Amino acid dipepetide frequency for Gonium pectorale (Green alga)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	38.589AlaAla: 38.589 ± 0.26	1.836AlaCys: 1.836 ± 0.018	6.497AlaAsp: 6.497 ± 0.034	8.474AlaGlu: 8.474 ± 0.064	3.076AlaPhe: 3.076 ± 0.023	15.716AlaGly: 15.716 ± 0.077	2.303AlaHis: 2.303 ± 0.018	2.925AlaIle: 2.925 ± 0.022	3.59AlaLys: 3.59 ± 0.031	12.819AlaLeu: 12.819 ± 0.057	2.687AlaMet: 2.687 ± 0.02	2.657AlaAsn: 2.657 ± 0.024	9.304AlaPro: 9.304 ± 0.068	4.82AlaGln: 4.82 ± 0.039	7.867AlaArg: 7.867 ± 0.039	10.484AlaSer: 10.484 ± 0.055	7.07AlaThr: 7.07 ± 0.041	10.163AlaVal: 10.163 ± 0.052	1.591AlaTrp: 1.591 ± 0.019	2.123AlaTyr: 2.123 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.629CysAla: 1.629 ± 0.017	0.386CysCys: 0.386 ± 0.008	0.717CysAsp: 0.717 ± 0.011	0.681CysGlu: 0.681 ± 0.008	0.439CysPhe: 0.439 ± 0.008	1.542CysGly: 1.542 ± 0.019	0.302CysHis: 0.302 ± 0.006	0.415CysIle: 0.415 ± 0.007	0.428CysLys: 0.428 ± 0.007	1.451CysLeu: 1.451 ± 0.017	0.305CysMet: 0.305 ± 0.006	0.397CysAsn: 0.397 ± 0.008	0.982CysPro: 0.982 ± 0.015	0.431CysGln: 0.431 ± 0.008	1.052CysArg: 1.052 ± 0.012	1.109CysSer: 1.109 ± 0.015	0.773CysThr: 0.773 ± 0.013	0.995CysVal: 0.995 ± 0.012	0.266CysTrp: 0.266 ± 0.007	0.32CysTyr: 0.32 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.373AspAla: 6.373 ± 0.034	0.701AspCys: 0.701 ± 0.011	3.193AspAsp: 3.193 ± 0.031	3.279AspGlu: 3.279 ± 0.029	1.349AspPhe: 1.349 ± 0.016	5.762AspGly: 5.762 ± 0.041	0.721AspHis: 0.721 ± 0.01	1.371AspIle: 1.371 ± 0.014	1.485AspLys: 1.485 ± 0.022	4.202AspLeu: 4.202 ± 0.028	1.103AspMet: 1.103 ± 0.012	1.019AspAsn: 1.019 ± 0.011	3.171AspPro: 3.171 ± 0.021	1.19AspGln: 1.19 ± 0.013	2.572AspArg: 2.572 ± 0.022	2.969AspSer: 2.969 ± 0.022	2.069AspThr: 2.069 ± 0.018	3.627AspVal: 3.627 ± 0.019	0.762AspTrp: 0.762 ± 0.012	0.994AspTyr: 0.994 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	9.25GluAla: 9.25 ± 0.065	0.601GluCys: 0.601 ± 0.009	2.998GluAsp: 2.998 ± 0.027	5.146GluGlu: 5.146 ± 0.054	1.105GluPhe: 1.105 ± 0.013	4.932GluGly: 4.932 ± 0.031	1.065GluHis: 1.065 ± 0.013	1.121GluIle: 1.121 ± 0.017	1.511GluLys: 1.511 ± 0.021	6.203GluLeu: 6.203 ± 0.037	1.049GluMet: 1.049 ± 0.012	0.822GluAsn: 0.822 ± 0.012	2.957GluPro: 2.957 ± 0.031	2.531GluGln: 2.531 ± 0.023	4.146GluArg: 4.146 ± 0.035	2.516GluSer: 2.516 ± 0.019	1.773GluThr: 1.773 ± 0.017	3.912GluVal: 3.912 ± 0.025	0.803GluTrp: 0.803 ± 0.011	1.076GluTyr: 1.076 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	2.676PheAla: 2.676 ± 0.021	0.431PheCys: 0.431 ± 0.007	1.333PheAsp: 1.333 ± 0.014	1.253PheGlu: 1.253 ± 0.013	0.854PhePhe: 0.854 ± 0.012	2.329PheGly: 2.329 ± 0.022	0.472PheHis: 0.472 ± 0.008	0.769PheIle: 0.769 ± 0.011	0.92PheLys: 0.92 ± 0.012	2.273PheLeu: 2.273 ± 0.02	0.582PheMet: 0.582 ± 0.009	0.806PheAsn: 0.806 ± 0.012	1.206PhePro: 1.206 ± 0.012	0.753PheGln: 0.753 ± 0.011	1.525PheArg: 1.525 ± 0.015	1.705PheSer: 1.705 ± 0.016	1.409PheThr: 1.409 ± 0.017	1.763PheVal: 1.763 ± 0.018	0.351PheTrp: 0.351 ± 0.007	0.61PheTyr: 0.61 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	14.743GlyAla: 14.743 ± 0.079	1.709GlyCys: 1.709 ± 0.019	4.821GlyAsp: 4.821 ± 0.034	4.474GlyGlu: 4.474 ± 0.032	2.184GlyPhe: 2.184 ± 0.021	18.648GlyGly: 18.648 ± 0.154	1.998GlyHis: 1.998 ± 0.02	2.036GlyIle: 2.036 ± 0.018	2.519GlyLys: 2.519 ± 0.023	7.898GlyLeu: 7.898 ± 0.038	1.945GlyMet: 1.945 ± 0.025	2.094GlyAsn: 2.094 ± 0.021	6.374GlyPro: 6.374 ± 0.041	3.098GlyGln: 3.098 ± 0.021	6.715GlyArg: 6.715 ± 0.039	8.942GlySer: 8.942 ± 0.061	4.39GlyThr: 4.39 ± 0.03	5.724GlyVal: 5.724 ± 0.028	1.283GlyTrp: 1.283 ± 0.015	1.797GlyTyr: 1.797 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.35HisAla: 2.35 ± 0.018	0.318HisCys: 0.318 ± 0.007	0.892HisAsp: 0.892 ± 0.012	0.945HisGlu: 0.945 ± 0.012	0.591HisPhe: 0.591 ± 0.009	2.041HisGly: 2.041 ± 0.019	0.785HisHis: 0.785 ± 0.018	0.638HisIle: 0.638 ± 0.01	0.584HisLys: 0.584 ± 0.01	2.038HisLeu: 2.038 ± 0.018	0.499HisMet: 0.499 ± 0.008	0.494HisAsn: 0.494 ± 0.008	1.442HisPro: 1.442 ± 0.016	0.785HisGln: 0.785 ± 0.011	1.39HisArg: 1.39 ± 0.013	1.372HisSer: 1.372 ± 0.014	0.95HisThr: 0.95 ± 0.01	1.497HisVal: 1.497 ± 0.017	0.323HisTrp: 0.323 ± 0.006	0.453HisTyr: 0.453 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.855IleAla: 2.855 ± 0.023	0.391IleCys: 0.391 ± 0.009	1.251IleAsp: 1.251 ± 0.014	1.214IleGlu: 1.214 ± 0.015	0.735IlePhe: 0.735 ± 0.012	1.744IleGly: 1.744 ± 0.016	0.509IleHis: 0.509 ± 0.009	0.892IleIle: 0.892 ± 0.015	1.067IleLys: 1.067 ± 0.016	2.005IleLeu: 2.005 ± 0.019	0.599IleMet: 0.599 ± 0.01	0.82IleAsn: 0.82 ± 0.012	1.274IlePro: 1.274 ± 0.015	0.83IleGln: 0.83 ± 0.011	1.63IleArg: 1.63 ± 0.017	1.762IleSer: 1.762 ± 0.017	1.495IleThr: 1.495 ± 0.017	1.742IleVal: 1.742 ± 0.016	0.301IleTrp: 0.301 ± 0.007	0.576IleTyr: 0.576 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.755LysAla: 3.755 ± 0.035	0.327LysCys: 0.327 ± 0.006	1.466LysAsp: 1.466 ± 0.02	1.896LysGlu: 1.896 ± 0.024	0.662LysPhe: 0.662 ± 0.011	2.2LysGly: 2.2 ± 0.024	0.574LysHis: 0.574 ± 0.009	0.747LysIle: 0.747 ± 0.012	1.473LysLys: 1.473 ± 0.026	2.842LysLeu: 2.842 ± 0.024	0.585LysMet: 0.585 ± 0.011	0.624LysAsn: 0.624 ± 0.011	1.74LysPro: 1.74 ± 0.02	1.236LysGln: 1.236 ± 0.015	2.021LysArg: 2.021 ± 0.02	1.429LysSer: 1.429 ± 0.016	1.195LysThr: 1.195 ± 0.014	1.98LysVal: 1.98 ± 0.02	0.358LysTrp: 0.358 ± 0.007	0.723LysTyr: 0.723 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	13.079LeuAla: 13.079 ± 0.06	1.387LeuCys: 1.387 ± 0.016	4.617LeuAsp: 4.617 ± 0.029	5.729LeuGlu: 5.729 ± 0.038	2.244LeuPhe: 2.244 ± 0.023	7.35LeuGly: 7.35 ± 0.039	2.351LeuHis: 2.351 ± 0.021	2.011LeuIle: 2.011 ± 0.02	2.673LeuLys: 2.673 ± 0.025	11.401LeuLeu: 11.401 ± 0.066	1.921LeuMet: 1.921 ± 0.017	1.929LeuAsn: 1.929 ± 0.018	6.993LeuPro: 6.993 ± 0.038	4.74LeuGln: 4.74 ± 0.031	7.803LeuArg: 7.803 ± 0.043	6.396LeuSer: 6.396 ± 0.035	4.537LeuThr: 4.537 ± 0.029	6.219LeuVal: 6.219 ± 0.036	1.178LeuTrp: 1.178 ± 0.014	1.994LeuTyr: 1.994 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.871MetAla: 2.871 ± 0.023	0.29MetCys: 0.29 ± 0.006	1.014MetAsp: 1.014 ± 0.011	1.216MetGlu: 1.216 ± 0.014	0.494MetPhe: 0.494 ± 0.009	1.675MetGly: 1.675 ± 0.023	0.419MetHis: 0.419 ± 0.007	0.445MetIle: 0.445 ± 0.008	0.519MetLys: 0.519 ± 0.011	2.082MetLeu: 2.082 ± 0.02	0.508MetMet: 0.508 ± 0.015	0.397MetAsn: 0.397 ± 0.007	1.333MetPro: 1.333 ± 0.013	0.918MetGln: 0.918 ± 0.013	1.425MetArg: 1.425 ± 0.012	1.29MetSer: 1.29 ± 0.012	0.89MetThr: 0.89 ± 0.011	1.254MetVal: 1.254 ± 0.014	0.261MetTrp: 0.261 ± 0.006	0.493MetTyr: 0.493 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.506AsnAla: 2.506 ± 0.023	0.347AsnCys: 0.347 ± 0.007	0.965AsnAsp: 0.965 ± 0.01	0.922AsnGlu: 0.922 ± 0.013	0.645AsnPhe: 0.645 ± 0.01	2.369AsnGly: 2.369 ± 0.026	0.392AsnHis: 0.392 ± 0.007	0.81AsnIle: 0.81 ± 0.012	0.825AsnLys: 0.825 ± 0.012	1.925AsnLeu: 1.925 ± 0.019	0.523AsnMet: 0.523 ± 0.01	0.706AsnAsn: 0.706 ± 0.012	1.356AsnPro: 1.356 ± 0.017	0.616AsnGln: 0.616 ± 0.011	1.216AsnArg: 1.216 ± 0.014	1.452AsnSer: 1.452 ± 0.015	1.188AsnThr: 1.188 ± 0.015	1.568AsnVal: 1.568 ± 0.018	0.304AsnTrp: 0.304 ± 0.007	0.514AsnTyr: 0.514 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	10.401ProAla: 10.401 ± 0.061	0.77ProCys: 0.77 ± 0.012	3.151ProAsp: 3.151 ± 0.023	3.636ProGlu: 3.636 ± 0.032	1.419ProPhe: 1.419 ± 0.013	6.811ProGly: 6.811 ± 0.04	1.463ProHis: 1.463 ± 0.016	1.235ProIle: 1.235 ± 0.014	1.464ProLys: 1.464 ± 0.018	6.035ProLeu: 6.035 ± 0.033	1.025ProMet: 1.025 ± 0.013	1.279ProAsn: 1.279 ± 0.015	8.416ProPro: 8.416 ± 0.076	2.699ProGln: 2.699 ± 0.028	3.881ProArg: 3.881 ± 0.027	5.659ProSer: 5.659 ± 0.04	3.092ProThr: 3.092 ± 0.02	3.961ProVal: 3.961 ± 0.029	0.819ProTrp: 0.819 ± 0.012	1.333ProTyr: 1.333 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	5.133GlnAla: 5.133 ± 0.037	0.418GlnCys: 0.418 ± 0.008	1.409GlnAsp: 1.409 ± 0.014	2.191GlnGlu: 2.191 ± 0.02	0.715GlnPhe: 0.715 ± 0.011	2.801GlnGly: 2.801 ± 0.023	1.158GlnHis: 1.158 ± 0.013	0.798GlnIle: 0.798 ± 0.012	0.877GlnLys: 0.877 ± 0.014	4.976GlnLeu: 4.976 ± 0.035	0.714GlnMet: 0.714 ± 0.012	0.581GlnAsn: 0.581 ± 0.009	3.308GlnPro: 3.308 ± 0.027	4.41GlnGln: 4.41 ± 0.07	3.286GlnArg: 3.286 ± 0.024	1.872GlnSer: 1.872 ± 0.017	1.261GlnThr: 1.261 ± 0.014	2.273GlnVal: 2.273 ± 0.022	0.444GlnTrp: 0.444 ± 0.009	0.774GlnTyr: 0.774 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	7.908ArgAla: 7.908 ± 0.04	1.182ArgCys: 1.182 ± 0.012	3.062ArgAsp: 3.062 ± 0.026	3.767ArgGlu: 3.767 ± 0.029	1.679ArgPhe: 1.679 ± 0.015	5.799ArgGly: 5.799 ± 0.035	1.612ArgHis: 1.612 ± 0.017	1.754ArgIle: 1.754 ± 0.019	1.963ArgLys: 1.963 ± 0.019	7.428ArgLeu: 7.428 ± 0.038	1.454ArgMet: 1.454 ± 0.014	1.513ArgAsn: 1.513 ± 0.016	4.409ArgPro: 4.409 ± 0.029	3.056ArgGln: 3.056 ± 0.023	6.35ArgArg: 6.35 ± 0.047	4.704ArgSer: 4.704 ± 0.03	2.859ArgThr: 2.859 ± 0.021	4.149ArgVal: 4.149 ± 0.025	0.967ArgTrp: 0.967 ± 0.012	1.346ArgTyr: 1.346 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	9.949SerAla: 9.949 ± 0.06	1.118SerCys: 1.118 ± 0.014	3.146SerAsp: 3.146 ± 0.022	2.987SerGlu: 2.987 ± 0.022	1.8SerPhe: 1.8 ± 0.016	8.759SerGly: 8.759 ± 0.05	1.274SerHis: 1.274 ± 0.014	1.718SerIle: 1.718 ± 0.017	1.771SerLys: 1.771 ± 0.015	6.299SerLeu: 6.299 ± 0.034	1.29SerMet: 1.29 ± 0.014	1.526SerAsn: 1.526 ± 0.018	5.109SerPro: 5.109 ± 0.041	2.213SerGln: 2.213 ± 0.02	4.545SerArg: 4.545 ± 0.032	6.993SerSer: 6.993 ± 0.056	3.522SerThr: 3.522 ± 0.027	4.238SerVal: 4.238 ± 0.026	0.912SerTrp: 0.912 ± 0.012	1.472SerTyr: 1.472 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	7.624ThrAla: 7.624 ± 0.043	0.771ThrCys: 0.771 ± 0.015	2.095ThrAsp: 2.095 ± 0.017	2.051ThrGlu: 2.051 ± 0.017	1.315ThrPhe: 1.315 ± 0.016	4.414ThrGly: 4.414 ± 0.027	0.893ThrHis: 0.893 ± 0.011	1.366ThrIle: 1.366 ± 0.015	1.19ThrLys: 1.19 ± 0.015	4.27ThrLeu: 4.27 ± 0.028	0.805ThrMet: 0.805 ± 0.01	1.031ThrAsn: 1.031 ± 0.013	3.348ThrPro: 3.348 ± 0.028	1.41ThrGln: 1.41 ± 0.015	2.508ThrArg: 2.508 ± 0.016	3.529ThrSer: 3.529 ± 0.029	2.591ThrThr: 2.591 ± 0.025	3.278ThrVal: 3.278 ± 0.026	0.624ThrTrp: 0.624 ± 0.01	1.037ThrTyr: 1.037 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	9.621ValAla: 9.621 ± 0.045	1.03ValCys: 1.03 ± 0.012	3.247ValAsp: 3.247 ± 0.022	3.829ValGlu: 3.829 ± 0.028	1.777ValPhe: 1.777 ± 0.019	5.184ValGly: 5.184 ± 0.028	1.374ValHis: 1.374 ± 0.013	1.674ValIle: 1.674 ± 0.016	1.908ValLys: 1.908 ± 0.019	6.905ValLeu: 6.905 ± 0.039	1.415ValMet: 1.415 ± 0.014	1.435ValAsn: 1.435 ± 0.016	4.155ValPro: 4.155 ± 0.022	2.414ValGln: 2.414 ± 0.019	4.512ValArg: 4.512 ± 0.028	4.298ValSer: 4.298 ± 0.028	3.432ValThr: 3.432 ± 0.025	5.299ValVal: 5.299 ± 0.04	0.926ValTrp: 0.926 ± 0.012	1.428ValTyr: 1.428 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	1.451TrpAla: 1.451 ± 0.014	0.22TrpCys: 0.22 ± 0.006	0.721TrpAsp: 0.721 ± 0.012	0.748TrpGlu: 0.748 ± 0.01	0.313TrpPhe: 0.313 ± 0.007	1.036TrpGly: 1.036 ± 0.013	0.308TrpHis: 0.308 ± 0.008	0.31TrpIle: 0.31 ± 0.007	0.355TrpLys: 0.355 ± 0.007	1.637TrpLeu: 1.637 ± 0.022	0.28TrpMet: 0.28 ± 0.007	0.313TrpAsn: 0.313 ± 0.008	0.728TrpPro: 0.728 ± 0.009	0.587TrpGln: 0.587 ± 0.009	1.222TrpArg: 1.222 ± 0.014	0.849TrpSer: 0.849 ± 0.011	0.566TrpThr: 0.566 ± 0.009	0.833TrpVal: 0.833 ± 0.011	0.247TrpTrp: 0.247 ± 0.006	0.295TrpTyr: 0.295 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.828TyrAla: 1.828 ± 0.014	0.39TyrCys: 0.39 ± 0.008	1.315TyrAsp: 1.315 ± 0.015	1.081TyrGlu: 1.081 ± 0.014	0.62TyrPhe: 0.62 ± 0.01	2.278TyrGly: 2.278 ± 0.029	0.413TyrHis: 0.413 ± 0.007	0.656TyrIle: 0.656 ± 0.011	0.712TyrLys: 0.712 ± 0.011	1.867TyrLeu: 1.867 ± 0.017	0.506TyrMet: 0.506 ± 0.009	0.705TyrAsn: 0.705 ± 0.012	0.945TyrPro: 0.945 ± 0.013	0.663TyrGln: 0.663 ± 0.01	1.295TyrArg: 1.295 ± 0.016	1.306TyrSer: 1.306 ± 0.014	1.089TyrThr: 1.089 ± 0.015	1.389TyrVal: 1.389 ± 0.015	0.3TyrTrp: 0.3 ± 0.007	0.597TyrTyr: 0.597 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 16224 proteins (8125833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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