Amino acid dipepetide frequency for Mustela putorius furo (European domestic ferret) (Mustela furo)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.021AlaAla: 7.021 ± 0.047	1.487AlaCys: 1.487 ± 0.015	2.904AlaAsp: 2.904 ± 0.017	4.731AlaGlu: 4.731 ± 0.033	2.698AlaPhe: 2.698 ± 0.019	5.166AlaGly: 5.166 ± 0.039	1.626AlaHis: 1.626 ± 0.014	2.718AlaIle: 2.718 ± 0.018	3.287AlaLys: 3.287 ± 0.024	7.371AlaLeu: 7.371 ± 0.04	1.462AlaMet: 1.462 ± 0.013	1.951AlaAsn: 1.951 ± 0.012	4.608AlaPro: 4.608 ± 0.038	3.239AlaGln: 3.239 ± 0.022	3.974AlaArg: 3.974 ± 0.025	5.861AlaSer: 5.861 ± 0.03	3.543AlaThr: 3.543 ± 0.022	4.801AlaVal: 4.801 ± 0.023	0.854AlaTrp: 0.854 ± 0.01	1.532AlaTyr: 1.532 ± 0.014	0.006AlaXaa: 0.006 ± 0.001
Cys	1.366CysAla: 1.366 ± 0.015	0.63CysCys: 0.63 ± 0.009	1.031CysAsp: 1.031 ± 0.015	1.276CysGlu: 1.276 ± 0.017	0.879CysPhe: 0.879 ± 0.01	1.864CysGly: 1.864 ± 0.026	0.685CysHis: 0.685 ± 0.009	0.931CysIle: 0.931 ± 0.011	1.114CysLys: 1.114 ± 0.014	2.228CysLeu: 2.228 ± 0.018	0.422CysMet: 0.422 ± 0.007	0.779CysAsn: 0.779 ± 0.01	1.521CysPro: 1.521 ± 0.024	1.065CysGln: 1.065 ± 0.014	1.364CysArg: 1.364 ± 0.015	2.055CysSer: 2.055 ± 0.018	1.125CysThr: 1.125 ± 0.013	1.362CysVal: 1.362 ± 0.014	0.311CysTrp: 0.311 ± 0.006	0.591CysTyr: 0.591 ± 0.009	0.001CysXaa: 0.001 ± 0.0
Asp	2.798AspAla: 2.798 ± 0.019	1.046AspCys: 1.046 ± 0.012	2.443AspAsp: 2.443 ± 0.02	3.248AspGlu: 3.248 ± 0.023	2.08AspPhe: 2.08 ± 0.017	3.287AspGly: 3.287 ± 0.028	1.128AspHis: 1.128 ± 0.012	2.488AspIle: 2.488 ± 0.019	2.387AspLys: 2.387 ± 0.016	4.883AspLeu: 4.883 ± 0.029	1.075AspMet: 1.075 ± 0.01	1.591AspAsn: 1.591 ± 0.015	2.968AspPro: 2.968 ± 0.017	1.767AspGln: 1.767 ± 0.015	2.474AspArg: 2.474 ± 0.019	4.046AspSer: 4.046 ± 0.025	2.418AspThr: 2.418 ± 0.017	2.982AspVal: 2.982 ± 0.025	0.623AspTrp: 0.623 ± 0.009	1.39AspTyr: 1.39 ± 0.013	0.001AspXaa: 0.001 ± 0.0
Glu	5.232GluAla: 5.232 ± 0.033	1.436GluCys: 1.436 ± 0.028	4.276GluAsp: 4.276 ± 0.026	7.653GluGlu: 7.653 ± 0.059	1.997GluPhe: 1.997 ± 0.014	4.283GluGly: 4.283 ± 0.026	1.473GluHis: 1.473 ± 0.014	2.995GluIle: 2.995 ± 0.024	5.166GluLys: 5.166 ± 0.041	6.267GluLeu: 6.267 ± 0.04	1.571GluMet: 1.571 ± 0.015	2.955GluAsn: 2.955 ± 0.022	3.351GluPro: 3.351 ± 0.031	3.017GluGln: 3.017 ± 0.025	3.99GluArg: 3.99 ± 0.026	4.248GluSer: 4.248 ± 0.025	3.298GluThr: 3.298 ± 0.022	4.089GluVal: 4.089 ± 0.028	0.697GluTrp: 0.697 ± 0.009	1.505GluTyr: 1.505 ± 0.018	0.002GluXaa: 0.002 ± 0.0
Phe	2.005PheAla: 2.005 ± 0.016	1.014PheCys: 1.014 ± 0.012	1.612PheAsp: 1.612 ± 0.013	1.938PheGlu: 1.938 ± 0.017	1.751PhePhe: 1.751 ± 0.016	2.238PheGly: 2.238 ± 0.02	1.043PheHis: 1.043 ± 0.011	1.88PheIle: 1.88 ± 0.017	1.716PheLys: 1.716 ± 0.017	4.338PheLeu: 4.338 ± 0.03	0.76PheMet: 0.76 ± 0.01	1.291PheAsn: 1.291 ± 0.011	2.099PhePro: 2.099 ± 0.017	1.789PheGln: 1.789 ± 0.014	2.002PheArg: 2.002 ± 0.017	3.523PheSer: 3.523 ± 0.023	2.025PheThr: 2.025 ± 0.016	2.174PheVal: 2.174 ± 0.017	0.512PheTrp: 0.512 ± 0.008	1.234PheTyr: 1.234 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	4.892GlyAla: 4.892 ± 0.034	1.363GlyCys: 1.363 ± 0.017	3.148GlyAsp: 3.148 ± 0.024	4.201GlyGlu: 4.201 ± 0.038	2.48GlyPhe: 2.48 ± 0.022	5.406GlyGly: 5.406 ± 0.043	1.774GlyHis: 1.774 ± 0.014	2.701GlyIle: 2.701 ± 0.017	3.756GlyLys: 3.756 ± 0.031	6.194GlyLeu: 6.194 ± 0.037	1.266GlyMet: 1.266 ± 0.014	2.344GlyAsn: 2.344 ± 0.018	4.718GlyPro: 4.718 ± 0.066	2.865GlyGln: 2.865 ± 0.023	4.134GlyArg: 4.134 ± 0.027	5.987GlySer: 5.987 ± 0.039	3.654GlyThr: 3.654 ± 0.028	3.672GlyVal: 3.672 ± 0.025	0.847GlyTrp: 0.847 ± 0.013	1.709GlyTyr: 1.709 ± 0.021	0.005GlyXaa: 0.005 ± 0.001
His	1.356HisAla: 1.356 ± 0.014	0.726HisCys: 0.726 ± 0.011	0.855HisAsp: 0.855 ± 0.01	1.268HisGlu: 1.268 ± 0.012	1.127HisPhe: 1.127 ± 0.01	1.61HisGly: 1.61 ± 0.015	0.899HisHis: 0.899 ± 0.016	1.213HisIle: 1.213 ± 0.013	1.191HisLys: 1.191 ± 0.012	2.983HisLeu: 2.983 ± 0.024	0.572HisMet: 0.572 ± 0.008	0.825HisAsn: 0.825 ± 0.01	1.708HisPro: 1.708 ± 0.016	1.348HisGln: 1.348 ± 0.017	1.666HisArg: 1.666 ± 0.014	2.289HisSer: 2.289 ± 0.019	1.555HisThr: 1.555 ± 0.02	1.516HisVal: 1.516 ± 0.014	0.368HisTrp: 0.368 ± 0.006	0.813HisTyr: 0.813 ± 0.01	0.001HisXaa: 0.001 ± 0.0
Ile	2.471IleAla: 2.471 ± 0.019	1.108IleCys: 1.108 ± 0.013	1.894IleAsp: 1.894 ± 0.016	2.401IleGlu: 2.401 ± 0.024	1.928IlePhe: 1.928 ± 0.017	2.133IleGly: 2.133 ± 0.015	1.325IleHis: 1.325 ± 0.017	2.371IleIle: 2.371 ± 0.021	2.477IleLys: 2.477 ± 0.021	4.609IleLeu: 4.609 ± 0.024	0.983IleMet: 0.983 ± 0.01	1.714IleAsn: 1.714 ± 0.014	2.559IlePro: 2.559 ± 0.02	2.19IleGln: 2.19 ± 0.018	2.322IleArg: 2.322 ± 0.016	3.647IleSer: 3.647 ± 0.022	2.484IleThr: 2.484 ± 0.022	2.45IleVal: 2.45 ± 0.019	0.518IleTrp: 0.518 ± 0.008	1.427IleTyr: 1.427 ± 0.014	0.001IleXaa: 0.001 ± 0.0
Lys	3.957LysAla: 3.957 ± 0.027	1.1LysCys: 1.1 ± 0.015	3.002LysAsp: 3.002 ± 0.024	4.896LysGlu: 4.896 ± 0.041	1.667LysPhe: 1.667 ± 0.019	3.206LysGly: 3.206 ± 0.037	1.347LysHis: 1.347 ± 0.015	2.669LysIle: 2.669 ± 0.023	4.577LysLys: 4.577 ± 0.041	4.961LysLeu: 4.961 ± 0.032	1.413LysMet: 1.413 ± 0.016	2.298LysAsn: 2.298 ± 0.017	3.094LysPro: 3.094 ± 0.026	2.465LysGln: 2.465 ± 0.021	3.199LysArg: 3.199 ± 0.018	3.75LysSer: 3.75 ± 0.024	2.993LysThr: 2.993 ± 0.021	3.33LysVal: 3.33 ± 0.028	0.585LysTrp: 0.585 ± 0.01	1.51LysTyr: 1.51 ± 0.015	0.002LysXaa: 0.002 ± 0.0
Leu	7.047LeuAla: 7.047 ± 0.036	2.272LeuCys: 2.272 ± 0.018	4.621LeuAsp: 4.621 ± 0.026	7.06LeuGlu: 7.06 ± 0.043	3.497LeuPhe: 3.497 ± 0.026	6.205LeuGly: 6.205 ± 0.032	2.775LeuHis: 2.775 ± 0.018	3.891LeuIle: 3.891 ± 0.022	5.617LeuLys: 5.617 ± 0.039	11.086LeuLeu: 11.086 ± 0.064	1.967LeuMet: 1.967 ± 0.017	3.406LeuAsn: 3.406 ± 0.022	6.254LeuPro: 6.254 ± 0.039	5.655LeuGln: 5.655 ± 0.043	6.174LeuArg: 6.174 ± 0.032	8.142LeuSer: 8.142 ± 0.035	5.133LeuThr: 5.133 ± 0.023	5.649LeuVal: 5.649 ± 0.029	1.196LeuTrp: 1.196 ± 0.013	2.534LeuTyr: 2.534 ± 0.02	0.003LeuXaa: 0.003 ± 0.001
Met	1.914MetAla: 1.914 ± 0.016	0.395MetCys: 0.395 ± 0.007	1.195MetAsp: 1.195 ± 0.012	1.761MetGlu: 1.761 ± 0.016	0.726MetPhe: 0.726 ± 0.009	1.281MetGly: 1.281 ± 0.013	0.435MetHis: 0.435 ± 0.007	0.822MetIle: 0.822 ± 0.009	1.39MetLys: 1.39 ± 0.015	1.954MetLeu: 1.954 ± 0.015	0.535MetMet: 0.535 ± 0.007	0.857MetAsn: 0.857 ± 0.01	1.057MetPro: 1.057 ± 0.014	0.866MetGln: 0.866 ± 0.01	1.033MetArg: 1.033 ± 0.011	1.508MetSer: 1.508 ± 0.012	1.082MetThr: 1.082 ± 0.011	1.377MetVal: 1.377 ± 0.013	0.238MetTrp: 0.238 ± 0.004	0.621MetTyr: 0.621 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	1.957AsnAla: 1.957 ± 0.014	0.811AsnCys: 0.811 ± 0.01	1.41AsnAsp: 1.41 ± 0.015	2.074AsnGlu: 2.074 ± 0.017	1.46AsnPhe: 1.46 ± 0.012	2.319AsnGly: 2.319 ± 0.022	0.937AsnHis: 0.937 ± 0.011	2.018AsnIle: 2.018 ± 0.016	2.102AsnLys: 2.102 ± 0.018	3.609AsnLeu: 3.609 ± 0.024	0.859AsnMet: 0.859 ± 0.011	1.417AsnAsn: 1.417 ± 0.016	2.185AsnPro: 2.185 ± 0.017	1.585AsnGln: 1.585 ± 0.016	1.786AsnArg: 1.786 ± 0.015	2.941AsnSer: 2.941 ± 0.02	1.869AsnThr: 1.869 ± 0.015	2.133AsnVal: 2.133 ± 0.017	0.439AsnTrp: 0.439 ± 0.007	1.071AsnTyr: 1.071 ± 0.011	0.002AsnXaa: 0.002 ± 0.0
Pro	5.248ProAla: 5.248 ± 0.043	1.27ProCys: 1.27 ± 0.019	2.811ProAsp: 2.811 ± 0.019	4.556ProGlu: 4.556 ± 0.03	1.987ProPhe: 1.987 ± 0.018	5.799ProGly: 5.799 ± 0.091	1.506ProHis: 1.506 ± 0.014	1.805ProIle: 1.805 ± 0.017	2.807ProLys: 2.807 ± 0.026	5.548ProLeu: 5.548 ± 0.034	1.098ProMet: 1.098 ± 0.013	1.748ProAsn: 1.748 ± 0.014	6.47ProPro: 6.47 ± 0.075	2.915ProGln: 2.915 ± 0.024	3.803ProArg: 3.803 ± 0.027	5.861ProSer: 5.861 ± 0.042	3.121ProThr: 3.121 ± 0.027	3.853ProVal: 3.853 ± 0.027	0.757ProTrp: 0.757 ± 0.011	1.501ProTyr: 1.501 ± 0.02	0.006ProXaa: 0.006 ± 0.001
Gln	3.526GlnAla: 3.526 ± 0.025	0.941GlnCys: 0.941 ± 0.012	2.288GlnAsp: 2.288 ± 0.017	3.807GlnGlu: 3.807 ± 0.029	1.315GlnPhe: 1.315 ± 0.012	2.909GlnGly: 2.909 ± 0.025	1.272GlnHis: 1.272 ± 0.014	1.933GlnIle: 1.933 ± 0.015	2.871GlnLys: 2.871 ± 0.021	4.64GlnLeu: 4.64 ± 0.031	1.071GlnMet: 1.071 ± 0.011	1.78GlnAsn: 1.78 ± 0.016	2.823GlnPro: 2.823 ± 0.025	2.812GlnGln: 2.812 ± 0.033	3.026GlnArg: 3.026 ± 0.023	3.026GlnSer: 3.026 ± 0.022	2.254GlnThr: 2.254 ± 0.017	2.771GlnVal: 2.771 ± 0.018	0.54GlnTrp: 0.54 ± 0.007	1.088GlnTyr: 1.088 ± 0.01	0.003GlnXaa: 0.003 ± 0.0
Arg	4.255ArgAla: 4.255 ± 0.028	1.286ArgCys: 1.286 ± 0.016	2.76ArgAsp: 2.76 ± 0.021	4.066ArgGlu: 4.066 ± 0.029	1.878ArgPhe: 1.878 ± 0.015	4.009ArgGly: 4.009 ± 0.033	1.571ArgHis: 1.571 ± 0.014	2.371ArgIle: 2.371 ± 0.019	3.659ArgLys: 3.659 ± 0.022	5.57ArgLeu: 5.57 ± 0.031	1.152ArgMet: 1.152 ± 0.011	2.1ArgAsn: 2.1 ± 0.016	3.587ArgPro: 3.587 ± 0.025	2.641ArgGln: 2.641 ± 0.02	4.63ArgArg: 4.63 ± 0.028	4.364ArgSer: 4.364 ± 0.029	2.901ArgThr: 2.901 ± 0.016	3.252ArgVal: 3.252 ± 0.021	0.742ArgTrp: 0.742 ± 0.009	1.477ArgTyr: 1.477 ± 0.012	0.004ArgXaa: 0.004 ± 0.001
Ser	5.397SerAla: 5.397 ± 0.03	1.923SerCys: 1.923 ± 0.018	3.729SerAsp: 3.729 ± 0.024	5.029SerGlu: 5.029 ± 0.033	3.127SerPhe: 3.127 ± 0.016	5.798SerGly: 5.798 ± 0.038	2.151SerHis: 2.151 ± 0.017	3.106SerIle: 3.106 ± 0.02	3.909SerLys: 3.909 ± 0.025	8.31SerLeu: 8.31 ± 0.04	1.527SerMet: 1.527 ± 0.012	2.526SerAsn: 2.526 ± 0.016	6.192SerPro: 6.192 ± 0.051	3.794SerGln: 3.794 ± 0.026	4.696SerArg: 4.696 ± 0.029	9.098SerSer: 9.098 ± 0.069	4.313SerThr: 4.313 ± 0.027	4.926SerVal: 4.926 ± 0.025	1.125SerTrp: 1.125 ± 0.012	2.089SerTyr: 2.089 ± 0.018	0.004SerXaa: 0.004 ± 0.001
Thr	3.782ThrAla: 3.782 ± 0.024	1.364ThrCys: 1.364 ± 0.015	2.376ThrAsp: 2.376 ± 0.018	3.427ThrGlu: 3.427 ± 0.022	2.148ThrPhe: 2.148 ± 0.018	3.602ThrGly: 3.602 ± 0.027	1.314ThrHis: 1.314 ± 0.013	2.327ThrIle: 2.327 ± 0.018	2.528ThrLys: 2.528 ± 0.022	5.281ThrLeu: 5.281 ± 0.024	1.085ThrMet: 1.085 ± 0.012	1.639ThrAsn: 1.639 ± 0.014	3.613ThrPro: 3.613 ± 0.028	2.263ThrGln: 2.263 ± 0.017	2.542ThrArg: 2.542 ± 0.017	4.468ThrSer: 4.468 ± 0.03	2.882ThrThr: 2.882 ± 0.029	3.881ThrVal: 3.881 ± 0.028	0.708ThrTrp: 0.708 ± 0.011	1.396ThrTyr: 1.396 ± 0.012	0.003ThrXaa: 0.003 ± 0.0
Val	4.361ValAla: 4.361 ± 0.026	1.492ValCys: 1.492 ± 0.016	2.841ValAsp: 2.841 ± 0.023	3.66ValGlu: 3.66 ± 0.026	2.467ValPhe: 2.467 ± 0.022	3.51ValGly: 3.51 ± 0.021	1.577ValHis: 1.577 ± 0.013	2.893ValIle: 2.893 ± 0.021	3.241ValLys: 3.241 ± 0.026	6.413ValLeu: 6.413 ± 0.032	1.316ValMet: 1.316 ± 0.012	2.176ValAsn: 2.176 ± 0.018	3.793ValPro: 3.793 ± 0.03	2.671ValGln: 2.671 ± 0.018	3.127ValArg: 3.127 ± 0.019	4.883ValSer: 4.883 ± 0.027	3.799ValThr: 3.799 ± 0.032	4.026ValVal: 4.026 ± 0.028	0.739ValTrp: 0.739 ± 0.01	1.597ValTyr: 1.597 ± 0.015	0.001ValXaa: 0.001 ± 0.0
Trp	0.853TrpAla: 0.853 ± 0.01	0.25TrpCys: 0.25 ± 0.005	0.665TrpAsp: 0.665 ± 0.008	0.818TrpGlu: 0.818 ± 0.009	0.456TrpPhe: 0.456 ± 0.008	0.824TrpGly: 0.824 ± 0.013	0.303TrpHis: 0.303 ± 0.006	0.545TrpIle: 0.545 ± 0.008	0.805TrpLys: 0.805 ± 0.009	1.243TrpLeu: 1.243 ± 0.012	0.311TrpMet: 0.311 ± 0.006	0.533TrpAsn: 0.533 ± 0.007	0.567TrpPro: 0.567 ± 0.009	0.535TrpGln: 0.535 ± 0.009	0.778TrpArg: 0.778 ± 0.009	0.894TrpSer: 0.894 ± 0.012	0.687TrpThr: 0.687 ± 0.011	0.738TrpVal: 0.738 ± 0.008	0.197TrpTrp: 0.197 ± 0.004	0.34TrpTyr: 0.34 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.395TyrAla: 1.395 ± 0.012	0.683TyrCys: 0.683 ± 0.009	1.26TyrAsp: 1.26 ± 0.013	1.626TyrGlu: 1.626 ± 0.017	1.275TyrPhe: 1.275 ± 0.013	1.664TyrGly: 1.664 ± 0.016	0.747TyrHis: 0.747 ± 0.01	1.336TyrIle: 1.336 ± 0.014	1.418TyrLys: 1.418 ± 0.02	2.692TyrLeu: 2.692 ± 0.02	0.592TyrMet: 0.592 ± 0.007	1.052TyrAsn: 1.052 ± 0.011	1.298TyrPro: 1.298 ± 0.014	1.212TyrGln: 1.212 ± 0.011	1.551TyrArg: 1.551 ± 0.015	2.175TyrSer: 2.175 ± 0.016	1.494TyrThr: 1.494 ± 0.017	1.601TyrVal: 1.601 ± 0.014	0.354TyrTrp: 0.354 ± 0.006	0.929TyrTyr: 0.929 ± 0.012	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.006XaaAla: 0.006 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.003XaaGlu: 0.003 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.005XaaGly: 0.005 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.01XaaMet: 0.01 ± 0.001	0.001XaaAsn: 0.001 ± 0.0	0.007XaaPro: 0.007 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.005XaaArg: 0.005 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.557XaaXaa: 0.557 ± 0.04

Statistics based on 20057 proteins (10723400 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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