Amino acid dipepetide frequency for Brugia malayi (Filarial nematode worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.998AlaAla: 4.998 ± 0.059	1.137AlaCys: 1.137 ± 0.018	3.044AlaAsp: 3.044 ± 0.026	4.145AlaGlu: 4.145 ± 0.04	2.468AlaPhe: 2.468 ± 0.026	2.893AlaGly: 2.893 ± 0.038	1.361AlaHis: 1.361 ± 0.019	4.072AlaIle: 4.072 ± 0.036	3.58AlaLys: 3.58 ± 0.03	5.889AlaLeu: 5.889 ± 0.045	1.538AlaMet: 1.538 ± 0.019	2.946AlaAsn: 2.946 ± 0.027	2.28AlaPro: 2.28 ± 0.029	2.416AlaGln: 2.416 ± 0.029	2.991AlaArg: 2.991 ± 0.032	4.772AlaSer: 4.772 ± 0.038	3.663AlaThr: 3.663 ± 0.03	4.584AlaVal: 4.584 ± 0.045	0.535AlaTrp: 0.535 ± 0.012	1.775AlaTyr: 1.775 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.256CysAla: 1.256 ± 0.018	0.662CysCys: 0.662 ± 0.015	1.254CysAsp: 1.254 ± 0.026	1.305CysGlu: 1.305 ± 0.022	0.942CysPhe: 0.942 ± 0.016	1.355CysGly: 1.355 ± 0.022	0.567CysHis: 0.567 ± 0.014	1.439CysIle: 1.439 ± 0.025	1.294CysLys: 1.294 ± 0.028	1.912CysLeu: 1.912 ± 0.026	0.472CysMet: 0.472 ± 0.01	1.116CysAsn: 1.116 ± 0.023	1.07CysPro: 1.07 ± 0.026	0.818CysGln: 0.818 ± 0.017	1.296CysArg: 1.296 ± 0.021	1.981CysSer: 1.981 ± 0.03	1.153CysThr: 1.153 ± 0.018	1.205CysVal: 1.205 ± 0.021	0.247CysTrp: 0.247 ± 0.008	0.703CysTyr: 0.703 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.171AspAla: 3.171 ± 0.031	1.099AspCys: 1.099 ± 0.019	4.317AspAsp: 4.317 ± 0.06	4.789AspGlu: 4.789 ± 0.051	2.333AspPhe: 2.333 ± 0.024	3.415AspGly: 3.415 ± 0.041	1.135AspHis: 1.135 ± 0.018	3.615AspIle: 3.615 ± 0.036	2.946AspLys: 2.946 ± 0.036	4.723AspLeu: 4.723 ± 0.042	1.286AspMet: 1.286 ± 0.018	2.708AspAsn: 2.708 ± 0.036	1.966AspPro: 1.966 ± 0.025	1.806AspGln: 1.806 ± 0.023	2.816AspArg: 2.816 ± 0.036	4.161AspSer: 4.161 ± 0.037	2.515AspThr: 2.515 ± 0.023	3.351AspVal: 3.351 ± 0.031	0.65AspTrp: 0.65 ± 0.013	1.81AspTyr: 1.81 ± 0.026	0.001AspXaa: 0.001 ± 0.0
Glu	3.849GluAla: 3.849 ± 0.044	1.344GluCys: 1.344 ± 0.024	3.288GluAsp: 3.288 ± 0.034	5.713GluGlu: 5.713 ± 0.079	2.172GluPhe: 2.172 ± 0.028	2.722GluGly: 2.722 ± 0.03	1.516GluHis: 1.516 ± 0.022	4.479GluIle: 4.479 ± 0.053	5.599GluLys: 5.599 ± 0.086	6.01GluLeu: 6.01 ± 0.06	2.089GluMet: 2.089 ± 0.028	3.941GluAsn: 3.941 ± 0.046	2.126GluPro: 2.126 ± 0.031	3.292GluGln: 3.292 ± 0.038	4.239GluArg: 4.239 ± 0.051	4.579GluSer: 4.579 ± 0.048	3.57GluThr: 3.57 ± 0.047	3.567GluVal: 3.567 ± 0.045	0.759GluTrp: 0.759 ± 0.022	2.001GluTyr: 2.001 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	2.596PheAla: 2.596 ± 0.027	1.058PheCys: 1.058 ± 0.018	2.48PheAsp: 2.48 ± 0.029	2.455PheGlu: 2.455 ± 0.027	1.803PhePhe: 1.803 ± 0.026	2.633PheGly: 2.633 ± 0.028	1.049PheHis: 1.049 ± 0.02	2.825PheIle: 2.825 ± 0.029	1.883PheLys: 1.883 ± 0.023	3.832PheLeu: 3.832 ± 0.034	0.98PheMet: 0.98 ± 0.017	1.826PheAsn: 1.826 ± 0.021	1.708PhePro: 1.708 ± 0.025	1.459PheGln: 1.459 ± 0.018	2.097PheArg: 2.097 ± 0.024	3.274PheSer: 3.274 ± 0.03	2.32PheThr: 2.32 ± 0.027	2.585PheVal: 2.585 ± 0.027	0.498PheTrp: 0.498 ± 0.011	1.409PheTyr: 1.409 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	2.84GlyAla: 2.84 ± 0.038	1.088GlyCys: 1.088 ± 0.019	2.726GlyAsp: 2.726 ± 0.029	3.147GlyGlu: 3.147 ± 0.039	2.166GlyPhe: 2.166 ± 0.029	3.083GlyGly: 3.083 ± 0.051	1.232GlyHis: 1.232 ± 0.02	3.412GlyIle: 3.412 ± 0.036	3.163GlyLys: 3.163 ± 0.038	4.653GlyLeu: 4.653 ± 0.255	1.237GlyMet: 1.237 ± 0.019	2.697GlyAsn: 2.697 ± 0.033	1.911GlyPro: 1.911 ± 0.044	2.002GlyGln: 2.002 ± 0.023	3.097GlyArg: 3.097 ± 0.038	4.267GlySer: 4.267 ± 0.039	3.066GlyThr: 3.066 ± 0.032	2.82GlyVal: 2.82 ± 0.034	0.613GlyTrp: 0.613 ± 0.018	1.771GlyTyr: 1.771 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.336HisAla: 1.336 ± 0.018	0.669HisCys: 0.669 ± 0.014	1.108HisAsp: 1.108 ± 0.017	1.397HisGlu: 1.397 ± 0.023	1.216HisPhe: 1.216 ± 0.017	1.262HisGly: 1.262 ± 0.022	0.821HisHis: 0.821 ± 0.037	1.541HisIle: 1.541 ± 0.017	1.185HisLys: 1.185 ± 0.019	2.412HisLeu: 2.412 ± 0.026	0.714HisMet: 0.714 ± 0.021	1.036HisAsn: 1.036 ± 0.015	1.159HisPro: 1.159 ± 0.016	1.048HisGln: 1.048 ± 0.018	1.517HisArg: 1.517 ± 0.02	2.09HisSer: 2.09 ± 0.025	1.236HisThr: 1.236 ± 0.026	1.285HisVal: 1.285 ± 0.018	0.303HisTrp: 0.303 ± 0.008	0.922HisTyr: 0.922 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.359IleAla: 4.359 ± 0.034	1.728IleCys: 1.728 ± 0.027	3.813IleAsp: 3.813 ± 0.031	3.988IleGlu: 3.988 ± 0.05	2.76IlePhe: 2.76 ± 0.029	3.339IleGly: 3.339 ± 0.031	1.589IleHis: 1.589 ± 0.022	4.42IleIle: 4.42 ± 0.068	3.407IleLys: 3.407 ± 0.035	5.583IleLeu: 5.583 ± 0.049	1.428IleMet: 1.428 ± 0.019	3.245IleAsn: 3.245 ± 0.039	3.082IlePro: 3.082 ± 0.031	2.366IleGln: 2.366 ± 0.026	3.613IleArg: 3.613 ± 0.03	5.833IleSer: 5.833 ± 0.045	3.878IleThr: 3.878 ± 0.04	3.805IleVal: 3.805 ± 0.033	0.743IleTrp: 0.743 ± 0.014	2.04IleTyr: 2.04 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.383LysAla: 3.383 ± 0.032	1.398LysCys: 1.398 ± 0.025	3.042LysAsp: 3.042 ± 0.03	4.642LysGlu: 4.642 ± 0.059	2.207LysPhe: 2.207 ± 0.023	2.613LysGly: 2.613 ± 0.037	1.516LysHis: 1.516 ± 0.021	3.981LysIle: 3.981 ± 0.04	5.258LysLys: 5.258 ± 0.068	5.856LysLeu: 5.856 ± 0.066	1.821LysMet: 1.821 ± 0.023	3.402LysAsn: 3.402 ± 0.035	2.427LysPro: 2.427 ± 0.042	2.949LysGln: 2.949 ± 0.035	4.11LysArg: 4.11 ± 0.035	4.348LysSer: 4.348 ± 0.039	3.295LysThr: 3.295 ± 0.035	3.235LysVal: 3.235 ± 0.031	0.733LysTrp: 0.733 ± 0.014	2.037LysTyr: 2.037 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	5.599LeuAla: 5.599 ± 0.045	2.074LeuCys: 2.074 ± 0.029	4.619LeuAsp: 4.619 ± 0.04	5.719LeuGlu: 5.719 ± 0.069	3.859LeuPhe: 3.859 ± 0.036	4.197LeuGly: 4.197 ± 0.25	2.42LeuHis: 2.42 ± 0.026	5.765LeuIle: 5.765 ± 0.047	6.036LeuLys: 6.036 ± 0.048	9.666LeuLeu: 9.666 ± 0.077	2.256LeuMet: 2.256 ± 0.024	4.598LeuAsn: 4.598 ± 0.044	4.608LeuPro: 4.608 ± 0.048	4.321LeuGln: 4.321 ± 0.05	5.521LeuArg: 5.521 ± 0.045	7.841LeuSer: 7.841 ± 0.054	4.893LeuThr: 4.893 ± 0.035	4.657LeuVal: 4.657 ± 0.036	0.966LeuTrp: 0.966 ± 0.016	2.731LeuTyr: 2.731 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.524MetAla: 1.524 ± 0.018	0.45MetCys: 0.45 ± 0.01	1.439MetAsp: 1.439 ± 0.021	1.966MetGlu: 1.966 ± 0.026	0.922MetPhe: 0.922 ± 0.015	1.046MetGly: 1.046 ± 0.018	0.646MetHis: 0.646 ± 0.011	1.627MetIle: 1.627 ± 0.022	1.962MetLys: 1.962 ± 0.032	2.384MetLeu: 2.384 ± 0.026	0.78MetMet: 0.78 ± 0.019	1.4MetAsn: 1.4 ± 0.021	1.053MetPro: 1.053 ± 0.017	1.264MetGln: 1.264 ± 0.016	1.374MetArg: 1.374 ± 0.018	1.835MetSer: 1.835 ± 0.024	1.354MetThr: 1.354 ± 0.022	1.4MetVal: 1.4 ± 0.021	0.213MetTrp: 0.213 ± 0.007	0.647MetTyr: 0.647 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.295AsnAla: 3.295 ± 0.031	1.175AsnCys: 1.175 ± 0.019	3.512AsnAsp: 3.512 ± 0.058	3.97AsnGlu: 3.97 ± 0.048	2.211AsnPhe: 2.211 ± 0.028	3.193AsnGly: 3.193 ± 0.036	1.097AsnHis: 1.097 ± 0.017	3.47AsnIle: 3.47 ± 0.042	2.782AsnLys: 2.782 ± 0.03	4.36AsnLeu: 4.36 ± 0.041	1.226AsnMet: 1.226 ± 0.018	2.871AsnAsn: 2.871 ± 0.042	1.866AsnPro: 1.866 ± 0.02	1.821AsnGln: 1.821 ± 0.022	2.627AsnArg: 2.627 ± 0.025	4.184AsnSer: 4.184 ± 0.041	2.494AsnThr: 2.494 ± 0.026	3.238AsnVal: 3.238 ± 0.03	0.559AsnTrp: 0.559 ± 0.011	1.712AsnTyr: 1.712 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	2.333ProAla: 2.333 ± 0.031	0.748ProCys: 0.748 ± 0.017	2.13ProAsp: 2.13 ± 0.027	2.673ProGlu: 2.673 ± 0.031	1.816ProPhe: 1.816 ± 0.029	2.378ProGly: 2.378 ± 0.088	0.937ProHis: 0.937 ± 0.017	2.576ProIle: 2.576 ± 0.034	2.302ProLys: 2.302 ± 0.036	3.808ProLeu: 3.808 ± 0.038	0.919ProMet: 0.919 ± 0.014	2.005ProAsn: 2.005 ± 0.023	3.054ProPro: 3.054 ± 0.058	1.707ProGln: 1.707 ± 0.026	1.959ProArg: 1.959 ± 0.023	4.092ProSer: 4.092 ± 0.054	2.559ProThr: 2.559 ± 0.034	2.875ProVal: 2.875 ± 0.032	0.403ProTrp: 0.403 ± 0.01	1.473ProTyr: 1.473 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	2.156GlnAla: 2.156 ± 0.028	0.973GlnCys: 0.973 ± 0.021	1.442GlnAsp: 1.442 ± 0.02	2.415GlnGlu: 2.415 ± 0.027	1.755GlnPhe: 1.755 ± 0.019	1.464GlnGly: 1.464 ± 0.021	1.173GlnHis: 1.173 ± 0.018	2.791GlnIle: 2.791 ± 0.032	2.955GlnLys: 2.955 ± 0.037	4.533GlnLeu: 4.533 ± 0.055	1.328GlnMet: 1.328 ± 0.018	2.296GlnAsn: 2.296 ± 0.03	1.746GlnPro: 1.746 ± 0.03	3.756GlnGln: 3.756 ± 0.099	2.623GlnArg: 2.623 ± 0.025	3.117GlnSer: 3.117 ± 0.032	2.264GlnThr: 2.264 ± 0.029	1.932GlnVal: 1.932 ± 0.023	0.503GlnTrp: 0.503 ± 0.013	1.362GlnTyr: 1.362 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	2.92ArgAla: 2.92 ± 0.031	1.334ArgCys: 1.334 ± 0.023	2.677ArgAsp: 2.677 ± 0.029	3.542ArgGlu: 3.542 ± 0.041	2.297ArgPhe: 2.297 ± 0.026	2.539ArgGly: 2.539 ± 0.037	1.464ArgHis: 1.464 ± 0.022	3.824ArgIle: 3.824 ± 0.034	4.278ArgLys: 4.278 ± 0.034	5.269ArgLeu: 5.269 ± 0.046	1.449ArgMet: 1.449 ± 0.018	3.303ArgAsn: 3.303 ± 0.042	2.131ArgPro: 2.131 ± 0.025	2.532ArgGln: 2.532 ± 0.029	4.317ArgArg: 4.317 ± 0.05	4.555ArgSer: 4.555 ± 0.049	3.055ArgThr: 3.055 ± 0.03	2.737ArgVal: 2.737 ± 0.028	0.651ArgTrp: 0.651 ± 0.014	1.852ArgTyr: 1.852 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	5.135SerAla: 5.135 ± 0.041	1.727SerCys: 1.727 ± 0.029	4.737SerAsp: 4.737 ± 0.04	4.868SerGlu: 4.868 ± 0.054	3.352SerPhe: 3.352 ± 0.03	4.686SerGly: 4.686 ± 0.042	1.81SerHis: 1.81 ± 0.024	4.877SerIle: 4.877 ± 0.035	4.584SerLys: 4.584 ± 0.042	7.386SerLeu: 7.386 ± 0.052	1.915SerMet: 1.915 ± 0.025	4.33SerAsn: 4.33 ± 0.046	3.555SerPro: 3.555 ± 0.051	2.999SerGln: 2.999 ± 0.029	4.356SerArg: 4.356 ± 0.052	9.613SerSer: 9.613 ± 0.14	5.31SerThr: 5.31 ± 0.052	5.169SerVal: 5.169 ± 0.04	0.792SerTrp: 0.792 ± 0.016	2.269SerTyr: 2.269 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	3.961ThrAla: 3.961 ± 0.035	1.093ThrCys: 1.093 ± 0.019	3.068ThrAsp: 3.068 ± 0.035	3.481ThrGlu: 3.481 ± 0.044	2.329ThrPhe: 2.329 ± 0.023	3.012ThrGly: 3.012 ± 0.035	1.316ThrHis: 1.316 ± 0.025	3.674ThrIle: 3.674 ± 0.04	3.135ThrLys: 3.135 ± 0.031	4.827ThrLeu: 4.827 ± 0.032	1.263ThrMet: 1.263 ± 0.016	2.883ThrAsn: 2.883 ± 0.031	2.494ThrPro: 2.494 ± 0.03	1.889ThrGln: 1.889 ± 0.024	2.433ThrArg: 2.433 ± 0.025	5.157ThrSer: 5.157 ± 0.047	4.222ThrThr: 4.222 ± 0.063	4.087ThrVal: 4.087 ± 0.037	0.483ThrTrp: 0.483 ± 0.011	1.585ThrTyr: 1.585 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	3.983ValAla: 3.983 ± 0.032	1.233ValCys: 1.233 ± 0.02	3.45ValAsp: 3.45 ± 0.039	4.095ValGlu: 4.095 ± 0.05	2.213ValPhe: 2.213 ± 0.025	2.847ValGly: 2.847 ± 0.031	1.444ValHis: 1.444 ± 0.017	3.973ValIle: 3.973 ± 0.035	3.424ValLys: 3.424 ± 0.035	5.287ValLeu: 5.287 ± 0.044	1.467ValMet: 1.467 ± 0.02	2.823ValAsn: 2.823 ± 0.032	2.785ValPro: 2.785 ± 0.03	2.429ValGln: 2.429 ± 0.025	3.13ValArg: 3.13 ± 0.028	4.474ValSer: 4.474 ± 0.043	3.438ValThr: 3.438 ± 0.032	3.813ValVal: 3.813 ± 0.042	0.602ValTrp: 0.602 ± 0.012	1.718ValTyr: 1.718 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.536TrpAla: 0.536 ± 0.011	0.228TrpCys: 0.228 ± 0.007	0.572TrpAsp: 0.572 ± 0.012	0.585TrpGlu: 0.585 ± 0.012	0.48TrpPhe: 0.48 ± 0.01	0.378TrpGly: 0.378 ± 0.011	0.293TrpHis: 0.293 ± 0.009	0.769TrpIle: 0.769 ± 0.013	0.846TrpLys: 0.846 ± 0.015	1.137TrpLeu: 1.137 ± 0.021	0.329TrpMet: 0.329 ± 0.015	0.699TrpAsn: 0.699 ± 0.018	0.409TrpPro: 0.409 ± 0.01	0.437TrpGln: 0.437 ± 0.011	0.666TrpArg: 0.666 ± 0.013	0.867TrpSer: 0.867 ± 0.016	0.613TrpThr: 0.613 ± 0.012	0.457TrpVal: 0.457 ± 0.009	0.162TrpTrp: 0.162 ± 0.006	0.358TrpTyr: 0.358 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.855TyrAla: 1.855 ± 0.021	0.831TyrCys: 0.831 ± 0.017	1.895TyrAsp: 1.895 ± 0.029	1.958TyrGlu: 1.958 ± 0.023	1.469TyrPhe: 1.469 ± 0.022	1.931TyrGly: 1.931 ± 0.03	0.869TyrHis: 0.869 ± 0.014	1.888TyrIle: 1.888 ± 0.022	1.634TyrLys: 1.634 ± 0.021	2.819TyrLeu: 2.819 ± 0.029	0.789TyrMet: 0.789 ± 0.015	1.542TyrAsn: 1.542 ± 0.021	1.318TyrPro: 1.318 ± 0.021	1.274TyrGln: 1.274 ± 0.017	1.942TyrArg: 1.942 ± 0.026	2.431TyrSer: 2.431 ± 0.028	1.494TyrThr: 1.494 ± 0.019	1.827TyrVal: 1.827 ± 0.021	0.406TyrTrp: 0.406 ± 0.009	1.261TyrTyr: 1.261 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10206 proteins (4761086 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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