Amino acid dipepetide frequency for Nocardioides zeae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.161AlaAla: 23.161 ± 0.202	0.975AlaCys: 0.975 ± 0.028	9.302AlaAsp: 9.302 ± 0.101	8.811AlaGlu: 8.811 ± 0.106	3.481AlaPhe: 3.481 ± 0.055	13.536AlaGly: 13.536 ± 0.115	2.721AlaHis: 2.721 ± 0.052	3.881AlaIle: 3.881 ± 0.062	1.957AlaLys: 1.957 ± 0.05	14.753AlaLeu: 14.753 ± 0.132	2.602AlaMet: 2.602 ± 0.047	1.686AlaAsn: 1.686 ± 0.04	7.507AlaPro: 7.507 ± 0.093	3.353AlaGln: 3.353 ± 0.057	10.568AlaArg: 10.568 ± 0.119	6.603AlaSer: 6.603 ± 0.086	8.496AlaThr: 8.496 ± 0.085	13.593AlaVal: 13.593 ± 0.132	2.184AlaTrp: 2.184 ± 0.047	2.574AlaTyr: 2.574 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.864CysAla: 0.864 ± 0.027	0.061CysCys: 0.061 ± 0.007	0.442CysAsp: 0.442 ± 0.017	0.329CysGlu: 0.329 ± 0.016	0.196CysPhe: 0.196 ± 0.011	0.837CysGly: 0.837 ± 0.024	0.153CysHis: 0.153 ± 0.01	0.176CysIle: 0.176 ± 0.011	0.073CysLys: 0.073 ± 0.007	0.587CysLeu: 0.587 ± 0.021	0.094CysMet: 0.094 ± 0.009	0.11CysAsn: 0.11 ± 0.009	0.39CysPro: 0.39 ± 0.019	0.13CysGln: 0.13 ± 0.009	0.53CysArg: 0.53 ± 0.019	0.416CysSer: 0.416 ± 0.015	0.412CysThr: 0.412 ± 0.018	0.65CysVal: 0.65 ± 0.021	0.097CysTrp: 0.097 ± 0.008	0.125CysTyr: 0.125 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.376AspAla: 9.376 ± 0.099	0.34AspCys: 0.34 ± 0.017	4.835AspAsp: 4.835 ± 0.078	4.643AspGlu: 4.643 ± 0.065	1.45AspPhe: 1.45 ± 0.038	6.926AspGly: 6.926 ± 0.078	1.481AspHis: 1.481 ± 0.035	1.589AspIle: 1.589 ± 0.04	0.818AspLys: 0.818 ± 0.032	7.777AspLeu: 7.777 ± 0.086	0.716AspMet: 0.716 ± 0.027	0.758AspAsn: 0.758 ± 0.022	4.911AspPro: 4.911 ± 0.059	1.52AspGln: 1.52 ± 0.037	4.977AspArg: 4.977 ± 0.063	1.977AspSer: 1.977 ± 0.043	2.792AspThr: 2.792 ± 0.044	6.72AspVal: 6.72 ± 0.073	0.885AspTrp: 0.885 ± 0.026	1.093AspTyr: 1.093 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.475GluAla: 7.475 ± 0.09	0.286GluCys: 0.286 ± 0.013	3.065GluAsp: 3.065 ± 0.052	3.483GluGlu: 3.483 ± 0.064	1.258GluPhe: 1.258 ± 0.036	4.575GluGly: 4.575 ± 0.063	1.678GluHis: 1.678 ± 0.04	2.24GluIle: 2.24 ± 0.051	1.066GluLys: 1.066 ± 0.039	6.416GluLeu: 6.416 ± 0.083	0.871GluMet: 0.871 ± 0.025	0.876GluAsn: 0.876 ± 0.029	3.491GluPro: 3.491 ± 0.071	2.298GluGln: 2.298 ± 0.042	5.662GluArg: 5.662 ± 0.077	2.338GluSer: 2.338 ± 0.045	2.858GluThr: 2.858 ± 0.055	6.07GluVal: 6.07 ± 0.068	0.708GluTrp: 0.708 ± 0.025	0.839GluTyr: 0.839 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.569PheAla: 3.569 ± 0.055	0.268PheCys: 0.268 ± 0.015	1.977PheAsp: 1.977 ± 0.042	1.435PheGlu: 1.435 ± 0.034	0.797PhePhe: 0.797 ± 0.027	2.813PheGly: 2.813 ± 0.053	0.525PheHis: 0.525 ± 0.017	0.618PheIle: 0.618 ± 0.027	0.356PheLys: 0.356 ± 0.019	2.449PheLeu: 2.449 ± 0.049	0.332PheMet: 0.332 ± 0.015	0.463PheAsn: 0.463 ± 0.019	1.192PhePro: 1.192 ± 0.029	0.553PheGln: 0.553 ± 0.022	1.638PheArg: 1.638 ± 0.035	1.327PheSer: 1.327 ± 0.041	1.691PheThr: 1.691 ± 0.039	2.67PheVal: 2.67 ± 0.049	0.378PheTrp: 0.378 ± 0.018	0.562PheTyr: 0.562 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	12.192GlyAla: 12.192 ± 0.109	0.784GlyCys: 0.784 ± 0.03	5.89GlyAsp: 5.89 ± 0.074	5.322GlyGlu: 5.322 ± 0.067	2.92GlyPhe: 2.92 ± 0.05	8.936GlyGly: 8.936 ± 0.125	1.957GlyHis: 1.957 ± 0.04	3.614GlyIle: 3.614 ± 0.062	1.686GlyLys: 1.686 ± 0.039	9.672GlyLeu: 9.672 ± 0.094	1.865GlyMet: 1.865 ± 0.039	1.499GlyAsn: 1.499 ± 0.041	4.909GlyPro: 4.909 ± 0.068	2.397GlyGln: 2.397 ± 0.058	7.67GlyArg: 7.67 ± 0.086	5.486GlySer: 5.486 ± 0.079	6.266GlyThr: 6.266 ± 0.084	8.829GlyVal: 8.829 ± 0.095	1.737GlyTrp: 1.737 ± 0.037	2.097GlyTyr: 2.097 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.707HisAla: 2.707 ± 0.052	0.165HisCys: 0.165 ± 0.011	1.558HisAsp: 1.558 ± 0.035	1.203HisGlu: 1.203 ± 0.029	0.503HisPhe: 0.503 ± 0.019	2.205HisGly: 2.205 ± 0.044	0.663HisHis: 0.663 ± 0.024	0.359HisIle: 0.359 ± 0.018	0.236HisLys: 0.236 ± 0.012	2.609HisLeu: 2.609 ± 0.052	0.227HisMet: 0.227 ± 0.014	0.279HisAsn: 0.279 ± 0.013	1.595HisPro: 1.595 ± 0.039	0.547HisGln: 0.547 ± 0.018	1.875HisArg: 1.875 ± 0.048	0.684HisSer: 0.684 ± 0.022	0.968HisThr: 0.968 ± 0.03	2.146HisVal: 2.146 ± 0.042	0.269HisTrp: 0.269 ± 0.014	0.376HisTyr: 0.376 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.585IleAla: 4.585 ± 0.067	0.25IleCys: 0.25 ± 0.014	2.344IleAsp: 2.344 ± 0.044	1.943IleGlu: 1.943 ± 0.042	0.689IlePhe: 0.689 ± 0.026	3.487IleGly: 3.487 ± 0.063	0.507IleHis: 0.507 ± 0.019	0.866IleIle: 0.866 ± 0.031	0.511IleLys: 0.511 ± 0.02	2.061IleLeu: 2.061 ± 0.042	0.399IleMet: 0.399 ± 0.021	0.602IleAsn: 0.602 ± 0.024	1.483IlePro: 1.483 ± 0.038	0.612IleGln: 0.612 ± 0.021	1.74IleArg: 1.74 ± 0.038	1.468IleSer: 1.468 ± 0.033	1.909IleThr: 1.909 ± 0.039	3.0IleVal: 3.0 ± 0.05	0.32IleTrp: 0.32 ± 0.017	0.48IleTyr: 0.48 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	1.932LysAla: 1.932 ± 0.044	0.072LysCys: 0.072 ± 0.007	0.818LysAsp: 0.818 ± 0.031	0.834LysGlu: 0.834 ± 0.029	0.362LysPhe: 0.362 ± 0.019	1.277LysGly: 1.277 ± 0.037	0.355LysHis: 0.355 ± 0.018	0.632LysIle: 0.632 ± 0.027	0.573LysLys: 0.573 ± 0.034	1.339LysLeu: 1.339 ± 0.037	0.273LysMet: 0.273 ± 0.017	0.33LysAsn: 0.33 ± 0.017	0.897LysPro: 0.897 ± 0.028	0.485LysGln: 0.485 ± 0.021	1.127LysArg: 1.127 ± 0.036	0.775LysSer: 0.775 ± 0.026	0.859LysThr: 0.859 ± 0.032	1.533LysVal: 1.533 ± 0.041	0.154LysTrp: 0.154 ± 0.011	0.3LysTyr: 0.3 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.414LeuAla: 16.414 ± 0.148	0.638LeuCys: 0.638 ± 0.022	7.43LeuAsp: 7.43 ± 0.082	5.597LeuGlu: 5.597 ± 0.076	2.236LeuPhe: 2.236 ± 0.046	10.157LeuGly: 10.157 ± 0.106	2.045LeuHis: 2.045 ± 0.042	2.112LeuIle: 2.112 ± 0.043	1.311LeuLys: 1.311 ± 0.042	11.466LeuLeu: 11.466 ± 0.128	1.337LeuMet: 1.337 ± 0.03	1.388LeuAsn: 1.388 ± 0.032	6.029LeuPro: 6.029 ± 0.073	2.317LeuGln: 2.317 ± 0.051	8.331LeuArg: 8.331 ± 0.085	4.509LeuSer: 4.509 ± 0.065	6.42LeuThr: 6.42 ± 0.067	11.856LeuVal: 11.856 ± 0.13	1.138LeuTrp: 1.138 ± 0.032	1.399LeuTyr: 1.399 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	1.977MetAla: 1.977 ± 0.04	0.111MetCys: 0.111 ± 0.01	0.73MetAsp: 0.73 ± 0.023	0.655MetGlu: 0.655 ± 0.025	0.407MetPhe: 0.407 ± 0.017	1.281MetGly: 1.281 ± 0.036	0.292MetHis: 0.292 ± 0.016	0.529MetIle: 0.529 ± 0.023	0.356MetLys: 0.356 ± 0.018	1.66MetLeu: 1.66 ± 0.036	0.276MetMet: 0.276 ± 0.017	0.336MetAsn: 0.336 ± 0.016	0.959MetPro: 0.959 ± 0.027	0.402MetGln: 0.402 ± 0.018	1.332MetArg: 1.332 ± 0.027	1.294MetSer: 1.294 ± 0.027	1.598MetThr: 1.598 ± 0.038	1.356MetVal: 1.356 ± 0.034	0.168MetTrp: 0.168 ± 0.012	0.216MetTyr: 0.216 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	1.944AsnAla: 1.944 ± 0.044	0.097AsnCys: 0.097 ± 0.01	0.91AsnAsp: 0.91 ± 0.024	0.747AsnGlu: 0.747 ± 0.025	0.405AsnPhe: 0.405 ± 0.018	1.55AsnGly: 1.55 ± 0.044	0.316AsnHis: 0.316 ± 0.015	0.543AsnIle: 0.543 ± 0.021	0.27AsnLys: 0.27 ± 0.018	1.595AsnLeu: 1.595 ± 0.031	0.236AsnMet: 0.236 ± 0.014	0.313AsnAsn: 0.313 ± 0.017	1.167AsnPro: 1.167 ± 0.03	0.461AsnGln: 0.461 ± 0.021	1.04AsnArg: 1.04 ± 0.03	0.623AsnSer: 0.623 ± 0.025	0.802AsnThr: 0.802 ± 0.034	1.421AsnVal: 1.421 ± 0.035	0.214AsnTrp: 0.214 ± 0.011	0.338AsnTyr: 0.338 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.411ProAla: 8.411 ± 0.093	0.281ProCys: 0.281 ± 0.016	4.618ProAsp: 4.618 ± 0.059	3.986ProGlu: 3.986 ± 0.066	1.409ProPhe: 1.409 ± 0.036	6.409ProGly: 6.409 ± 0.082	1.247ProHis: 1.247 ± 0.033	1.359ProIle: 1.359 ± 0.035	0.717ProLys: 0.717 ± 0.023	5.109ProLeu: 5.109 ± 0.07	0.853ProMet: 0.853 ± 0.024	0.704ProAsn: 0.704 ± 0.027	3.19ProPro: 3.19 ± 0.067	1.349ProGln: 1.349 ± 0.035	4.044ProArg: 4.044 ± 0.067	3.105ProSer: 3.105 ± 0.056	3.857ProThr: 3.857 ± 0.059	5.709ProVal: 5.709 ± 0.076	0.932ProTrp: 0.932 ± 0.025	1.153ProTyr: 1.153 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.26GlnAla: 3.26 ± 0.052	0.127GlnCys: 0.127 ± 0.01	1.12GlnAsp: 1.12 ± 0.031	1.239GlnGlu: 1.239 ± 0.031	0.646GlnPhe: 0.646 ± 0.025	2.029GlnGly: 2.029 ± 0.049	0.655GlnHis: 0.655 ± 0.021	0.858GlnIle: 0.858 ± 0.028	0.451GlnLys: 0.451 ± 0.02	2.848GlnLeu: 2.848 ± 0.057	0.424GlnMet: 0.424 ± 0.017	0.409GlnAsn: 0.409 ± 0.018	1.563GlnPro: 1.563 ± 0.039	1.092GlnGln: 1.092 ± 0.031	2.424GlnArg: 2.424 ± 0.049	0.991GlnSer: 0.991 ± 0.03	1.227GlnThr: 1.227 ± 0.031	2.794GlnVal: 2.794 ± 0.043	0.361GlnTrp: 0.361 ± 0.016	0.45GlnTyr: 0.45 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.996ArgAla: 9.996 ± 0.103	0.544ArgCys: 0.544 ± 0.021	4.691ArgAsp: 4.691 ± 0.067	4.347ArgGlu: 4.347 ± 0.07	2.199ArgPhe: 2.199 ± 0.043	6.179ArgGly: 6.179 ± 0.072	1.843ArgHis: 1.843 ± 0.043	2.819ArgIle: 2.819 ± 0.043	1.102ArgLys: 1.102 ± 0.035	8.403ArgLeu: 8.403 ± 0.098	1.616ArgMet: 1.616 ± 0.035	1.191ArgAsn: 1.191 ± 0.036	4.674ArgPro: 4.674 ± 0.075	1.943ArgGln: 1.943 ± 0.042	8.072ArgArg: 8.072 ± 0.114	4.243ArgSer: 4.243 ± 0.066	5.071ArgThr: 5.071 ± 0.065	6.891ArgVal: 6.891 ± 0.078	1.449ArgTrp: 1.449 ± 0.038	1.561ArgTyr: 1.561 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.202SerAla: 6.202 ± 0.073	0.316SerCys: 0.316 ± 0.016	2.837SerAsp: 2.837 ± 0.048	2.254SerGlu: 2.254 ± 0.046	1.535SerPhe: 1.535 ± 0.04	5.373SerGly: 5.373 ± 0.08	0.868SerHis: 0.868 ± 0.027	1.561SerIle: 1.561 ± 0.032	0.751SerLys: 0.751 ± 0.025	4.659SerLeu: 4.659 ± 0.063	0.985SerMet: 0.985 ± 0.03	0.864SerAsn: 0.864 ± 0.026	2.914SerPro: 2.914 ± 0.051	1.087SerGln: 1.087 ± 0.034	3.367SerArg: 3.367 ± 0.052	3.044SerSer: 3.044 ± 0.066	3.422SerThr: 3.422 ± 0.054	4.328SerVal: 4.328 ± 0.066	0.892SerTrp: 0.892 ± 0.025	1.158SerTyr: 1.158 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	8.206ThrAla: 8.206 ± 0.079	0.424ThrCys: 0.424 ± 0.02	3.76ThrAsp: 3.76 ± 0.052	2.989ThrGlu: 2.989 ± 0.052	1.762ThrPhe: 1.762 ± 0.04	6.29ThrGly: 6.29 ± 0.077	1.172ThrHis: 1.172 ± 0.031	2.05ThrIle: 2.05 ± 0.044	0.859ThrLys: 0.859 ± 0.027	5.84ThrLeu: 5.84 ± 0.069	0.929ThrMet: 0.929 ± 0.027	1.001ThrAsn: 1.001 ± 0.035	4.099ThrPro: 4.099 ± 0.059	1.345ThrGln: 1.345 ± 0.034	3.968ThrArg: 3.968 ± 0.053	3.534ThrSer: 3.534 ± 0.059	4.739ThrThr: 4.739 ± 0.078	6.125ThrVal: 6.125 ± 0.073	1.0ThrTrp: 1.0 ± 0.03	1.45ThrTyr: 1.45 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	15.272ValAla: 15.272 ± 0.129	0.633ValCys: 0.633 ± 0.026	6.877ValAsp: 6.877 ± 0.082	6.05ValGlu: 6.05 ± 0.079	2.271ValPhe: 2.271 ± 0.048	8.84ValGly: 8.84 ± 0.112	2.097ValHis: 2.097 ± 0.04	2.597ValIle: 2.597 ± 0.051	1.342ValLys: 1.342 ± 0.038	11.265ValLeu: 11.265 ± 0.117	1.41ValMet: 1.41 ± 0.029	1.574ValAsn: 1.574 ± 0.044	5.81ValPro: 5.81 ± 0.071	2.178ValGln: 2.178 ± 0.05	7.682ValArg: 7.682 ± 0.081	4.235ValSer: 4.235 ± 0.058	6.233ValThr: 6.233 ± 0.086	12.616ValVal: 12.616 ± 0.14	1.179ValTrp: 1.179 ± 0.032	1.41ValTyr: 1.41 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.629TrpAla: 1.629 ± 0.036	0.153TrpCys: 0.153 ± 0.011	0.836TrpAsp: 0.836 ± 0.027	0.714TrpGlu: 0.714 ± 0.023	0.521TrpPhe: 0.521 ± 0.019	1.108TrpGly: 1.108 ± 0.034	0.306TrpHis: 0.306 ± 0.016	0.533TrpIle: 0.533 ± 0.02	0.231TrpLys: 0.231 ± 0.014	1.664TrpLeu: 1.664 ± 0.039	0.282TrpMet: 0.282 ± 0.014	0.291TrpAsn: 0.291 ± 0.016	0.737TrpPro: 0.737 ± 0.025	0.441TrpGln: 0.441 ± 0.019	1.35TrpArg: 1.35 ± 0.035	0.993TrpSer: 0.993 ± 0.028	0.982TrpThr: 0.982 ± 0.027	1.28TrpVal: 1.28 ± 0.031	0.41TrpTrp: 0.41 ± 0.019	0.269TrpTyr: 0.269 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.572TyrAla: 2.572 ± 0.043	0.148TyrCys: 0.148 ± 0.01	1.546TyrAsp: 1.546 ± 0.038	0.971TyrGlu: 0.971 ± 0.03	0.566TyrPhe: 0.566 ± 0.018	1.921TyrGly: 1.921 ± 0.038	0.294TyrHis: 0.294 ± 0.014	0.321TyrIle: 0.321 ± 0.015	0.262TyrLys: 0.262 ± 0.014	1.955TyrLeu: 1.955 ± 0.041	0.21TyrMet: 0.21 ± 0.013	0.316TyrAsn: 0.316 ± 0.016	0.925TyrPro: 0.925 ± 0.026	0.46TyrGln: 0.46 ± 0.018	1.435TyrArg: 1.435 ± 0.035	0.772TyrSer: 0.772 ± 0.028	0.94TyrThr: 0.94 ± 0.033	1.982TyrVal: 1.982 ± 0.04	0.255TyrTrp: 0.255 ± 0.014	0.345TyrTyr: 0.345 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4048 proteins (1324490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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