Amino acid dipepetide frequency for Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.328AlaAla: 4.328 ± 0.064	0.633AlaCys: 0.633 ± 0.017	2.718AlaAsp: 2.718 ± 0.037	3.258AlaGlu: 3.258 ± 0.044	2.192AlaPhe: 2.192 ± 0.029	3.167AlaGly: 3.167 ± 0.043	1.098AlaHis: 1.098 ± 0.018	3.972AlaIle: 3.972 ± 0.044	4.137AlaLys: 4.137 ± 0.048	4.92AlaLeu: 4.92 ± 0.053	1.155AlaMet: 1.155 ± 0.02	3.129AlaAsn: 3.129 ± 0.037	2.599AlaPro: 2.599 ± 0.039	2.124AlaGln: 2.124 ± 0.035	2.451AlaArg: 2.451 ± 0.033	4.674AlaSer: 4.674 ± 0.048	3.737AlaThr: 3.737 ± 0.044	3.266AlaVal: 3.266 ± 0.043	0.505AlaTrp: 0.505 ± 0.015	1.783AlaTyr: 1.783 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.554CysAla: 0.554 ± 0.016	0.218CysCys: 0.218 ± 0.009	0.657CysAsp: 0.657 ± 0.018	0.548CysGlu: 0.548 ± 0.016	0.596CysPhe: 0.596 ± 0.016	0.793CysGly: 0.793 ± 0.018	0.307CysHis: 0.307 ± 0.011	0.843CysIle: 0.843 ± 0.018	0.674CysLys: 0.674 ± 0.014	1.148CysLeu: 1.148 ± 0.021	0.235CysMet: 0.235 ± 0.011	0.559CysAsn: 0.559 ± 0.016	0.47CysPro: 0.47 ± 0.015	0.393CysGln: 0.393 ± 0.013	0.442CysArg: 0.442 ± 0.014	0.866CysSer: 0.866 ± 0.019	0.544CysThr: 0.544 ± 0.016	0.671CysVal: 0.671 ± 0.016	0.152CysTrp: 0.152 ± 0.008	0.429CysTyr: 0.429 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	2.952AspAla: 2.952 ± 0.037	0.598AspCys: 0.598 ± 0.016	4.807AspAsp: 4.807 ± 0.064	5.285AspGlu: 5.285 ± 0.061	2.694AspPhe: 2.694 ± 0.033	2.715AspGly: 2.715 ± 0.044	1.195AspHis: 1.195 ± 0.027	4.266AspIle: 4.266 ± 0.047	3.859AspLys: 3.859 ± 0.043	5.75AspLeu: 5.75 ± 0.053	1.088AspMet: 1.088 ± 0.024	3.041AspAsn: 3.041 ± 0.032	2.621AspPro: 2.621 ± 0.037	2.065AspGln: 2.065 ± 0.029	1.936AspArg: 1.936 ± 0.027	4.628AspSer: 4.628 ± 0.048	2.873AspThr: 2.873 ± 0.036	3.555AspVal: 3.555 ± 0.039	0.637AspTrp: 0.637 ± 0.016	2.391AspTyr: 2.391 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	3.456GluAla: 3.456 ± 0.049	0.603GluCys: 0.603 ± 0.017	4.439GluAsp: 4.439 ± 0.05	7.03GluGlu: 7.03 ± 0.111	3.112GluPhe: 3.112 ± 0.034	2.789GluGly: 2.789 ± 0.04	1.309GluHis: 1.309 ± 0.021	4.832GluIle: 4.832 ± 0.047	4.627GluLys: 4.627 ± 0.055	6.8GluLeu: 6.8 ± 0.073	1.253GluMet: 1.253 ± 0.022	3.498GluAsn: 3.498 ± 0.038	2.36GluPro: 2.36 ± 0.038	3.053GluGln: 3.053 ± 0.042	2.686GluArg: 2.686 ± 0.036	5.185GluSer: 5.185 ± 0.059	3.66GluThr: 3.66 ± 0.056	3.839GluVal: 3.839 ± 0.041	0.619GluTrp: 0.619 ± 0.015	2.444GluTyr: 2.444 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	2.518PheAla: 2.518 ± 0.033	0.509PheCys: 0.509 ± 0.014	2.884PheAsp: 2.884 ± 0.035	2.84PheGlu: 2.84 ± 0.034	1.912PhePhe: 1.912 ± 0.033	2.81PheGly: 2.81 ± 0.05	1.009PheHis: 1.009 ± 0.022	3.187PheIle: 3.187 ± 0.041	3.16PheLys: 3.16 ± 0.037	3.841PheLeu: 3.841 ± 0.04	0.946PheMet: 0.946 ± 0.018	2.852PheAsn: 2.852 ± 0.039	1.896PhePro: 1.896 ± 0.028	1.804PheGln: 1.804 ± 0.026	1.647PheArg: 1.647 ± 0.025	3.262PheSer: 3.262 ± 0.043	2.723PheThr: 2.723 ± 0.035	2.673PheVal: 2.673 ± 0.035	0.525PheTrp: 0.525 ± 0.016	1.536PheTyr: 1.536 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	3.13GlyAla: 3.13 ± 0.049	0.709GlyCys: 0.709 ± 0.017	2.955GlyAsp: 2.955 ± 0.04	3.09GlyGlu: 3.09 ± 0.038	2.562GlyPhe: 2.562 ± 0.035	3.802GlyGly: 3.802 ± 0.086	1.137GlyHis: 1.137 ± 0.023	3.706GlyIle: 3.706 ± 0.042	3.652GlyLys: 3.652 ± 0.035	4.714GlyLeu: 4.714 ± 0.059	0.969GlyMet: 0.969 ± 0.021	2.818GlyAsn: 2.818 ± 0.048	1.665GlyPro: 1.665 ± 0.03	1.701GlyGln: 1.701 ± 0.029	2.079GlyArg: 2.079 ± 0.036	4.366GlySer: 4.366 ± 0.052	3.012GlyThr: 3.012 ± 0.044	3.322GlyVal: 3.322 ± 0.041	0.658GlyTrp: 0.658 ± 0.016	2.14GlyTyr: 2.14 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	1.092HisAla: 1.092 ± 0.022	0.257HisCys: 0.257 ± 0.011	1.364HisAsp: 1.364 ± 0.022	1.447HisGlu: 1.447 ± 0.028	0.943HisPhe: 0.943 ± 0.017	1.188HisGly: 1.188 ± 0.023	0.862HisHis: 0.862 ± 0.026	1.492HisIle: 1.492 ± 0.025	1.389HisLys: 1.389 ± 0.021	2.084HisLeu: 2.084 ± 0.029	0.393HisMet: 0.393 ± 0.012	1.198HisAsn: 1.198 ± 0.02	1.242HisPro: 1.242 ± 0.021	1.023HisGln: 1.023 ± 0.021	0.953HisArg: 0.953 ± 0.022	1.748HisSer: 1.748 ± 0.029	1.18HisThr: 1.18 ± 0.023	1.16HisVal: 1.16 ± 0.019	0.244HisTrp: 0.244 ± 0.011	0.863HisTyr: 0.863 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.974IleAla: 3.974 ± 0.049	0.805IleCys: 0.805 ± 0.02	4.5IleAsp: 4.5 ± 0.042	4.568IleGlu: 4.568 ± 0.05	2.857IlePhe: 2.857 ± 0.041	3.464IleGly: 3.464 ± 0.046	1.596IleHis: 1.596 ± 0.025	4.739IleIle: 4.739 ± 0.048	4.754IleLys: 4.754 ± 0.047	6.179IleLeu: 6.179 ± 0.053	1.327IleMet: 1.327 ± 0.027	4.163IleAsn: 4.163 ± 0.046	3.699IlePro: 3.699 ± 0.037	2.616IleGln: 2.616 ± 0.035	2.763IleArg: 2.763 ± 0.032	5.79IleSer: 5.79 ± 0.052	4.272IleThr: 4.272 ± 0.044	4.184IleVal: 4.184 ± 0.05	0.693IleTrp: 0.693 ± 0.018	2.314IleTyr: 2.314 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.364LysAla: 3.364 ± 0.04	0.727LysCys: 0.727 ± 0.019	3.649LysAsp: 3.649 ± 0.037	4.715LysGlu: 4.715 ± 0.06	3.307LysPhe: 3.307 ± 0.041	2.811LysGly: 2.811 ± 0.037	1.584LysHis: 1.584 ± 0.024	4.429LysIle: 4.429 ± 0.045	5.727LysLys: 5.727 ± 0.071	7.626LysLeu: 7.626 ± 0.071	1.196LysMet: 1.196 ± 0.023	3.487LysAsn: 3.487 ± 0.038	3.105LysPro: 3.105 ± 0.043	3.318LysGln: 3.318 ± 0.041	3.489LysArg: 3.489 ± 0.045	5.66LysSer: 5.66 ± 0.058	3.63LysThr: 3.63 ± 0.031	4.157LysVal: 4.157 ± 0.041	0.716LysTrp: 0.716 ± 0.017	2.899LysTyr: 2.899 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	5.657LeuAla: 5.657 ± 0.052	1.091LeuCys: 1.091 ± 0.023	5.381LeuAsp: 5.381 ± 0.054	5.803LeuGlu: 5.803 ± 0.057	4.073LeuPhe: 4.073 ± 0.047	4.706LeuGly: 4.706 ± 0.051	2.021LeuHis: 2.021 ± 0.028	6.414LeuIle: 6.414 ± 0.061	6.597LeuLys: 6.597 ± 0.065	8.757LeuLeu: 8.757 ± 0.078	1.849LeuMet: 1.849 ± 0.031	5.534LeuAsn: 5.534 ± 0.062	4.485LeuPro: 4.485 ± 0.049	4.016LeuGln: 4.016 ± 0.043	3.986LeuArg: 3.986 ± 0.041	7.875LeuSer: 7.875 ± 0.068	5.558LeuThr: 5.558 ± 0.051	5.764LeuVal: 5.764 ± 0.058	0.82LeuTrp: 0.82 ± 0.017	3.123LeuTyr: 3.123 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	1.217MetAla: 1.217 ± 0.019	0.218MetCys: 0.218 ± 0.009	1.091MetAsp: 1.091 ± 0.022	1.088MetGlu: 1.088 ± 0.024	0.887MetPhe: 0.887 ± 0.018	1.07MetGly: 1.07 ± 0.021	0.33MetHis: 0.33 ± 0.012	1.326MetIle: 1.326 ± 0.023	1.365MetLys: 1.365 ± 0.023	1.634MetLeu: 1.634 ± 0.026	0.463MetMet: 0.463 ± 0.014	1.196MetAsn: 1.196 ± 0.023	0.751MetPro: 0.751 ± 0.017	0.613MetGln: 0.613 ± 0.017	0.698MetArg: 0.698 ± 0.014	1.914MetSer: 1.914 ± 0.025	1.189MetThr: 1.189 ± 0.026	1.14MetVal: 1.14 ± 0.023	0.175MetTrp: 0.175 ± 0.009	0.64MetTyr: 0.64 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.763AsnAla: 2.763 ± 0.036	0.629AsnCys: 0.629 ± 0.016	3.389AsnAsp: 3.389 ± 0.039	3.701AsnGlu: 3.701 ± 0.045	2.485AsnPhe: 2.485 ± 0.036	3.045AsnGly: 3.045 ± 0.045	1.298AsnHis: 1.298 ± 0.019	3.742AsnIle: 3.742 ± 0.045	3.867AsnLys: 3.867 ± 0.042	5.301AsnLeu: 5.301 ± 0.058	1.019AsnMet: 1.019 ± 0.017	3.6AsnAsn: 3.6 ± 0.058	2.668AsnPro: 2.668 ± 0.035	2.437AsnGln: 2.437 ± 0.035	2.027AsnArg: 2.027 ± 0.03	4.799AsnSer: 4.799 ± 0.052	3.078AsnThr: 3.078 ± 0.035	3.121AsnVal: 3.121 ± 0.036	0.676AsnTrp: 0.676 ± 0.016	2.347AsnTyr: 2.347 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	2.644ProAla: 2.644 ± 0.041	0.346ProCys: 0.346 ± 0.011	2.368ProAsp: 2.368 ± 0.031	3.409ProGlu: 3.409 ± 0.04	1.871ProPhe: 1.871 ± 0.028	2.326ProGly: 2.326 ± 0.047	1.024ProHis: 1.024 ± 0.02	3.234ProIle: 3.234 ± 0.039	3.106ProLys: 3.106 ± 0.042	3.647ProLeu: 3.647 ± 0.035	0.77ProMet: 0.77 ± 0.018	2.484ProAsn: 2.484 ± 0.031	3.237ProPro: 3.237 ± 0.093	2.312ProGln: 2.312 ± 0.053	1.807ProArg: 1.807 ± 0.032	4.087ProSer: 4.087 ± 0.05	3.204ProThr: 3.204 ± 0.044	3.026ProVal: 3.026 ± 0.04	0.401ProTrp: 0.401 ± 0.013	1.498ProTyr: 1.498 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	2.368GlnAla: 2.368 ± 0.033	0.419GlnCys: 0.419 ± 0.014	2.244GlnAsp: 2.244 ± 0.029	3.199GlnGlu: 3.199 ± 0.041	1.998GlnPhe: 1.998 ± 0.028	1.884GlnGly: 1.884 ± 0.03	1.021GlnHis: 1.021 ± 0.024	2.681GlnIle: 2.681 ± 0.031	2.279GlnLys: 2.279 ± 0.031	4.39GlnLeu: 4.39 ± 0.055	0.773GlnMet: 0.773 ± 0.019	1.751GlnAsn: 1.751 ± 0.031	2.189GlnPro: 2.189 ± 0.046	4.048GlnGln: 4.048 ± 0.136	1.747GlnArg: 1.747 ± 0.026	3.118GlnSer: 3.118 ± 0.046	2.141GlnThr: 2.141 ± 0.032	2.467GlnVal: 2.467 ± 0.032	0.398GlnTrp: 0.398 ± 0.012	1.578GlnTyr: 1.578 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.307ArgAla: 2.307 ± 0.031	0.45ArgCys: 0.45 ± 0.014	2.326ArgAsp: 2.326 ± 0.034	2.655ArgGlu: 2.655 ± 0.036	1.911ArgPhe: 1.911 ± 0.028	2.09ArgGly: 2.09 ± 0.043	0.938ArgHis: 0.938 ± 0.023	2.885ArgIle: 2.885 ± 0.036	3.234ArgLys: 3.234 ± 0.04	3.944ArgLeu: 3.944 ± 0.045	0.845ArgMet: 0.845 ± 0.016	2.269ArgAsn: 2.269 ± 0.032	1.597ArgPro: 1.597 ± 0.025	1.781ArgGln: 1.781 ± 0.032	2.427ArgArg: 2.427 ± 0.043	3.161ArgSer: 3.161 ± 0.037	2.164ArgThr: 2.164 ± 0.027	2.313ArgVal: 2.313 ± 0.032	0.407ArgTrp: 0.407 ± 0.014	1.449ArgTyr: 1.449 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	4.351SerAla: 4.351 ± 0.048	0.818SerCys: 0.818 ± 0.017	4.55SerAsp: 4.55 ± 0.05	4.816SerGlu: 4.816 ± 0.055	3.627SerPhe: 3.627 ± 0.041	4.472SerGly: 4.472 ± 0.05	1.788SerHis: 1.788 ± 0.028	6.097SerIle: 6.097 ± 0.053	5.784SerLys: 5.784 ± 0.053	7.598SerLeu: 7.598 ± 0.06	1.588SerMet: 1.588 ± 0.024	4.854SerAsn: 4.854 ± 0.052	4.05SerPro: 4.05 ± 0.065	3.372SerGln: 3.372 ± 0.044	3.481SerArg: 3.481 ± 0.039	9.136SerSer: 9.136 ± 0.106	5.796SerThr: 5.796 ± 0.062	4.598SerVal: 4.598 ± 0.045	0.822SerTrp: 0.822 ± 0.019	2.737SerTyr: 2.737 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	3.315ThrAla: 3.315 ± 0.044	0.659ThrCys: 0.659 ± 0.017	2.827ThrAsp: 2.827 ± 0.036	3.295ThrGlu: 3.295 ± 0.047	2.531ThrPhe: 2.531 ± 0.032	3.332ThrGly: 3.332 ± 0.05	1.233ThrHis: 1.233 ± 0.022	4.303ThrIle: 4.303 ± 0.05	4.14ThrLys: 4.14 ± 0.045	5.054ThrLeu: 5.054 ± 0.046	1.035ThrMet: 1.035 ± 0.02	3.42ThrAsn: 3.42 ± 0.041	3.494ThrPro: 3.494 ± 0.049	2.047ThrGln: 2.047 ± 0.034	2.368ThrArg: 2.368 ± 0.031	5.627ThrSer: 5.627 ± 0.064	4.915ThrThr: 4.915 ± 0.084	3.496ThrVal: 3.496 ± 0.063	0.6ThrTrp: 0.6 ± 0.02	1.913ThrTyr: 1.913 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	3.614ValAla: 3.614 ± 0.042	0.701ValCys: 0.701 ± 0.015	3.816ValAsp: 3.816 ± 0.042	4.054ValGlu: 4.054 ± 0.049	2.594ValPhe: 2.594 ± 0.035	3.149ValGly: 3.149 ± 0.045	1.234ValHis: 1.234 ± 0.022	4.014ValIle: 4.014 ± 0.045	4.162ValLys: 4.162 ± 0.048	5.436ValLeu: 5.436 ± 0.051	1.177ValMet: 1.177 ± 0.023	3.307ValAsn: 3.307 ± 0.032	2.865ValPro: 2.865 ± 0.041	2.056ValGln: 2.056 ± 0.03	2.264ValArg: 2.264 ± 0.032	4.807ValSer: 4.807 ± 0.045	3.389ValThr: 3.389 ± 0.059	3.956ValVal: 3.956 ± 0.048	0.608ValTrp: 0.608 ± 0.018	2.089ValTyr: 2.089 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.504TrpAla: 0.504 ± 0.015	0.207TrpCys: 0.207 ± 0.009	0.641TrpAsp: 0.641 ± 0.017	0.587TrpGlu: 0.587 ± 0.016	0.57TrpPhe: 0.57 ± 0.016	0.563TrpGly: 0.563 ± 0.019	0.206TrpHis: 0.206 ± 0.008	0.705TrpIle: 0.705 ± 0.018	0.779TrpLys: 0.779 ± 0.019	1.024TrpLeu: 1.024 ± 0.021	0.22TrpMet: 0.22 ± 0.009	0.651TrpAsn: 0.651 ± 0.017	0.307TrpPro: 0.307 ± 0.012	0.333TrpGln: 0.333 ± 0.011	0.464TrpArg: 0.464 ± 0.014	0.782TrpSer: 0.782 ± 0.02	0.555TrpThr: 0.555 ± 0.018	0.569TrpVal: 0.569 ± 0.016	0.173TrpTrp: 0.173 ± 0.009	0.415TrpTyr: 0.415 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.738TyrAla: 1.738 ± 0.029	0.504TyrCys: 0.504 ± 0.013	2.35TyrAsp: 2.35 ± 0.034	2.208TyrGlu: 2.208 ± 0.028	1.809TyrPhe: 1.809 ± 0.032	2.011TyrGly: 2.011 ± 0.03	0.929TyrHis: 0.929 ± 0.022	2.392TyrIle: 2.392 ± 0.031	2.305TyrLys: 2.305 ± 0.029	3.664TyrLeu: 3.664 ± 0.043	0.705TyrMet: 0.705 ± 0.017	2.179TyrAsn: 2.179 ± 0.035	1.5TyrPro: 1.5 ± 0.026	1.581TyrGln: 1.581 ± 0.025	1.44TyrArg: 1.44 ± 0.025	2.852TyrSer: 2.852 ± 0.035	1.98TyrThr: 1.98 ± 0.032	2.013TyrVal: 2.013 ± 0.028	0.426TyrTrp: 0.426 ± 0.012	1.585TyrTyr: 1.585 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5973 proteins (2693134 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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