Amino acid dipepetide frequency for Gymnopilus dilepis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.087AlaAla: 8.087 ± 0.045	1.062AlaCys: 1.062 ± 0.011	3.893AlaAsp: 3.893 ± 0.025	4.601AlaGlu: 4.601 ± 0.029	3.327AlaPhe: 3.327 ± 0.023	5.072AlaGly: 5.072 ± 0.035	1.914AlaHis: 1.914 ± 0.019	4.039AlaIle: 4.039 ± 0.027	3.732AlaLys: 3.732 ± 0.032	8.093AlaLeu: 8.093 ± 0.04	1.738AlaMet: 1.738 ± 0.018	2.843AlaAsn: 2.843 ± 0.019	5.017AlaPro: 5.017 ± 0.033	3.208AlaGln: 3.208 ± 0.025	4.761AlaArg: 4.761 ± 0.026	7.715AlaSer: 7.715 ± 0.043	4.875AlaThr: 4.875 ± 0.03	4.992AlaVal: 4.992 ± 0.027	1.099AlaTrp: 1.099 ± 0.013	2.153AlaTyr: 2.153 ± 0.019	0.002AlaXaa: 0.002 ± 0.0
Cys	0.902CysAla: 0.902 ± 0.013	0.246CysCys: 0.246 ± 0.006	0.653CysAsp: 0.653 ± 0.011	0.576CysGlu: 0.576 ± 0.01	0.559CysPhe: 0.559 ± 0.009	0.837CysGly: 0.837 ± 0.011	0.389CysHis: 0.389 ± 0.007	0.735CysIle: 0.735 ± 0.011	0.543CysLys: 0.543 ± 0.009	1.388CysLeu: 1.388 ± 0.016	0.247CysMet: 0.247 ± 0.006	0.433CysAsn: 0.433 ± 0.008	0.799CysPro: 0.799 ± 0.012	0.508CysGln: 0.508 ± 0.01	0.843CysArg: 0.843 ± 0.013	1.082CysSer: 1.082 ± 0.015	0.717CysThr: 0.717 ± 0.009	0.756CysVal: 0.756 ± 0.011	0.197CysTrp: 0.197 ± 0.006	0.342CysTyr: 0.342 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.412AspAla: 4.412 ± 0.026	0.668AspCys: 0.668 ± 0.011	4.107AspAsp: 4.107 ± 0.029	4.173AspGlu: 4.173 ± 0.03	2.311AspPhe: 2.311 ± 0.016	3.638AspGly: 3.638 ± 0.023	1.27AspHis: 1.27 ± 0.012	3.188AspIle: 3.188 ± 0.023	2.183AspLys: 2.183 ± 0.02	5.361AspLeu: 5.361 ± 0.033	1.159AspMet: 1.159 ± 0.012	1.816AspAsn: 1.816 ± 0.016	3.441AspPro: 3.441 ± 0.024	1.697AspGln: 1.697 ± 0.015	2.844AspArg: 2.844 ± 0.026	4.176AspSer: 4.176 ± 0.028	2.807AspThr: 2.807 ± 0.02	3.921AspVal: 3.921 ± 0.021	0.867AspTrp: 0.867 ± 0.012	1.477AspTyr: 1.477 ± 0.013	0.001AspXaa: 0.001 ± 0.0
Glu	4.978GluAla: 4.978 ± 0.036	0.669GluCys: 0.669 ± 0.011	4.218GluAsp: 4.218 ± 0.032	5.613GluGlu: 5.613 ± 0.046	1.892GluPhe: 1.892 ± 0.016	3.786GluGly: 3.786 ± 0.027	1.395GluHis: 1.395 ± 0.014	2.941GluIle: 2.941 ± 0.024	3.274GluLys: 3.274 ± 0.025	5.211GluLeu: 5.211 ± 0.032	1.26GluMet: 1.26 ± 0.012	2.022GluAsn: 2.022 ± 0.017	2.685GluPro: 2.685 ± 0.024	2.137GluGln: 2.137 ± 0.019	3.99GluArg: 3.99 ± 0.035	4.047GluSer: 4.047 ± 0.029	2.916GluThr: 2.916 ± 0.022	3.666GluVal: 3.666 ± 0.024	0.888GluTrp: 0.888 ± 0.011	1.529GluTyr: 1.529 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.982PheAla: 2.982 ± 0.022	0.613PheCys: 0.613 ± 0.009	2.336PheAsp: 2.336 ± 0.021	2.169PheGlu: 2.169 ± 0.017	1.756PhePhe: 1.756 ± 0.02	2.647PheGly: 2.647 ± 0.025	0.976PheHis: 0.976 ± 0.013	1.93PheIle: 1.93 ± 0.019	1.637PheLys: 1.637 ± 0.016	3.868PheLeu: 3.868 ± 0.028	0.747PheMet: 0.747 ± 0.01	1.49PheAsn: 1.49 ± 0.016	2.241PhePro: 2.241 ± 0.016	1.403PheGln: 1.403 ± 0.014	2.155PheArg: 2.155 ± 0.019	3.418PheSer: 3.418 ± 0.024	2.105PheThr: 2.105 ± 0.019	2.506PheVal: 2.506 ± 0.02	0.606PheTrp: 0.606 ± 0.01	1.121PheTyr: 1.121 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	4.604GlyAla: 4.604 ± 0.033	0.812GlyCys: 0.812 ± 0.012	3.221GlyAsp: 3.221 ± 0.023	3.259GlyGlu: 3.259 ± 0.025	2.435GlyPhe: 2.435 ± 0.02	5.172GlyGly: 5.172 ± 0.053	1.749GlyHis: 1.749 ± 0.018	3.114GlyIle: 3.114 ± 0.024	3.205GlyLys: 3.205 ± 0.023	5.591GlyLeu: 5.591 ± 0.03	1.39GlyMet: 1.39 ± 0.019	2.286GlyAsn: 2.286 ± 0.02	3.393GlyPro: 3.393 ± 0.025	2.372GlyGln: 2.372 ± 0.024	3.958GlyArg: 3.958 ± 0.023	5.65GlySer: 5.65 ± 0.041	3.636GlyThr: 3.636 ± 0.028	4.063GlyVal: 4.063 ± 0.024	1.004GlyTrp: 1.004 ± 0.014	1.794GlyTyr: 1.794 ± 0.019	0.001GlyXaa: 0.001 ± 0.0
His	1.967HisAla: 1.967 ± 0.018	0.39HisCys: 0.39 ± 0.007	1.343HisAsp: 1.343 ± 0.013	1.291HisGlu: 1.291 ± 0.013	1.057HisPhe: 1.057 ± 0.014	1.633HisGly: 1.633 ± 0.017	0.937HisHis: 0.937 ± 0.019	1.368HisIle: 1.368 ± 0.014	0.903HisLys: 0.903 ± 0.012	2.742HisLeu: 2.742 ± 0.022	0.45HisMet: 0.45 ± 0.007	0.825HisAsn: 0.825 ± 0.011	2.018HisPro: 2.018 ± 0.021	0.983HisGln: 0.983 ± 0.014	1.62HisArg: 1.62 ± 0.018	2.192HisSer: 2.192 ± 0.02	1.363HisThr: 1.363 ± 0.015	1.582HisVal: 1.582 ± 0.014	0.345HisTrp: 0.345 ± 0.007	0.69HisTyr: 0.69 ± 0.009	0.001HisXaa: 0.001 ± 0.0
Ile	3.954IleAla: 3.954 ± 0.026	0.757IleCys: 0.757 ± 0.011	2.788IleAsp: 2.788 ± 0.022	2.688IleGlu: 2.688 ± 0.021	2.123IlePhe: 2.123 ± 0.018	2.822IleGly: 2.822 ± 0.024	1.274IleHis: 1.274 ± 0.013	2.492IleIle: 2.492 ± 0.02	2.06IleLys: 2.06 ± 0.018	4.875IleLeu: 4.875 ± 0.03	0.905IleMet: 0.905 ± 0.011	1.684IleAsn: 1.684 ± 0.015	3.387IlePro: 3.387 ± 0.022	1.92IleGln: 1.92 ± 0.018	2.901IleArg: 2.901 ± 0.017	4.277IleSer: 4.277 ± 0.026	2.741IleThr: 2.741 ± 0.021	3.156IleVal: 3.156 ± 0.024	0.784IleTrp: 0.784 ± 0.011	1.392IleTyr: 1.392 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.276LysAla: 4.276 ± 0.029	0.496LysCys: 0.496 ± 0.009	2.639LysAsp: 2.639 ± 0.023	3.373LysGlu: 3.373 ± 0.027	1.52LysPhe: 1.52 ± 0.016	2.839LysGly: 2.839 ± 0.023	1.111LysHis: 1.111 ± 0.012	2.15LysIle: 2.15 ± 0.019	3.168LysLys: 3.168 ± 0.034	4.044LysLeu: 4.044 ± 0.029	0.904LysMet: 0.904 ± 0.011	1.58LysAsn: 1.58 ± 0.017	2.55LysPro: 2.55 ± 0.022	1.609LysGln: 1.609 ± 0.017	3.319LysArg: 3.319 ± 0.027	3.409LysSer: 3.409 ± 0.026	2.571LysThr: 2.571 ± 0.022	2.746LysVal: 2.746 ± 0.023	0.634LysTrp: 0.634 ± 0.009	1.278LysTyr: 1.278 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.87LeuAla: 7.87 ± 0.032	1.278LeuCys: 1.278 ± 0.015	5.36LeuAsp: 5.36 ± 0.032	5.844LeuGlu: 5.844 ± 0.037	3.576LeuPhe: 3.576 ± 0.027	5.482LeuGly: 5.482 ± 0.031	2.599LeuHis: 2.599 ± 0.024	4.07LeuIle: 4.07 ± 0.028	4.482LeuLys: 4.482 ± 0.028	8.95LeuLeu: 8.95 ± 0.046	1.651LeuMet: 1.651 ± 0.016	3.309LeuAsn: 3.309 ± 0.022	6.659LeuPro: 6.659 ± 0.033	3.992LeuGln: 3.992 ± 0.027	6.262LeuArg: 6.262 ± 0.033	8.545LeuSer: 8.545 ± 0.037	5.383LeuThr: 5.383 ± 0.029	5.615LeuVal: 5.615 ± 0.03	1.239LeuTrp: 1.239 ± 0.014	2.397LeuTyr: 2.397 ± 0.02	0.001LeuXaa: 0.001 ± 0.0
Met	1.743MetAla: 1.743 ± 0.015	0.217MetCys: 0.217 ± 0.006	1.175MetAsp: 1.175 ± 0.013	1.128MetGlu: 1.128 ± 0.015	0.695MetPhe: 0.695 ± 0.01	1.196MetGly: 1.196 ± 0.018	0.48MetHis: 0.48 ± 0.008	0.886MetIle: 0.886 ± 0.011	0.937MetLys: 0.937 ± 0.013	1.706MetLeu: 1.706 ± 0.019	0.429MetMet: 0.429 ± 0.009	0.748MetAsn: 0.748 ± 0.01	1.281MetPro: 1.281 ± 0.012	0.794MetGln: 0.794 ± 0.009	1.184MetArg: 1.184 ± 0.013	1.868MetSer: 1.868 ± 0.017	1.208MetThr: 1.208 ± 0.012	1.105MetVal: 1.105 ± 0.013	0.236MetTrp: 0.236 ± 0.006	0.475MetTyr: 0.475 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.174AsnAla: 3.174 ± 0.023	0.437AsnCys: 0.437 ± 0.008	1.866AsnAsp: 1.866 ± 0.015	1.788AsnGlu: 1.788 ± 0.016	1.445AsnPhe: 1.445 ± 0.014	2.568AsnGly: 2.568 ± 0.027	0.888AsnHis: 0.888 ± 0.01	1.958AsnIle: 1.958 ± 0.016	1.374AsnLys: 1.374 ± 0.013	3.559AsnLeu: 3.559 ± 0.025	0.749AsnMet: 0.749 ± 0.01	1.366AsnAsn: 1.366 ± 0.019	2.458AsnPro: 2.458 ± 0.023	1.221AsnGln: 1.221 ± 0.014	1.778AsnArg: 1.778 ± 0.015	2.864AsnSer: 2.864 ± 0.02	2.113AsnThr: 2.113 ± 0.02	2.377AsnVal: 2.377 ± 0.018	0.501AsnTrp: 0.501 ± 0.008	0.932AsnTyr: 0.932 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	5.467ProAla: 5.467 ± 0.037	0.582ProCys: 0.582 ± 0.011	3.269ProAsp: 3.269 ± 0.023	3.639ProGlu: 3.639 ± 0.024	2.395ProPhe: 2.395 ± 0.017	3.8ProGly: 3.8 ± 0.03	1.62ProHis: 1.62 ± 0.018	2.767ProIle: 2.767 ± 0.02	2.62ProLys: 2.62 ± 0.021	5.651ProLeu: 5.651 ± 0.03	1.047ProMet: 1.047 ± 0.014	2.354ProAsn: 2.354 ± 0.018	6.767ProPro: 6.767 ± 0.067	2.575ProGln: 2.575 ± 0.027	3.662ProArg: 3.662 ± 0.023	7.812ProSer: 7.812 ± 0.048	4.38ProThr: 4.38 ± 0.032	3.781ProVal: 3.781 ± 0.026	0.731ProTrp: 0.731 ± 0.01	1.619ProTyr: 1.619 ± 0.015	0.001ProXaa: 0.001 ± 0.0
Gln	3.338GlnAla: 3.338 ± 0.026	0.481GlnCys: 0.481 ± 0.008	2.048GlnAsp: 2.048 ± 0.018	2.311GlnGlu: 2.311 ± 0.02	1.303GlnPhe: 1.303 ± 0.015	2.326GlnGly: 2.326 ± 0.02	1.111GlnHis: 1.111 ± 0.013	1.798GlnIle: 1.798 ± 0.017	1.739GlnLys: 1.739 ± 0.018	3.42GlnLeu: 3.42 ± 0.026	0.759GlnMet: 0.759 ± 0.012	1.412GlnAsn: 1.412 ± 0.014	2.572GlnPro: 2.572 ± 0.026	2.096GlnGln: 2.096 ± 0.036	2.508GlnArg: 2.508 ± 0.018	3.21GlnSer: 3.21 ± 0.023	2.233GlnThr: 2.233 ± 0.019	2.214GlnVal: 2.214 ± 0.016	0.533GlnTrp: 0.533 ± 0.009	1.023GlnTyr: 1.023 ± 0.011	0.001GlnXaa: 0.001 ± 0.0
Arg	4.633ArgAla: 4.633 ± 0.03	0.803ArgCys: 0.803 ± 0.013	3.102ArgAsp: 3.102 ± 0.026	3.655ArgGlu: 3.655 ± 0.032	2.233ArgPhe: 2.233 ± 0.017	3.425ArgGly: 3.425 ± 0.024	1.709ArgHis: 1.709 ± 0.017	3.075ArgIle: 3.075 ± 0.021	3.418ArgLys: 3.418 ± 0.023	6.021ArgLeu: 6.021 ± 0.033	1.248ArgMet: 1.248 ± 0.012	2.144ArgAsn: 2.144 ± 0.017	3.852ArgPro: 3.852 ± 0.029	2.466ArgGln: 2.466 ± 0.019	5.304ArgArg: 5.304 ± 0.037	5.266ArgSer: 5.266 ± 0.031	3.4ArgThr: 3.4 ± 0.022	3.538ArgVal: 3.538 ± 0.022	0.934ArgTrp: 0.934 ± 0.013	1.661ArgTyr: 1.661 ± 0.015	0.001ArgXaa: 0.001 ± 0.0
Ser	7.105SerAla: 7.105 ± 0.044	1.015SerCys: 1.015 ± 0.014	4.47SerAsp: 4.47 ± 0.032	4.256SerGlu: 4.256 ± 0.029	3.423SerPhe: 3.423 ± 0.027	5.567SerGly: 5.567 ± 0.039	2.182SerHis: 2.182 ± 0.02	4.203SerIle: 4.203 ± 0.024	3.795SerLys: 3.795 ± 0.027	8.496SerLeu: 8.496 ± 0.043	1.703SerMet: 1.703 ± 0.015	3.22SerAsn: 3.22 ± 0.02	6.555SerPro: 6.555 ± 0.053	3.462SerGln: 3.462 ± 0.023	5.495SerArg: 5.495 ± 0.037	11.296SerSer: 11.296 ± 0.081	6.399SerThr: 6.399 ± 0.038	5.042SerVal: 5.042 ± 0.03	1.128SerTrp: 1.128 ± 0.012	2.122SerTyr: 2.122 ± 0.018	0.001SerXaa: 0.001 ± 0.0
Thr	4.75ThrAla: 4.75 ± 0.031	0.772ThrCys: 0.772 ± 0.012	2.715ThrAsp: 2.715 ± 0.022	2.72ThrGlu: 2.72 ± 0.02	2.453ThrPhe: 2.453 ± 0.018	3.659ThrGly: 3.659 ± 0.029	1.406ThrHis: 1.406 ± 0.016	3.034ThrIle: 3.034 ± 0.023	2.364ThrLys: 2.364 ± 0.02	5.67ThrLeu: 5.67 ± 0.031	1.088ThrMet: 1.088 ± 0.013	2.015ThrAsn: 2.015 ± 0.019	4.657ThrPro: 4.657 ± 0.032	2.01ThrGln: 2.01 ± 0.017	3.256ThrArg: 3.256 ± 0.022	6.129ThrSer: 6.129 ± 0.038	4.234ThrThr: 4.234 ± 0.033	3.562ThrVal: 3.562 ± 0.026	0.798ThrTrp: 0.798 ± 0.011	1.546ThrTyr: 1.546 ± 0.017	0.001ThrXaa: 0.001 ± 0.0
Val	4.911ValAla: 4.911 ± 0.03	0.876ValCys: 0.876 ± 0.011	3.802ValAsp: 3.802 ± 0.022	3.791ValGlu: 3.791 ± 0.028	2.471ValPhe: 2.471 ± 0.02	3.7ValGly: 3.7 ± 0.025	1.578ValHis: 1.578 ± 0.016	3.083ValIle: 3.083 ± 0.022	2.913ValLys: 2.913 ± 0.025	5.994ValLeu: 5.994 ± 0.027	1.172ValMet: 1.172 ± 0.015	2.231ValAsn: 2.231 ± 0.016	3.971ValPro: 3.971 ± 0.027	2.469ValGln: 2.469 ± 0.02	3.437ValArg: 3.437 ± 0.022	4.778ValSer: 4.778 ± 0.033	3.299ValThr: 3.299 ± 0.023	4.377ValVal: 4.377 ± 0.03	0.879ValTrp: 0.879 ± 0.013	1.68ValTyr: 1.68 ± 0.018	0.001ValXaa: 0.001 ± 0.0
Trp	1.026TrpAla: 1.026 ± 0.012	0.191TrpCys: 0.191 ± 0.005	0.918TrpAsp: 0.918 ± 0.014	0.818TrpGlu: 0.818 ± 0.011	0.559TrpPhe: 0.559 ± 0.01	0.805TrpGly: 0.805 ± 0.013	0.341TrpHis: 0.341 ± 0.008	0.748TrpIle: 0.748 ± 0.012	0.83TrpLys: 0.83 ± 0.011	1.28TrpLeu: 1.28 ± 0.014	0.319TrpMet: 0.319 ± 0.007	0.624TrpAsn: 0.624 ± 0.01	0.614TrpPro: 0.614 ± 0.009	0.498TrpGln: 0.498 ± 0.009	1.015TrpArg: 1.015 ± 0.014	1.074TrpSer: 1.074 ± 0.012	0.895TrpThr: 0.895 ± 0.012	0.81TrpVal: 0.81 ± 0.01	0.264TrpTrp: 0.264 ± 0.008	0.394TrpTyr: 0.394 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.044TyrAla: 2.044 ± 0.018	0.388TyrCys: 0.388 ± 0.008	1.592TyrAsp: 1.592 ± 0.017	1.419TyrGlu: 1.419 ± 0.015	1.17TyrPhe: 1.17 ± 0.015	1.734TyrGly: 1.734 ± 0.019	0.768TyrHis: 0.768 ± 0.011	1.401TyrIle: 1.401 ± 0.013	1.043TyrLys: 1.043 ± 0.012	2.64TyrLeu: 2.64 ± 0.021	0.525TyrMet: 0.525 ± 0.009	1.015TyrAsn: 1.015 ± 0.013	1.618TyrPro: 1.618 ± 0.015	1.016TyrGln: 1.016 ± 0.013	1.595TyrArg: 1.595 ± 0.016	2.126TyrSer: 2.126 ± 0.019	1.565TyrThr: 1.565 ± 0.015	1.607TyrVal: 1.607 ± 0.016	0.36TyrTrp: 0.36 ± 0.008	0.859TyrTyr: 0.859 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.04XaaXaa: 0.04 ± 0.014

Statistics based on 16218 proteins (7632278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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