Amino acid dipepetide frequency for Nitrospina gracilis (strain 3/211)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.677AlaAla: 6.677 ± 0.122	0.981AlaCys: 0.981 ± 0.032	4.225AlaAsp: 4.225 ± 0.079	5.433AlaGlu: 5.433 ± 0.092	3.388AlaPhe: 3.388 ± 0.066	6.149AlaGly: 6.149 ± 0.094	1.721AlaHis: 1.721 ± 0.044	4.41AlaIle: 4.41 ± 0.07	3.827AlaLys: 3.827 ± 0.086	8.959AlaLeu: 8.959 ± 0.127	2.195AlaMet: 2.195 ± 0.046	2.663AlaAsn: 2.663 ± 0.06	3.054AlaPro: 3.054 ± 0.069	2.826AlaGln: 2.826 ± 0.055	4.813AlaArg: 4.813 ± 0.079	4.114AlaSer: 4.114 ± 0.072	3.741AlaThr: 3.741 ± 0.067	6.159AlaVal: 6.159 ± 0.104	0.984AlaTrp: 0.984 ± 0.035	2.225AlaTyr: 2.225 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.732CysAla: 0.732 ± 0.026	0.139CysCys: 0.139 ± 0.014	0.574CysAsp: 0.574 ± 0.03	0.578CysGlu: 0.578 ± 0.025	0.444CysPhe: 0.444 ± 0.022	1.029CysGly: 1.029 ± 0.038	0.371CysHis: 0.371 ± 0.031	0.577CysIle: 0.577 ± 0.03	0.439CysLys: 0.439 ± 0.025	1.009CysLeu: 1.009 ± 0.035	0.259CysMet: 0.259 ± 0.016	0.322CysAsn: 0.322 ± 0.021	0.584CysPro: 0.584 ± 0.026	0.318CysGln: 0.318 ± 0.019	0.713CysArg: 0.713 ± 0.029	0.603CysSer: 0.603 ± 0.026	0.519CysThr: 0.519 ± 0.023	0.598CysVal: 0.598 ± 0.026	0.124CysTrp: 0.124 ± 0.012	0.281CysTyr: 0.281 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.512AspAla: 4.512 ± 0.088	0.615AspCys: 0.615 ± 0.032	2.859AspAsp: 2.859 ± 0.08	3.753AspGlu: 3.753 ± 0.071	2.598AspPhe: 2.598 ± 0.052	3.888AspGly: 3.888 ± 0.069	1.388AspHis: 1.388 ± 0.041	3.419AspIle: 3.419 ± 0.072	2.785AspLys: 2.785 ± 0.065	5.994AspLeu: 5.994 ± 0.087	1.316AspMet: 1.316 ± 0.04	1.834AspAsn: 1.834 ± 0.049	3.3AspPro: 3.3 ± 0.062	1.891AspGln: 1.891 ± 0.047	3.8AspArg: 3.8 ± 0.069	2.802AspSer: 2.802 ± 0.06	2.817AspThr: 2.817 ± 0.068	3.581AspVal: 3.581 ± 0.065	0.83AspTrp: 0.83 ± 0.029	1.875AspTyr: 1.875 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.826GluAla: 5.826 ± 0.098	0.555GluCys: 0.555 ± 0.028	3.763GluAsp: 3.763 ± 0.074	5.623GluGlu: 5.623 ± 0.116	2.729GluPhe: 2.729 ± 0.051	4.907GluGly: 4.907 ± 0.077	1.433GluHis: 1.433 ± 0.043	4.439GluIle: 4.439 ± 0.077	5.085GluLys: 5.085 ± 0.086	5.943GluLeu: 5.943 ± 0.095	1.919GluMet: 1.919 ± 0.047	2.951GluAsn: 2.951 ± 0.055	2.82GluPro: 2.82 ± 0.057	2.594GluGln: 2.594 ± 0.051	3.925GluArg: 3.925 ± 0.084	3.815GluSer: 3.815 ± 0.075	4.057GluThr: 4.057 ± 0.066	4.84GluVal: 4.84 ± 0.093	0.855GluTrp: 0.855 ± 0.029	1.87GluTyr: 1.87 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.112PheAla: 3.112 ± 0.062	0.546PheCys: 0.546 ± 0.027	2.815PheAsp: 2.815 ± 0.061	2.943PheGlu: 2.943 ± 0.062	2.212PhePhe: 2.212 ± 0.056	3.41PheGly: 3.41 ± 0.068	1.154PheHis: 1.154 ± 0.037	2.504PheIle: 2.504 ± 0.056	2.216PheLys: 2.216 ± 0.051	4.849PheLeu: 4.849 ± 0.083	1.069PheMet: 1.069 ± 0.039	1.731PheAsn: 1.731 ± 0.047	2.016PhePro: 2.016 ± 0.048	1.768PheGln: 1.768 ± 0.047	2.52PheArg: 2.52 ± 0.057	2.911PheSer: 2.911 ± 0.058	2.28PheThr: 2.28 ± 0.061	2.924PheVal: 2.924 ± 0.058	0.591PheTrp: 0.591 ± 0.026	1.531PheTyr: 1.531 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.32GlyAla: 5.32 ± 0.096	0.933GlyCys: 0.933 ± 0.033	4.005GlyAsp: 4.005 ± 0.08	4.626GlyGlu: 4.626 ± 0.071	3.734GlyPhe: 3.734 ± 0.068	5.707GlyGly: 5.707 ± 0.097	1.833GlyHis: 1.833 ± 0.043	4.646GlyIle: 4.646 ± 0.085	4.589GlyLys: 4.589 ± 0.09	7.422GlyLeu: 7.422 ± 0.106	2.334GlyMet: 2.334 ± 0.047	2.959GlyAsn: 2.959 ± 0.078	2.635GlyPro: 2.635 ± 0.057	2.562GlyGln: 2.562 ± 0.059	4.278GlyArg: 4.278 ± 0.074	4.006GlySer: 4.006 ± 0.067	4.213GlyThr: 4.213 ± 0.075	5.536GlyVal: 5.536 ± 0.088	1.082GlyTrp: 1.082 ± 0.037	2.316GlyTyr: 2.316 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.759HisAla: 1.759 ± 0.048	0.331HisCys: 0.331 ± 0.02	1.198HisAsp: 1.198 ± 0.035	1.403HisGlu: 1.403 ± 0.041	1.187HisPhe: 1.187 ± 0.039	1.669HisGly: 1.669 ± 0.047	0.727HisHis: 0.727 ± 0.036	1.374HisIle: 1.374 ± 0.037	1.092HisLys: 1.092 ± 0.038	2.582HisLeu: 2.582 ± 0.057	0.548HisMet: 0.548 ± 0.025	0.831HisAsn: 0.831 ± 0.034	1.626HisPro: 1.626 ± 0.046	0.826HisGln: 0.826 ± 0.031	1.457HisArg: 1.457 ± 0.045	1.361HisSer: 1.361 ± 0.043	1.15HisThr: 1.15 ± 0.035	1.434HisVal: 1.434 ± 0.039	0.327HisTrp: 0.327 ± 0.02	0.882HisTyr: 0.882 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.735IleAla: 4.735 ± 0.075	0.594IleCys: 0.594 ± 0.024	3.669IleAsp: 3.669 ± 0.062	4.229IleGlu: 4.229 ± 0.072	2.272IlePhe: 2.272 ± 0.059	4.369IleGly: 4.369 ± 0.084	1.497IleHis: 1.497 ± 0.04	3.009IleIle: 3.009 ± 0.067	2.97IleLys: 2.97 ± 0.061	6.187IleLeu: 6.187 ± 0.098	1.169IleMet: 1.169 ± 0.038	2.135IleAsn: 2.135 ± 0.053	3.053IlePro: 3.053 ± 0.06	2.459IleGln: 2.459 ± 0.055	3.459IleArg: 3.459 ± 0.068	3.069IleSer: 3.069 ± 0.066	2.986IleThr: 2.986 ± 0.056	3.8IleVal: 3.8 ± 0.074	0.578IleTrp: 0.578 ± 0.025	1.586IleTyr: 1.586 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.402LysAla: 4.402 ± 0.091	0.413LysCys: 0.413 ± 0.023	3.163LysAsp: 3.163 ± 0.058	4.562LysGlu: 4.562 ± 0.081	1.876LysPhe: 1.876 ± 0.05	3.782LysGly: 3.782 ± 0.075	1.111LysHis: 1.111 ± 0.041	3.368LysIle: 3.368 ± 0.061	4.437LysLys: 4.437 ± 0.093	4.934LysLeu: 4.934 ± 0.086	1.548LysMet: 1.548 ± 0.04	2.583LysAsn: 2.583 ± 0.056	2.736LysPro: 2.736 ± 0.063	2.252LysGln: 2.252 ± 0.05	3.179LysArg: 3.179 ± 0.051	3.125LysSer: 3.125 ± 0.061	3.402LysThr: 3.402 ± 0.064	3.855LysVal: 3.855 ± 0.082	0.592LysTrp: 0.592 ± 0.026	1.527LysTyr: 1.527 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	8.441LeuAla: 8.441 ± 0.115	0.985LeuCys: 0.985 ± 0.037	5.994LeuAsp: 5.994 ± 0.097	7.062LeuGlu: 7.062 ± 0.109	4.636LeuPhe: 4.636 ± 0.086	7.345LeuGly: 7.345 ± 0.109	2.265LeuHis: 2.265 ± 0.057	5.611LeuIle: 5.611 ± 0.096	6.673LeuLys: 6.673 ± 0.097	9.439LeuLeu: 9.439 ± 0.127	2.584LeuMet: 2.584 ± 0.056	4.205LeuAsn: 4.205 ± 0.074	4.921LeuPro: 4.921 ± 0.07	3.513LeuGln: 3.513 ± 0.061	5.248LeuArg: 5.248 ± 0.08	5.867LeuSer: 5.867 ± 0.081	5.283LeuThr: 5.283 ± 0.077	6.951LeuVal: 6.951 ± 0.102	1.077LeuTrp: 1.077 ± 0.042	2.672LeuTyr: 2.672 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.235MetAla: 2.235 ± 0.05	0.19MetCys: 0.19 ± 0.016	1.613MetAsp: 1.613 ± 0.047	1.952MetGlu: 1.952 ± 0.053	0.907MetPhe: 0.907 ± 0.037	2.055MetGly: 2.055 ± 0.052	0.475MetHis: 0.475 ± 0.023	1.506MetIle: 1.506 ± 0.043	1.822MetLys: 1.822 ± 0.047	2.095MetLeu: 2.095 ± 0.048	0.708MetMet: 0.708 ± 0.031	1.158MetAsn: 1.158 ± 0.04	1.129MetPro: 1.129 ± 0.033	0.942MetGln: 0.942 ± 0.032	1.275MetArg: 1.275 ± 0.036	1.439MetSer: 1.439 ± 0.043	1.486MetThr: 1.486 ± 0.04	2.067MetVal: 2.067 ± 0.051	0.247MetTrp: 0.247 ± 0.017	0.535MetTyr: 0.535 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.852AsnAla: 2.852 ± 0.055	0.389AsnCys: 0.389 ± 0.021	1.833AsnAsp: 1.833 ± 0.046	2.234AsnGlu: 2.234 ± 0.05	1.622AsnPhe: 1.622 ± 0.048	2.992AsnGly: 2.992 ± 0.078	0.965AsnHis: 0.965 ± 0.036	2.308AsnIle: 2.308 ± 0.053	1.888AsnLys: 1.888 ± 0.053	4.457AsnLeu: 4.457 ± 0.079	0.958AsnMet: 0.958 ± 0.032	1.377AsnAsn: 1.377 ± 0.043	2.5AsnPro: 2.5 ± 0.05	1.521AsnGln: 1.521 ± 0.042	2.46AsnArg: 2.46 ± 0.055	1.764AsnSer: 1.764 ± 0.042	1.78AsnThr: 1.78 ± 0.044	2.59AsnVal: 2.59 ± 0.056	0.505AsnTrp: 0.505 ± 0.022	1.132AsnTyr: 1.132 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.868ProAla: 3.868 ± 0.068	0.382ProCys: 0.382 ± 0.022	3.249ProAsp: 3.249 ± 0.063	4.335ProGlu: 4.335 ± 0.074	2.277ProPhe: 2.277 ± 0.053	3.838ProGly: 3.838 ± 0.068	1.219ProHis: 1.219 ± 0.037	2.276ProIle: 2.276 ± 0.055	2.433ProLys: 2.433 ± 0.054	4.237ProLeu: 4.237 ± 0.072	1.142ProMet: 1.142 ± 0.035	1.629ProAsn: 1.629 ± 0.044	2.446ProPro: 2.446 ± 0.066	1.827ProGln: 1.827 ± 0.043	2.208ProArg: 2.208 ± 0.052	2.5ProSer: 2.5 ± 0.057	2.222ProThr: 2.222 ± 0.052	3.932ProVal: 3.932 ± 0.077	0.561ProTrp: 0.561 ± 0.025	1.349ProTyr: 1.349 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.34GlnAla: 3.34 ± 0.069	0.336GlnCys: 0.336 ± 0.018	1.892GlnAsp: 1.892 ± 0.042	2.78GlnGlu: 2.78 ± 0.062	1.629GlnPhe: 1.629 ± 0.045	2.589GlnGly: 2.589 ± 0.061	0.773GlnHis: 0.773 ± 0.032	2.122GlnIle: 2.122 ± 0.049	2.465GlnLys: 2.465 ± 0.055	3.158GlnLeu: 3.158 ± 0.062	0.973GlnMet: 0.973 ± 0.034	1.532GlnAsn: 1.532 ± 0.048	1.82GlnPro: 1.82 ± 0.051	1.372GlnGln: 1.372 ± 0.047	2.114GlnArg: 2.114 ± 0.053	2.063GlnSer: 2.063 ± 0.046	2.004GlnThr: 2.004 ± 0.049	2.747GlnVal: 2.747 ± 0.059	0.447GlnTrp: 0.447 ± 0.021	1.095GlnTyr: 1.095 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.24ArgAla: 4.24 ± 0.084	0.547ArgCys: 0.547 ± 0.024	3.247ArgAsp: 3.247 ± 0.061	4.284ArgGlu: 4.284 ± 0.069	3.147ArgPhe: 3.147 ± 0.055	3.618ArgGly: 3.618 ± 0.07	1.399ArgHis: 1.399 ± 0.04	3.846ArgIle: 3.846 ± 0.066	3.403ArgLys: 3.403 ± 0.068	5.982ArgLeu: 5.982 ± 0.092	1.623ArgMet: 1.623 ± 0.044	2.338ArgAsn: 2.338 ± 0.053	2.365ArgPro: 2.365 ± 0.051	2.289ArgGln: 2.289 ± 0.054	3.305ArgArg: 3.305 ± 0.072	2.827ArgSer: 2.827 ± 0.063	2.844ArgThr: 2.844 ± 0.059	4.151ArgVal: 4.151 ± 0.061	0.78ArgTrp: 0.78 ± 0.027	1.84ArgTyr: 1.84 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.05SerAla: 4.05 ± 0.075	0.542SerCys: 0.542 ± 0.024	2.657SerAsp: 2.657 ± 0.057	3.19SerGlu: 3.19 ± 0.057	2.485SerPhe: 2.485 ± 0.055	4.897SerGly: 4.897 ± 0.085	1.275SerHis: 1.275 ± 0.041	3.286SerIle: 3.286 ± 0.062	2.811SerLys: 2.811 ± 0.053	5.779SerLeu: 5.779 ± 0.09	1.534SerMet: 1.534 ± 0.039	2.051SerAsn: 2.051 ± 0.05	2.811SerPro: 2.811 ± 0.063	1.964SerGln: 1.964 ± 0.053	3.343SerArg: 3.343 ± 0.071	2.914SerSer: 2.914 ± 0.062	2.725SerThr: 2.725 ± 0.057	3.625SerVal: 3.625 ± 0.077	0.702SerTrp: 0.702 ± 0.033	1.447SerTyr: 1.447 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.232ThrAla: 4.232 ± 0.081	0.511ThrCys: 0.511 ± 0.024	2.645ThrAsp: 2.645 ± 0.06	3.141ThrGlu: 3.141 ± 0.062	2.378ThrPhe: 2.378 ± 0.056	4.606ThrGly: 4.606 ± 0.08	1.379ThrHis: 1.379 ± 0.035	2.771ThrIle: 2.771 ± 0.058	2.047ThrLys: 2.047 ± 0.047	6.15ThrLeu: 6.15 ± 0.088	1.153ThrMet: 1.153 ± 0.04	1.618ThrAsn: 1.618 ± 0.05	2.97ThrPro: 2.97 ± 0.064	2.009ThrGln: 2.009 ± 0.049	3.091ThrArg: 3.091 ± 0.05	2.567ThrSer: 2.567 ± 0.06	2.635ThrThr: 2.635 ± 0.061	4.189ThrVal: 4.189 ± 0.071	0.618ThrTrp: 0.618 ± 0.023	1.493ThrTyr: 1.493 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.397ValAla: 5.397 ± 0.085	0.787ValCys: 0.787 ± 0.031	4.084ValAsp: 4.084 ± 0.061	5.116ValGlu: 5.116 ± 0.078	3.454ValPhe: 3.454 ± 0.068	4.84ValGly: 4.84 ± 0.079	1.739ValHis: 1.739 ± 0.04	4.061ValIle: 4.061 ± 0.083	3.68ValLys: 3.68 ± 0.073	7.311ValLeu: 7.311 ± 0.11	1.737ValMet: 1.737 ± 0.054	2.558ValAsn: 2.558 ± 0.056	3.278ValPro: 3.278 ± 0.067	2.6ValGln: 2.6 ± 0.061	4.097ValArg: 4.097 ± 0.071	4.059ValSer: 4.059 ± 0.074	3.951ValThr: 3.951 ± 0.075	5.523ValVal: 5.523 ± 0.095	0.872ValTrp: 0.872 ± 0.036	2.085ValTyr: 2.085 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.884TrpAla: 0.884 ± 0.034	0.112TrpCys: 0.112 ± 0.011	0.676TrpAsp: 0.676 ± 0.031	0.831TrpGlu: 0.831 ± 0.03	0.547TrpPhe: 0.547 ± 0.028	0.893TrpGly: 0.893 ± 0.03	0.252TrpHis: 0.252 ± 0.016	0.739TrpIle: 0.739 ± 0.03	0.76TrpLys: 0.76 ± 0.03	1.172TrpLeu: 1.172 ± 0.04	0.408TrpMet: 0.408 ± 0.021	0.555TrpAsn: 0.555 ± 0.031	0.442TrpPro: 0.442 ± 0.021	0.507TrpGln: 0.507 ± 0.022	0.668TrpArg: 0.668 ± 0.029	0.625TrpSer: 0.625 ± 0.027	0.688TrpThr: 0.688 ± 0.029	1.053TrpVal: 1.053 ± 0.039	0.202TrpTrp: 0.202 ± 0.018	0.388TrpTyr: 0.388 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.93TyrAla: 1.93 ± 0.043	0.325TyrCys: 0.325 ± 0.021	1.698TyrAsp: 1.698 ± 0.053	1.875TyrGlu: 1.875 ± 0.052	1.579TyrPhe: 1.579 ± 0.046	2.15TyrGly: 2.15 ± 0.055	0.786TyrHis: 0.786 ± 0.03	1.554TyrIle: 1.554 ± 0.041	1.424TyrLys: 1.424 ± 0.046	3.114TyrLeu: 3.114 ± 0.067	0.657TyrMet: 0.657 ± 0.027	1.099TyrAsn: 1.099 ± 0.038	1.424TyrPro: 1.424 ± 0.042	1.208TyrGln: 1.208 ± 0.033	2.119TyrArg: 2.119 ± 0.046	1.657TyrSer: 1.657 ± 0.046	1.423TyrThr: 1.423 ± 0.039	1.673TyrVal: 1.673 ± 0.037	0.432TyrTrp: 0.432 ± 0.021	1.095TyrTyr: 1.095 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2962 proteins (888891 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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