Amino acid dipepetide frequency for Torque teno virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.719AlaAla: 7.719 ± 3.902
1.404AlaCys: 1.404 ± 0.623
0.702AlaAsp: 0.702 ± 0.368
2.105AlaGlu: 2.105 ± 1.309
0.702AlaPhe: 0.702 ± 0.72
2.105AlaGly: 2.105 ± 1.309
0.702AlaHis: 0.702 ± 0.368
2.807AlaIle: 2.807 ± 0.968
1.404AlaLys: 1.404 ± 0.878
3.509AlaLeu: 3.509 ± 0.697
1.404AlaMet: 1.404 ± 0.735
0.702AlaAsn: 0.702 ± 0.368
5.614AlaPro: 5.614 ± 3.418
0.0AlaGln: 0.0 ± 0.0
2.105AlaArg: 2.105 ± 0.726
4.912AlaSer: 4.912 ± 1.082
4.211AlaThr: 4.211 ± 1.452
0.0AlaVal: 0.0 ± 0.0
2.807AlaTrp: 2.807 ± 1.471
3.509AlaTyr: 3.509 ± 0.697
0.0AlaXaa: 0.0 ± 0.0
Cys
0.702CysAla: 0.702 ± 0.72
0.0CysCys: 0.0 ± 0.0
2.105CysAsp: 2.105 ± 1.309
0.702CysGlu: 0.702 ± 0.72
1.404CysPhe: 1.404 ± 0.735
3.509CysGly: 3.509 ± 0.697
0.702CysHis: 0.702 ± 0.368
0.0CysIle: 0.0 ± 0.0
0.702CysLys: 0.702 ± 0.72
0.702CysLeu: 0.702 ± 0.737
0.702CysMet: 0.702 ± 0.368
0.0CysAsn: 0.0 ± 0.0
1.404CysPro: 1.404 ± 0.591
0.702CysGln: 0.702 ± 0.368
0.702CysArg: 0.702 ± 0.72
2.105CysSer: 2.105 ± 0.652
0.0CysThr: 0.0 ± 0.0
0.702CysVal: 0.702 ± 0.368
0.0CysTrp: 0.0 ± 0.0
0.702CysTyr: 0.702 ± 0.368
0.0CysXaa: 0.0 ± 0.0
Asp
4.912AspAla: 4.912 ± 0.583
0.702AspCys: 0.702 ± 0.368
3.509AspAsp: 3.509 ± 0.697
0.702AspGlu: 0.702 ± 0.368
0.0AspPhe: 0.0 ± 0.0
4.211AspGly: 4.211 ± 2.618
0.702AspHis: 0.702 ± 0.72
4.912AspIle: 4.912 ± 0.756
2.105AspLys: 2.105 ± 1.103
8.421AspLeu: 8.421 ± 2.154
2.807AspMet: 2.807 ± 0.88
3.509AspAsn: 3.509 ± 2.022
2.807AspPro: 2.807 ± 1.471
0.702AspGln: 0.702 ± 0.368
4.211AspArg: 4.211 ± 3.058
2.105AspSer: 2.105 ± 2.212
5.614AspThr: 5.614 ± 1.964
2.105AspVal: 2.105 ± 0.652
0.702AspTrp: 0.702 ± 0.72
2.105AspTyr: 2.105 ± 1.103
0.0AspXaa: 0.0 ± 0.0
Glu
2.105GluAla: 2.105 ± 1.103
0.702GluCys: 0.702 ± 0.72
7.018GluAsp: 7.018 ± 3.593
9.123GluGlu: 9.123 ± 1.048
1.404GluPhe: 1.404 ± 0.735
0.0GluGly: 0.0 ± 0.0
3.509GluHis: 3.509 ± 0.697
0.0GluIle: 0.0 ± 0.0
0.702GluLys: 0.702 ± 0.368
4.211GluLeu: 4.211 ± 0.527
0.702GluMet: 0.702 ± 0.541
1.404GluAsn: 1.404 ± 0.591
7.719GluPro: 7.719 ± 4.65
4.912GluGln: 4.912 ± 0.583
0.702GluArg: 0.702 ± 0.72
4.912GluSer: 4.912 ± 3.292
2.105GluThr: 2.105 ± 0.652
0.0GluVal: 0.0 ± 0.0
0.702GluTrp: 0.702 ± 0.368
2.807GluTyr: 2.807 ± 0.878
0.0GluXaa: 0.0 ± 0.0
Phe
2.807PheAla: 2.807 ± 0.982
2.807PheCys: 2.807 ± 1.709
1.404PheAsp: 1.404 ± 0.623
0.702PheGlu: 0.702 ± 0.368
0.0PhePhe: 0.0 ± 0.0
0.0PheGly: 0.0 ± 0.0
0.702PheHis: 0.702 ± 0.368
2.105PheIle: 2.105 ± 1.103
1.404PheLys: 1.404 ± 0.623
1.404PheLeu: 1.404 ± 0.735
2.105PheMet: 2.105 ± 1.103
1.404PheAsn: 1.404 ± 0.735
1.404PhePro: 1.404 ± 0.878
0.702PheGln: 0.702 ± 0.368
1.404PheArg: 1.404 ± 0.591
2.105PheSer: 2.105 ± 0.726
1.404PheThr: 1.404 ± 0.623
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
2.105PheTyr: 2.105 ± 0.726
0.0PheXaa: 0.0 ± 0.0
Gly
2.807GlyAla: 2.807 ± 1.709
2.105GlyCys: 2.105 ± 1.309
7.719GlyAsp: 7.719 ± 3.265
2.105GlyGlu: 2.105 ± 1.309
0.702GlyPhe: 0.702 ± 0.368
7.719GlyGly: 7.719 ± 3.265
0.702GlyHis: 0.702 ± 0.368
2.807GlyIle: 2.807 ± 1.471
2.105GlyLys: 2.105 ± 0.726
4.912GlyLeu: 4.912 ± 0.583
0.0GlyMet: 0.0 ± 0.0
2.807GlyAsn: 2.807 ± 0.968
3.509GlyPro: 3.509 ± 0.697
0.702GlyGln: 0.702 ± 0.368
4.912GlyArg: 4.912 ± 1.671
2.807GlySer: 2.807 ± 0.346
2.105GlyThr: 2.105 ± 1.285
3.509GlyVal: 3.509 ± 0.697
0.702GlyTrp: 0.702 ± 0.368
2.105GlyTyr: 2.105 ± 1.103
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
4.211HisAsp: 4.211 ± 0.527
0.702HisGlu: 0.702 ± 0.368
0.0HisPhe: 0.0 ± 0.0
2.105HisGly: 2.105 ± 0.726
1.404HisHis: 1.404 ± 0.735
0.702HisIle: 0.702 ± 0.368
0.0HisLys: 0.0 ± 0.0
4.912HisLeu: 4.912 ± 0.828
0.702HisMet: 0.702 ± 0.368
2.807HisAsn: 2.807 ± 0.982
0.702HisPro: 0.702 ± 0.368
1.404HisGln: 1.404 ± 0.735
1.404HisArg: 1.404 ± 0.735
2.105HisSer: 2.105 ± 0.557
1.404HisThr: 1.404 ± 0.735
0.702HisVal: 0.702 ± 0.368
0.702HisTrp: 0.702 ± 0.368
0.702HisTyr: 0.702 ± 0.368
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
1.404IleCys: 1.404 ± 0.623
0.702IleAsp: 0.702 ± 0.368
0.702IleGlu: 0.702 ± 0.368
0.702IlePhe: 0.702 ± 0.737
2.807IleGly: 2.807 ± 1.471
0.0IleHis: 0.0 ± 0.0
2.105IleIle: 2.105 ± 0.726
4.912IleLys: 4.912 ± 1.947
4.211IleLeu: 4.211 ± 1.656
0.0IleMet: 0.0 ± 0.0
1.404IleAsn: 1.404 ± 0.623
8.421IlePro: 8.421 ± 1.0
2.807IleGln: 2.807 ± 1.182
7.018IleArg: 7.018 ± 1.965
1.404IleSer: 1.404 ± 0.735
3.509IleThr: 3.509 ± 1.839
2.105IleVal: 2.105 ± 1.103
0.0IleTrp: 0.0 ± 0.0
2.105IleTyr: 2.105 ± 1.103
0.0IleXaa: 0.0 ± 0.0
Lys
1.404LysAla: 1.404 ± 0.623
0.702LysCys: 0.702 ± 0.368
0.702LysAsp: 0.702 ± 0.368
4.211LysGlu: 4.211 ± 1.304
0.702LysPhe: 0.702 ± 0.72
2.105LysGly: 2.105 ± 1.103
2.807LysHis: 2.807 ± 0.878
2.105LysIle: 2.105 ± 1.295
9.825LysLys: 9.825 ± 5.818
3.509LysLeu: 3.509 ± 1.839
0.0LysMet: 0.0 ± 0.0
3.509LysAsn: 3.509 ± 1.189
3.509LysPro: 3.509 ± 1.272
0.0LysGln: 0.0 ± 0.0
7.018LysArg: 7.018 ± 1.847
3.509LysSer: 3.509 ± 1.189
5.614LysThr: 5.614 ± 1.436
1.404LysVal: 1.404 ± 0.878
2.807LysTrp: 2.807 ± 1.471
1.404LysTyr: 1.404 ± 0.591
0.0LysXaa: 0.0 ± 0.0
Leu
2.105LeuAla: 2.105 ± 0.726
0.702LeuCys: 0.702 ± 0.368
0.702LeuAsp: 0.702 ± 0.368
5.614LeuGlu: 5.614 ± 0.693
4.912LeuPhe: 4.912 ± 1.694
2.807LeuGly: 2.807 ± 0.982
0.0LeuHis: 0.0 ± 0.0
2.807LeuIle: 2.807 ± 1.182
2.807LeuLys: 2.807 ± 0.878
4.211LeuLeu: 4.211 ± 1.077
3.509LeuMet: 3.509 ± 1.134
1.404LeuAsn: 1.404 ± 0.735
9.825LeuPro: 9.825 ± 4.223
2.807LeuGln: 2.807 ± 0.878
7.018LeuArg: 7.018 ± 3.013
2.807LeuSer: 2.807 ± 0.878
7.018LeuThr: 7.018 ± 0.868
2.807LeuVal: 2.807 ± 0.968
4.211LeuTrp: 4.211 ± 0.527
4.211LeuTyr: 4.211 ± 0.527
0.0LeuXaa: 0.0 ± 0.0
Met
1.404MetAla: 1.404 ± 0.735
0.0MetCys: 0.0 ± 0.0
0.702MetAsp: 0.702 ± 0.368
0.0MetGlu: 0.0 ± 0.0
0.702MetPhe: 0.702 ± 0.368
0.702MetGly: 0.702 ± 0.368
0.702MetHis: 0.702 ± 0.368
0.702MetIle: 0.702 ± 0.368
1.404MetLys: 1.404 ± 0.735
4.211MetLeu: 4.211 ± 1.508
1.404MetMet: 1.404 ± 0.756
1.404MetAsn: 1.404 ± 0.591
3.509MetPro: 3.509 ± 0.697
0.0MetGln: 0.0 ± 0.0
2.105MetArg: 2.105 ± 1.295
0.702MetSer: 0.702 ± 0.368
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.404AsnAla: 1.404 ± 0.735
0.0AsnCys: 0.0 ± 0.0
0.702AsnAsp: 0.702 ± 0.368
2.807AsnGlu: 2.807 ± 1.471
2.807AsnPhe: 2.807 ± 1.245
1.404AsnGly: 1.404 ± 0.735
0.702AsnHis: 0.702 ± 0.368
4.912AsnIle: 4.912 ± 3.038
2.105AsnLys: 2.105 ± 0.652
2.105AsnLeu: 2.105 ± 1.103
0.0AsnMet: 0.0 ± 0.0
0.0AsnAsn: 0.0 ± 0.0
7.719AsnPro: 7.719 ± 0.818
2.105AsnGln: 2.105 ± 0.726
2.105AsnArg: 2.105 ± 1.103
2.105AsnSer: 2.105 ± 0.652
8.421AsnThr: 8.421 ± 3.24
0.0AsnVal: 0.0 ± 0.0
1.404AsnTrp: 1.404 ± 0.735
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
9.123ProAla: 9.123 ± 4.577
1.404ProCys: 1.404 ± 0.591
4.211ProAsp: 4.211 ± 0.742
9.825ProGlu: 9.825 ± 5.198
1.404ProPhe: 1.404 ± 0.735
2.105ProGly: 2.105 ± 1.309
2.105ProHis: 2.105 ± 0.726
5.614ProIle: 5.614 ± 1.41
6.316ProLys: 6.316 ± 2.047
6.316ProLeu: 6.316 ± 1.193
1.404ProMet: 1.404 ± 0.623
0.702ProAsn: 0.702 ± 0.72
16.842ProPro: 16.842 ± 5.213
4.912ProGln: 4.912 ± 0.866
11.228ProArg: 11.228 ± 3.525
2.105ProSer: 2.105 ± 1.295
5.614ProThr: 5.614 ± 3.271
1.404ProVal: 1.404 ± 0.735
4.912ProTrp: 4.912 ± 0.828
2.105ProTyr: 2.105 ± 1.103
0.0ProXaa: 0.0 ± 0.0
Gln
2.105GlnAla: 2.105 ± 0.652
0.0GlnCys: 0.0 ± 0.0
3.509GlnAsp: 3.509 ± 0.697
2.807GlnGlu: 2.807 ± 0.878
0.702GlnPhe: 0.702 ± 0.368
1.404GlnGly: 1.404 ± 0.735
1.404GlnHis: 1.404 ± 0.735
1.404GlnIle: 1.404 ± 0.735
4.912GlnLys: 4.912 ± 1.082
2.807GlnLeu: 2.807 ± 1.471
0.0GlnMet: 0.0 ± 0.0
0.702GlnAsn: 0.702 ± 0.737
2.105GlnPro: 2.105 ± 1.103
1.404GlnGln: 1.404 ± 0.735
1.404GlnArg: 1.404 ± 0.735
4.912GlnSer: 4.912 ± 1.291
6.316GlnThr: 6.316 ± 2.476
0.702GlnVal: 0.702 ± 0.368
0.702GlnTrp: 0.702 ± 0.368
2.807GlnTyr: 2.807 ± 0.878
0.0GlnXaa: 0.0 ± 0.0
Arg
2.105ArgAla: 2.105 ± 1.295
2.105ArgCys: 2.105 ± 0.652
2.807ArgAsp: 2.807 ± 2.001
4.211ArgGlu: 4.211 ± 2.075
1.404ArgPhe: 1.404 ± 0.623
9.123ArgGly: 9.123 ± 2.26
4.912ArgHis: 4.912 ± 0.828
1.404ArgIle: 1.404 ± 0.735
2.807ArgLys: 2.807 ± 0.346
1.404ArgLeu: 1.404 ± 0.623
0.0ArgMet: 0.0 ± 0.0
4.211ArgAsn: 4.211 ± 1.133
7.018ArgPro: 7.018 ± 1.729
5.614ArgGln: 5.614 ± 2.205
27.368ArgArg: 27.368 ± 6.199
3.509ArgSer: 3.509 ± 1.446
5.614ArgThr: 5.614 ± 0.928
3.509ArgVal: 3.509 ± 1.272
2.105ArgTrp: 2.105 ± 1.103
4.211ArgTyr: 4.211 ± 2.206
0.0ArgXaa: 0.0 ± 0.0
Ser
2.105SerAla: 2.105 ± 1.103
1.404SerCys: 1.404 ± 0.591
7.018SerAsp: 7.018 ± 4.529
3.509SerGlu: 3.509 ± 1.189
0.0SerPhe: 0.0 ± 0.0
0.702SerGly: 0.702 ± 0.368
2.105SerHis: 2.105 ± 1.309
3.509SerIle: 3.509 ± 0.697
4.211SerLys: 4.211 ± 1.772
6.316SerLeu: 6.316 ± 2.285
0.702SerMet: 0.702 ± 0.737
6.316SerAsn: 6.316 ± 2.045
7.018SerPro: 7.018 ± 3.113
0.702SerGln: 0.702 ± 0.737
0.702SerArg: 0.702 ± 0.368
4.912SerSer: 4.912 ± 3.292
7.018SerThr: 7.018 ± 2.675
0.702SerVal: 0.702 ± 0.368
2.105SerTrp: 2.105 ± 0.652
4.211SerTyr: 4.211 ± 1.772
0.0SerXaa: 0.0 ± 0.0
Thr
2.807ThrAla: 2.807 ± 1.245
0.0ThrCys: 0.0 ± 0.0
4.912ThrAsp: 4.912 ± 0.583
2.105ThrGlu: 2.105 ± 0.726
4.912ThrPhe: 4.912 ± 0.863
9.825ThrGly: 9.825 ± 1.229
2.105ThrHis: 2.105 ± 1.103
3.509ThrIle: 3.509 ± 0.697
3.509ThrLys: 3.509 ± 1.178
2.807ThrLeu: 2.807 ± 1.182
1.404ThrMet: 1.404 ± 0.735
4.211ThrAsn: 4.211 ± 1.508
6.316ThrPro: 6.316 ± 2.476
4.211ThrGln: 4.211 ± 0.816
5.614ThrArg: 5.614 ± 3.464
7.719ThrSer: 7.719 ± 4.314
7.719ThrThr: 7.719 ± 1.541
0.702ThrVal: 0.702 ± 0.368
0.702ThrTrp: 0.702 ± 0.368
2.105ThrTyr: 2.105 ± 0.726
0.0ThrXaa: 0.0 ± 0.0
Val
0.702ValAla: 0.702 ± 0.368
1.404ValCys: 1.404 ± 0.735
1.404ValAsp: 1.404 ± 0.591
0.0ValGlu: 0.0 ± 0.0
0.0ValPhe: 0.0 ± 0.0
1.404ValGly: 1.404 ± 0.735
0.702ValHis: 0.702 ± 0.368
1.404ValIle: 1.404 ± 0.735
0.702ValLys: 0.702 ± 0.368
3.509ValLeu: 3.509 ± 1.178
0.0ValMet: 0.0 ± 0.0
0.702ValAsn: 0.702 ± 0.72
0.702ValPro: 0.702 ± 0.368
4.211ValGln: 4.211 ± 1.077
4.211ValArg: 4.211 ± 0.527
2.105ValSer: 2.105 ± 1.103
0.0ValThr: 0.0 ± 0.0
2.807ValVal: 2.807 ± 1.471
0.0ValTrp: 0.0 ± 0.0
1.404ValTyr: 1.404 ± 0.623
0.0ValXaa: 0.0 ± 0.0
Trp
0.702TrpAla: 0.702 ± 0.368
0.0TrpCys: 0.0 ± 0.0
1.404TrpAsp: 1.404 ± 0.735
1.404TrpGlu: 1.404 ± 0.878
0.702TrpPhe: 0.702 ± 0.368
1.404TrpGly: 1.404 ± 0.735
0.702TrpHis: 0.702 ± 0.368
0.0TrpIle: 0.0 ± 0.0
1.404TrpLys: 1.404 ± 0.735
2.105TrpLeu: 2.105 ± 0.726
1.404TrpMet: 1.404 ± 0.504
1.404TrpAsn: 1.404 ± 0.735
0.0TrpPro: 0.0 ± 0.0
2.105TrpGln: 2.105 ± 1.103
2.105TrpArg: 2.105 ± 1.103
3.509TrpSer: 3.509 ± 0.697
0.702TrpThr: 0.702 ± 0.368
2.105TrpVal: 2.105 ± 1.309
1.404TrpTrp: 1.404 ± 0.735
2.105TrpTyr: 2.105 ± 1.103
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.404TyrAla: 1.404 ± 0.735
0.702TyrCys: 0.702 ± 0.368
1.404TyrAsp: 1.404 ± 0.735
2.105TyrGlu: 2.105 ± 1.309
2.807TyrPhe: 2.807 ± 1.471
1.404TyrGly: 1.404 ± 0.735
0.0TyrHis: 0.0 ± 0.0
3.509TyrIle: 3.509 ± 1.839
3.509TyrLys: 3.509 ± 1.178
0.702TyrLeu: 0.702 ± 0.368
0.702TyrMet: 0.702 ± 0.368
4.211TyrAsn: 4.211 ± 1.508
3.509TyrPro: 3.509 ± 1.9
2.105TyrGln: 2.105 ± 1.285
2.105TyrArg: 2.105 ± 1.103
4.912TyrSer: 4.912 ± 0.863
2.807TyrThr: 2.807 ± 1.471
2.105TyrVal: 2.105 ± 1.103
0.702TyrTrp: 0.702 ± 0.737
0.702TyrTyr: 0.702 ± 0.368
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski