Amino acid dipepetide frequency for Thermogemmatispora tikiterensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.26AlaAla: 13.26 ± 0.127	1.355AlaCys: 1.355 ± 0.034	4.186AlaAsp: 4.186 ± 0.057	6.862AlaGlu: 6.862 ± 0.081	3.595AlaPhe: 3.595 ± 0.055	8.494AlaGly: 8.494 ± 0.087	2.368AlaHis: 2.368 ± 0.043	5.419AlaIle: 5.419 ± 0.06	1.565AlaLys: 1.565 ± 0.031	15.437AlaLeu: 15.437 ± 0.135	2.082AlaMet: 2.082 ± 0.039	2.198AlaAsn: 2.198 ± 0.045	5.357AlaPro: 5.357 ± 0.072	5.002AlaGln: 5.002 ± 0.063	9.079AlaArg: 9.079 ± 0.097	6.785AlaSer: 6.785 ± 0.076	5.59AlaThr: 5.59 ± 0.073	7.3AlaVal: 7.3 ± 0.075	1.608AlaTrp: 1.608 ± 0.035	2.829AlaTyr: 2.829 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.012CysAla: 1.012 ± 0.028	0.227CysCys: 0.227 ± 0.014	0.494CysAsp: 0.494 ± 0.016	0.571CysGlu: 0.571 ± 0.022	0.385CysPhe: 0.385 ± 0.016	1.114CysGly: 1.114 ± 0.03	0.259CysHis: 0.259 ± 0.013	0.42CysIle: 0.42 ± 0.018	0.184CysLys: 0.184 ± 0.011	1.257CysLeu: 1.257 ± 0.038	0.168CysMet: 0.168 ± 0.011	0.266CysAsn: 0.266 ± 0.012	0.652CysPro: 0.652 ± 0.021	0.507CysGln: 0.507 ± 0.02	0.719CysArg: 0.719 ± 0.024	0.734CysSer: 0.734 ± 0.025	0.517CysThr: 0.517 ± 0.021	0.566CysVal: 0.566 ± 0.018	0.245CysTrp: 0.245 ± 0.015	0.414CysTyr: 0.414 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.616AspAla: 3.616 ± 0.055	0.394AspCys: 0.394 ± 0.015	1.762AspAsp: 1.762 ± 0.041	3.23AspGlu: 3.23 ± 0.047	1.475AspPhe: 1.475 ± 0.031	3.384AspGly: 3.384 ± 0.055	0.961AspHis: 0.961 ± 0.026	2.007AspIle: 2.007 ± 0.036	0.687AspLys: 0.687 ± 0.023	5.369AspLeu: 5.369 ± 0.053	0.722AspMet: 0.722 ± 0.022	0.851AspAsn: 0.851 ± 0.022	3.135AspPro: 3.135 ± 0.051	1.885AspGln: 1.885 ± 0.038	2.757AspArg: 2.757 ± 0.048	1.879AspSer: 1.879 ± 0.041	1.632AspThr: 1.632 ± 0.032	2.828AspVal: 2.828 ± 0.042	0.772AspTrp: 0.772 ± 0.023	1.5AspTyr: 1.5 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.16GluAla: 8.16 ± 0.096	0.42GluCys: 0.42 ± 0.015	2.359GluAsp: 2.359 ± 0.034	6.069GluGlu: 6.069 ± 0.106	1.317GluPhe: 1.317 ± 0.029	4.524GluGly: 4.524 ± 0.057	1.629GluHis: 1.629 ± 0.031	3.094GluIle: 3.094 ± 0.05	1.587GluLys: 1.587 ± 0.036	7.163GluLeu: 7.163 ± 0.092	1.326GluMet: 1.326 ± 0.027	1.156GluAsn: 1.156 ± 0.029	3.081GluPro: 3.081 ± 0.044	4.613GluGln: 4.613 ± 0.068	6.845GluArg: 6.845 ± 0.097	2.689GluSer: 2.689 ± 0.046	2.973GluThr: 2.973 ± 0.046	4.404GluVal: 4.404 ± 0.061	0.68GluTrp: 0.68 ± 0.023	1.304GluTyr: 1.304 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.366PheAla: 3.366 ± 0.048	0.467PheCys: 0.467 ± 0.016	1.578PheAsp: 1.578 ± 0.033	1.701PheGlu: 1.701 ± 0.032	1.459PhePhe: 1.459 ± 0.041	2.648PheGly: 2.648 ± 0.049	0.747PheHis: 0.747 ± 0.02	1.527PheIle: 1.527 ± 0.032	0.667PheLys: 0.667 ± 0.022	3.917PheLeu: 3.917 ± 0.06	0.584PheMet: 0.584 ± 0.02	0.814PheAsn: 0.814 ± 0.025	1.784PhePro: 1.784 ± 0.034	1.245PheGln: 1.245 ± 0.028	1.843PheArg: 1.843 ± 0.039	2.211PheSer: 2.211 ± 0.037	1.7PheThr: 1.7 ± 0.033	2.292PheVal: 2.292 ± 0.04	0.563PheTrp: 0.563 ± 0.021	1.093PheTyr: 1.093 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	7.039GlyAla: 7.039 ± 0.076	0.88GlyCys: 0.88 ± 0.026	2.981GlyAsp: 2.981 ± 0.045	4.909GlyGlu: 4.909 ± 0.07	2.51GlyPhe: 2.51 ± 0.044	6.232GlyGly: 6.232 ± 0.082	1.751GlyHis: 1.751 ± 0.036	3.65GlyIle: 3.65 ± 0.06	2.308GlyLys: 2.308 ± 0.042	9.44GlyLeu: 9.44 ± 0.093	1.577GlyMet: 1.577 ± 0.032	1.931GlyAsn: 1.931 ± 0.037	3.749GlyPro: 3.749 ± 0.055	4.294GlyGln: 4.294 ± 0.055	5.864GlyArg: 5.864 ± 0.066	5.052GlySer: 5.052 ± 0.067	4.045GlyThr: 4.045 ± 0.056	5.033GlyVal: 5.033 ± 0.063	1.419GlyTrp: 1.419 ± 0.03	2.468GlyTyr: 2.468 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.947HisAla: 1.947 ± 0.034	0.327HisCys: 0.327 ± 0.014	0.951HisAsp: 0.951 ± 0.023	1.373HisGlu: 1.373 ± 0.033	0.906HisPhe: 0.906 ± 0.026	1.775HisGly: 1.775 ± 0.031	0.627HisHis: 0.627 ± 0.021	1.038HisIle: 1.038 ± 0.028	0.402HisLys: 0.402 ± 0.017	3.063HisLeu: 3.063 ± 0.046	0.424HisMet: 0.424 ± 0.019	0.486HisAsn: 0.486 ± 0.018	1.643HisPro: 1.643 ± 0.033	1.056HisGln: 1.056 ± 0.027	1.501HisArg: 1.501 ± 0.036	1.2HisSer: 1.2 ± 0.03	0.94HisThr: 0.94 ± 0.027	1.427HisVal: 1.427 ± 0.031	0.433HisTrp: 0.433 ± 0.019	0.855HisTyr: 0.855 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.481IleAla: 5.481 ± 0.061	0.605IleCys: 0.605 ± 0.019	2.361IleAsp: 2.361 ± 0.042	3.18IleGlu: 3.18 ± 0.048	1.735IlePhe: 1.735 ± 0.041	3.77IleGly: 3.77 ± 0.056	0.982IleHis: 0.982 ± 0.025	2.316IleIle: 2.316 ± 0.045	1.119IleLys: 1.119 ± 0.025	4.688IleLeu: 4.688 ± 0.058	0.804IleMet: 0.804 ± 0.024	1.349IleAsn: 1.349 ± 0.029	2.437IlePro: 2.437 ± 0.042	1.665IleGln: 1.665 ± 0.032	2.883IleArg: 2.883 ± 0.05	2.778IleSer: 2.778 ± 0.043	2.544IleThr: 2.544 ± 0.043	3.699IleVal: 3.699 ± 0.05	0.652IleTrp: 0.652 ± 0.02	1.394IleTyr: 1.394 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.341LysAla: 2.341 ± 0.043	0.13LysCys: 0.13 ± 0.009	0.883LysAsp: 0.883 ± 0.022	1.557LysGlu: 1.557 ± 0.034	0.418LysPhe: 0.418 ± 0.017	1.559LysGly: 1.559 ± 0.034	0.439LysHis: 0.439 ± 0.016	1.014LysIle: 1.014 ± 0.025	0.672LysLys: 0.672 ± 0.022	2.12LysLeu: 2.12 ± 0.043	0.413LysMet: 0.413 ± 0.018	0.489LysAsn: 0.489 ± 0.019	1.262LysPro: 1.262 ± 0.031	1.066LysGln: 1.066 ± 0.029	1.826LysArg: 1.826 ± 0.036	0.97LysSer: 0.97 ± 0.031	1.184LysThr: 1.184 ± 0.03	1.509LysVal: 1.509 ± 0.036	0.191LysTrp: 0.191 ± 0.011	0.525LysTyr: 0.525 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.514LeuAla: 15.514 ± 0.143	1.39LeuCys: 1.39 ± 0.031	5.131LeuAsp: 5.131 ± 0.064	7.522LeuGlu: 7.522 ± 0.079	3.956LeuPhe: 3.956 ± 0.064	8.754LeuGly: 8.754 ± 0.091	2.635LeuHis: 2.635 ± 0.043	5.834LeuIle: 5.834 ± 0.066	2.805LeuLys: 2.805 ± 0.051	17.861LeuLeu: 17.861 ± 0.17	2.036LeuMet: 2.036 ± 0.04	2.709LeuAsn: 2.709 ± 0.043	7.854LeuPro: 7.854 ± 0.083	5.841LeuGln: 5.841 ± 0.07	9.452LeuArg: 9.452 ± 0.099	7.572LeuSer: 7.572 ± 0.066	6.574LeuThr: 6.574 ± 0.061	8.798LeuVal: 8.798 ± 0.089	1.717LeuTrp: 1.717 ± 0.038	3.15LeuTyr: 3.15 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.129MetAla: 2.129 ± 0.039	0.118MetCys: 0.118 ± 0.008	0.686MetAsp: 0.686 ± 0.023	1.053MetGlu: 1.053 ± 0.029	0.409MetPhe: 0.409 ± 0.018	1.292MetGly: 1.292 ± 0.031	0.408MetHis: 0.408 ± 0.016	0.891MetIle: 0.891 ± 0.025	0.514MetLys: 0.514 ± 0.019	2.327MetLeu: 2.327 ± 0.041	0.345MetMet: 0.345 ± 0.016	0.485MetAsn: 0.485 ± 0.017	1.131MetPro: 1.131 ± 0.025	0.915MetGln: 0.915 ± 0.023	1.428MetArg: 1.428 ± 0.027	1.126MetSer: 1.126 ± 0.025	1.131MetThr: 1.131 ± 0.027	1.26MetVal: 1.26 ± 0.035	0.138MetTrp: 0.138 ± 0.009	0.347MetTyr: 0.347 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.287AsnAla: 2.287 ± 0.046	0.218AsnCys: 0.218 ± 0.012	0.963AsnAsp: 0.963 ± 0.024	1.24AsnGlu: 1.24 ± 0.029	0.691AsnPhe: 0.691 ± 0.023	2.144AsnGly: 2.144 ± 0.042	0.457AsnHis: 0.457 ± 0.016	1.136AsnIle: 1.136 ± 0.028	0.46AsnLys: 0.46 ± 0.016	2.55AsnLeu: 2.55 ± 0.042	0.433AsnMet: 0.433 ± 0.017	0.65AsnAsn: 0.65 ± 0.026	1.632AsnPro: 1.632 ± 0.037	0.919AsnGln: 0.919 ± 0.022	1.503AsnArg: 1.503 ± 0.032	1.158AsnSer: 1.158 ± 0.029	1.152AsnThr: 1.152 ± 0.029	1.54AsnVal: 1.54 ± 0.033	0.38AsnTrp: 0.38 ± 0.015	0.721AsnTyr: 0.721 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.137ProAla: 7.137 ± 0.079	0.473ProCys: 0.473 ± 0.02	2.834ProAsp: 2.834 ± 0.044	4.367ProGlu: 4.367 ± 0.061	2.015ProPhe: 2.015 ± 0.038	5.183ProGly: 5.183 ± 0.062	1.259ProHis: 1.259 ± 0.032	2.01ProIle: 2.01 ± 0.038	0.843ProLys: 0.843 ± 0.023	7.135ProLeu: 7.135 ± 0.069	0.828ProMet: 0.828 ± 0.025	1.166ProAsn: 1.166 ± 0.03	3.946ProPro: 3.946 ± 0.067	2.628ProGln: 2.628 ± 0.042	3.749ProArg: 3.749 ± 0.058	3.552ProSer: 3.552 ± 0.061	3.264ProThr: 3.264 ± 0.063	4.056ProVal: 4.056 ± 0.05	0.917ProTrp: 0.917 ± 0.026	1.571ProTyr: 1.571 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	6.408GlnAla: 6.408 ± 0.081	0.333GlnCys: 0.333 ± 0.015	1.652GlnAsp: 1.652 ± 0.031	3.649GlnGlu: 3.649 ± 0.06	1.125GlnPhe: 1.125 ± 0.024	3.721GlnGly: 3.721 ± 0.054	1.177GlnHis: 1.177 ± 0.032	2.127GlnIle: 2.127 ± 0.038	1.016GlnLys: 1.016 ± 0.027	5.552GlnLeu: 5.552 ± 0.064	0.914GlnMet: 0.914 ± 0.027	0.86GlnAsn: 0.86 ± 0.026	3.219GlnPro: 3.219 ± 0.055	3.596GlnGln: 3.596 ± 0.068	4.719GlnArg: 4.719 ± 0.061	2.408GlnSer: 2.408 ± 0.05	2.303GlnThr: 2.303 ± 0.045	3.41GlnVal: 3.41 ± 0.047	0.584GlnTrp: 0.584 ± 0.02	1.016GlnTyr: 1.016 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.622ArgAla: 7.622 ± 0.083	0.907ArgCys: 0.907 ± 0.026	2.925ArgAsp: 2.925 ± 0.048	5.442ArgGlu: 5.442 ± 0.078	2.589ArgPhe: 2.589 ± 0.045	4.929ArgGly: 4.929 ± 0.06	1.844ArgHis: 1.844 ± 0.035	3.246ArgIle: 3.246 ± 0.046	1.593ArgLys: 1.593 ± 0.032	10.914ArgLeu: 10.914 ± 0.116	1.343ArgMet: 1.343 ± 0.033	1.418ArgAsn: 1.418 ± 0.027	4.156ArgPro: 4.156 ± 0.054	4.696ArgGln: 4.696 ± 0.068	7.43ArgArg: 7.43 ± 0.09	4.287ArgSer: 4.287 ± 0.059	3.267ArgThr: 3.267 ± 0.05	4.672ArgVal: 4.672 ± 0.064	1.457ArgTrp: 1.457 ± 0.028	2.515ArgTyr: 2.515 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.008SerAla: 6.008 ± 0.073	0.657SerCys: 0.657 ± 0.024	2.574SerAsp: 2.574 ± 0.04	3.55SerGlu: 3.55 ± 0.054	2.097SerPhe: 2.097 ± 0.033	5.287SerGly: 5.287 ± 0.069	1.153SerHis: 1.153 ± 0.029	2.346SerIle: 2.346 ± 0.043	1.033SerLys: 1.033 ± 0.028	7.175SerLeu: 7.175 ± 0.08	1.184SerMet: 1.184 ± 0.027	1.366SerAsn: 1.366 ± 0.035	3.817SerPro: 3.817 ± 0.053	2.787SerGln: 2.787 ± 0.048	3.643SerArg: 3.643 ± 0.051	4.339SerSer: 4.339 ± 0.087	3.02SerThr: 3.02 ± 0.055	3.415SerVal: 3.415 ± 0.048	1.113SerTrp: 1.113 ± 0.028	1.731SerTyr: 1.731 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.601ThrAla: 5.601 ± 0.072	0.55ThrCys: 0.55 ± 0.02	1.751ThrAsp: 1.751 ± 0.037	2.216ThrGlu: 2.216 ± 0.042	1.954ThrPhe: 1.954 ± 0.037	4.23ThrGly: 4.23 ± 0.06	1.073ThrHis: 1.073 ± 0.028	2.899ThrIle: 2.899 ± 0.053	0.722ThrLys: 0.722 ± 0.022	6.746ThrLeu: 6.746 ± 0.072	0.89ThrMet: 0.89 ± 0.027	1.187ThrAsn: 1.187 ± 0.027	3.818ThrPro: 3.818 ± 0.068	1.803ThrGln: 1.803 ± 0.035	3.311ThrArg: 3.311 ± 0.047	3.029ThrSer: 3.029 ± 0.052	3.021ThrThr: 3.021 ± 0.052	3.928ThrVal: 3.928 ± 0.054	0.752ThrTrp: 0.752 ± 0.022	1.385ThrTyr: 1.385 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.667ValAla: 7.667 ± 0.08	0.717ValCys: 0.717 ± 0.024	2.919ValAsp: 2.919 ± 0.044	4.276ValGlu: 4.276 ± 0.063	2.127ValPhe: 2.127 ± 0.045	4.832ValGly: 4.832 ± 0.063	1.429ValHis: 1.429 ± 0.033	3.757ValIle: 3.757 ± 0.055	1.525ValLys: 1.525 ± 0.033	8.381ValLeu: 8.381 ± 0.088	1.335ValMet: 1.335 ± 0.032	1.724ValAsn: 1.724 ± 0.038	3.805ValPro: 3.805 ± 0.052	2.716ValGln: 2.716 ± 0.042	4.895ValArg: 4.895 ± 0.059	4.04ValSer: 4.04 ± 0.052	3.933ValThr: 3.933 ± 0.061	5.344ValVal: 5.344 ± 0.07	0.885ValTrp: 0.885 ± 0.022	1.773ValTyr: 1.773 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.12TrpAla: 1.12 ± 0.026	0.155TrpCys: 0.155 ± 0.01	0.548TrpAsp: 0.548 ± 0.022	0.883TrpGlu: 0.883 ± 0.025	0.478TrpPhe: 0.478 ± 0.018	0.991TrpGly: 0.991 ± 0.031	0.394TrpHis: 0.394 ± 0.017	0.581TrpIle: 0.581 ± 0.02	0.367TrpLys: 0.367 ± 0.015	2.474TrpLeu: 2.474 ± 0.051	0.304TrpMet: 0.304 ± 0.015	0.393TrpAsn: 0.393 ± 0.018	0.901TrpPro: 0.901 ± 0.028	1.126TrpGln: 1.126 ± 0.03	1.33TrpArg: 1.33 ± 0.034	1.038TrpSer: 1.038 ± 0.024	0.666TrpThr: 0.666 ± 0.022	0.801TrpVal: 0.801 ± 0.024	0.304TrpTrp: 0.304 ± 0.014	0.415TrpTyr: 0.415 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.655TyrAla: 2.655 ± 0.044	0.39TyrCys: 0.39 ± 0.018	1.306TyrAsp: 1.306 ± 0.041	1.746TyrGlu: 1.746 ± 0.037	0.965TyrPhe: 0.965 ± 0.025	2.265TyrGly: 2.265 ± 0.041	0.781TyrHis: 0.781 ± 0.02	1.129TyrIle: 1.129 ± 0.029	0.499TyrLys: 0.499 ± 0.016	3.538TyrLeu: 3.538 ± 0.051	0.424TyrMet: 0.424 ± 0.017	0.736TyrAsn: 0.736 ± 0.025	1.554TyrPro: 1.554 ± 0.034	1.428TyrGln: 1.428 ± 0.034	2.474TyrArg: 2.474 ± 0.044	1.449TyrSer: 1.449 ± 0.031	1.412TyrThr: 1.412 ± 0.031	1.799TyrVal: 1.799 ± 0.037	0.456TyrTrp: 0.456 ± 0.018	1.002TyrTyr: 1.002 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4652 proteins (1557656 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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