Amino acid dipepetide frequency for Tuber borchii (White truffle)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.441AlaAla: 7.441 ± 0.051	0.94AlaCys: 0.94 ± 0.017	3.425AlaAsp: 3.425 ± 0.031	4.927AlaGlu: 4.927 ± 0.042	2.662AlaPhe: 2.662 ± 0.031	5.768AlaGly: 5.768 ± 0.047	1.603AlaHis: 1.603 ± 0.018	4.126AlaIle: 4.126 ± 0.031	4.045AlaLys: 4.045 ± 0.038	7.118AlaLeu: 7.118 ± 0.05	1.702AlaMet: 1.702 ± 0.02	2.658AlaAsn: 2.658 ± 0.025	4.586AlaPro: 4.586 ± 0.041	2.726AlaGln: 2.726 ± 0.034	4.623AlaArg: 4.623 ± 0.036	6.376AlaSer: 6.376 ± 0.043	4.777AlaThr: 4.777 ± 0.037	4.986AlaVal: 4.986 ± 0.038	0.917AlaTrp: 0.917 ± 0.015	1.871AlaTyr: 1.871 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.899CysAla: 0.899 ± 0.016	0.303CysCys: 0.303 ± 0.008	0.624CysAsp: 0.624 ± 0.011	0.666CysGlu: 0.666 ± 0.012	0.591CysPhe: 0.591 ± 0.012	1.045CysGly: 1.045 ± 0.018	0.336CysHis: 0.336 ± 0.009	0.698CysIle: 0.698 ± 0.014	0.589CysLys: 0.589 ± 0.014	1.312CysLeu: 1.312 ± 0.017	0.296CysMet: 0.296 ± 0.008	0.427CysAsn: 0.427 ± 0.009	0.744CysPro: 0.744 ± 0.016	0.411CysGln: 0.411 ± 0.011	0.767CysArg: 0.767 ± 0.015	0.995CysSer: 0.995 ± 0.017	0.722CysThr: 0.722 ± 0.015	0.793CysVal: 0.793 ± 0.014	0.208CysTrp: 0.208 ± 0.007	0.368CysTyr: 0.368 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.61AspAla: 3.61 ± 0.025	0.614AspCys: 0.614 ± 0.012	3.671AspAsp: 3.671 ± 0.039	4.22AspGlu: 4.22 ± 0.039	2.043AspPhe: 2.043 ± 0.022	4.042AspGly: 4.042 ± 0.032	1.077AspHis: 1.077 ± 0.014	3.01AspIle: 3.01 ± 0.031	2.4AspLys: 2.4 ± 0.027	4.571AspLeu: 4.571 ± 0.033	1.18AspMet: 1.18 ± 0.016	1.819AspAsn: 1.819 ± 0.019	3.076AspPro: 3.076 ± 0.028	1.587AspGln: 1.587 ± 0.019	2.879AspArg: 2.879 ± 0.025	4.0AspSer: 4.0 ± 0.035	2.752AspThr: 2.752 ± 0.028	3.202AspVal: 3.202 ± 0.027	0.772AspTrp: 0.772 ± 0.014	1.519AspTyr: 1.519 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.119GluAla: 5.119 ± 0.046	0.735GluCys: 0.735 ± 0.014	4.317GluAsp: 4.317 ± 0.044	6.916GluGlu: 6.916 ± 0.079	2.192GluPhe: 2.192 ± 0.024	4.957GluGly: 4.957 ± 0.046	1.275GluHis: 1.275 ± 0.017	3.4GluIle: 3.4 ± 0.029	4.512GluLys: 4.512 ± 0.045	5.373GluLeu: 5.373 ± 0.044	1.602GluMet: 1.602 ± 0.02	2.488GluAsn: 2.488 ± 0.024	2.602GluPro: 2.602 ± 0.032	2.159GluGln: 2.159 ± 0.026	4.443GluArg: 4.443 ± 0.049	4.325GluSer: 4.325 ± 0.035	3.239GluThr: 3.239 ± 0.031	4.148GluVal: 4.148 ± 0.033	0.968GluTrp: 0.968 ± 0.015	1.768GluTyr: 1.768 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.65PheAla: 2.65 ± 0.029	0.596PheCys: 0.596 ± 0.013	2.02PheAsp: 2.02 ± 0.024	2.127PheGlu: 2.127 ± 0.021	1.833PhePhe: 1.833 ± 0.026	2.755PheGly: 2.755 ± 0.029	0.929PheHis: 0.929 ± 0.014	1.788PheIle: 1.788 ± 0.021	1.576PheLys: 1.576 ± 0.02	3.798PheLeu: 3.798 ± 0.036	0.744PheMet: 0.744 ± 0.014	1.371PheAsn: 1.371 ± 0.019	2.122PhePro: 2.122 ± 0.025	1.257PheGln: 1.257 ± 0.019	2.057PheArg: 2.057 ± 0.021	3.231PheSer: 3.231 ± 0.031	2.2PheThr: 2.2 ± 0.025	2.323PheVal: 2.323 ± 0.024	0.565PheTrp: 0.565 ± 0.012	1.177PheTyr: 1.177 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.19GlyAla: 5.19 ± 0.041	0.958GlyCys: 0.958 ± 0.017	3.892GlyAsp: 3.892 ± 0.033	4.728GlyGlu: 4.728 ± 0.037	2.787GlyPhe: 2.787 ± 0.021	7.786GlyGly: 7.786 ± 0.074	1.562GlyHis: 1.562 ± 0.021	3.851GlyIle: 3.851 ± 0.032	4.091GlyLys: 4.091 ± 0.035	5.89GlyLeu: 5.89 ± 0.042	1.788GlyMet: 1.788 ± 0.027	2.793GlyAsn: 2.793 ± 0.027	3.227GlyPro: 3.227 ± 0.033	2.221GlyGln: 2.221 ± 0.026	4.685GlyArg: 4.685 ± 0.037	6.093GlySer: 6.093 ± 0.049	3.935GlyThr: 3.935 ± 0.035	4.943GlyVal: 4.943 ± 0.037	1.246GlyTrp: 1.246 ± 0.018	2.168GlyTyr: 2.168 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.552HisAla: 1.552 ± 0.02	0.333HisCys: 0.333 ± 0.008	1.041HisAsp: 1.041 ± 0.014	1.267HisGlu: 1.267 ± 0.015	0.924HisPhe: 0.924 ± 0.015	1.579HisGly: 1.579 ± 0.021	0.99HisHis: 0.99 ± 0.022	1.219HisIle: 1.219 ± 0.018	1.013HisLys: 1.013 ± 0.015	2.264HisLeu: 2.264 ± 0.026	0.443HisMet: 0.443 ± 0.011	0.834HisAsn: 0.834 ± 0.013	1.795HisPro: 1.795 ± 0.023	1.008HisGln: 1.008 ± 0.017	1.516HisArg: 1.516 ± 0.018	1.965HisSer: 1.965 ± 0.023	1.348HisThr: 1.348 ± 0.019	1.231HisVal: 1.231 ± 0.018	0.319HisTrp: 0.319 ± 0.009	0.716HisTyr: 0.716 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.036IleAla: 4.036 ± 0.029	0.801IleCys: 0.801 ± 0.013	2.665IleAsp: 2.665 ± 0.025	3.092IleGlu: 3.092 ± 0.03	2.06IlePhe: 2.06 ± 0.024	3.319IleGly: 3.319 ± 0.032	1.25IleHis: 1.25 ± 0.017	2.633IleIle: 2.633 ± 0.027	2.443IleLys: 2.443 ± 0.024	4.802IleLeu: 4.802 ± 0.043	1.06IleMet: 1.06 ± 0.016	1.851IleAsn: 1.851 ± 0.022	3.422IlePro: 3.422 ± 0.028	1.759IleGln: 1.759 ± 0.018	2.968IleArg: 2.968 ± 0.025	4.288IleSer: 4.288 ± 0.035	3.177IleThr: 3.177 ± 0.026	3.178IleVal: 3.178 ± 0.027	0.705IleTrp: 0.705 ± 0.012	1.444IleTyr: 1.444 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.177LysAla: 4.177 ± 0.04	0.625LysCys: 0.625 ± 0.012	2.813LysAsp: 2.813 ± 0.027	4.116LysGlu: 4.116 ± 0.04	1.652LysPhe: 1.652 ± 0.019	3.624LysGly: 3.624 ± 0.034	1.133LysHis: 1.133 ± 0.017	2.692LysIle: 2.692 ± 0.027	4.085LysLys: 4.085 ± 0.05	4.399LysLeu: 4.399 ± 0.037	1.133LysMet: 1.133 ± 0.017	1.993LysAsn: 1.993 ± 0.024	2.943LysPro: 2.943 ± 0.031	1.78LysGln: 1.78 ± 0.022	3.888LysArg: 3.888 ± 0.036	3.757LysSer: 3.757 ± 0.033	2.909LysThr: 2.909 ± 0.026	3.216LysVal: 3.216 ± 0.03	0.715LysTrp: 0.715 ± 0.011	1.427LysTyr: 1.427 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.193LeuAla: 7.193 ± 0.042	1.242LeuCys: 1.242 ± 0.016	4.665LeuAsp: 4.665 ± 0.035	5.929LeuGlu: 5.929 ± 0.045	3.45LeuPhe: 3.45 ± 0.034	6.1LeuGly: 6.1 ± 0.046	2.278LeuHis: 2.278 ± 0.025	3.978LeuIle: 3.978 ± 0.033	4.69LeuLys: 4.69 ± 0.038	8.863LeuLeu: 8.863 ± 0.07	1.725LeuMet: 1.725 ± 0.023	3.015LeuAsn: 3.015 ± 0.025	5.693LeuPro: 5.693 ± 0.037	3.421LeuGln: 3.421 ± 0.034	5.728LeuArg: 5.728 ± 0.043	7.456LeuSer: 7.456 ± 0.047	4.827LeuThr: 4.827 ± 0.04	5.379LeuVal: 5.379 ± 0.04	1.124LeuTrp: 1.124 ± 0.02	2.324LeuTyr: 2.324 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.931MetAla: 1.931 ± 0.023	0.254MetCys: 0.254 ± 0.008	1.211MetAsp: 1.211 ± 0.017	1.524MetGlu: 1.524 ± 0.019	0.736MetPhe: 0.736 ± 0.015	1.617MetGly: 1.617 ± 0.023	0.458MetHis: 0.458 ± 0.011	1.068MetIle: 1.068 ± 0.015	1.142MetLys: 1.142 ± 0.015	1.802MetLeu: 1.802 ± 0.023	0.541MetMet: 0.541 ± 0.013	0.765MetAsn: 0.765 ± 0.015	1.226MetPro: 1.226 ± 0.02	0.719MetGln: 0.719 ± 0.012	1.266MetArg: 1.266 ± 0.019	1.789MetSer: 1.789 ± 0.019	1.165MetThr: 1.165 ± 0.016	1.353MetVal: 1.353 ± 0.018	0.276MetTrp: 0.276 ± 0.008	0.477MetTyr: 0.477 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.701AsnAla: 2.701 ± 0.024	0.49AsnCys: 0.49 ± 0.012	1.728AsnAsp: 1.728 ± 0.019	1.987AsnGlu: 1.987 ± 0.02	1.412AsnPhe: 1.412 ± 0.018	2.868AsnGly: 2.868 ± 0.025	0.902AsnHis: 0.902 ± 0.014	2.054AsnIle: 2.054 ± 0.023	1.654AsnLys: 1.654 ± 0.019	3.26AsnLeu: 3.26 ± 0.029	0.792AsnMet: 0.792 ± 0.013	1.556AsnAsn: 1.556 ± 0.022	2.669AsnPro: 2.669 ± 0.024	1.258AsnGln: 1.258 ± 0.018	2.122AsnArg: 2.122 ± 0.023	3.182AsnSer: 3.182 ± 0.033	2.312AsnThr: 2.312 ± 0.023	2.144AsnVal: 2.144 ± 0.021	0.514AsnTrp: 0.514 ± 0.011	1.079AsnTyr: 1.079 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.884ProAla: 4.884 ± 0.045	0.538ProCys: 0.538 ± 0.014	2.873ProAsp: 2.873 ± 0.028	3.803ProGlu: 3.803 ± 0.031	2.073ProPhe: 2.073 ± 0.025	4.063ProGly: 4.063 ± 0.039	1.499ProHis: 1.499 ± 0.022	2.863ProIle: 2.863 ± 0.025	2.97ProLys: 2.97 ± 0.027	5.141ProLeu: 5.141 ± 0.038	1.011ProMet: 1.011 ± 0.017	2.272ProAsn: 2.272 ± 0.027	6.859ProPro: 6.859 ± 0.094	2.471ProGln: 2.471 ± 0.037	3.439ProArg: 3.439 ± 0.039	6.171ProSer: 6.171 ± 0.054	4.559ProThr: 4.559 ± 0.037	3.54ProVal: 3.54 ± 0.035	0.612ProTrp: 0.612 ± 0.012	1.463ProTyr: 1.463 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.797GlnAla: 2.797 ± 0.03	0.42GlnCys: 0.42 ± 0.008	1.712GlnAsp: 1.712 ± 0.021	2.442GlnGlu: 2.442 ± 0.028	1.221GlnPhe: 1.221 ± 0.017	2.182GlnGly: 2.182 ± 0.022	0.936GlnHis: 0.936 ± 0.016	1.779GlnIle: 1.779 ± 0.021	2.019GlnLys: 2.019 ± 0.022	3.016GlnLeu: 3.016 ± 0.03	0.798GlnMet: 0.798 ± 0.018	1.502GlnAsn: 1.502 ± 0.023	2.193GlnPro: 2.193 ± 0.028	2.373GlnGln: 2.373 ± 0.062	2.348GlnArg: 2.348 ± 0.028	2.735GlnSer: 2.735 ± 0.028	2.044GlnThr: 2.044 ± 0.022	1.972GlnVal: 1.972 ± 0.025	0.449GlnTrp: 0.449 ± 0.01	0.992GlnTyr: 0.992 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.503ArgAla: 4.503 ± 0.029	0.766ArgCys: 0.766 ± 0.013	3.213ArgAsp: 3.213 ± 0.034	4.488ArgGlu: 4.488 ± 0.048	2.163ArgPhe: 2.163 ± 0.023	4.409ArgGly: 4.409 ± 0.035	1.486ArgHis: 1.486 ± 0.019	3.158ArgIle: 3.158 ± 0.026	4.011ArgLys: 4.011 ± 0.036	5.231ArgLeu: 5.231 ± 0.036	1.452ArgMet: 1.452 ± 0.017	2.407ArgAsn: 2.407 ± 0.025	3.286ArgPro: 3.286 ± 0.033	2.306ArgGln: 2.306 ± 0.025	5.24ArgArg: 5.24 ± 0.051	4.82ArgSer: 4.82 ± 0.045	3.266ArgThr: 3.266 ± 0.03	3.656ArgVal: 3.656 ± 0.028	0.905ArgTrp: 0.905 ± 0.016	1.671ArgTyr: 1.671 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.22SerAla: 6.22 ± 0.042	0.934SerCys: 0.934 ± 0.017	3.921SerAsp: 3.921 ± 0.034	4.428SerGlu: 4.428 ± 0.037	3.084SerPhe: 3.084 ± 0.03	6.171SerGly: 6.171 ± 0.05	1.909SerHis: 1.909 ± 0.024	4.14SerIle: 4.14 ± 0.032	3.816SerLys: 3.816 ± 0.036	7.433SerLeu: 7.433 ± 0.048	1.698SerMet: 1.698 ± 0.02	2.981SerAsn: 2.981 ± 0.026	6.289SerPro: 6.289 ± 0.062	2.985SerGln: 2.985 ± 0.027	5.016SerArg: 5.016 ± 0.044	9.304SerSer: 9.304 ± 0.085	5.713SerThr: 5.713 ± 0.04	4.48SerVal: 4.48 ± 0.034	0.997SerTrp: 0.997 ± 0.014	2.089SerTyr: 2.089 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	4.802ThrAla: 4.802 ± 0.035	0.717ThrCys: 0.717 ± 0.013	2.587ThrAsp: 2.587 ± 0.027	3.09ThrGlu: 3.09 ± 0.027	2.182ThrPhe: 2.182 ± 0.023	4.143ThrGly: 4.143 ± 0.034	1.359ThrHis: 1.359 ± 0.017	3.28ThrIle: 3.28 ± 0.029	2.754ThrLys: 2.754 ± 0.028	5.341ThrLeu: 5.341 ± 0.04	1.089ThrMet: 1.089 ± 0.017	2.122ThrAsn: 2.122 ± 0.024	4.896ThrPro: 4.896 ± 0.046	1.973ThrGln: 1.973 ± 0.023	3.224ThrArg: 3.224 ± 0.027	5.422ThrSer: 5.422 ± 0.042	4.707ThrThr: 4.707 ± 0.055	3.46ThrVal: 3.46 ± 0.033	0.709ThrTrp: 0.709 ± 0.015	1.535ThrTyr: 1.535 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.695ValAla: 4.695 ± 0.032	0.889ValCys: 0.889 ± 0.016	3.347ValAsp: 3.347 ± 0.031	4.315ValGlu: 4.315 ± 0.033	2.363ValPhe: 2.363 ± 0.022	4.451ValGly: 4.451 ± 0.036	1.326ValHis: 1.326 ± 0.017	3.093ValIle: 3.093 ± 0.029	3.206ValLys: 3.206 ± 0.027	5.626ValLeu: 5.626 ± 0.042	1.348ValMet: 1.348 ± 0.019	2.15ValAsn: 2.15 ± 0.021	3.406ValPro: 3.406 ± 0.036	2.04ValGln: 2.04 ± 0.019	3.617ValArg: 3.617 ± 0.034	4.557ValSer: 4.557 ± 0.035	3.336ValThr: 3.336 ± 0.033	4.448ValVal: 4.448 ± 0.042	0.866ValTrp: 0.866 ± 0.015	1.711ValTyr: 1.711 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.993TrpAla: 0.993 ± 0.015	0.184TrpCys: 0.184 ± 0.006	0.793TrpAsp: 0.793 ± 0.016	0.933TrpGlu: 0.933 ± 0.013	0.479TrpPhe: 0.479 ± 0.011	1.023TrpGly: 1.023 ± 0.016	0.312TrpHis: 0.312 ± 0.008	0.736TrpIle: 0.736 ± 0.012	0.849TrpLys: 0.849 ± 0.014	1.246TrpLeu: 1.246 ± 0.019	0.36TrpMet: 0.36 ± 0.009	0.553TrpAsn: 0.553 ± 0.011	0.504TrpPro: 0.504 ± 0.01	0.43TrpGln: 0.43 ± 0.011	0.956TrpArg: 0.956 ± 0.014	0.943TrpSer: 0.943 ± 0.016	0.733TrpThr: 0.733 ± 0.015	0.875TrpVal: 0.875 ± 0.012	0.279TrpTrp: 0.279 ± 0.008	0.381TrpTyr: 0.381 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.878TyrAla: 1.878 ± 0.021	0.455TyrCys: 0.455 ± 0.011	1.528TyrAsp: 1.528 ± 0.02	1.54TyrGlu: 1.54 ± 0.02	1.211TyrPhe: 1.211 ± 0.018	1.933TyrGly: 1.933 ± 0.024	0.741TyrHis: 0.741 ± 0.011	1.388TyrIle: 1.388 ± 0.019	1.214TyrLys: 1.214 ± 0.015	2.591TyrLeu: 2.591 ± 0.03	0.557TyrMet: 0.557 ± 0.011	1.126TyrAsn: 1.126 ± 0.021	1.564TyrPro: 1.564 ± 0.022	1.047TyrGln: 1.047 ± 0.017	1.654TyrArg: 1.654 ± 0.021	2.203TyrSer: 2.203 ± 0.023	1.669TyrThr: 1.669 ± 0.024	1.463TyrVal: 1.463 ± 0.021	0.418TyrTrp: 0.418 ± 0.009	0.922TyrTyr: 0.922 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12324 proteins (4666832 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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