Amino acid dipepetide frequency for Macaca mulatta (Rhesus macaque)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.718AlaAla: 6.718 ± 0.03	1.347AlaCys: 1.347 ± 0.01	2.854AlaAsp: 2.854 ± 0.012	4.749AlaGlu: 4.749 ± 0.02	2.578AlaPhe: 2.578 ± 0.014	4.778AlaGly: 4.778 ± 0.021	1.55AlaHis: 1.55 ± 0.009	2.784AlaIle: 2.784 ± 0.012	3.423AlaLys: 3.423 ± 0.015	6.95AlaLeu: 6.95 ± 0.026	1.419AlaMet: 1.419 ± 0.008	2.049AlaAsn: 2.049 ± 0.01	4.229AlaPro: 4.229 ± 0.023	3.264AlaGln: 3.264 ± 0.015	3.675AlaArg: 3.675 ± 0.017	5.831AlaSer: 5.831 ± 0.019	3.585AlaThr: 3.585 ± 0.013	4.536AlaVal: 4.536 ± 0.016	0.818AlaTrp: 0.818 ± 0.006	1.429AlaTyr: 1.429 ± 0.009	0.0AlaXaa: 0.0 ± 0.0
Cys	1.187CysAla: 1.187 ± 0.008	0.619CysCys: 0.619 ± 0.007	0.967CysAsp: 0.967 ± 0.009	1.278CysGlu: 1.278 ± 0.011	0.815CysPhe: 0.815 ± 0.006	1.729CysGly: 1.729 ± 0.016	0.667CysHis: 0.667 ± 0.006	0.921CysIle: 0.921 ± 0.008	1.167CysLys: 1.167 ± 0.01	2.166CysLeu: 2.166 ± 0.012	0.405CysMet: 0.405 ± 0.005	0.82CysAsn: 0.82 ± 0.008	1.375CysPro: 1.375 ± 0.011	1.039CysGln: 1.039 ± 0.009	1.266CysArg: 1.266 ± 0.009	1.994CysSer: 1.994 ± 0.012	1.076CysThr: 1.076 ± 0.009	1.279CysVal: 1.279 ± 0.014	0.323CysTrp: 0.323 ± 0.004	0.548CysTyr: 0.548 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.797AspAla: 2.797 ± 0.011	1.042AspCys: 1.042 ± 0.008	2.573AspAsp: 2.573 ± 0.011	3.409AspGlu: 3.409 ± 0.014	2.098AspPhe: 2.098 ± 0.009	3.253AspGly: 3.253 ± 0.016	1.134AspHis: 1.134 ± 0.007	2.583AspIle: 2.583 ± 0.015	2.597AspLys: 2.597 ± 0.011	5.018AspLeu: 5.018 ± 0.014	1.096AspMet: 1.096 ± 0.007	1.654AspAsn: 1.654 ± 0.01	2.866AspPro: 2.866 ± 0.014	1.859AspGln: 1.859 ± 0.009	2.352AspArg: 2.352 ± 0.012	4.223AspSer: 4.223 ± 0.016	2.503AspThr: 2.503 ± 0.01	3.02AspVal: 3.02 ± 0.023	0.611AspTrp: 0.611 ± 0.005	1.449AspTyr: 1.449 ± 0.008	0.0AspXaa: 0.0 ± 0.0
Glu	5.187GluAla: 5.187 ± 0.022	1.477GluCys: 1.477 ± 0.017	4.423GluAsp: 4.423 ± 0.015	8.124GluGlu: 8.124 ± 0.04	2.014GluPhe: 2.014 ± 0.009	4.164GluGly: 4.164 ± 0.019	1.503GluHis: 1.503 ± 0.008	3.244GluIle: 3.244 ± 0.017	5.672GluLys: 5.672 ± 0.028	6.555GluLeu: 6.555 ± 0.027	1.713GluMet: 1.713 ± 0.01	3.285GluAsn: 3.285 ± 0.015	3.246GluPro: 3.246 ± 0.019	3.206GluGln: 3.206 ± 0.017	4.047GluArg: 4.047 ± 0.02	4.544GluSer: 4.544 ± 0.017	3.513GluThr: 3.513 ± 0.015	4.136GluVal: 4.136 ± 0.016	0.692GluTrp: 0.692 ± 0.006	1.551GluTyr: 1.551 ± 0.009	0.0GluXaa: 0.0 ± 0.0
Phe	1.892PheAla: 1.892 ± 0.009	0.918PheCys: 0.918 ± 0.007	1.645PheAsp: 1.645 ± 0.008	1.974PheGlu: 1.974 ± 0.01	1.657PhePhe: 1.657 ± 0.011	2.089PheGly: 2.089 ± 0.01	1.039PheHis: 1.039 ± 0.007	1.775PheIle: 1.775 ± 0.009	1.811PheLys: 1.811 ± 0.011	4.035PheLeu: 4.035 ± 0.02	0.76PheMet: 0.76 ± 0.006	1.357PheAsn: 1.357 ± 0.009	1.991PhePro: 1.991 ± 0.011	1.773PheGln: 1.773 ± 0.009	1.902PheArg: 1.902 ± 0.009	3.453PheSer: 3.453 ± 0.015	2.017PheThr: 2.017 ± 0.012	2.042PheVal: 2.042 ± 0.01	0.466PheTrp: 0.466 ± 0.004	1.139PheTyr: 1.139 ± 0.007	0.0PheXaa: 0.0 ± 0.0
Gly	4.426GlyAla: 4.426 ± 0.021	1.253GlyCys: 1.253 ± 0.009	3.095GlyAsp: 3.095 ± 0.016	4.148GlyGlu: 4.148 ± 0.018	2.348GlyPhe: 2.348 ± 0.014	4.977GlyGly: 4.977 ± 0.035	1.67GlyHis: 1.67 ± 0.01	2.749GlyIle: 2.749 ± 0.012	3.84GlyLys: 3.84 ± 0.017	5.736GlyLeu: 5.736 ± 0.023	1.295GlyMet: 1.295 ± 0.007	2.292GlyAsn: 2.292 ± 0.013	4.225GlyPro: 4.225 ± 0.035	2.776GlyGln: 2.776 ± 0.014	3.782GlyArg: 3.782 ± 0.019	5.838GlySer: 5.838 ± 0.021	3.535GlyThr: 3.535 ± 0.014	3.49GlyVal: 3.49 ± 0.017	0.807GlyTrp: 0.807 ± 0.008	1.618GlyTyr: 1.618 ± 0.011	0.0GlyXaa: 0.0 ± 0.0
His	1.333HisAla: 1.333 ± 0.008	0.769HisCys: 0.769 ± 0.007	0.886HisAsp: 0.886 ± 0.006	1.341HisGlu: 1.341 ± 0.008	1.065HisPhe: 1.065 ± 0.007	1.507HisGly: 1.507 ± 0.008	0.99HisHis: 0.99 ± 0.01	1.288HisIle: 1.288 ± 0.008	1.318HisLys: 1.318 ± 0.009	2.968HisLeu: 2.968 ± 0.012	0.599HisMet: 0.599 ± 0.005	0.855HisAsn: 0.855 ± 0.006	1.72HisPro: 1.72 ± 0.013	1.371HisGln: 1.371 ± 0.01	1.61HisArg: 1.61 ± 0.01	2.394HisSer: 2.394 ± 0.016	1.649HisThr: 1.649 ± 0.024	1.487HisVal: 1.487 ± 0.008	0.342HisTrp: 0.342 ± 0.004	0.767HisTyr: 0.767 ± 0.005	0.0HisXaa: 0.0 ± 0.0
Ile	2.542IleAla: 2.542 ± 0.012	1.033IleCys: 1.033 ± 0.007	2.071IleAsp: 2.071 ± 0.012	2.589IleGlu: 2.589 ± 0.014	1.825IlePhe: 1.825 ± 0.011	2.165IleGly: 2.165 ± 0.012	1.477IleHis: 1.477 ± 0.014	2.398IleIle: 2.398 ± 0.012	2.797IleLys: 2.797 ± 0.019	4.524IleLeu: 4.524 ± 0.017	0.952IleMet: 0.952 ± 0.007	1.886IleAsn: 1.886 ± 0.009	2.633IlePro: 2.633 ± 0.012	2.389IleGln: 2.389 ± 0.012	2.39IleArg: 2.39 ± 0.011	3.745IleSer: 3.745 ± 0.015	2.56IleThr: 2.56 ± 0.015	2.412IleVal: 2.412 ± 0.011	0.498IleTrp: 0.498 ± 0.005	1.407IleTyr: 1.407 ± 0.009	0.0IleXaa: 0.0 ± 0.0
Lys	4.088LysAla: 4.088 ± 0.017	1.22LysCys: 1.22 ± 0.011	3.235LysAsp: 3.235 ± 0.015	5.364LysGlu: 5.364 ± 0.025	1.743LysPhe: 1.743 ± 0.011	3.221LysGly: 3.221 ± 0.022	1.431LysHis: 1.431 ± 0.009	2.964LysIle: 2.964 ± 0.017	4.781LysLys: 4.781 ± 0.028	5.359LysLeu: 5.359 ± 0.021	1.463LysMet: 1.463 ± 0.014	2.469LysAsn: 2.469 ± 0.011	3.258LysPro: 3.258 ± 0.017	2.717LysGln: 2.717 ± 0.013	3.328LysArg: 3.328 ± 0.014	4.053LysSer: 4.053 ± 0.017	3.269LysThr: 3.269 ± 0.014	3.429LysVal: 3.429 ± 0.018	0.649LysTrp: 0.649 ± 0.005	1.493LysTyr: 1.493 ± 0.009	0.0LysXaa: 0.0 ± 0.0
Leu	6.634LeuAla: 6.634 ± 0.023	2.12LeuCys: 2.12 ± 0.013	4.627LeuAsp: 4.627 ± 0.015	7.361LeuGlu: 7.361 ± 0.031	3.304LeuPhe: 3.304 ± 0.017	5.765LeuGly: 5.765 ± 0.02	2.739LeuHis: 2.739 ± 0.013	3.863LeuIle: 3.863 ± 0.016	5.96LeuLys: 5.96 ± 0.025	10.642LeuLeu: 10.642 ± 0.038	1.941LeuMet: 1.941 ± 0.009	3.602LeuAsn: 3.602 ± 0.014	6.189LeuPro: 6.189 ± 0.025	5.852LeuGln: 5.852 ± 0.024	5.859LeuArg: 5.859 ± 0.025	8.115LeuSer: 8.115 ± 0.022	5.104LeuThr: 5.104 ± 0.016	5.283LeuVal: 5.283 ± 0.02	1.127LeuTrp: 1.127 ± 0.009	2.453LeuTyr: 2.453 ± 0.011	0.0LeuXaa: 0.0 ± 0.0
Met	1.843MetAla: 1.843 ± 0.009	0.384MetCys: 0.384 ± 0.005	1.221MetAsp: 1.221 ± 0.007	1.867MetGlu: 1.867 ± 0.01	0.699MetPhe: 0.699 ± 0.005	1.253MetGly: 1.253 ± 0.008	0.475MetHis: 0.475 ± 0.005	0.836MetIle: 0.836 ± 0.006	1.447MetLys: 1.447 ± 0.009	1.913MetLeu: 1.913 ± 0.01	0.541MetMet: 0.541 ± 0.005	0.897MetAsn: 0.897 ± 0.007	1.076MetPro: 1.076 ± 0.015	0.956MetGln: 0.956 ± 0.006	1.017MetArg: 1.017 ± 0.007	1.545MetSer: 1.545 ± 0.008	1.082MetThr: 1.082 ± 0.007	1.305MetVal: 1.305 ± 0.007	0.241MetTrp: 0.241 ± 0.003	0.527MetTyr: 0.527 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.025AsnAla: 2.025 ± 0.01	0.795AsnCys: 0.795 ± 0.007	1.518AsnAsp: 1.518 ± 0.009	2.289AsnGlu: 2.289 ± 0.012	1.475AsnPhe: 1.475 ± 0.007	2.392AsnGly: 2.392 ± 0.013	0.961AsnHis: 0.961 ± 0.008	2.199AsnIle: 2.199 ± 0.012	2.32AsnLys: 2.32 ± 0.011	3.765AsnLeu: 3.765 ± 0.017	0.885AsnMet: 0.885 ± 0.007	1.551AsnAsn: 1.551 ± 0.008	2.138AsnPro: 2.138 ± 0.01	1.726AsnGln: 1.726 ± 0.009	1.945AsnArg: 1.945 ± 0.011	3.21AsnSer: 3.21 ± 0.013	1.968AsnThr: 1.968 ± 0.009	2.163AsnVal: 2.163 ± 0.01	0.456AsnTrp: 0.456 ± 0.005	1.073AsnTyr: 1.073 ± 0.006	0.0AsnXaa: 0.0 ± 0.0
Pro	4.983ProAla: 4.983 ± 0.024	1.144ProCys: 1.144 ± 0.009	2.759ProAsp: 2.759 ± 0.017	4.432ProGlu: 4.432 ± 0.021	1.958ProPhe: 1.958 ± 0.01	5.306ProGly: 5.306 ± 0.046	1.475ProHis: 1.475 ± 0.01	1.925ProIle: 1.925 ± 0.01	2.884ProLys: 2.884 ± 0.028	5.321ProLeu: 5.321 ± 0.018	1.014ProMet: 1.014 ± 0.006	1.82ProAsn: 1.82 ± 0.01	6.285ProPro: 6.285 ± 0.052	2.905ProGln: 2.905 ± 0.018	3.47ProArg: 3.47 ± 0.017	5.93ProSer: 5.93 ± 0.03	3.206ProThr: 3.206 ± 0.018	3.813ProVal: 3.813 ± 0.016	0.68ProTrp: 0.68 ± 0.005	1.555ProTyr: 1.555 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.603GlnAla: 3.603 ± 0.015	0.93GlnCys: 0.93 ± 0.008	2.349GlnAsp: 2.349 ± 0.011	4.077GlnGlu: 4.077 ± 0.021	1.36GlnPhe: 1.36 ± 0.009	2.872GlnGly: 2.872 ± 0.016	1.356GlnHis: 1.356 ± 0.009	2.023GlnIle: 2.023 ± 0.01	3.093GlnLys: 3.093 ± 0.016	4.812GlnLeu: 4.812 ± 0.02	1.101GlnMet: 1.101 ± 0.008	1.9GlnAsn: 1.9 ± 0.01	2.933GlnPro: 2.933 ± 0.017	3.246GlnGln: 3.246 ± 0.029	2.978GlnArg: 2.978 ± 0.016	3.275GlnSer: 3.275 ± 0.015	2.362GlnThr: 2.362 ± 0.011	2.812GlnVal: 2.812 ± 0.013	0.568GlnTrp: 0.568 ± 0.005	1.119GlnTyr: 1.119 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.847ArgAla: 3.847 ± 0.018	1.192ArgCys: 1.192 ± 0.011	2.788ArgAsp: 2.788 ± 0.013	4.015ArgGlu: 4.015 ± 0.018	1.827ArgPhe: 1.827 ± 0.009	3.601ArgGly: 3.601 ± 0.021	1.586ArgHis: 1.586 ± 0.01	2.429ArgIle: 2.429 ± 0.011	3.667ArgLys: 3.667 ± 0.015	5.408ArgLeu: 5.408 ± 0.023	1.173ArgMet: 1.173 ± 0.007	2.102ArgAsn: 2.102 ± 0.009	3.332ArgPro: 3.332 ± 0.017	2.704ArgGln: 2.704 ± 0.012	4.342ArgArg: 4.342 ± 0.023	4.331ArgSer: 4.331 ± 0.022	2.861ArgThr: 2.861 ± 0.012	3.07ArgVal: 3.07 ± 0.012	0.713ArgTrp: 0.713 ± 0.006	1.383ArgTyr: 1.383 ± 0.008	0.0ArgXaa: 0.0 ± 0.0
Ser	5.431SerAla: 5.431 ± 0.019	1.817SerCys: 1.817 ± 0.012	3.923SerAsp: 3.923 ± 0.015	5.32SerGlu: 5.32 ± 0.021	3.093SerPhe: 3.093 ± 0.016	5.625SerGly: 5.625 ± 0.021	2.217SerHis: 2.217 ± 0.013	3.244SerIle: 3.244 ± 0.017	4.243SerLys: 4.243 ± 0.017	8.404SerLeu: 8.404 ± 0.023	1.572SerMet: 1.572 ± 0.01	2.754SerAsn: 2.754 ± 0.012	6.251SerPro: 6.251 ± 0.03	4.079SerGln: 4.079 ± 0.017	4.615SerArg: 4.615 ± 0.019	9.784SerSer: 9.784 ± 0.043	4.596SerThr: 4.596 ± 0.026	4.872SerVal: 4.872 ± 0.017	1.103SerTrp: 1.103 ± 0.008	1.987SerTyr: 1.987 ± 0.01	0.0SerXaa: 0.0 ± 0.0
Thr	3.779ThrAla: 3.779 ± 0.014	1.257ThrCys: 1.257 ± 0.011	2.447ThrAsp: 2.447 ± 0.011	3.651ThrGlu: 3.651 ± 0.017	2.029ThrPhe: 2.029 ± 0.01	3.634ThrGly: 3.634 ± 0.017	1.394ThrHis: 1.394 ± 0.02	2.408ThrIle: 2.408 ± 0.011	2.731ThrLys: 2.731 ± 0.014	5.29ThrLeu: 5.29 ± 0.016	1.09ThrMet: 1.09 ± 0.007	1.743ThrAsn: 1.743 ± 0.008	3.682ThrPro: 3.682 ± 0.023	2.36ThrGln: 2.36 ± 0.013	2.521ThrArg: 2.521 ± 0.01	4.777ThrSer: 4.777 ± 0.027	3.118ThrThr: 3.118 ± 0.032	3.715ThrVal: 3.715 ± 0.017	0.705ThrTrp: 0.705 ± 0.006	1.4ThrTyr: 1.4 ± 0.008	0.0ThrXaa: 0.0 ± 0.0
Val	4.139ValAla: 4.139 ± 0.016	1.422ValCys: 1.422 ± 0.014	2.851ValAsp: 2.851 ± 0.019	3.829ValGlu: 3.829 ± 0.016	2.289ValPhe: 2.289 ± 0.011	3.282ValGly: 3.282 ± 0.014	1.542ValHis: 1.542 ± 0.01	2.788ValIle: 2.788 ± 0.013	3.376ValLys: 3.376 ± 0.016	5.916ValLeu: 5.916 ± 0.021	1.237ValMet: 1.237 ± 0.008	2.224ValAsn: 2.224 ± 0.013	3.642ValPro: 3.642 ± 0.019	2.761ValGln: 2.761 ± 0.013	2.942ValArg: 2.942 ± 0.013	4.879ValSer: 4.879 ± 0.018	3.652ValThr: 3.652 ± 0.018	3.709ValVal: 3.709 ± 0.016	0.686ValTrp: 0.686 ± 0.006	1.541ValTyr: 1.541 ± 0.009	0.0ValXaa: 0.0 ± 0.0
Trp	0.788TrpAla: 0.788 ± 0.006	0.263TrpCys: 0.263 ± 0.003	0.687TrpAsp: 0.687 ± 0.006	0.821TrpGlu: 0.821 ± 0.006	0.436TrpPhe: 0.436 ± 0.005	0.742TrpGly: 0.742 ± 0.008	0.323TrpHis: 0.323 ± 0.004	0.565TrpIle: 0.565 ± 0.005	0.813TrpLys: 0.813 ± 0.006	1.187TrpLeu: 1.187 ± 0.008	0.308TrpMet: 0.308 ± 0.003	0.556TrpAsn: 0.556 ± 0.005	0.551TrpPro: 0.551 ± 0.005	0.528TrpGln: 0.528 ± 0.005	0.76TrpArg: 0.76 ± 0.005	0.872TrpSer: 0.872 ± 0.007	0.641TrpThr: 0.641 ± 0.006	0.666TrpVal: 0.666 ± 0.006	0.203TrpTrp: 0.203 ± 0.003	0.337TrpTyr: 0.337 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.325TyrAla: 1.325 ± 0.007	0.637TyrCys: 0.637 ± 0.005	1.219TyrAsp: 1.219 ± 0.007	1.659TyrGlu: 1.659 ± 0.01	1.121TyrPhe: 1.121 ± 0.008	1.542TyrGly: 1.542 ± 0.009	0.729TyrHis: 0.729 ± 0.006	1.311TyrIle: 1.311 ± 0.009	1.59TyrLys: 1.59 ± 0.012	2.57TyrLeu: 2.57 ± 0.012	0.56TyrMet: 0.56 ± 0.004	1.037TyrAsn: 1.037 ± 0.007	1.244TyrPro: 1.244 ± 0.008	1.262TyrGln: 1.262 ± 0.007	1.57TyrArg: 1.57 ± 0.009	2.136TyrSer: 2.136 ± 0.011	1.434TyrThr: 1.434 ± 0.01	1.467TyrVal: 1.467 ± 0.008	0.362TyrTrp: 0.362 ± 0.005	0.906TyrTyr: 0.906 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.011XaaXaa: 0.011 ± 0.008

Statistics based on 44415 proteins (28520000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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