 ± 0.024	0.601LysTrp: 0.601 ± 0.011	1.166LysTyr: 1.166 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.575LeuAla: 8.575 ± 0.053	1.279LeuCys: 1.279 ± 0.016	5.244LeuAsp: 5.244 ± 0.034	5.214LeuGlu: 5.214 ± 0.046	3.499LeuPhe: 3.499 ± 0.029	5.714LeuGly: 5.714 ± 0.038	2.566LeuHis: 2.566 ± 0.022	3.976LeuIle: 3.976 ± 0.034	3.791LeuLys: 3.791 ± 0.034	8.911LeuLeu: 8.911 ± 0.058	1.769LeuMet: 1.769 ± 0.019	2.947LeuAsn: 2.947 ± 0.029	6.439LeuPro: 6.439 ± 0.047	3.624LeuGln: 3.624 ± 0.038	6.237LeuArg: 6.237 ± 0.047	8.225LeuSer: 8.225 ± 0.047	5.086LeuThr: 5.086 ± 0.035	5.83LeuVal: 5.83 ± 0.04	1.208LeuTrp: 1.208 ± 0.02	2.33LeuTyr: 2.33 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.859MetAla: 1.859 ± 0.019	0.249MetCys: 0.249 ± 0.007	1.191MetAsp: 1.191 ± 0.015	1.15MetGlu: 1.15 ± 0.017	0.775MetPhe: 0.775 ± 0.013	1.335MetGly: 1.335 ± 0.021	0.577MetHis: 0.577 ± 0.011	0.934MetIle: 0.934 ± 0.016	0.878MetLys: 0.878 ± 0.014	1.903MetLeu: 1.903 ± 0.02	0.501MetMet: 0.501 ± 0.011	0.71MetAsn: 0.71 ± 0.012	1.345MetPro: 1.345 ± 0.015	0.792MetGln: 0.792 ± 0.013	1.42MetArg: 1.42 ± 0.019	1.981MetSer: 1.981 ± 0.024	1.223MetThr: 1.223 ± 0.017	1.158MetVal: 1.158 ± 0.016	0.284MetTrp: 0.284 ± 0.008	0.52MetTyr: 0.52 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.028AsnAla: 3.028 ± 0.03	0.377AsnCys: 0.377 ± 0.01	1.662AsnAsp: 1.662 ± 0.02	1.664AsnGlu: 1.664 ± 0.02	1.211AsnPhe: 1.211 ± 0.017	2.377AsnGly: 2.377 ± 0.027	0.769AsnHis: 0.769 ± 0.012	1.739AsnIle: 1.739 ± 0.021	1.235AsnLys: 1.235 ± 0.014	2.896AsnLeu: 2.896 ± 0.028	0.69AsnMet: 0.69 ± 0.013	1.208AsnAsn: 1.208 ± 0.019	2.167AsnPro: 2.167 ± 0.026	1.039AsnGln: 1.039 ± 0.015	1.706AsnArg: 1.706 ± 0.02	2.381AsnSer: 2.381 ± 0.024	1.948AsnThr: 1.948 ± 0.021	2.24AsnVal: 2.24 ± 0.023	0.436AsnTrp: 0.436 ± 0.01	0.825AsnTyr: 0.825 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.127ProAla: 6.127 ± 0.051	0.646ProCys: 0.646 ± 0.015	3.355ProAsp: 3.355 ± 0.027	3.318ProGlu: 3.318 ± 0.028	2.313ProPhe: 2.313 ± 0.023	3.778ProGly: 3.778 ± 0.036	1.982ProHis: 1.982 ± 0.022	2.749ProIle: 2.749 ± 0.024	2.234ProLys: 2.234 ± 0.024	5.667ProLeu: 5.667 ± 0.037	1.147ProMet: 1.147 ± 0.016	2.015ProAsn: 2.015 ± 0.021	7.07ProPro: 7.07 ± 0.09	2.291ProGln: 2.291 ± 0.029	4.323ProArg: 4.323 ± 0.043	7.711ProSer: 7.711 ± 0.068	4.51ProThr: 4.51 ± 0.041	3.898ProVal: 3.898 ± 0.03	0.704ProTrp: 0.704 ± 0.014	1.601ProTyr: 1.601 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.255GlnAla: 3.255 ± 0.03	0.497GlnCys: 0.497 ± 0.01	1.862GlnAsp: 1.862 ± 0.022	1.936GlnGlu: 1.936 ± 0.023	1.205GlnPhe: 1.205 ± 0.018	2.267GlnGly: 2.267 ± 0.022	1.065GlnHis: 1.065 ± 0.019	1.697GlnIle: 1.697 ± 0.018	1.55GlnLys: 1.55 ± 0.018	3.199GlnLeu: 3.199 ± 0.03	0.808GlnMet: 0.808 ± 0.012	1.188GlnAsn: 1.188 ± 0.017	2.41GlnPro: 2.41 ± 0.028	1.962GlnGln: 1.962 ± 0.046	2.612GlnArg: 2.612 ± 0.029	2.884GlnSer: 2.884 ± 0.028	2.171GlnThr: 2.171 ± 0.022	2.039GlnVal: 2.039 ± 0.022	0.525GlnTrp: 0.525 ± 0.012	1.009GlnTyr: 1.009 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	6.383ArgAla: 6.383 ± 0.052	0.891ArgCys: 0.891 ± 0.016	3.376ArgAsp: 3.376 ± 0.033	3.991ArgGlu: 3.991 ± 0.039	2.293ArgPhe: 2.293 ± 0.025	4.257ArgGly: 4.257 ± 0.038	1.827ArgHis: 1.827 ± 0.021	3.077ArgIle: 3.077 ± 0.026	3.112ArgLys: 3.112 ± 0.027	5.968ArgLeu: 5.968 ± 0.042	1.46ArgMet: 1.46 ± 0.016	2.078ArgAsn: 2.078 ± 0.025	4.314ArgPro: 4.314 ± 0.039	2.361ArgGln: 2.361 ± 0.021	6.009ArgArg: 6.009 ± 0.051	5.513ArgSer: 5.513 ± 0.04	4.004ArgThr: 4.004 ± 0.036	4.044ArgVal: 4.044 ± 0.032	1.041ArgTrp: 1.041 ± 0.016	1.659ArgTyr: 1.659 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.894SerAla: 7.894 ± 0.049	0.985SerCys: 0.985 ± 0.016	4.246SerAsp: 4.246 ± 0.032	3.814SerGlu: 3.814 ± 0.028	3.086SerPhe: 3.086 ± 0.028	5.498SerGly: 5.498 ± 0.044	2.278SerHis: 2.278 ± 0.024	4.028SerIle: 4.028 ± 0.036	3.17SerLys: 3.17 ± 0.029	7.936SerLeu: 7.936 ± 0.053	1.77SerMet: 1.77 ± 0.018	2.672SerAsn: 2.672 ± 0.025	6.57SerPro: 6.57 ± 0.065	3.092SerGln: 3.092 ± 0.034	5.511SerArg: 5.511 ± 0.042	9.968SerSer: 9.968 ± 0.082	5.952SerThr: 5.952 ± 0.045	5.187SerVal: 5.187 ± 0.04	1.06SerTrp: 1.06 ± 0.015	1.94SerTyr: 1.94 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.242ThrAla: 5.242 ± 0.036	0.737ThrCys: 0.737 ± 0.011	2.879ThrAsp: 2.879 ± 0.024	2.628ThrGlu: 2.628 ± 0.024	2.285ThrPhe: 2.285 ± 0.023	3.764ThrGly: 3.764 ± 0.031	1.669ThrHis: 1.669 ± 0.019	3.024ThrIle: 3.024 ± 0.03	2.149ThrLys: 2.149 ± 0.026	5.748ThrLeu: 5.748 ± 0.038	1.161ThrMet: 1.161 ± 0.015	1.891ThrAsn: 1.891 ± 0.02	4.639ThrPro: 4.639 ± 0.043	1.926ThrGln: 1.926 ± 0.021	3.647ThrArg: 3.647 ± 0.03	5.572ThrSer: 5.572 ± 0.041	3.981ThrThr: 3.981 ± 0.037	3.766ThrVal: 3.766 ± 0.027	0.816ThrTrp: 0.816 ± 0.012	1.549ThrTyr: 1.549 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.52ValAla: 5.52 ± 0.041	0.851ValCys: 0.851 ± 0.015	3.847ValAsp: 3.847 ± 0.029	3.719ValGlu: 3.719 ± 0.033	2.438ValPhe: 2.438 ± 0.024	4.097ValGly: 4.097 ± 0.034	1.759ValHis: 1.759 ± 0.022	3.006ValIle: 3.006 ± 0.03	2.702ValLys: 2.702 ± 0.03	6.18ValLeu: 6.18 ± 0.04	1.273ValMet: 1.273 ± 0.02	2.003ValAsn: 2.003 ± 0.023	4.177ValPro: 4.177 ± 0.034	2.426ValGln: 2.426 ± 0.021	4.123ValArg: 4.123 ± 0.032	4.929ValSer: 4.929 ± 0.035	3.366ValThr: 3.366 ± 0.029	4.638ValVal: 4.638 ± 0.036	0.957ValTrp: 0.957 ± 0.016	1.696ValTyr: 1.696 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.167TrpAla: 1.167 ± 0.019	0.206TrpCys: 0.206 ± 0.006	0.901TrpAsp: 0.901 ± 0.017	0.819TrpGlu: 0.819 ± 0.015	0.507TrpPhe: 0.507 ± 0.011	0.877TrpGly: 0.877 ± 0.014	0.374TrpHis: 0.374 ± 0.009	0.752TrpIle: 0.752 ± 0.012	0.697TrpLys: 0.697 ± 0.013	1.263TrpLeu: 1.263 ± 0.015	0.354TrpMet: 0.354 ± 0.008	0.584TrpAsn: 0.584 ± 0.01	0.644TrpPro: 0.644 ± 0.011	0.496TrpGln: 0.496 ± 0.01	1.063TrpArg: 1.063 ± 0.016	1.056TrpSer: 1.056 ± 0.015	0.904TrpThr: 0.904 ± 0.016	0.885TrpVal: 0.885 ± 0.014	0.275TrpTrp: 0.275 ± 0.008	0.414TrpTyr: 0.414 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.21TyrAla: 2.21 ± 0.02	0.37TyrCys: 0.37 ± 0.008	1.582TyrAsp: 1.582 ± 0.019	1.325TyrGlu: 1.325 ± 0.017	1.075TyrPhe: 1.075 ± 0.016	1.785TyrGly: 1.785 ± 0.024	0.748TyrHis: 0.748 ± 0.013	1.32TyrIle: 1.32 ± 0.017	0.97TyrLys: 0.97 ± 0.013	2.455TyrLeu: 2.455 ± 0.024	0.567TyrMet: 0.567 ± 0.01	0.917TyrAsn: 0.917 ± 0.013	1.52TyrPro: 1.52 ± 0.021	0.896TyrGln: 0.896 ± 0.017	1.602TyrArg: 1.602 ± 0.018	1.908TyrSer: 1.908 ± 0.021	1.574TyrThr: 1.574 ± 0.017	1.654TyrVal: 1.654 ± 0.017	0.375TyrTrp: 0.375 ± 0.009	0.785TyrTyr: 0.785 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13159 proteins (5008163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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