Amino acid dipepetide frequency for Wallemia mellicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.915AlaAla: 5.915 ± 0.078
0.739AlaCys: 0.739 ± 0.019
3.53AlaAsp: 3.53 ± 0.039
4.07AlaGlu: 4.07 ± 0.043
2.991AlaPhe: 2.991 ± 0.045
4.264AlaGly: 4.264 ± 0.053
1.57AlaHis: 1.57 ± 0.027
4.58AlaIle: 4.58 ± 0.051
4.295AlaLys: 4.295 ± 0.049
7.06AlaLeu: 7.06 ± 0.081
1.513AlaMet: 1.513 ± 0.03
3.167AlaAsn: 3.167 ± 0.038
3.435AlaPro: 3.435 ± 0.057
3.095AlaGln: 3.095 ± 0.045
3.553AlaArg: 3.553 ± 0.044
5.893AlaSer: 5.893 ± 0.063
4.185AlaThr: 4.185 ± 0.048
4.098AlaVal: 4.098 ± 0.05
0.721AlaTrp: 0.721 ± 0.019
2.125AlaTyr: 2.125 ± 0.033
0.0AlaXaa: 0.0 ± 0.0
Cys
0.684CysAla: 0.684 ± 0.021
0.178CysCys: 0.178 ± 0.01
0.573CysAsp: 0.573 ± 0.016
0.505CysGlu: 0.505 ± 0.017
0.422CysPhe: 0.422 ± 0.014
0.7CysGly: 0.7 ± 0.025
0.249CysHis: 0.249 ± 0.012
0.634CysIle: 0.634 ± 0.018
0.553CysLys: 0.553 ± 0.016
1.052CysLeu: 1.052 ± 0.022
0.201CysMet: 0.201 ± 0.009
0.444CysAsn: 0.444 ± 0.016
0.467CysPro: 0.467 ± 0.019
0.358CysGln: 0.358 ± 0.012
0.508CysArg: 0.508 ± 0.017
0.755CysSer: 0.755 ± 0.02
0.584CysThr: 0.584 ± 0.019
0.667CysVal: 0.667 ± 0.02
0.14CysTrp: 0.14 ± 0.008
0.341CysTyr: 0.341 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.181AspAla: 4.181 ± 0.043
0.558AspCys: 0.558 ± 0.015
5.258AspAsp: 5.258 ± 0.07
5.341AspGlu: 5.341 ± 0.059
2.324AspPhe: 2.324 ± 0.037
3.485AspGly: 3.485 ± 0.041
1.14AspHis: 1.14 ± 0.023
4.056AspIle: 4.056 ± 0.046
3.868AspLys: 3.868 ± 0.048
5.528AspLeu: 5.528 ± 0.051
1.194AspMet: 1.194 ± 0.023
3.318AspAsn: 3.318 ± 0.043
2.505AspPro: 2.505 ± 0.036
2.151AspGln: 2.151 ± 0.035
2.647AspArg: 2.647 ± 0.042
4.542AspSer: 4.542 ± 0.057
3.023AspThr: 3.023 ± 0.037
4.023AspVal: 4.023 ± 0.047
0.76AspTrp: 0.76 ± 0.02
2.035AspTyr: 2.035 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
4.572GluAla: 4.572 ± 0.053
0.643GluCys: 0.643 ± 0.019
4.66GluAsp: 4.66 ± 0.061
6.209GluGlu: 6.209 ± 0.093
2.233GluPhe: 2.233 ± 0.03
3.302GluGly: 3.302 ± 0.042
1.398GluHis: 1.398 ± 0.028
3.883GluIle: 3.883 ± 0.042
4.735GluLys: 4.735 ± 0.058
5.919GluLeu: 5.919 ± 0.057
1.463GluMet: 1.463 ± 0.029
3.323GluAsn: 3.323 ± 0.043
2.284GluPro: 2.284 ± 0.034
2.931GluGln: 2.931 ± 0.044
3.852GluArg: 3.852 ± 0.06
4.934GluSer: 4.934 ± 0.051
3.255GluThr: 3.255 ± 0.035
3.44GluVal: 3.44 ± 0.043
0.75GluTrp: 0.75 ± 0.024
1.939GluTyr: 1.939 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
2.679PheAla: 2.679 ± 0.04
0.472PheCys: 0.472 ± 0.017
2.716PheAsp: 2.716 ± 0.037
2.443PheGlu: 2.443 ± 0.035
1.491PhePhe: 1.491 ± 0.032
2.741PheGly: 2.741 ± 0.054
0.756PheHis: 0.756 ± 0.018
2.357PheIle: 2.357 ± 0.035
2.422PheLys: 2.422 ± 0.034
3.132PheLeu: 3.132 ± 0.044
0.728PheMet: 0.728 ± 0.021
2.268PheAsn: 2.268 ± 0.033
1.496PhePro: 1.496 ± 0.029
1.201PheGln: 1.201 ± 0.023
1.645PheArg: 1.645 ± 0.026
3.073PheSer: 3.073 ± 0.04
2.212PheThr: 2.212 ± 0.035
2.353PheVal: 2.353 ± 0.036
0.486PheTrp: 0.486 ± 0.015
1.248PheTyr: 1.248 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
3.787GlyAla: 3.787 ± 0.053
0.698GlyCys: 0.698 ± 0.021
3.158GlyAsp: 3.158 ± 0.042
3.184GlyGlu: 3.184 ± 0.037
2.445GlyPhe: 2.445 ± 0.035
4.159GlyGly: 4.159 ± 0.074
1.355GlyHis: 1.355 ± 0.033
3.394GlyIle: 3.394 ± 0.046
3.503GlyLys: 3.503 ± 0.045
5.409GlyLeu: 5.409 ± 0.06
1.274GlyMet: 1.274 ± 0.029
2.398GlyAsn: 2.398 ± 0.032
2.043GlyPro: 2.043 ± 0.038
2.17GlyGln: 2.17 ± 0.032
2.856GlyArg: 2.856 ± 0.038
4.497GlySer: 4.497 ± 0.053
3.082GlyThr: 3.082 ± 0.038
3.838GlyVal: 3.838 ± 0.047
0.847GlyTrp: 0.847 ± 0.02
1.97GlyTyr: 1.97 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
1.45HisAla: 1.45 ± 0.025
0.248HisCys: 0.248 ± 0.013
1.231HisAsp: 1.231 ± 0.025
1.241HisGlu: 1.241 ± 0.029
0.912HisPhe: 0.912 ± 0.019
1.211HisGly: 1.211 ± 0.032
0.737HisHis: 0.737 ± 0.033
1.361HisIle: 1.361 ± 0.026
1.294HisLys: 1.294 ± 0.024
2.344HisLeu: 2.344 ± 0.032
0.407HisMet: 0.407 ± 0.013
1.087HisAsn: 1.087 ± 0.024
1.405HisPro: 1.405 ± 0.026
1.009HisGln: 1.009 ± 0.021
1.145HisArg: 1.145 ± 0.024
2.029HisSer: 2.029 ± 0.034
1.282HisThr: 1.282 ± 0.027
1.242HisVal: 1.242 ± 0.026
0.255HisTrp: 0.255 ± 0.01
0.738HisTyr: 0.738 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.403IleAla: 4.403 ± 0.051
0.703IleCys: 0.703 ± 0.019
4.14IleAsp: 4.14 ± 0.043
4.074IleGlu: 4.074 ± 0.054
2.076IlePhe: 2.076 ± 0.038
3.386IleGly: 3.386 ± 0.04
1.367IleHis: 1.367 ± 0.025
3.423IleIle: 3.423 ± 0.043
3.722IleLys: 3.722 ± 0.044
5.25IleLeu: 5.25 ± 0.059
1.068IleMet: 1.068 ± 0.023
3.155IleAsn: 3.155 ± 0.043
3.347IlePro: 3.347 ± 0.04
2.347IleGln: 2.347 ± 0.033
2.886IleArg: 2.886 ± 0.036
4.906IleSer: 4.906 ± 0.05
3.214IleThr: 3.214 ± 0.045
3.502IleVal: 3.502 ± 0.038
0.684IleTrp: 0.684 ± 0.019
1.797IleTyr: 1.797 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.615LysAla: 4.615 ± 0.059
0.57LysCys: 0.57 ± 0.018
3.878LysAsp: 3.878 ± 0.043
4.818LysGlu: 4.818 ± 0.061
2.068LysPhe: 2.068 ± 0.034
3.109LysGly: 3.109 ± 0.039
1.512LysHis: 1.512 ± 0.028
3.215LysIle: 3.215 ± 0.045
4.82LysLys: 4.82 ± 0.082
5.996LysLeu: 5.996 ± 0.067
1.255LysMet: 1.255 ± 0.022
2.892LysAsn: 2.892 ± 0.039
3.256LysPro: 3.256 ± 0.049
2.937LysGln: 2.937 ± 0.038
3.947LysArg: 3.947 ± 0.049
5.447LysSer: 5.447 ± 0.06
3.334LysThr: 3.334 ± 0.039
3.55LysVal: 3.55 ± 0.044
0.665LysTrp: 0.665 ± 0.017
1.945LysTyr: 1.945 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
6.797LeuAla: 6.797 ± 0.064
0.985LeuCys: 0.985 ± 0.024
5.877LeuAsp: 5.877 ± 0.058
6.042LeuGlu: 6.042 ± 0.067
3.509LeuPhe: 3.509 ± 0.048
5.158LeuGly: 5.158 ± 0.057
2.15LeuHis: 2.15 ± 0.031
5.288LeuIle: 5.288 ± 0.054
5.869LeuLys: 5.869 ± 0.063
8.702LeuLeu: 8.702 ± 0.091
1.7LeuMet: 1.7 ± 0.029
4.974LeuAsn: 4.974 ± 0.052
4.91LeuPro: 4.91 ± 0.047
3.809LeuGln: 3.809 ± 0.049
4.962LeuArg: 4.962 ± 0.059
8.41LeuSer: 8.41 ± 0.072
5.187LeuThr: 5.187 ± 0.054
5.195LeuVal: 5.195 ± 0.057
0.913LeuTrp: 0.913 ± 0.023
2.57LeuTyr: 2.57 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
1.434MetAla: 1.434 ± 0.027
0.168MetCys: 0.168 ± 0.01
1.121MetAsp: 1.121 ± 0.026
1.147MetGlu: 1.147 ± 0.022
0.728MetPhe: 0.728 ± 0.018
1.078MetGly: 1.078 ± 0.023
0.407MetHis: 0.407 ± 0.014
1.116MetIle: 1.116 ± 0.024
1.269MetLys: 1.269 ± 0.025
1.807MetLeu: 1.807 ± 0.028
0.494MetMet: 0.494 ± 0.019
0.983MetAsn: 0.983 ± 0.021
1.014MetPro: 1.014 ± 0.024
0.876MetGln: 0.876 ± 0.021
1.134MetArg: 1.134 ± 0.023
2.087MetSer: 2.087 ± 0.032
1.257MetThr: 1.257 ± 0.025
1.018MetVal: 1.018 ± 0.023
0.17MetTrp: 0.17 ± 0.009
0.502MetTyr: 0.502 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.576AsnAla: 3.576 ± 0.04
0.452AsnCys: 0.452 ± 0.016
3.432AsnAsp: 3.432 ± 0.043
3.385AsnGlu: 3.385 ± 0.039
1.702AsnPhe: 1.702 ± 0.029
2.794AsnGly: 2.794 ± 0.041
1.074AsnHis: 1.074 ± 0.022
3.025AsnIle: 3.025 ± 0.036
3.422AsnLys: 3.422 ± 0.045
4.606AsnLeu: 4.606 ± 0.047
0.947AsnMet: 0.947 ± 0.02
3.051AsnAsn: 3.051 ± 0.049
2.376AsnPro: 2.376 ± 0.04
2.156AsnGln: 2.156 ± 0.031
2.197AsnArg: 2.197 ± 0.03
4.071AsnSer: 4.071 ± 0.049
2.894AsnThr: 2.894 ± 0.047
3.143AsnVal: 3.143 ± 0.036
0.628AsnTrp: 0.628 ± 0.015
1.638AsnTyr: 1.638 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.55ProAla: 3.55 ± 0.063
0.306ProCys: 0.306 ± 0.015
2.486ProAsp: 2.486 ± 0.037
3.21ProGlu: 3.21 ± 0.041
1.924ProPhe: 1.924 ± 0.033
2.404ProGly: 2.404 ± 0.035
1.09ProHis: 1.09 ± 0.023
2.858ProIle: 2.858 ± 0.038
2.796ProLys: 2.796 ± 0.041
4.168ProLeu: 4.168 ± 0.046
0.825ProMet: 0.825 ± 0.023
2.302ProAsn: 2.302 ± 0.036
3.99ProPro: 3.99 ± 0.087
2.38ProGln: 2.38 ± 0.038
2.244ProArg: 2.244 ± 0.032
5.342ProSer: 5.342 ± 0.065
3.515ProThr: 3.515 ± 0.048
2.743ProVal: 2.743 ± 0.041
0.456ProTrp: 0.456 ± 0.015
1.47ProTyr: 1.47 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.148GlnAla: 3.148 ± 0.048
0.325GlnCys: 0.325 ± 0.012
2.241GlnAsp: 2.241 ± 0.036
2.625GlnGlu: 2.625 ± 0.036
1.571GlnPhe: 1.571 ± 0.031
1.918GlnGly: 1.918 ± 0.033
1.075GlnHis: 1.075 ± 0.023
2.362GlnIle: 2.362 ± 0.036
2.451GlnLys: 2.451 ± 0.034
4.212GlnLeu: 4.212 ± 0.047
0.916GlnMet: 0.916 ± 0.024
1.95GlnAsn: 1.95 ± 0.031
2.539GlnPro: 2.539 ± 0.049
3.234GlnGln: 3.234 ± 0.092
2.423GlnArg: 2.423 ± 0.036
4.149GlnSer: 4.149 ± 0.048
2.41GlnThr: 2.41 ± 0.033
2.351GlnVal: 2.351 ± 0.035
0.407GlnTrp: 0.407 ± 0.012
1.126GlnTyr: 1.126 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
3.426ArgAla: 3.426 ± 0.043
0.53ArgCys: 0.53 ± 0.016
2.943ArgAsp: 2.943 ± 0.044
3.275ArgGlu: 3.275 ± 0.056
1.855ArgPhe: 1.855 ± 0.026
2.689ArgGly: 2.689 ± 0.048
1.176ArgHis: 1.176 ± 0.023
2.891ArgIle: 2.891 ± 0.038
3.741ArgLys: 3.741 ± 0.046
4.855ArgLeu: 4.855 ± 0.054
1.176ArgMet: 1.176 ± 0.024
2.449ArgAsn: 2.449 ± 0.032
2.344ArgPro: 2.344 ± 0.035
2.438ArgGln: 2.438 ± 0.04
3.766ArgArg: 3.766 ± 0.06
4.325ArgSer: 4.325 ± 0.048
2.693ArgThr: 2.693 ± 0.036
2.953ArgVal: 2.953 ± 0.033
0.59ArgTrp: 0.59 ± 0.016
1.548ArgTyr: 1.548 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
5.725SerAla: 5.725 ± 0.059
0.759SerCys: 0.759 ± 0.022
4.918SerAsp: 4.918 ± 0.057
4.623SerGlu: 4.623 ± 0.053
3.307SerPhe: 3.307 ± 0.041
4.496SerGly: 4.496 ± 0.049
1.985SerHis: 1.985 ± 0.03
5.352SerIle: 5.352 ± 0.06
5.373SerLys: 5.373 ± 0.058
8.041SerLeu: 8.041 ± 0.075
1.561SerMet: 1.561 ± 0.028
4.77SerAsn: 4.77 ± 0.054
4.437SerPro: 4.437 ± 0.077
3.913SerGln: 3.913 ± 0.052
4.298SerArg: 4.298 ± 0.054
9.037SerSer: 9.037 ± 0.118
5.984SerThr: 5.984 ± 0.062
4.627SerVal: 4.627 ± 0.051
0.877SerTrp: 0.877 ± 0.022
2.38SerTyr: 2.38 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
3.926ThrAla: 3.926 ± 0.041
0.524ThrCys: 0.524 ± 0.016
2.826ThrAsp: 2.826 ± 0.04
3.048ThrGlu: 3.048 ± 0.038
2.338ThrPhe: 2.338 ± 0.038
3.294ThrGly: 3.294 ± 0.043
1.278ThrHis: 1.278 ± 0.024
3.649ThrIle: 3.649 ± 0.048
3.349ThrLys: 3.349 ± 0.041
5.673ThrLeu: 5.673 ± 0.063
1.015ThrMet: 1.015 ± 0.023
2.863ThrAsn: 2.863 ± 0.043
3.868ThrPro: 3.868 ± 0.053
2.386ThrGln: 2.386 ± 0.038
2.772ThrArg: 2.772 ± 0.038
5.379ThrSer: 5.379 ± 0.058
3.821ThrThr: 3.821 ± 0.041
3.189ThrVal: 3.189 ± 0.044
0.554ThrTrp: 0.554 ± 0.018
1.596ThrTyr: 1.596 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
4.123ValAla: 4.123 ± 0.047
0.655ValCys: 0.655 ± 0.018
4.218ValAsp: 4.218 ± 0.044
4.033ValGlu: 4.033 ± 0.048
2.283ValPhe: 2.283 ± 0.036
3.474ValGly: 3.474 ± 0.053
1.323ValHis: 1.323 ± 0.026
3.503ValIle: 3.503 ± 0.042
3.761ValLys: 3.761 ± 0.039
5.238ValLeu: 5.238 ± 0.056
1.201ValMet: 1.201 ± 0.025
2.85ValAsn: 2.85 ± 0.038
2.647ValPro: 2.647 ± 0.04
2.35ValGln: 2.35 ± 0.038
2.733ValArg: 2.733 ± 0.039
4.327ValSer: 4.327 ± 0.047
2.963ValThr: 2.963 ± 0.046
3.809ValVal: 3.809 ± 0.056
0.663ValTrp: 0.663 ± 0.018
1.841ValTyr: 1.841 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
0.666TrpAla: 0.666 ± 0.018
0.149TrpCys: 0.149 ± 0.008
0.725TrpAsp: 0.725 ± 0.022
0.625TrpGlu: 0.625 ± 0.017
0.474TrpPhe: 0.474 ± 0.016
0.6TrpGly: 0.6 ± 0.017
0.256TrpHis: 0.256 ± 0.011
0.683TrpIle: 0.683 ± 0.02
0.762TrpLys: 0.762 ± 0.02
1.086TrpLeu: 1.086 ± 0.024
0.283TrpMet: 0.283 ± 0.013
0.594TrpAsn: 0.594 ± 0.018
0.393TrpPro: 0.393 ± 0.013
0.433TrpGln: 0.433 ± 0.015
0.625TrpArg: 0.625 ± 0.018
0.987TrpSer: 0.987 ± 0.019
0.652TrpThr: 0.652 ± 0.017
0.574TrpVal: 0.574 ± 0.016
0.178TrpTrp: 0.178 ± 0.009
0.356TrpTyr: 0.356 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.142TyrAla: 2.142 ± 0.035
0.351TyrCys: 0.351 ± 0.014
2.009TyrAsp: 2.009 ± 0.033
1.826TyrGlu: 1.826 ± 0.03
1.268TyrPhe: 1.268 ± 0.024
1.803TyrGly: 1.803 ± 0.034
0.733TyrHis: 0.733 ± 0.018
1.82TyrIle: 1.82 ± 0.03
1.821TyrLys: 1.821 ± 0.027
2.929TyrLeu: 2.929 ± 0.042
0.591TyrMet: 0.591 ± 0.017
1.73TyrAsn: 1.73 ± 0.033
1.303TyrPro: 1.303 ± 0.026
1.257TyrGln: 1.257 ± 0.026
1.467TyrArg: 1.467 ± 0.027
2.274TyrSer: 2.274 ± 0.036
1.802TyrThr: 1.802 ± 0.032
1.682TyrVal: 1.682 ± 0.029
0.356TyrTrp: 0.356 ± 0.014
1.006TyrTyr: 1.006 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4289 proteins (2169282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski