Amino acid dipepetide frequency for Aspergillus sclerotioniger CBS 115572

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.363AlaAla: 8.363 ± 0.055	1.148AlaCys: 1.148 ± 0.019	4.087AlaAsp: 4.087 ± 0.026	4.827AlaGlu: 4.827 ± 0.035	3.152AlaPhe: 3.152 ± 0.025	5.63AlaGly: 5.63 ± 0.038	1.782AlaHis: 1.782 ± 0.02	4.34AlaIle: 4.34 ± 0.031	3.519AlaLys: 3.519 ± 0.029	7.782AlaLeu: 7.782 ± 0.044	1.999AlaMet: 1.999 ± 0.02	2.724AlaAsn: 2.724 ± 0.025	4.52AlaPro: 4.52 ± 0.042	3.245AlaGln: 3.245 ± 0.035	4.867AlaArg: 4.867 ± 0.033	7.1AlaSer: 7.1 ± 0.049	5.215AlaThr: 5.215 ± 0.034	5.402AlaVal: 5.402 ± 0.033	1.204AlaTrp: 1.204 ± 0.016	2.255AlaTyr: 2.255 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.972CysAla: 0.972 ± 0.014	0.283CysCys: 0.283 ± 0.009	0.703CysAsp: 0.703 ± 0.013	0.625CysGlu: 0.625 ± 0.012	0.582CysPhe: 0.582 ± 0.011	0.957CysGly: 0.957 ± 0.016	0.387CysHis: 0.387 ± 0.009	0.781CysIle: 0.781 ± 0.015	0.477CysLys: 0.477 ± 0.01	1.469CysLeu: 1.469 ± 0.019	0.309CysMet: 0.309 ± 0.008	0.449CysAsn: 0.449 ± 0.01	0.702CysPro: 0.702 ± 0.014	0.491CysGln: 0.491 ± 0.01	0.863CysArg: 0.863 ± 0.016	1.042CysSer: 1.042 ± 0.016	0.751CysThr: 0.751 ± 0.013	0.864CysVal: 0.864 ± 0.013	0.231CysTrp: 0.231 ± 0.007	0.4CysTyr: 0.4 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.472AspAla: 4.472 ± 0.034	0.669AspCys: 0.669 ± 0.011	3.903AspAsp: 3.903 ± 0.042	4.179AspGlu: 4.179 ± 0.035	2.137AspPhe: 2.137 ± 0.021	3.942AspGly: 3.942 ± 0.029	1.306AspHis: 1.306 ± 0.016	3.113AspIle: 3.113 ± 0.026	2.123AspLys: 2.123 ± 0.029	5.242AspLeu: 5.242 ± 0.03	1.264AspMet: 1.264 ± 0.015	1.823AspAsn: 1.823 ± 0.02	3.405AspPro: 3.405 ± 0.028	1.955AspGln: 1.955 ± 0.016	3.164AspArg: 3.164 ± 0.03	4.02AspSer: 4.02 ± 0.03	3.002AspThr: 3.002 ± 0.024	3.61AspVal: 3.61 ± 0.028	0.926AspTrp: 0.926 ± 0.012	1.655AspTyr: 1.655 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.081GluAla: 5.081 ± 0.04	0.657GluCys: 0.657 ± 0.011	3.937GluAsp: 3.937 ± 0.029	5.27GluGlu: 5.27 ± 0.055	1.922GluPhe: 1.922 ± 0.02	3.747GluGly: 3.747 ± 0.032	1.358GluHis: 1.358 ± 0.016	3.015GluIle: 3.015 ± 0.027	3.328GluLys: 3.328 ± 0.031	5.056GluLeu: 5.056 ± 0.032	1.481GluMet: 1.481 ± 0.018	2.156GluAsn: 2.156 ± 0.021	2.754GluPro: 2.754 ± 0.043	2.427GluGln: 2.427 ± 0.028	3.876GluArg: 3.876 ± 0.032	4.267GluSer: 4.267 ± 0.031	3.488GluThr: 3.488 ± 0.028	3.614GluVal: 3.614 ± 0.03	0.911GluTrp: 0.911 ± 0.013	1.735GluTyr: 1.735 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.986PheAla: 2.986 ± 0.023	0.617PheCys: 0.617 ± 0.011	2.258PheAsp: 2.258 ± 0.021	2.048PheGlu: 2.048 ± 0.02	1.695PhePhe: 1.695 ± 0.02	2.802PheGly: 2.802 ± 0.027	1.003PheHis: 1.003 ± 0.014	1.881PheIle: 1.881 ± 0.022	1.334PheLys: 1.334 ± 0.019	3.751PheLeu: 3.751 ± 0.028	0.782PheMet: 0.782 ± 0.014	1.389PheAsn: 1.389 ± 0.016	2.096PhePro: 2.096 ± 0.02	1.445PheGln: 1.445 ± 0.018	2.068PheArg: 2.068 ± 0.019	3.074PheSer: 3.074 ± 0.027	2.219PheThr: 2.219 ± 0.022	2.394PheVal: 2.394 ± 0.022	0.676PheTrp: 0.676 ± 0.012	1.171PheTyr: 1.171 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.099GlyAla: 5.099 ± 0.036	0.958GlyCys: 0.958 ± 0.014	3.583GlyAsp: 3.583 ± 0.027	3.649GlyGlu: 3.649 ± 0.03	2.846GlyPhe: 2.846 ± 0.025	5.406GlyGly: 5.406 ± 0.045	1.686GlyHis: 1.686 ± 0.02	3.617GlyIle: 3.617 ± 0.029	3.137GlyLys: 3.137 ± 0.03	6.36GlyLeu: 6.36 ± 0.038	1.637GlyMet: 1.637 ± 0.02	2.407GlyAsn: 2.407 ± 0.024	3.376GlyPro: 3.376 ± 0.029	2.546GlyGln: 2.546 ± 0.023	4.126GlyArg: 4.126 ± 0.03	5.706GlySer: 5.706 ± 0.042	3.961GlyThr: 3.961 ± 0.028	4.554GlyVal: 4.554 ± 0.032	1.254GlyTrp: 1.254 ± 0.015	2.235GlyTyr: 2.235 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.905HisAla: 1.905 ± 0.022	0.365HisCys: 0.365 ± 0.009	1.35HisAsp: 1.35 ± 0.014	1.317HisGlu: 1.317 ± 0.017	0.934HisPhe: 0.934 ± 0.012	1.741HisGly: 1.741 ± 0.02	0.972HisHis: 0.972 ± 0.018	1.285HisIle: 1.285 ± 0.014	0.8HisLys: 0.8 ± 0.013	2.481HisLeu: 2.481 ± 0.025	0.52HisMet: 0.52 ± 0.009	0.846HisAsn: 0.846 ± 0.012	1.888HisPro: 1.888 ± 0.017	1.028HisGln: 1.028 ± 0.013	1.652HisArg: 1.652 ± 0.018	1.893HisSer: 1.893 ± 0.019	1.382HisThr: 1.382 ± 0.016	1.467HisVal: 1.467 ± 0.018	0.389HisTrp: 0.389 ± 0.009	0.751HisTyr: 0.751 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.175IleAla: 4.175 ± 0.033	0.851IleCys: 0.851 ± 0.011	2.833IleAsp: 2.833 ± 0.022	2.76IleGlu: 2.76 ± 0.024	2.078IlePhe: 2.078 ± 0.021	3.269IleGly: 3.269 ± 0.029	1.358IleHis: 1.358 ± 0.016	2.67IleIle: 2.67 ± 0.026	1.964IleLys: 1.964 ± 0.019	4.909IleLeu: 4.909 ± 0.034	1.05IleMet: 1.05 ± 0.016	1.783IleAsn: 1.783 ± 0.018	3.309IlePro: 3.309 ± 0.024	2.018IleGln: 2.018 ± 0.021	2.889IleArg: 2.889 ± 0.024	3.965IleSer: 3.965 ± 0.025	2.976IleThr: 2.976 ± 0.024	3.214IleVal: 3.214 ± 0.025	0.763IleTrp: 0.763 ± 0.012	1.539IleTyr: 1.539 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.707LysAla: 3.707 ± 0.03	0.484LysCys: 0.484 ± 0.01	2.467LysAsp: 2.467 ± 0.032	3.022LysGlu: 3.022 ± 0.028	1.276LysPhe: 1.276 ± 0.015	2.733LysGly: 2.733 ± 0.024	1.024LysHis: 1.024 ± 0.012	2.044LysIle: 2.044 ± 0.022	2.731LysLys: 2.731 ± 0.041	3.692LysLeu: 3.692 ± 0.029	0.913LysMet: 0.913 ± 0.014	1.518LysAsn: 1.518 ± 0.019	2.474LysPro: 2.474 ± 0.025	1.711LysGln: 1.711 ± 0.02	3.131LysArg: 3.131 ± 0.026	3.149LysSer: 3.149 ± 0.027	2.485LysThr: 2.485 ± 0.024	2.666LysVal: 2.666 ± 0.026	0.62LysTrp: 0.62 ± 0.01	1.296LysTyr: 1.296 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.912LeuAla: 7.912 ± 0.041	1.315LeuCys: 1.315 ± 0.016	5.283LeuAsp: 5.283 ± 0.033	5.537LeuGlu: 5.537 ± 0.038	3.534LeuPhe: 3.534 ± 0.031	6.269LeuGly: 6.269 ± 0.042	2.412LeuHis: 2.412 ± 0.018	4.227LeuIle: 4.227 ± 0.038	3.844LeuLys: 3.844 ± 0.031	8.976LeuLeu: 8.976 ± 0.053	1.863LeuMet: 1.863 ± 0.018	3.199LeuAsn: 3.199 ± 0.023	5.713LeuPro: 5.713 ± 0.035	3.991LeuGln: 3.991 ± 0.026	5.963LeuArg: 5.963 ± 0.036	7.781LeuSer: 7.781 ± 0.045	5.146LeuThr: 5.146 ± 0.032	5.734LeuVal: 5.734 ± 0.041	1.283LeuTrp: 1.283 ± 0.018	2.596LeuTyr: 2.596 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.166MetAla: 2.166 ± 0.018	0.25MetCys: 0.25 ± 0.007	1.259MetAsp: 1.259 ± 0.017	1.313MetGlu: 1.313 ± 0.017	0.774MetPhe: 0.774 ± 0.012	1.522MetGly: 1.522 ± 0.018	0.506MetHis: 0.506 ± 0.01	1.065MetIle: 1.065 ± 0.015	0.96MetLys: 0.96 ± 0.014	1.919MetLeu: 1.919 ± 0.019	0.584MetMet: 0.584 ± 0.012	0.8MetAsn: 0.8 ± 0.013	1.235MetPro: 1.235 ± 0.014	0.866MetGln: 0.866 ± 0.014	1.259MetArg: 1.259 ± 0.017	1.897MetSer: 1.897 ± 0.02	1.355MetThr: 1.355 ± 0.015	1.443MetVal: 1.443 ± 0.016	0.275MetTrp: 0.275 ± 0.007	0.553MetTyr: 0.553 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.926AsnAla: 2.926 ± 0.024	0.472AsnCys: 0.472 ± 0.01	1.836AsnAsp: 1.836 ± 0.018	1.897AsnGlu: 1.897 ± 0.022	1.295AsnPhe: 1.295 ± 0.016	2.719AsnGly: 2.719 ± 0.023	0.878AsnHis: 0.878 ± 0.014	2.025AsnIle: 2.025 ± 0.018	1.38AsnLys: 1.38 ± 0.019	3.259AsnLeu: 3.259 ± 0.024	0.81AsnMet: 0.81 ± 0.013	1.398AsnAsn: 1.398 ± 0.02	2.563AsnPro: 2.563 ± 0.021	1.325AsnGln: 1.325 ± 0.015	1.939AsnArg: 1.939 ± 0.019	2.534AsnSer: 2.534 ± 0.022	2.156AsnThr: 2.156 ± 0.022	2.238AsnVal: 2.238 ± 0.021	0.565AsnTrp: 0.565 ± 0.011	1.085AsnTyr: 1.085 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.05ProAla: 5.05 ± 0.038	0.609ProCys: 0.609 ± 0.013	3.339ProAsp: 3.339 ± 0.025	3.844ProGlu: 3.844 ± 0.039	2.153ProPhe: 2.153 ± 0.019	3.968ProGly: 3.968 ± 0.029	1.434ProHis: 1.434 ± 0.017	2.65ProIle: 2.65 ± 0.023	2.375ProLys: 2.375 ± 0.024	4.914ProLeu: 4.914 ± 0.031	1.101ProMet: 1.101 ± 0.014	2.156ProAsn: 2.156 ± 0.02	4.861ProPro: 4.861 ± 0.052	2.415ProGln: 2.415 ± 0.028	3.505ProArg: 3.505 ± 0.031	6.214ProSer: 6.214 ± 0.039	4.13ProThr: 4.13 ± 0.034	3.803ProVal: 3.803 ± 0.034	0.811ProTrp: 0.811 ± 0.012	1.611ProTyr: 1.611 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.405GlnAla: 3.405 ± 0.033	0.496GlnCys: 0.496 ± 0.009	2.036GlnAsp: 2.036 ± 0.02	2.395GlnGlu: 2.395 ± 0.023	1.3GlnPhe: 1.3 ± 0.016	2.421GlnGly: 2.421 ± 0.023	1.071GlnHis: 1.071 ± 0.013	1.938GlnIle: 1.938 ± 0.02	1.847GlnLys: 1.847 ± 0.022	3.552GlnLeu: 3.552 ± 0.029	0.883GlnMet: 0.883 ± 0.013	1.458GlnAsn: 1.458 ± 0.018	2.579GlnPro: 2.579 ± 0.03	2.228GlnGln: 2.228 ± 0.041	2.638GlnArg: 2.638 ± 0.023	3.205GlnSer: 3.205 ± 0.025	2.402GlnThr: 2.402 ± 0.021	2.236GlnVal: 2.236 ± 0.02	0.61GlnTrp: 0.61 ± 0.01	1.196GlnTyr: 1.196 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.592ArgAla: 4.592 ± 0.031	0.807ArgCys: 0.807 ± 0.014	3.365ArgAsp: 3.365 ± 0.03	3.794ArgGlu: 3.794 ± 0.03	2.261ArgPhe: 2.261 ± 0.021	3.784ArgGly: 3.784 ± 0.03	1.621ArgHis: 1.621 ± 0.02	2.948ArgIle: 2.948 ± 0.021	3.203ArgLys: 3.203 ± 0.025	5.815ArgLeu: 5.815 ± 0.035	1.358ArgMet: 1.358 ± 0.014	2.193ArgAsn: 2.193 ± 0.018	3.573ArgPro: 3.573 ± 0.03	2.629ArgGln: 2.629 ± 0.025	5.072ArgArg: 5.072 ± 0.04	4.832ArgSer: 4.832 ± 0.039	3.351ArgThr: 3.351 ± 0.024	3.599ArgVal: 3.599 ± 0.025	1.004ArgTrp: 1.004 ± 0.014	1.783ArgTyr: 1.783 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.523SerAla: 6.523 ± 0.041	0.961SerCys: 0.961 ± 0.015	4.277SerAsp: 4.277 ± 0.028	4.112SerGlu: 4.112 ± 0.032	3.111SerPhe: 3.111 ± 0.026	5.536SerGly: 5.536 ± 0.035	2.065SerHis: 2.065 ± 0.019	4.091SerIle: 4.091 ± 0.026	3.326SerLys: 3.326 ± 0.029	7.674SerLeu: 7.674 ± 0.046	1.734SerMet: 1.734 ± 0.019	2.884SerAsn: 2.884 ± 0.022	5.586SerPro: 5.586 ± 0.045	3.285SerGln: 3.285 ± 0.026	5.055SerArg: 5.055 ± 0.038	8.73SerSer: 8.73 ± 0.075	5.771SerThr: 5.771 ± 0.045	4.764SerVal: 4.764 ± 0.036	1.206SerTrp: 1.206 ± 0.014	2.211SerTyr: 2.211 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.184ThrAla: 5.184 ± 0.028	0.823ThrCys: 0.823 ± 0.014	2.992ThrAsp: 2.992 ± 0.024	3.161ThrGlu: 3.161 ± 0.029	2.266ThrPhe: 2.266 ± 0.019	4.342ThrGly: 4.342 ± 0.032	1.404ThrHis: 1.404 ± 0.017	3.22ThrIle: 3.22 ± 0.024	2.345ThrLys: 2.345 ± 0.023	5.501ThrLeu: 5.501 ± 0.035	1.228ThrMet: 1.228 ± 0.014	2.094ThrAsn: 2.094 ± 0.02	4.322ThrPro: 4.322 ± 0.033	2.113ThrGln: 2.113 ± 0.021	3.179ThrArg: 3.179 ± 0.024	5.372ThrSer: 5.372 ± 0.041	4.562ThrThr: 4.562 ± 0.048	3.928ThrVal: 3.928 ± 0.03	0.916ThrTrp: 0.916 ± 0.013	1.755ThrTyr: 1.755 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.235ValAla: 5.235 ± 0.034	0.907ValCys: 0.907 ± 0.013	3.785ValAsp: 3.785 ± 0.029	3.875ValGlu: 3.875 ± 0.032	2.569ValPhe: 2.569 ± 0.028	4.189ValGly: 4.189 ± 0.032	1.474ValHis: 1.474 ± 0.017	3.104ValIle: 3.104 ± 0.026	2.642ValLys: 2.642 ± 0.026	5.893ValLeu: 5.893 ± 0.037	1.399ValMet: 1.399 ± 0.017	2.208ValAsn: 2.208 ± 0.021	3.667ValPro: 3.667 ± 0.028	2.439ValGln: 2.439 ± 0.022	3.599ValArg: 3.599 ± 0.024	4.871ValSer: 4.871 ± 0.032	3.613ValThr: 3.613 ± 0.029	4.471ValVal: 4.471 ± 0.031	0.926ValTrp: 0.926 ± 0.013	1.871ValTyr: 1.871 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.168TrpAla: 1.168 ± 0.014	0.215TrpCys: 0.215 ± 0.006	0.932TrpAsp: 0.932 ± 0.014	0.882TrpGlu: 0.882 ± 0.012	0.576TrpPhe: 0.576 ± 0.012	0.997TrpGly: 0.997 ± 0.015	0.379TrpHis: 0.379 ± 0.008	0.813TrpIle: 0.813 ± 0.014	0.796TrpLys: 0.796 ± 0.013	1.435TrpLeu: 1.435 ± 0.018	0.412TrpMet: 0.412 ± 0.008	0.661TrpAsn: 0.661 ± 0.011	0.663TrpPro: 0.663 ± 0.011	0.571TrpGln: 0.571 ± 0.011	1.004TrpArg: 1.004 ± 0.014	1.115TrpSer: 1.115 ± 0.014	0.996TrpThr: 0.996 ± 0.015	0.985TrpVal: 0.985 ± 0.013	0.304TrpTrp: 0.304 ± 0.008	0.454TrpTyr: 0.454 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.24TyrAla: 2.24 ± 0.02	0.453TyrCys: 0.453 ± 0.009	1.687TyrAsp: 1.687 ± 0.019	1.572TyrGlu: 1.572 ± 0.018	1.228TyrPhe: 1.228 ± 0.017	2.169TyrGly: 2.169 ± 0.023	0.847TyrHis: 0.847 ± 0.012	1.544TyrIle: 1.544 ± 0.017	1.013TyrLys: 1.013 ± 0.014	2.896TyrLeu: 2.896 ± 0.026	0.672TyrMet: 0.672 ± 0.011	1.156TyrAsn: 1.156 ± 0.014	1.655TyrPro: 1.655 ± 0.019	1.162TyrGln: 1.162 ± 0.015	1.737TyrArg: 1.737 ± 0.016	2.136TyrSer: 2.136 ± 0.021	1.748TyrThr: 1.748 ± 0.017	1.753TyrVal: 1.753 ± 0.02	0.483TyrTrp: 0.483 ± 0.01	1.045TyrTyr: 1.045 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12304 proteins (5731707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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