Amino acid dipepetide frequency for Anopheles darlingi (Mosquito)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.675AlaAla: 8.675 ± 0.1
1.162AlaCys: 1.162 ± 0.024
3.499AlaAsp: 3.499 ± 0.025
4.17AlaGlu: 4.17 ± 0.036
2.267AlaPhe: 2.267 ± 0.021
5.618AlaGly: 5.618 ± 0.051
1.623AlaHis: 1.623 ± 0.019
3.87AlaIle: 3.87 ± 0.026
3.775AlaLys: 3.775 ± 0.031
6.307AlaLeu: 6.307 ± 0.041
1.691AlaMet: 1.691 ± 0.019
3.212AlaAsn: 3.212 ± 0.027
3.795AlaPro: 3.795 ± 0.037
2.809AlaGln: 2.809 ± 0.027
3.558AlaArg: 3.558 ± 0.03
6.439AlaSer: 6.439 ± 0.043
5.493AlaThr: 5.493 ± 0.046
4.723AlaVal: 4.723 ± 0.032
0.575AlaTrp: 0.575 ± 0.01
1.763AlaTyr: 1.763 ± 0.02
0.0AlaXaa: 0.0 ± 0.0
Cys
1.157CysAla: 1.157 ± 0.021
0.484CysCys: 0.484 ± 0.011
1.099CysAsp: 1.099 ± 0.021
1.102CysGlu: 1.102 ± 0.019
0.702CysPhe: 0.702 ± 0.014
1.322CysGly: 1.322 ± 0.024
0.476CysHis: 0.476 ± 0.011
0.94CysIle: 0.94 ± 0.019
0.837CysLys: 0.837 ± 0.016
1.629CysLeu: 1.629 ± 0.021
0.369CysMet: 0.369 ± 0.01
0.791CysAsn: 0.791 ± 0.015
0.973CysPro: 0.973 ± 0.026
0.697CysGln: 0.697 ± 0.015
1.112CysArg: 1.112 ± 0.026
1.53CysSer: 1.53 ± 0.026
1.044CysThr: 1.044 ± 0.019
1.172CysVal: 1.172 ± 0.022
0.23CysTrp: 0.23 ± 0.007
0.591CysTyr: 0.591 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.511AspAla: 3.511 ± 0.025
1.017AspCys: 1.017 ± 0.02
4.32AspAsp: 4.32 ± 0.053
4.424AspGlu: 4.424 ± 0.042
1.95AspPhe: 1.95 ± 0.024
4.007AspGly: 4.007 ± 0.039
1.243AspHis: 1.243 ± 0.017
2.706AspIle: 2.706 ± 0.023
2.331AspLys: 2.331 ± 0.022
4.464AspLeu: 4.464 ± 0.032
1.124AspMet: 1.124 ± 0.013
2.068AspAsn: 2.068 ± 0.024
2.586AspPro: 2.586 ± 0.031
1.897AspGln: 1.897 ± 0.02
3.204AspArg: 3.204 ± 0.029
3.956AspSer: 3.956 ± 0.032
2.716AspThr: 2.716 ± 0.019
3.286AspVal: 3.286 ± 0.021
0.597AspTrp: 0.597 ± 0.011
1.685AspTyr: 1.685 ± 0.018
0.0AspXaa: 0.0 ± 0.0
Glu
4.259GluAla: 4.259 ± 0.039
1.178GluCys: 1.178 ± 0.028
3.695GluAsp: 3.695 ± 0.036
5.684GluGlu: 5.684 ± 0.064
1.98GluPhe: 1.98 ± 0.02
3.114GluGly: 3.114 ± 0.025
1.555GluHis: 1.555 ± 0.016
3.127GluIle: 3.127 ± 0.029
3.865GluLys: 3.865 ± 0.042
6.058GluLeu: 6.058 ± 0.043
1.577GluMet: 1.577 ± 0.018
2.666GluAsn: 2.666 ± 0.021
2.84GluPro: 2.84 ± 0.034
3.391GluGln: 3.391 ± 0.03
4.197GluArg: 4.197 ± 0.04
4.208GluSer: 4.208 ± 0.031
3.441GluThr: 3.441 ± 0.029
3.46GluVal: 3.46 ± 0.036
0.607GluTrp: 0.607 ± 0.011
1.838GluTyr: 1.838 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.275PheAla: 2.275 ± 0.022
0.721PheCys: 0.721 ± 0.012
2.034PheAsp: 2.034 ± 0.022
2.062PheGlu: 2.062 ± 0.022
1.381PhePhe: 1.381 ± 0.019
2.453PheGly: 2.453 ± 0.027
0.883PheHis: 0.883 ± 0.012
1.77PheIle: 1.77 ± 0.02
1.585PheLys: 1.585 ± 0.017
3.311PheLeu: 3.311 ± 0.03
0.757PheMet: 0.757 ± 0.01
1.543PheAsn: 1.543 ± 0.016
1.544PhePro: 1.544 ± 0.017
1.329PheGln: 1.329 ± 0.016
2.056PheArg: 2.056 ± 0.022
2.539PheSer: 2.539 ± 0.023
1.861PheThr: 1.861 ± 0.022
2.375PheVal: 2.375 ± 0.024
0.416PheTrp: 0.416 ± 0.01
1.23PheTyr: 1.23 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
5.198GlyAla: 5.198 ± 0.048
1.103GlyCys: 1.103 ± 0.021
3.291GlyAsp: 3.291 ± 0.03
3.394GlyGlu: 3.394 ± 0.033
2.196GlyPhe: 2.196 ± 0.022
8.487GlyGly: 8.487 ± 0.13
1.676GlyHis: 1.676 ± 0.023
3.023GlyIle: 3.023 ± 0.028
3.216GlyLys: 3.216 ± 0.028
4.881GlyLeu: 4.881 ± 0.035
1.488GlyMet: 1.488 ± 0.018
2.936GlyAsn: 2.936 ± 0.028
3.034GlyPro: 3.034 ± 0.047
2.463GlyGln: 2.463 ± 0.028
3.504GlyArg: 3.504 ± 0.029
6.652GlySer: 6.652 ± 0.065
4.512GlyThr: 4.512 ± 0.041
3.959GlyVal: 3.959 ± 0.03
0.684GlyTrp: 0.684 ± 0.013
2.04GlyTyr: 2.04 ± 0.025
0.0GlyXaa: 0.0 ± 0.0
His
1.496HisAla: 1.496 ± 0.018
0.558HisCys: 0.558 ± 0.011
1.207HisAsp: 1.207 ± 0.016
1.347HisGlu: 1.347 ± 0.014
0.947HisPhe: 0.947 ± 0.013
1.73HisGly: 1.73 ± 0.021
2.28HisHis: 2.28 ± 0.051
1.217HisIle: 1.217 ± 0.014
1.064HisLys: 1.064 ± 0.017
2.414HisLeu: 2.414 ± 0.023
0.566HisMet: 0.566 ± 0.012
1.08HisAsn: 1.08 ± 0.016
1.59HisPro: 1.59 ± 0.02
1.869HisGln: 1.869 ± 0.03
1.752HisArg: 1.752 ± 0.021
2.027HisSer: 2.027 ± 0.023
1.352HisThr: 1.352 ± 0.016
1.409HisVal: 1.409 ± 0.017
0.293HisTrp: 0.293 ± 0.007
0.903HisTyr: 0.903 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
3.769IleAla: 3.769 ± 0.028
1.04IleCys: 1.04 ± 0.016
3.009IleAsp: 3.009 ± 0.024
3.311IleGlu: 3.311 ± 0.033
1.765IlePhe: 1.765 ± 0.021
3.237IleGly: 3.237 ± 0.027
1.136IleHis: 1.136 ± 0.015
2.593IleIle: 2.593 ± 0.027
2.474IleLys: 2.474 ± 0.025
4.197IleLeu: 4.197 ± 0.036
1.048IleMet: 1.048 ± 0.014
2.231IleAsn: 2.231 ± 0.021
2.664IlePro: 2.664 ± 0.021
1.901IleGln: 1.901 ± 0.021
2.844IleArg: 2.844 ± 0.025
3.645IleSer: 3.645 ± 0.027
2.908IleThr: 2.908 ± 0.026
3.713IleVal: 3.713 ± 0.027
0.46IleTrp: 0.46 ± 0.009
1.436IleTyr: 1.436 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
3.378LysAla: 3.378 ± 0.026
0.959LysCys: 0.959 ± 0.018
2.642LysAsp: 2.642 ± 0.026
3.598LysGlu: 3.598 ± 0.032
1.65LysPhe: 1.65 ± 0.019
2.469LysGly: 2.469 ± 0.029
1.418LysHis: 1.418 ± 0.017
2.611LysIle: 2.611 ± 0.024
3.717LysLys: 3.717 ± 0.049
5.002LysLeu: 5.002 ± 0.036
1.302LysMet: 1.302 ± 0.017
2.093LysAsn: 2.093 ± 0.022
2.809LysPro: 2.809 ± 0.034
2.64LysGln: 2.64 ± 0.027
3.509LysArg: 3.509 ± 0.03
3.625LysSer: 3.625 ± 0.032
2.815LysThr: 2.815 ± 0.023
3.041LysVal: 3.041 ± 0.028
0.489LysTrp: 0.489 ± 0.01
1.603LysTyr: 1.603 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
6.714LeuAla: 6.714 ± 0.043
1.645LeuCys: 1.645 ± 0.022
4.68LeuAsp: 4.68 ± 0.031
5.795LeuGlu: 5.795 ± 0.046
3.126LeuPhe: 3.126 ± 0.031
4.78LeuGly: 4.78 ± 0.034
2.439LeuHis: 2.439 ± 0.024
4.108LeuIle: 4.108 ± 0.034
4.969LeuLys: 4.969 ± 0.037
9.314LeuLeu: 9.314 ± 0.071
2.018LeuMet: 2.018 ± 0.021
3.84LeuAsn: 3.84 ± 0.028
4.864LeuPro: 4.864 ± 0.032
4.639LeuGln: 4.639 ± 0.034
5.393LeuArg: 5.393 ± 0.04
6.57LeuSer: 6.57 ± 0.037
4.95LeuThr: 4.95 ± 0.031
5.49LeuVal: 5.49 ± 0.034
0.883LeuTrp: 0.883 ± 0.013
2.594LeuTyr: 2.594 ± 0.025
0.0LeuXaa: 0.0 ± 0.0
Met
1.981MetAla: 1.981 ± 0.017
0.372MetCys: 0.372 ± 0.008
1.249MetAsp: 1.249 ± 0.014
1.483MetGlu: 1.483 ± 0.017
0.83MetPhe: 0.83 ± 0.013
1.24MetGly: 1.24 ± 0.02
0.56MetHis: 0.56 ± 0.01
1.112MetIle: 1.112 ± 0.013
1.312MetLys: 1.312 ± 0.015
2.186MetLeu: 2.186 ± 0.021
0.766MetMet: 0.766 ± 0.012
0.986MetAsn: 0.986 ± 0.013
1.084MetPro: 1.084 ± 0.016
1.05MetGln: 1.05 ± 0.016
1.263MetArg: 1.263 ± 0.016
1.62MetSer: 1.62 ± 0.02
1.187MetThr: 1.187 ± 0.012
1.475MetVal: 1.475 ± 0.018
0.21MetTrp: 0.21 ± 0.006
0.632MetTyr: 0.632 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.1AsnAla: 3.1 ± 0.027
0.792AsnCys: 0.792 ± 0.013
2.371AsnAsp: 2.371 ± 0.022
2.707AsnGlu: 2.707 ± 0.023
1.479AsnPhe: 1.479 ± 0.018
3.784AsnGly: 3.784 ± 0.039
1.175AsnHis: 1.175 ± 0.017
2.253AsnIle: 2.253 ± 0.024
1.861AsnLys: 1.861 ± 0.02
3.722AsnLeu: 3.722 ± 0.033
0.965AsnMet: 0.965 ± 0.015
2.727AsnAsn: 2.727 ± 0.045
2.194AsnPro: 2.194 ± 0.023
1.8AsnGln: 1.8 ± 0.022
2.655AsnArg: 2.655 ± 0.025
3.546AsnSer: 3.546 ± 0.037
2.34AsnThr: 2.34 ± 0.02
2.951AsnVal: 2.951 ± 0.025
0.43AsnTrp: 0.43 ± 0.008
1.35AsnTyr: 1.35 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
4.316ProAla: 4.316 ± 0.038
0.712ProCys: 0.712 ± 0.024
2.585ProAsp: 2.585 ± 0.025
3.258ProGlu: 3.258 ± 0.032
1.686ProPhe: 1.686 ± 0.019
3.334ProGly: 3.334 ± 0.051
1.285ProHis: 1.285 ± 0.02
2.562ProIle: 2.562 ± 0.019
2.651ProLys: 2.651 ± 0.028
4.273ProLeu: 4.273 ± 0.032
1.118ProMet: 1.118 ± 0.017
2.229ProAsn: 2.229 ± 0.021
4.716ProPro: 4.716 ± 0.07
2.327ProGln: 2.327 ± 0.033
2.446ProArg: 2.446 ± 0.021
4.84ProSer: 4.84 ± 0.046
3.616ProThr: 3.616 ± 0.033
3.657ProVal: 3.657 ± 0.034
0.459ProTrp: 0.459 ± 0.01
1.494ProTyr: 1.494 ± 0.02
0.0ProXaa: 0.0 ± 0.0
Gln
2.78GlnAla: 2.78 ± 0.027
0.825GlnCys: 0.825 ± 0.019
1.787GlnAsp: 1.787 ± 0.017
2.757GlnGlu: 2.757 ± 0.024
1.446GlnPhe: 1.446 ± 0.016
1.93GlnGly: 1.93 ± 0.024
2.035GlnHis: 2.035 ± 0.033
2.093GlnIle: 2.093 ± 0.022
2.266GlnLys: 2.266 ± 0.021
4.657GlnLeu: 4.657 ± 0.036
1.096GlnMet: 1.096 ± 0.016
1.822GlnAsn: 1.822 ± 0.019
2.75GlnPro: 2.75 ± 0.036
7.917GlnGln: 7.917 ± 0.201
2.917GlnArg: 2.917 ± 0.029
3.26GlnSer: 3.26 ± 0.027
2.445GlnThr: 2.445 ± 0.026
2.102GlnVal: 2.102 ± 0.023
0.444GlnTrp: 0.444 ± 0.009
1.401GlnTyr: 1.401 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
3.531ArgAla: 3.531 ± 0.03
1.175ArgCys: 1.175 ± 0.023
2.931ArgAsp: 2.931 ± 0.029
3.683ArgGlu: 3.683 ± 0.037
2.193ArgPhe: 2.193 ± 0.023
3.006ArgGly: 3.006 ± 0.034
1.602ArgHis: 1.602 ± 0.02
2.895ArgIle: 2.895 ± 0.023
3.734ArgLys: 3.734 ± 0.039
5.187ArgLeu: 5.187 ± 0.04
1.368ArgMet: 1.368 ± 0.016
2.764ArgAsn: 2.764 ± 0.026
2.737ArgPro: 2.737 ± 0.027
2.664ArgGln: 2.664 ± 0.023
4.295ArgArg: 4.295 ± 0.043
4.717ArgSer: 4.717 ± 0.049
3.346ArgThr: 3.346 ± 0.027
3.008ArgVal: 3.008 ± 0.025
0.689ArgTrp: 0.689 ± 0.011
1.956ArgTyr: 1.956 ± 0.024
0.0ArgXaa: 0.0 ± 0.0
Ser
6.091SerAla: 6.091 ± 0.052
1.373SerCys: 1.373 ± 0.022
4.08SerAsp: 4.08 ± 0.032
4.304SerGlu: 4.304 ± 0.028
2.769SerPhe: 2.769 ± 0.022
6.325SerGly: 6.325 ± 0.061
1.773SerHis: 1.773 ± 0.021
3.955SerIle: 3.955 ± 0.03
3.825SerLys: 3.825 ± 0.029
6.56SerLeu: 6.56 ± 0.04
1.695SerMet: 1.695 ± 0.019
4.043SerAsn: 4.043 ± 0.04
4.428SerPro: 4.428 ± 0.055
2.942SerGln: 2.942 ± 0.028
4.025SerArg: 4.025 ± 0.04
11.226SerSer: 11.226 ± 0.155
5.638SerThr: 5.638 ± 0.052
5.03SerVal: 5.03 ± 0.031
0.73SerTrp: 0.73 ± 0.011
2.179SerTyr: 2.179 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
5.186ThrAla: 5.186 ± 0.043
0.943ThrCys: 0.943 ± 0.019
3.02ThrAsp: 3.02 ± 0.025
3.455ThrGlu: 3.455 ± 0.03
1.957ThrPhe: 1.957 ± 0.019
4.445ThrGly: 4.445 ± 0.032
1.257ThrHis: 1.257 ± 0.017
3.524ThrIle: 3.524 ± 0.024
2.845ThrLys: 2.845 ± 0.027
5.171ThrLeu: 5.171 ± 0.035
1.388ThrMet: 1.388 ± 0.015
2.713ThrAsn: 2.713 ± 0.022
3.578ThrPro: 3.578 ± 0.034
2.003ThrGln: 2.003 ± 0.018
2.571ThrArg: 2.571 ± 0.028
5.146ThrSer: 5.146 ± 0.042
5.571ThrThr: 5.571 ± 0.092
4.647ThrVal: 4.647 ± 0.037
0.471ThrTrp: 0.471 ± 0.011
1.45ThrTyr: 1.45 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
5.194ValAla: 5.194 ± 0.034
1.32ValCys: 1.32 ± 0.023
3.244ValAsp: 3.244 ± 0.03
3.791ValGlu: 3.791 ± 0.037
2.204ValPhe: 2.204 ± 0.023
3.836ValGly: 3.836 ± 0.029
1.533ValHis: 1.533 ± 0.018
3.002ValIle: 3.002 ± 0.025
3.136ValLys: 3.136 ± 0.026
5.827ValLeu: 5.827 ± 0.04
1.346ValMet: 1.346 ± 0.015
2.537ValAsn: 2.537 ± 0.023
3.626ValPro: 3.626 ± 0.032
2.672ValGln: 2.672 ± 0.027
3.526ValArg: 3.526 ± 0.03
4.628ValSer: 4.628 ± 0.032
3.95ValThr: 3.95 ± 0.031
4.373ValVal: 4.373 ± 0.035
0.63ValTrp: 0.63 ± 0.011
1.808ValTyr: 1.808 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
0.528TrpAla: 0.528 ± 0.01
0.21TrpCys: 0.21 ± 0.006
0.53TrpAsp: 0.53 ± 0.011
0.538TrpGlu: 0.538 ± 0.011
0.412TrpPhe: 0.412 ± 0.01
0.518TrpGly: 0.518 ± 0.011
0.253TrpHis: 0.253 ± 0.007
0.604TrpIle: 0.604 ± 0.012
0.577TrpLys: 0.577 ± 0.011
0.999TrpLeu: 0.999 ± 0.015
0.283TrpMet: 0.283 ± 0.008
0.555TrpAsn: 0.555 ± 0.009
0.405TrpPro: 0.405 ± 0.01
0.421TrpGln: 0.421 ± 0.009
0.633TrpArg: 0.633 ± 0.011
0.742TrpSer: 0.742 ± 0.013
0.57TrpThr: 0.57 ± 0.011
0.525TrpVal: 0.525 ± 0.01
0.163TrpTrp: 0.163 ± 0.006
0.339TrpTyr: 0.339 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.887TyrAla: 1.887 ± 0.02
0.668TyrCys: 0.668 ± 0.013
1.82TyrAsp: 1.82 ± 0.02
1.875TyrGlu: 1.875 ± 0.02
1.184TyrPhe: 1.184 ± 0.016
2.1TyrGly: 2.1 ± 0.021
0.901TyrHis: 0.901 ± 0.013
1.417TyrIle: 1.417 ± 0.017
1.33TyrLys: 1.33 ± 0.017
2.651TyrLeu: 2.651 ± 0.026
0.63TyrMet: 0.63 ± 0.01
1.366TyrAsn: 1.366 ± 0.018
1.346TyrPro: 1.346 ± 0.021
1.3TyrGln: 1.3 ± 0.016
2.02TyrArg: 2.02 ± 0.024
2.075TyrSer: 2.075 ± 0.021
1.588TyrThr: 1.588 ± 0.018
1.787TyrVal: 1.787 ± 0.019
0.345TyrTrp: 0.345 ± 0.01
1.17TyrTyr: 1.17 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.001
Statistics based on 10447 proteins (6035843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski