Amino acid dipepetide frequency for Strongyloides ratti (Parasitic roundworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.368AlaAla: 2.368 ± 0.038	0.764AlaCys: 0.764 ± 0.014	1.763AlaAsp: 1.763 ± 0.025	2.283AlaGlu: 2.283 ± 0.034	2.024AlaPhe: 2.024 ± 0.025	1.904AlaGly: 1.904 ± 0.028	0.733AlaHis: 0.733 ± 0.013	3.4AlaIle: 3.4 ± 0.033	3.024AlaLys: 3.024 ± 0.032	3.827AlaLeu: 3.827 ± 0.04	0.932AlaMet: 0.932 ± 0.015	2.163AlaAsn: 2.163 ± 0.024	1.567AlaPro: 1.567 ± 0.032	1.254AlaGln: 1.254 ± 0.02	1.579AlaArg: 1.579 ± 0.023	3.085AlaSer: 3.085 ± 0.03	2.198AlaThr: 2.198 ± 0.03	2.348AlaVal: 2.348 ± 0.028	0.354AlaTrp: 0.354 ± 0.01	1.457AlaTyr: 1.457 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.711CysAla: 0.711 ± 0.015	0.559CysCys: 0.559 ± 0.016	1.192CysAsp: 1.192 ± 0.024	1.195CysGlu: 1.195 ± 0.023	1.01CysPhe: 1.01 ± 0.017	1.245CysGly: 1.245 ± 0.024	0.485CysHis: 0.485 ± 0.01	1.638CysIle: 1.638 ± 0.026	1.588CysLys: 1.588 ± 0.026	1.877CysLeu: 1.877 ± 0.027	0.418CysMet: 0.418 ± 0.01	1.412CysAsn: 1.412 ± 0.025	0.973CysPro: 0.973 ± 0.032	0.828CysGln: 0.828 ± 0.019	0.789CysArg: 0.789 ± 0.017	1.659CysSer: 1.659 ± 0.029	1.031CysThr: 1.031 ± 0.019	0.959CysVal: 0.959 ± 0.02	0.179CysTrp: 0.179 ± 0.007	0.881CysTyr: 0.881 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	1.908AspAla: 1.908 ± 0.022	1.069AspCys: 1.069 ± 0.023	4.073AspAsp: 4.073 ± 0.043	4.572AspGlu: 4.572 ± 0.041	2.68AspPhe: 2.68 ± 0.027	2.882AspGly: 2.882 ± 0.036	0.883AspHis: 0.883 ± 0.015	5.052AspIle: 5.052 ± 0.038	4.636AspLys: 4.636 ± 0.046	4.291AspLeu: 4.291 ± 0.041	1.2AspMet: 1.2 ± 0.015	4.238AspAsn: 4.238 ± 0.038	1.739AspPro: 1.739 ± 0.023	1.439AspGln: 1.439 ± 0.02	1.838AspArg: 1.838 ± 0.023	4.134AspSer: 4.134 ± 0.034	2.573AspThr: 2.573 ± 0.025	3.049AspVal: 3.049 ± 0.026	0.501AspTrp: 0.501 ± 0.011	2.345AspTyr: 2.345 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	2.782GluAla: 2.782 ± 0.034	1.362GluCys: 1.362 ± 0.027	3.888GluAsp: 3.888 ± 0.039	5.974GluGlu: 5.974 ± 0.082	2.564GluPhe: 2.564 ± 0.025	2.593GluGly: 2.593 ± 0.029	1.192GluHis: 1.192 ± 0.017	5.862GluIle: 5.862 ± 0.056	7.069GluLys: 7.069 ± 0.069	5.14GluLeu: 5.14 ± 0.045	1.713GluMet: 1.713 ± 0.022	5.599GluAsn: 5.599 ± 0.055	1.658GluPro: 1.658 ± 0.03	1.935GluGln: 1.935 ± 0.03	2.679GluArg: 2.679 ± 0.032	4.417GluSer: 4.417 ± 0.05	3.503GluThr: 3.503 ± 0.068	3.184GluVal: 3.184 ± 0.036	0.611GluTrp: 0.611 ± 0.013	2.669GluTyr: 2.669 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	1.962PheAla: 1.962 ± 0.024	1.074PheCys: 1.074 ± 0.018	2.935PheAsp: 2.935 ± 0.027	2.928PheGlu: 2.928 ± 0.026	2.679PhePhe: 2.679 ± 0.034	2.659PheGly: 2.659 ± 0.03	0.985PheHis: 0.985 ± 0.015	4.347PheIle: 4.347 ± 0.041	3.581PheLys: 3.581 ± 0.032	4.459PheLeu: 4.459 ± 0.038	1.069PheMet: 1.069 ± 0.016	3.521PheAsn: 3.521 ± 0.029	1.744PhePro: 1.744 ± 0.02	1.51PheGln: 1.51 ± 0.021	1.607PheArg: 1.607 ± 0.021	4.003PheSer: 4.003 ± 0.032	2.636PheThr: 2.636 ± 0.025	2.67PheVal: 2.67 ± 0.024	0.489PheTrp: 0.489 ± 0.01	2.2PheTyr: 2.2 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	1.963GlyAla: 1.963 ± 0.027	1.019GlyCys: 1.019 ± 0.025	2.484GlyAsp: 2.484 ± 0.028	2.821GlyGlu: 2.821 ± 0.038	2.279GlyPhe: 2.279 ± 0.028	3.02GlyGly: 3.02 ± 0.064	0.958GlyHis: 0.958 ± 0.015	4.062GlyIle: 4.062 ± 0.037	4.119GlyLys: 4.119 ± 0.037	3.596GlyLeu: 3.596 ± 0.047	1.141GlyMet: 1.141 ± 0.02	3.344GlyAsn: 3.344 ± 0.031	1.57GlyPro: 1.57 ± 0.038	1.572GlyGln: 1.572 ± 0.032	2.06GlyArg: 2.06 ± 0.029	3.642GlySer: 3.642 ± 0.042	2.73GlyThr: 2.73 ± 0.032	2.552GlyVal: 2.552 ± 0.032	0.454GlyTrp: 0.454 ± 0.011	2.161GlyTyr: 2.161 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	0.726HisAla: 0.726 ± 0.014	0.454HisCys: 0.454 ± 0.01	0.975HisAsp: 0.975 ± 0.014	1.172HisGlu: 1.172 ± 0.016	1.066HisPhe: 1.066 ± 0.015	1.055HisGly: 1.055 ± 0.018	0.575HisHis: 0.575 ± 0.014	1.582HisIle: 1.582 ± 0.021	1.306HisLys: 1.306 ± 0.019	1.897HisLeu: 1.897 ± 0.024	0.417HisMet: 0.417 ± 0.01	1.232HisAsn: 1.232 ± 0.015	0.883HisPro: 0.883 ± 0.013	0.754HisGln: 0.754 ± 0.017	0.82HisArg: 0.82 ± 0.016	1.598HisSer: 1.598 ± 0.022	0.928HisThr: 0.928 ± 0.016	1.016HisVal: 1.016 ± 0.015	0.194HisTrp: 0.194 ± 0.006	0.881HisTyr: 0.881 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.279IleAla: 3.279 ± 0.032	1.825IleCys: 1.825 ± 0.026	4.822IleAsp: 4.822 ± 0.04	5.53IleGlu: 5.53 ± 0.046	4.711IlePhe: 4.711 ± 0.043	3.839IleGly: 3.839 ± 0.038	1.716IleHis: 1.716 ± 0.02	7.487IleIle: 7.487 ± 0.06	7.106IleLys: 7.106 ± 0.055	7.63IleLeu: 7.63 ± 0.052	1.641IleMet: 1.641 ± 0.021	6.525IleAsn: 6.525 ± 0.054	3.786IlePro: 3.786 ± 0.035	2.786IleGln: 2.786 ± 0.028	2.942IleArg: 2.942 ± 0.027	7.085IleSer: 7.085 ± 0.045	4.588IleThr: 4.588 ± 0.046	4.365IleVal: 4.365 ± 0.033	0.719IleTrp: 0.719 ± 0.013	3.321IleTyr: 3.321 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.031LysAla: 3.031 ± 0.036	1.813LysCys: 1.813 ± 0.032	4.656LysAsp: 4.656 ± 0.041	6.604LysGlu: 6.604 ± 0.059	3.618LysPhe: 3.618 ± 0.03	3.133LysGly: 3.133 ± 0.038	1.615LysHis: 1.615 ± 0.021	7.556LysIle: 7.556 ± 0.058	9.434LysLys: 9.434 ± 0.085	7.061LysLeu: 7.061 ± 0.056	2.01LysMet: 2.01 ± 0.023	7.866LysAsn: 7.866 ± 0.069	2.656LysPro: 2.656 ± 0.045	2.654LysGln: 2.654 ± 0.031	3.714LysArg: 3.714 ± 0.036	5.861LysSer: 5.861 ± 0.045	4.373LysThr: 4.373 ± 0.04	4.084LysVal: 4.084 ± 0.037	0.762LysTrp: 0.762 ± 0.014	3.713LysTyr: 3.713 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	3.705LeuAla: 3.705 ± 0.04	1.674LeuCys: 1.674 ± 0.023	4.277LeuAsp: 4.277 ± 0.033	5.574LeuGlu: 5.574 ± 0.055	4.359LeuPhe: 4.359 ± 0.038	3.51LeuGly: 3.51 ± 0.034	1.774LeuHis: 1.774 ± 0.02	6.706LeuIle: 6.706 ± 0.045	7.734LeuLys: 7.734 ± 0.051	8.168LeuLeu: 8.168 ± 0.065	1.901LeuMet: 1.901 ± 0.022	5.946LeuAsn: 5.946 ± 0.041	3.924LeuPro: 3.924 ± 0.038	3.293LeuGln: 3.293 ± 0.034	3.51LeuArg: 3.51 ± 0.037	7.404LeuSer: 7.404 ± 0.05	4.884LeuThr: 4.884 ± 0.035	3.913LeuVal: 3.913 ± 0.034	0.761LeuTrp: 0.761 ± 0.017	3.261LeuTyr: 3.261 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	1.192MetAla: 1.192 ± 0.016	0.382MetCys: 0.382 ± 0.009	1.278MetAsp: 1.278 ± 0.015	1.573MetGlu: 1.573 ± 0.02	1.032MetPhe: 1.032 ± 0.017	1.014MetGly: 1.014 ± 0.018	0.385MetHis: 0.385 ± 0.009	1.821MetIle: 1.821 ± 0.022	2.005MetLys: 2.005 ± 0.023	1.864MetLeu: 1.864 ± 0.02	0.559MetMet: 0.559 ± 0.014	1.586MetAsn: 1.586 ± 0.021	0.868MetPro: 0.868 ± 0.014	0.609MetGln: 0.609 ± 0.013	0.82MetArg: 0.82 ± 0.013	1.787MetSer: 1.787 ± 0.023	1.256MetThr: 1.256 ± 0.017	1.14MetVal: 1.14 ± 0.014	0.184MetTrp: 0.184 ± 0.007	0.826MetTyr: 0.826 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.328AsnAla: 2.328 ± 0.024	1.564AsnCys: 1.564 ± 0.024	5.045AsnAsp: 5.045 ± 0.042	5.499AsnGlu: 5.499 ± 0.051	3.821AsnPhe: 3.821 ± 0.038	3.819AsnGly: 3.819 ± 0.039	1.348AsnHis: 1.348 ± 0.017	7.232AsnIle: 7.232 ± 0.06	6.009AsnLys: 6.009 ± 0.059	6.054AsnLeu: 6.054 ± 0.047	1.577AsnMet: 1.577 ± 0.02	7.289AsnAsn: 7.289 ± 0.075	2.387AsnPro: 2.387 ± 0.027	2.41AsnGln: 2.41 ± 0.028	2.327AsnArg: 2.327 ± 0.028	5.888AsnSer: 5.888 ± 0.047	3.74AsnThr: 3.74 ± 0.041	4.076AsnVal: 4.076 ± 0.028	0.583AsnTrp: 0.583 ± 0.012	3.189AsnTyr: 3.189 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	1.293ProAla: 1.293 ± 0.026	0.609ProCys: 0.609 ± 0.014	1.832ProAsp: 1.832 ± 0.02	2.412ProGlu: 2.412 ± 0.029	1.809ProPhe: 1.809 ± 0.026	2.063ProGly: 2.063 ± 0.08	0.708ProHis: 0.708 ± 0.013	3.181ProIle: 3.181 ± 0.03	2.981ProLys: 2.981 ± 0.03	3.304ProLeu: 3.304 ± 0.037	0.752ProMet: 0.752 ± 0.014	2.486ProAsn: 2.486 ± 0.03	2.278ProPro: 2.278 ± 0.047	1.467ProGln: 1.467 ± 0.024	1.349ProArg: 1.349 ± 0.02	3.499ProSer: 3.499 ± 0.037	2.472ProThr: 2.472 ± 0.035	1.966ProVal: 1.966 ± 0.032	0.31ProTrp: 0.31 ± 0.008	1.583ProTyr: 1.583 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	1.302GlnAla: 1.302 ± 0.021	0.729GlnCys: 0.729 ± 0.02	1.35GlnAsp: 1.35 ± 0.019	1.92GlnGlu: 1.92 ± 0.025	1.568GlnPhe: 1.568 ± 0.022	1.405GlnGly: 1.405 ± 0.036	0.725GlnHis: 0.725 ± 0.016	2.778GlnIle: 2.778 ± 0.027	2.925GlnLys: 2.925 ± 0.028	3.228GlnLeu: 3.228 ± 0.029	0.936GlnMet: 0.936 ± 0.016	2.691GlnAsn: 2.691 ± 0.03	1.298GlnPro: 1.298 ± 0.023	1.93GlnGln: 1.93 ± 0.047	1.503GlnArg: 1.503 ± 0.02	2.429GlnSer: 2.429 ± 0.029	1.786GlnThr: 1.786 ± 0.019	1.5GlnVal: 1.5 ± 0.018	0.327GlnTrp: 0.327 ± 0.009	1.387GlnTyr: 1.387 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	1.479ArgAla: 1.479 ± 0.022	0.82ArgCys: 0.82 ± 0.019	1.884ArgAsp: 1.884 ± 0.023	2.365ArgGlu: 2.365 ± 0.027	1.792ArgPhe: 1.792 ± 0.024	1.76ArgGly: 1.76 ± 0.026	0.884ArgHis: 0.884 ± 0.015	3.007ArgIle: 3.007 ± 0.028	3.738ArgLys: 3.738 ± 0.036	3.256ArgLeu: 3.256 ± 0.036	0.901ArgMet: 0.901 ± 0.016	2.869ArgAsn: 2.869 ± 0.028	1.321ArgPro: 1.321 ± 0.02	1.494ArgGln: 1.494 ± 0.019	2.375ArgArg: 2.375 ± 0.032	2.808ArgSer: 2.808 ± 0.035	1.801ArgThr: 1.801 ± 0.021	1.779ArgVal: 1.779 ± 0.02	0.379ArgTrp: 0.379 ± 0.01	1.598ArgTyr: 1.598 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	2.711SerAla: 2.711 ± 0.029	1.579SerCys: 1.579 ± 0.027	4.164SerAsp: 4.164 ± 0.034	4.481SerGlu: 4.481 ± 0.047	3.979SerPhe: 3.979 ± 0.032	3.957SerGly: 3.957 ± 0.051	1.513SerHis: 1.513 ± 0.019	6.751SerIle: 6.751 ± 0.046	6.452SerLys: 6.452 ± 0.052	7.157SerLeu: 7.157 ± 0.047	1.674SerMet: 1.674 ± 0.02	6.192SerAsn: 6.192 ± 0.053	3.157SerPro: 3.157 ± 0.037	2.799SerGln: 2.799 ± 0.028	2.922SerArg: 2.922 ± 0.032	8.155SerSer: 8.155 ± 0.08	5.182SerThr: 5.182 ± 0.071	3.762SerVal: 3.762 ± 0.032	0.636SerTrp: 0.636 ± 0.013	2.935SerTyr: 2.935 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	2.156ThrAla: 2.156 ± 0.022	1.119ThrCys: 1.119 ± 0.026	2.534ThrAsp: 2.534 ± 0.029	3.127ThrGlu: 3.127 ± 0.096	2.971ThrPhe: 2.971 ± 0.028	2.599ThrGly: 2.599 ± 0.03	0.936ThrHis: 0.936 ± 0.016	5.067ThrIle: 5.067 ± 0.044	4.372ThrLys: 4.372 ± 0.056	4.856ThrLeu: 4.856 ± 0.036	1.093ThrMet: 1.093 ± 0.016	4.055ThrAsn: 4.055 ± 0.045	2.537ThrPro: 2.537 ± 0.036	1.601ThrGln: 1.601 ± 0.021	1.737ThrArg: 1.737 ± 0.022	5.109ThrSer: 5.109 ± 0.053	4.427ThrThr: 4.427 ± 0.097	2.869ThrVal: 2.869 ± 0.024	0.447ThrTrp: 0.447 ± 0.01	1.955ThrTyr: 1.955 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	2.28ValAla: 2.28 ± 0.028	1.03ValCys: 1.03 ± 0.019	3.031ValAsp: 3.031 ± 0.028	3.37ValGlu: 3.37 ± 0.049	2.388ValPhe: 2.388 ± 0.025	2.451ValGly: 2.451 ± 0.027	0.952ValHis: 0.952 ± 0.015	4.166ValIle: 4.166 ± 0.034	4.208ValLys: 4.208 ± 0.032	4.162ValLeu: 4.162 ± 0.035	1.127ValMet: 1.127 ± 0.016	3.437ValAsn: 3.437 ± 0.026	2.172ValPro: 2.172 ± 0.026	1.567ValGln: 1.567 ± 0.02	1.825ValArg: 1.825 ± 0.023	3.967ValSer: 3.967 ± 0.033	2.991ValThr: 2.991 ± 0.032	2.987ValVal: 2.987 ± 0.028	0.475ValTrp: 0.475 ± 0.01	1.921ValTyr: 1.921 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.349TrpAla: 0.349 ± 0.009	0.177TrpCys: 0.177 ± 0.006	0.485TrpAsp: 0.485 ± 0.012	0.502TrpGlu: 0.502 ± 0.011	0.433TrpPhe: 0.433 ± 0.01	0.391TrpGly: 0.391 ± 0.011	0.188TrpHis: 0.188 ± 0.006	0.771TrpIle: 0.771 ± 0.013	0.882TrpLys: 0.882 ± 0.015	0.807TrpLeu: 0.807 ± 0.015	0.261TrpMet: 0.261 ± 0.012	0.679TrpAsn: 0.679 ± 0.014	0.303TrpPro: 0.303 ± 0.009	0.299TrpGln: 0.299 ± 0.008	0.41TrpArg: 0.41 ± 0.01	0.648TrpSer: 0.648 ± 0.014	0.435TrpThr: 0.435 ± 0.01	0.377TrpVal: 0.377 ± 0.009	0.112TrpTrp: 0.112 ± 0.005	0.378TrpTyr: 0.378 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.499TyrAla: 1.499 ± 0.018	1.006TyrCys: 1.006 ± 0.018	2.437TyrAsp: 2.437 ± 0.025	2.494TyrGlu: 2.494 ± 0.027	2.275TyrPhe: 2.275 ± 0.026	2.245TyrGly: 2.245 ± 0.027	0.978TyrHis: 0.978 ± 0.015	3.237TyrIle: 3.237 ± 0.033	3.047TyrLys: 3.047 ± 0.033	3.641TyrLeu: 3.641 ± 0.029	0.862TyrMet: 0.862 ± 0.014	3.057TyrAsn: 3.057 ± 0.032	1.529TyrPro: 1.529 ± 0.026	1.515TyrGln: 1.515 ± 0.02	1.504TyrArg: 1.504 ± 0.019	2.98TyrSer: 2.98 ± 0.025	2.032TyrThr: 2.032 ± 0.022	1.911TyrVal: 1.911 ± 0.022	0.408TyrTrp: 0.408 ± 0.01	1.973TyrTyr: 1.973 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.02XaaXaa: 0.02 ± 0.01

Statistics based on 9956 proteins (4680237 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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