Amino acid dipepetide frequency for Nakamurella silvestris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.261AlaAla: 20.261 ± 0.187	0.867AlaCys: 0.867 ± 0.029	8.369AlaAsp: 8.369 ± 0.088	7.68AlaGlu: 7.68 ± 0.106	3.409AlaPhe: 3.409 ± 0.048	13.529AlaGly: 13.529 ± 0.136	2.146AlaHis: 2.146 ± 0.043	4.739AlaIle: 4.739 ± 0.064	3.034AlaLys: 3.034 ± 0.058	12.03AlaLeu: 12.03 ± 0.12	2.287AlaMet: 2.287 ± 0.043	2.512AlaAsn: 2.512 ± 0.055	6.478AlaPro: 6.478 ± 0.104	3.667AlaGln: 3.667 ± 0.06	7.48AlaArg: 7.48 ± 0.096	6.18AlaSer: 6.18 ± 0.071	7.981AlaThr: 7.981 ± 0.114	11.852AlaVal: 11.852 ± 0.099	1.557AlaTrp: 1.557 ± 0.032	2.213AlaTyr: 2.213 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	0.853CysAla: 0.853 ± 0.027	0.087CysCys: 0.087 ± 0.008	0.387CysAsp: 0.387 ± 0.016	0.292CysGlu: 0.292 ± 0.016	0.202CysPhe: 0.202 ± 0.012	0.877CysGly: 0.877 ± 0.024	0.148CysHis: 0.148 ± 0.009	0.223CysIle: 0.223 ± 0.012	0.094CysLys: 0.094 ± 0.007	0.631CysLeu: 0.631 ± 0.022	0.099CysMet: 0.099 ± 0.008	0.148CysAsn: 0.148 ± 0.011	0.403CysPro: 0.403 ± 0.02	0.181CysGln: 0.181 ± 0.013	0.467CysArg: 0.467 ± 0.017	0.47CysSer: 0.47 ± 0.019	0.547CysThr: 0.547 ± 0.024	0.561CysVal: 0.561 ± 0.022	0.192CysTrp: 0.192 ± 0.019	0.144CysTyr: 0.144 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.476AspAla: 6.476 ± 0.073	0.365AspCys: 0.365 ± 0.015	3.111AspAsp: 3.111 ± 0.051	3.316AspGlu: 3.316 ± 0.061	1.665AspPhe: 1.665 ± 0.034	6.022AspGly: 6.022 ± 0.079	1.391AspHis: 1.391 ± 0.031	2.346AspIle: 2.346 ± 0.037	1.215AspLys: 1.215 ± 0.033	7.056AspLeu: 7.056 ± 0.081	0.76AspMet: 0.76 ± 0.024	1.366AspAsn: 1.366 ± 0.055	4.765AspPro: 4.765 ± 0.065	1.892AspGln: 1.892 ± 0.039	4.504AspArg: 4.504 ± 0.067	2.915AspSer: 2.915 ± 0.046	3.443AspThr: 3.443 ± 0.045	4.592AspVal: 4.592 ± 0.053	0.878AspTrp: 0.878 ± 0.022	1.26AspTyr: 1.26 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	5.702GluAla: 5.702 ± 0.087	0.279GluCys: 0.279 ± 0.014	2.554GluAsp: 2.554 ± 0.048	2.556GluGlu: 2.556 ± 0.056	1.663GluPhe: 1.663 ± 0.033	3.435GluGly: 3.435 ± 0.06	1.275GluHis: 1.275 ± 0.032	2.868GluIle: 2.868 ± 0.046	1.428GluLys: 1.428 ± 0.04	5.89GluLeu: 5.89 ± 0.081	0.961GluMet: 0.961 ± 0.03	1.286GluAsn: 1.286 ± 0.032	2.822GluPro: 2.822 ± 0.049	2.061GluGln: 2.061 ± 0.048	3.563GluArg: 3.563 ± 0.06	2.809GluSer: 2.809 ± 0.046	2.603GluThr: 2.603 ± 0.045	4.528GluVal: 4.528 ± 0.067	0.708GluTrp: 0.708 ± 0.022	1.08GluTyr: 1.08 ± 0.026	0.001GluXaa: 0.001 ± 0.001
Phe	3.704PheAla: 3.704 ± 0.053	0.335PheCys: 0.335 ± 0.016	2.243PheAsp: 2.243 ± 0.041	1.375PheGlu: 1.375 ± 0.032	0.929PhePhe: 0.929 ± 0.028	3.167PheGly: 3.167 ± 0.042	0.602PheHis: 0.602 ± 0.021	1.018PheIle: 1.018 ± 0.03	0.648PheLys: 0.648 ± 0.024	2.733PheLeu: 2.733 ± 0.047	0.365PheMet: 0.365 ± 0.014	0.775PheAsn: 0.775 ± 0.023	1.416PhePro: 1.416 ± 0.032	0.81PheGln: 0.81 ± 0.024	1.786PheArg: 1.786 ± 0.033	1.853PheSer: 1.853 ± 0.039	2.286PheThr: 2.286 ± 0.045	2.398PheVal: 2.398 ± 0.038	0.423PheTrp: 0.423 ± 0.018	0.671PheTyr: 0.671 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.018GlyAla: 10.018 ± 0.098	0.734GlyCys: 0.734 ± 0.022	4.892GlyAsp: 4.892 ± 0.054	4.335GlyGlu: 4.335 ± 0.065	3.03GlyPhe: 3.03 ± 0.051	8.067GlyGly: 8.067 ± 0.105	1.931GlyHis: 1.931 ± 0.037	4.329GlyIle: 4.329 ± 0.056	2.591GlyLys: 2.591 ± 0.062	9.101GlyLeu: 9.101 ± 0.09	1.936GlyMet: 1.936 ± 0.036	2.424GlyAsn: 2.424 ± 0.056	4.825GlyPro: 4.825 ± 0.075	2.993GlyGln: 2.993 ± 0.053	6.578GlyArg: 6.578 ± 0.088	6.912GlySer: 6.912 ± 0.087	7.184GlyThr: 7.184 ± 0.108	7.631GlyVal: 7.631 ± 0.084	1.645GlyTrp: 1.645 ± 0.034	2.378GlyTyr: 2.378 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.931HisAla: 1.931 ± 0.043	0.149HisCys: 0.149 ± 0.01	1.039HisAsp: 1.039 ± 0.028	0.931HisGlu: 0.931 ± 0.023	0.589HisPhe: 0.589 ± 0.021	1.836HisGly: 1.836 ± 0.038	0.62HisHis: 0.62 ± 0.024	0.715HisIle: 0.715 ± 0.025	0.281HisLys: 0.281 ± 0.013	2.207HisLeu: 2.207 ± 0.048	0.3HisMet: 0.3 ± 0.016	0.409HisAsn: 0.409 ± 0.015	1.596HisPro: 1.596 ± 0.035	0.734HisGln: 0.734 ± 0.023	1.771HisArg: 1.771 ± 0.037	0.985HisSer: 0.985 ± 0.024	1.206HisThr: 1.206 ± 0.031	1.417HisVal: 1.417 ± 0.033	0.283HisTrp: 0.283 ± 0.013	0.422HisTyr: 0.422 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.968IleAla: 5.968 ± 0.066	0.344IleCys: 0.344 ± 0.014	3.032IleAsp: 3.032 ± 0.05	2.334IleGlu: 2.334 ± 0.044	1.105IlePhe: 1.105 ± 0.033	4.616IleGly: 4.616 ± 0.057	0.735IleHis: 0.735 ± 0.025	1.588IleIle: 1.588 ± 0.041	0.951IleLys: 0.951 ± 0.032	3.43IleLeu: 3.43 ± 0.058	0.548IleMet: 0.548 ± 0.02	1.225IleAsn: 1.225 ± 0.031	2.314IlePro: 2.314 ± 0.036	1.027IleGln: 1.027 ± 0.028	2.655IleArg: 2.655 ± 0.047	2.924IleSer: 2.924 ± 0.047	3.41IleThr: 3.41 ± 0.067	3.44IleVal: 3.44 ± 0.052	0.529IleTrp: 0.529 ± 0.018	0.816IleTyr: 0.816 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.111LysAla: 3.111 ± 0.065	0.108LysCys: 0.108 ± 0.007	1.368LysAsp: 1.368 ± 0.033	1.031LysGlu: 1.031 ± 0.033	0.659LysPhe: 0.659 ± 0.02	1.795LysGly: 1.795 ± 0.041	0.37LysHis: 0.37 ± 0.016	1.267LysIle: 1.267 ± 0.034	0.903LysLys: 0.903 ± 0.031	2.109LysLeu: 2.109 ± 0.045	0.431LysMet: 0.431 ± 0.018	0.729LysAsn: 0.729 ± 0.026	1.287LysPro: 1.287 ± 0.032	0.646LysGln: 0.646 ± 0.022	1.284LysArg: 1.284 ± 0.035	1.413LysSer: 1.413 ± 0.037	1.493LysThr: 1.493 ± 0.034	2.363LysVal: 2.363 ± 0.043	0.309LysTrp: 0.309 ± 0.014	0.59LysTyr: 0.59 ± 0.021	0.001LysXaa: 0.001 ± 0.001
Leu	13.8LeuAla: 13.8 ± 0.132	0.665LeuCys: 0.665 ± 0.019	6.144LeuAsp: 6.144 ± 0.069	4.121LeuGlu: 4.121 ± 0.069	2.614LeuPhe: 2.614 ± 0.044	8.845LeuGly: 8.845 ± 0.096	1.774LeuHis: 1.774 ± 0.039	4.351LeuIle: 4.351 ± 0.065	2.151LeuLys: 2.151 ± 0.044	9.636LeuLeu: 9.636 ± 0.119	1.549LeuMet: 1.549 ± 0.034	2.103LeuAsn: 2.103 ± 0.043	5.832LeuPro: 5.832 ± 0.064	2.535LeuGln: 2.535 ± 0.039	6.583LeuArg: 6.583 ± 0.085	5.849LeuSer: 5.849 ± 0.066	7.056LeuThr: 7.056 ± 0.071	8.77LeuVal: 8.77 ± 0.097	1.154LeuTrp: 1.154 ± 0.031	1.673LeuTyr: 1.673 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.174MetAla: 2.174 ± 0.04	0.135MetCys: 0.135 ± 0.01	0.857MetAsp: 0.857 ± 0.025	0.665MetGlu: 0.665 ± 0.023	0.531MetPhe: 0.531 ± 0.017	1.236MetGly: 1.236 ± 0.033	0.298MetHis: 0.298 ± 0.014	0.814MetIle: 0.814 ± 0.025	0.51MetLys: 0.51 ± 0.019	1.677MetLeu: 1.677 ± 0.034	0.34MetMet: 0.34 ± 0.015	0.497MetAsn: 0.497 ± 0.017	0.928MetPro: 0.928 ± 0.023	0.456MetGln: 0.456 ± 0.019	1.078MetArg: 1.078 ± 0.026	1.434MetSer: 1.434 ± 0.032	1.673MetThr: 1.673 ± 0.035	1.466MetVal: 1.466 ± 0.037	0.186MetTrp: 0.186 ± 0.01	0.29MetTyr: 0.29 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.497AsnAla: 2.497 ± 0.049	0.182AsnCys: 0.182 ± 0.01	1.266AsnAsp: 1.266 ± 0.032	1.007AsnGlu: 1.007 ± 0.027	0.717AsnPhe: 0.717 ± 0.023	2.573AsnGly: 2.573 ± 0.06	0.473AsnHis: 0.473 ± 0.023	1.002AsnIle: 1.002 ± 0.031	0.614AsnLys: 0.614 ± 0.023	2.269AsnLeu: 2.269 ± 0.048	0.352AsnMet: 0.352 ± 0.016	0.795AsnAsn: 0.795 ± 0.033	1.844AsnPro: 1.844 ± 0.04	0.702AsnGln: 0.702 ± 0.023	1.495AsnArg: 1.495 ± 0.033	1.476AsnSer: 1.476 ± 0.04	1.706AsnThr: 1.706 ± 0.054	1.673AsnVal: 1.673 ± 0.046	0.399AsnTrp: 0.399 ± 0.02	0.628AsnTyr: 0.628 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.651ProAla: 8.651 ± 0.103	0.284ProCys: 0.284 ± 0.014	3.961ProAsp: 3.961 ± 0.054	3.64ProGlu: 3.64 ± 0.058	1.603ProPhe: 1.603 ± 0.03	5.985ProGly: 5.985 ± 0.068	0.967ProHis: 0.967 ± 0.026	2.076ProIle: 2.076 ± 0.036	1.171ProLys: 1.171 ± 0.028	4.441ProLeu: 4.441 ± 0.064	0.945ProMet: 0.945 ± 0.022	1.211ProAsn: 1.211 ± 0.033	3.04ProPro: 3.04 ± 0.081	1.612ProGln: 1.612 ± 0.039	3.025ProArg: 3.025 ± 0.05	3.441ProSer: 3.441 ± 0.056	4.291ProThr: 4.291 ± 0.077	5.711ProVal: 5.711 ± 0.097	0.797ProTrp: 0.797 ± 0.022	1.016ProTyr: 1.016 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.03GlnAla: 4.03 ± 0.064	0.13GlnCys: 0.13 ± 0.01	1.417GlnAsp: 1.417 ± 0.033	1.342GlnGlu: 1.342 ± 0.031	0.953GlnPhe: 0.953 ± 0.032	2.251GlnGly: 2.251 ± 0.047	0.636GlnHis: 0.636 ± 0.024	1.701GlnIle: 1.701 ± 0.038	0.661GlnLys: 0.661 ± 0.024	3.064GlnLeu: 3.064 ± 0.046	0.581GlnMet: 0.581 ± 0.021	0.755GlnAsn: 0.755 ± 0.024	1.671GlnPro: 1.671 ± 0.038	1.319GlnGln: 1.319 ± 0.045	2.095GlnArg: 2.095 ± 0.039	1.411GlnSer: 1.411 ± 0.032	1.767GlnThr: 1.767 ± 0.04	3.029GlnVal: 3.029 ± 0.049	0.452GlnTrp: 0.452 ± 0.018	0.635GlnTyr: 0.635 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.369ArgAla: 7.369 ± 0.088	0.464ArgCys: 0.464 ± 0.02	3.247ArgAsp: 3.247 ± 0.052	3.291ArgGlu: 3.291 ± 0.059	2.081ArgPhe: 2.081 ± 0.043	4.684ArgGly: 4.684 ± 0.066	1.503ArgHis: 1.503 ± 0.034	3.368ArgIle: 3.368 ± 0.055	1.476ArgLys: 1.476 ± 0.037	6.537ArgLeu: 6.537 ± 0.086	1.542ArgMet: 1.542 ± 0.039	1.403ArgAsn: 1.403 ± 0.029	3.944ArgPro: 3.944 ± 0.068	2.394ArgGln: 2.394 ± 0.04	5.985ArgArg: 5.985 ± 0.093	4.385ArgSer: 4.385 ± 0.062	4.667ArgThr: 4.667 ± 0.061	5.064ArgVal: 5.064 ± 0.066	1.197ArgTrp: 1.197 ± 0.028	1.632ArgTyr: 1.632 ± 0.036	0.001ArgXaa: 0.001 ± 0.001
Ser	7.812SerAla: 7.812 ± 0.088	0.439SerCys: 0.439 ± 0.019	3.33SerAsp: 3.33 ± 0.046	2.636SerGlu: 2.636 ± 0.045	1.882SerPhe: 1.882 ± 0.04	6.743SerGly: 6.743 ± 0.071	1.071SerHis: 1.071 ± 0.028	2.428SerIle: 2.428 ± 0.043	1.306SerLys: 1.306 ± 0.035	5.239SerLeu: 5.239 ± 0.057	1.219SerMet: 1.219 ± 0.031	1.368SerAsn: 1.368 ± 0.036	3.313SerPro: 3.313 ± 0.045	1.565SerGln: 1.565 ± 0.034	3.786SerArg: 3.786 ± 0.05	4.034SerSer: 4.034 ± 0.073	4.668SerThr: 4.668 ± 0.079	5.281SerVal: 5.281 ± 0.067	1.021SerTrp: 1.021 ± 0.03	1.366SerTyr: 1.366 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	9.346ThrAla: 9.346 ± 0.115	0.499ThrCys: 0.499 ± 0.022	4.38ThrAsp: 4.38 ± 0.061	3.388ThrGlu: 3.388 ± 0.055	2.219ThrPhe: 2.219 ± 0.039	7.541ThrGly: 7.541 ± 0.114	1.169ThrHis: 1.169 ± 0.032	2.764ThrIle: 2.764 ± 0.055	1.462ThrLys: 1.462 ± 0.036	6.038ThrLeu: 6.038 ± 0.082	1.052ThrMet: 1.052 ± 0.025	1.573ThrAsn: 1.573 ± 0.048	4.365ThrPro: 4.365 ± 0.072	1.619ThrGln: 1.619 ± 0.037	3.716ThrArg: 3.716 ± 0.052	4.488ThrSer: 4.488 ± 0.078	5.392ThrThr: 5.392 ± 0.126	7.224ThrVal: 7.224 ± 0.139	0.975ThrTrp: 0.975 ± 0.03	1.475ThrTyr: 1.475 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	10.895ValAla: 10.895 ± 0.102	0.602ValCys: 0.602 ± 0.02	5.75ValAsp: 5.75 ± 0.066	4.526ValGlu: 4.526 ± 0.069	2.498ValPhe: 2.498 ± 0.045	7.34ValGly: 7.34 ± 0.079	1.66ValHis: 1.66 ± 0.034	4.036ValIle: 4.036 ± 0.057	1.986ValLys: 1.986 ± 0.044	9.254ValLeu: 9.254 ± 0.109	1.42ValMet: 1.42 ± 0.033	2.12ValAsn: 2.12 ± 0.044	5.146ValPro: 5.146 ± 0.066	2.253ValGln: 2.253 ± 0.035	5.57ValArg: 5.57 ± 0.078	5.245ValSer: 5.245 ± 0.075	6.81ValThr: 6.81 ± 0.131	8.601ValVal: 8.601 ± 0.099	1.012ValTrp: 1.012 ± 0.026	1.542ValTyr: 1.542 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.543TrpAla: 1.543 ± 0.031	0.122TrpCys: 0.122 ± 0.009	0.758TrpAsp: 0.758 ± 0.022	0.656TrpGlu: 0.656 ± 0.019	0.443TrpPhe: 0.443 ± 0.018	1.072TrpGly: 1.072 ± 0.033	0.303TrpHis: 0.303 ± 0.014	0.669TrpIle: 0.669 ± 0.025	0.368TrpLys: 0.368 ± 0.017	1.508TrpLeu: 1.508 ± 0.036	0.325TrpMet: 0.325 ± 0.012	0.424TrpAsn: 0.424 ± 0.018	0.729TrpPro: 0.729 ± 0.023	0.602TrpGln: 0.602 ± 0.02	1.021TrpArg: 1.021 ± 0.032	1.017TrpSer: 1.017 ± 0.024	1.022TrpThr: 1.022 ± 0.032	1.131TrpVal: 1.131 ± 0.027	0.302TrpTrp: 0.302 ± 0.014	0.309TrpTyr: 0.309 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.132TyrAla: 2.132 ± 0.039	0.22TyrCys: 0.22 ± 0.017	1.231TyrAsp: 1.231 ± 0.034	0.95TyrGlu: 0.95 ± 0.027	0.744TyrPhe: 0.744 ± 0.023	1.918TyrGly: 1.918 ± 0.044	0.347TyrHis: 0.347 ± 0.016	0.688TyrIle: 0.688 ± 0.021	0.418TyrLys: 0.418 ± 0.017	2.357TyrLeu: 2.357 ± 0.045	0.234TyrMet: 0.234 ± 0.012	0.551TyrAsn: 0.551 ± 0.022	1.149TyrPro: 1.149 ± 0.028	0.831TyrGln: 0.831 ± 0.025	1.79TyrArg: 1.79 ± 0.04	1.263TyrSer: 1.263 ± 0.031	1.476TyrThr: 1.476 ± 0.045	1.532TyrVal: 1.532 ± 0.033	0.307TyrTrp: 0.307 ± 0.015	0.51TyrTyr: 0.51 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4524 proteins (1536067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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