Human papillomavirus type 2a

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 4

Average proteome isoelectric point is 6.24

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P25486|VL1_HPV2A Major capsid protein L1 OS=Human papillomavirus type 2a OX=10584 GN=L1 PE=3 SV=1
MM1 pKa = 7.34HH2 pKa = 7.62GNRR5 pKa = 11.84PSLKK9 pKa = 10.35DD10 pKa = 2.79ITLILDD16 pKa = 4.92EE17 pKa = 4.75IPEE20 pKa = 4.32IVDD23 pKa = 3.46LHH25 pKa = 8.08CDD27 pKa = 3.39EE28 pKa = 5.02QFDD31 pKa = 4.69SSEE34 pKa = 4.2EE35 pKa = 4.14EE36 pKa = 4.09NNHH39 pKa = 5.82QLTEE43 pKa = 4.38PDD45 pKa = 3.3VQAYY49 pKa = 9.44GVVTTCCKK57 pKa = 10.11CGRR60 pKa = 11.84TVRR63 pKa = 11.84LVVEE67 pKa = 5.05CGQADD72 pKa = 3.98LRR74 pKa = 11.84EE75 pKa = 4.19LEE77 pKa = 4.1QLFLKK82 pKa = 9.87TLTLVCPHH90 pKa = 7.05CAA92 pKa = 3.32

Molecular weight: 10.37 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P25484|VE6_HPV2A Protein E6 OS=Human papillomavirus type 2a OX=10584 GN=E6 PE=3 SV=1
MM1 pKa = 7.74EE2 pKa = 6.23DD3 pKa = 3.04SAAPRR8 pKa = 11.84PAPRR12 pKa = 11.84TTNHH16 pKa = 5.79YY17 pKa = 9.8PLLEE21 pKa = 3.98LLYY24 pKa = 9.83PQSQPQSQPQQNQQEE39 pKa = 4.43QEE41 pKa = 4.06EE42 pKa = 4.34QLRR45 pKa = 11.84PPKK48 pKa = 10.22RR49 pKa = 11.84CAPPRR54 pKa = 11.84RR55 pKa = 11.84QRR57 pKa = 11.84VRR59 pKa = 11.84RR60 pKa = 11.84PSASVSSSDD69 pKa = 3.85SSIPGPTLRR78 pKa = 11.84EE79 pKa = 3.44RR80 pKa = 11.84SEE82 pKa = 3.86RR83 pKa = 11.84GKK85 pKa = 10.19WSVTTSGASVTLTAQTPGGATVTLTLCLL113 pKa = 3.75

Molecular weight: 12.42 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2370

92

643

338.6

37.59

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.54 ± 0.674

2.447 ± 0.711

5.865 ± 0.521

5.696 ± 0.719

3.502 ± 0.491

6.962 ± 0.563

2.321 ± 0.286

3.713 ± 0.53

4.304 ± 0.729

8.354 ± 0.412

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.025 ± 0.291

3.165 ± 0.574

7.173 ± 1.279

4.262 ± 0.685

5.696 ± 0.542

8.017 ± 0.631

7.637 ± 0.733

7.131 ± 0.584

1.646 ± 0.415

3.544 ± 0.35
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski