Amino acid dipepetide frequency for Thalassoglobus polymorphus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.217AlaAla: 8.217 ± 0.094
0.962AlaCys: 0.962 ± 0.027
4.758AlaAsp: 4.758 ± 0.058
6.211AlaGlu: 6.211 ± 0.073
3.215AlaPhe: 3.215 ± 0.044
6.391AlaGly: 6.391 ± 0.083
1.481AlaHis: 1.481 ± 0.029
5.269AlaIle: 5.269 ± 0.059
4.239AlaLys: 4.239 ± 0.063
7.417AlaLeu: 7.417 ± 0.074
2.102AlaMet: 2.102 ± 0.035
3.08AlaAsn: 3.08 ± 0.052
3.379AlaPro: 3.379 ± 0.052
3.125AlaGln: 3.125 ± 0.051
4.25AlaArg: 4.25 ± 0.058
5.494AlaSer: 5.494 ± 0.056
4.753AlaThr: 4.753 ± 0.056
5.866AlaVal: 5.866 ± 0.066
1.054AlaTrp: 1.054 ± 0.024
1.945AlaTyr: 1.945 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.767CysAla: 0.767 ± 0.023
0.25CysCys: 0.25 ± 0.015
0.638CysAsp: 0.638 ± 0.017
0.715CysGlu: 0.715 ± 0.021
0.518CysPhe: 0.518 ± 0.016
0.978CysGly: 0.978 ± 0.025
0.457CysHis: 0.457 ± 0.018
0.499CysIle: 0.499 ± 0.019
0.378CysLys: 0.378 ± 0.021
1.15CysLeu: 1.15 ± 0.028
0.202CysMet: 0.202 ± 0.01
0.328CysAsn: 0.328 ± 0.015
0.587CysPro: 0.587 ± 0.02
0.424CysGln: 0.424 ± 0.018
0.67CysArg: 0.67 ± 0.021
0.755CysSer: 0.755 ± 0.021
0.544CysThr: 0.544 ± 0.017
0.779CysVal: 0.779 ± 0.023
0.187CysTrp: 0.187 ± 0.01
0.331CysTyr: 0.331 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.795AspAla: 4.795 ± 0.058
0.567AspCys: 0.567 ± 0.019
3.555AspAsp: 3.555 ± 0.059
4.476AspGlu: 4.476 ± 0.052
2.561AspPhe: 2.561 ± 0.041
4.774AspGly: 4.774 ± 0.065
1.447AspHis: 1.447 ± 0.035
2.635AspIle: 2.635 ± 0.051
1.924AspLys: 1.924 ± 0.037
5.888AspLeu: 5.888 ± 0.065
0.982AspMet: 0.982 ± 0.025
1.58AspAsn: 1.58 ± 0.042
3.146AspPro: 3.146 ± 0.046
2.63AspGln: 2.63 ± 0.038
3.453AspArg: 3.453 ± 0.043
3.753AspSer: 3.753 ± 0.045
2.078AspThr: 2.078 ± 0.035
4.053AspVal: 4.053 ± 0.056
1.136AspTrp: 1.136 ± 0.028
1.536AspTyr: 1.536 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
5.788GluAla: 5.788 ± 0.063
0.601GluCys: 0.601 ± 0.02
3.332GluAsp: 3.332 ± 0.047
5.129GluGlu: 5.129 ± 0.074
2.921GluPhe: 2.921 ± 0.041
3.906GluGly: 3.906 ± 0.051
1.464GluHis: 1.464 ± 0.03
4.505GluIle: 4.505 ± 0.062
3.991GluLys: 3.991 ± 0.057
7.311GluLeu: 7.311 ± 0.078
1.863GluMet: 1.863 ± 0.031
2.858GluAsn: 2.858 ± 0.044
2.656GluPro: 2.656 ± 0.036
3.475GluGln: 3.475 ± 0.059
3.941GluArg: 3.941 ± 0.05
4.73GluSer: 4.73 ± 0.061
4.319GluThr: 4.319 ± 0.051
4.626GluVal: 4.626 ± 0.062
0.906GluTrp: 0.906 ± 0.022
1.674GluTyr: 1.674 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.426PheAla: 3.426 ± 0.047
0.549PheCys: 0.549 ± 0.015
2.851PheAsp: 2.851 ± 0.042
2.764PheGlu: 2.764 ± 0.037
1.62PhePhe: 1.62 ± 0.035
3.358PheGly: 3.358 ± 0.048
0.927PheHis: 0.927 ± 0.026
1.885PheIle: 1.885 ± 0.034
1.405PheLys: 1.405 ± 0.029
4.043PheLeu: 4.043 ± 0.057
0.768PheMet: 0.768 ± 0.022
1.342PheAsn: 1.342 ± 0.03
1.919PhePro: 1.919 ± 0.039
1.71PheGln: 1.71 ± 0.033
2.351PheArg: 2.351 ± 0.038
2.902PheSer: 2.902 ± 0.04
2.1PheThr: 2.1 ± 0.034
2.916PheVal: 2.916 ± 0.039
0.632PheTrp: 0.632 ± 0.022
1.038PheTyr: 1.038 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
5.196GlyAla: 5.196 ± 0.077
0.908GlyCys: 0.908 ± 0.022
4.037GlyAsp: 4.037 ± 0.065
5.031GlyGlu: 5.031 ± 0.067
3.103GlyPhe: 3.103 ± 0.046
5.789GlyGly: 5.789 ± 0.1
1.682GlyHis: 1.682 ± 0.037
4.284GlyIle: 4.284 ± 0.057
4.1GlyLys: 4.1 ± 0.061
6.839GlyLeu: 6.839 ± 0.066
1.889GlyMet: 1.889 ± 0.037
2.75GlyAsn: 2.75 ± 0.061
2.825GlyPro: 2.825 ± 0.043
2.852GlyGln: 2.852 ± 0.042
4.226GlyArg: 4.226 ± 0.056
4.521GlySer: 4.521 ± 0.064
4.381GlyThr: 4.381 ± 0.063
5.088GlyVal: 5.088 ± 0.06
1.239GlyTrp: 1.239 ± 0.032
2.089GlyTyr: 2.089 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
1.734HisAla: 1.734 ± 0.036
0.323HisCys: 0.323 ± 0.014
1.292HisAsp: 1.292 ± 0.026
1.354HisGlu: 1.354 ± 0.029
1.016HisPhe: 1.016 ± 0.025
1.799HisGly: 1.799 ± 0.039
0.714HisHis: 0.714 ± 0.024
1.015HisIle: 1.015 ± 0.026
0.745HisLys: 0.745 ± 0.019
2.301HisLeu: 2.301 ± 0.041
0.364HisMet: 0.364 ± 0.016
0.732HisAsn: 0.732 ± 0.021
1.49HisPro: 1.49 ± 0.032
1.043HisGln: 1.043 ± 0.024
1.508HisArg: 1.508 ± 0.029
1.432HisSer: 1.432 ± 0.033
0.939HisThr: 0.939 ± 0.023
1.5HisVal: 1.5 ± 0.032
0.423HisTrp: 0.423 ± 0.018
0.617HisTyr: 0.617 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.331IleAla: 5.331 ± 0.053
0.73IleCys: 0.73 ± 0.019
3.84IleAsp: 3.84 ± 0.051
4.297IleGlu: 4.297 ± 0.05
2.01IlePhe: 2.01 ± 0.036
4.244IleGly: 4.244 ± 0.055
1.29IleHis: 1.29 ± 0.023
2.341IleIle: 2.341 ± 0.035
1.899IleLys: 1.899 ± 0.033
5.277IleLeu: 5.277 ± 0.066
0.818IleMet: 0.818 ± 0.022
1.808IleAsn: 1.808 ± 0.043
3.091IlePro: 3.091 ± 0.051
2.43IleGln: 2.43 ± 0.039
3.387IleArg: 3.387 ± 0.043
3.818IleSer: 3.818 ± 0.051
2.76IleThr: 2.76 ± 0.051
4.165IleVal: 4.165 ± 0.056
0.712IleTrp: 0.712 ± 0.022
1.294IleTyr: 1.294 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
3.664LysAla: 3.664 ± 0.063
0.367LysCys: 0.367 ± 0.015
2.423LysAsp: 2.423 ± 0.04
3.329LysGlu: 3.329 ± 0.052
1.689LysPhe: 1.689 ± 0.032
2.495LysGly: 2.495 ± 0.047
1.029LysHis: 1.029 ± 0.024
2.758LysIle: 2.758 ± 0.041
2.979LysLys: 2.979 ± 0.067
4.668LysLeu: 4.668 ± 0.055
1.185LysMet: 1.185 ± 0.025
1.896LysAsn: 1.896 ± 0.033
2.51LysPro: 2.51 ± 0.046
2.239LysGln: 2.239 ± 0.037
2.758LysArg: 2.758 ± 0.041
3.385LysSer: 3.385 ± 0.053
2.969LysThr: 2.969 ± 0.053
2.96LysVal: 2.96 ± 0.044
0.68LysTrp: 0.68 ± 0.021
1.186LysTyr: 1.186 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
8.795LeuAla: 8.795 ± 0.078
1.141LeuCys: 1.141 ± 0.029
5.458LeuAsp: 5.458 ± 0.062
6.331LeuGlu: 6.331 ± 0.068
4.0LeuPhe: 4.0 ± 0.059
6.735LeuGly: 6.735 ± 0.069
1.981LeuHis: 1.981 ± 0.038
5.523LeuIle: 5.523 ± 0.063
5.278LeuLys: 5.278 ± 0.072
9.78LeuLeu: 9.78 ± 0.101
2.094LeuMet: 2.094 ± 0.038
3.835LeuAsn: 3.835 ± 0.051
5.09LeuPro: 5.09 ± 0.057
3.913LeuGln: 3.913 ± 0.054
5.445LeuArg: 5.445 ± 0.06
7.036LeuSer: 7.036 ± 0.069
5.889LeuThr: 5.889 ± 0.061
6.57LeuVal: 6.57 ± 0.069
1.224LeuTrp: 1.224 ± 0.027
2.161LeuTyr: 2.161 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
1.855MetAla: 1.855 ± 0.031
0.21MetCys: 0.21 ± 0.011
0.966MetAsp: 0.966 ± 0.022
1.189MetGlu: 1.189 ± 0.027
0.82MetPhe: 0.82 ± 0.021
1.415MetGly: 1.415 ± 0.035
0.421MetHis: 0.421 ± 0.014
1.357MetIle: 1.357 ± 0.025
1.288MetLys: 1.288 ± 0.027
2.254MetLeu: 2.254 ± 0.044
0.58MetMet: 0.58 ± 0.02
1.051MetAsn: 1.051 ± 0.023
1.15MetPro: 1.15 ± 0.027
0.948MetGln: 0.948 ± 0.027
1.23MetArg: 1.23 ± 0.03
1.739MetSer: 1.739 ± 0.029
1.519MetThr: 1.519 ± 0.029
1.352MetVal: 1.352 ± 0.031
0.254MetTrp: 0.254 ± 0.013
0.436MetTyr: 0.436 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.908AsnAla: 2.908 ± 0.055
0.443AsnCys: 0.443 ± 0.018
2.122AsnAsp: 2.122 ± 0.041
2.39AsnGlu: 2.39 ± 0.038
1.435AsnPhe: 1.435 ± 0.03
3.018AsnGly: 3.018 ± 0.06
0.873AsnHis: 0.873 ± 0.025
1.857AsnIle: 1.857 ± 0.043
1.283AsnLys: 1.283 ± 0.031
3.512AsnLeu: 3.512 ± 0.051
0.691AsnMet: 0.691 ± 0.019
1.291AsnAsn: 1.291 ± 0.047
2.215AsnPro: 2.215 ± 0.038
1.636AsnGln: 1.636 ± 0.031
2.381AsnArg: 2.381 ± 0.042
2.685AsnSer: 2.685 ± 0.046
1.651AsnThr: 1.651 ± 0.035
2.599AsnVal: 2.599 ± 0.049
0.669AsnTrp: 0.669 ± 0.02
0.943AsnTyr: 0.943 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
4.184ProAla: 4.184 ± 0.065
0.387ProCys: 0.387 ± 0.02
3.13ProAsp: 3.13 ± 0.045
4.47ProGlu: 4.47 ± 0.056
1.98ProPhe: 1.98 ± 0.033
3.685ProGly: 3.685 ± 0.055
1.102ProHis: 1.102 ± 0.026
2.639ProIle: 2.639 ± 0.038
2.442ProLys: 2.442 ± 0.05
4.25ProLeu: 4.25 ± 0.049
1.004ProMet: 1.004 ± 0.024
1.976ProAsn: 1.976 ± 0.038
2.396ProPro: 2.396 ± 0.049
2.033ProGln: 2.033 ± 0.035
2.25ProArg: 2.25 ± 0.04
3.096ProSer: 3.096 ± 0.057
2.751ProThr: 2.751 ± 0.045
3.894ProVal: 3.894 ± 0.052
0.646ProTrp: 0.646 ± 0.018
1.181ProTyr: 1.181 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.826GlnAla: 3.826 ± 0.049
0.373GlnCys: 0.373 ± 0.016
1.841GlnAsp: 1.841 ± 0.031
2.679GlnGlu: 2.679 ± 0.048
1.84GlnPhe: 1.84 ± 0.032
2.551GlnGly: 2.551 ± 0.046
0.987GlnHis: 0.987 ± 0.025
2.569GlnIle: 2.569 ± 0.038
2.271GlnLys: 2.271 ± 0.048
4.669GlnLeu: 4.669 ± 0.067
0.963GlnMet: 0.963 ± 0.023
1.568GlnAsn: 1.568 ± 0.033
2.164GlnPro: 2.164 ± 0.042
2.486GlnGln: 2.486 ± 0.066
2.769GlnArg: 2.769 ± 0.042
2.991GlnSer: 2.991 ± 0.043
2.451GlnThr: 2.451 ± 0.041
2.842GlnVal: 2.842 ± 0.042
0.527GlnTrp: 0.527 ± 0.017
0.953GlnTyr: 0.953 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
3.772ArgAla: 3.772 ± 0.052
0.628ArgCys: 0.628 ± 0.021
3.242ArgAsp: 3.242 ± 0.041
4.065ArgGlu: 4.065 ± 0.053
2.65ArgPhe: 2.65 ± 0.035
3.615ArgGly: 3.615 ± 0.056
1.318ArgHis: 1.318 ± 0.028
3.615ArgIle: 3.615 ± 0.045
2.992ArgLys: 2.992 ± 0.046
5.919ArgLeu: 5.919 ± 0.064
1.442ArgMet: 1.442 ± 0.031
2.211ArgAsn: 2.211 ± 0.037
2.648ArgPro: 2.648 ± 0.049
2.499ArgGln: 2.499 ± 0.041
3.781ArgArg: 3.781 ± 0.05
3.816ArgSer: 3.816 ± 0.058
3.169ArgThr: 3.169 ± 0.044
3.878ArgVal: 3.878 ± 0.053
0.945ArgTrp: 0.945 ± 0.026
1.708ArgTyr: 1.708 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.354SerAla: 5.354 ± 0.062
0.682SerCys: 0.682 ± 0.022
3.783SerAsp: 3.783 ± 0.047
4.686SerGlu: 4.686 ± 0.052
2.571SerPhe: 2.571 ± 0.04
5.623SerGly: 5.623 ± 0.068
1.545SerHis: 1.545 ± 0.032
3.662SerIle: 3.662 ± 0.052
3.095SerLys: 3.095 ± 0.051
6.939SerLeu: 6.939 ± 0.073
1.648SerMet: 1.648 ± 0.034
2.446SerAsn: 2.446 ± 0.041
3.707SerPro: 3.707 ± 0.048
3.083SerGln: 3.083 ± 0.045
4.027SerArg: 4.027 ± 0.056
4.919SerSer: 4.919 ± 0.075
3.676SerThr: 3.676 ± 0.047
4.561SerVal: 4.561 ± 0.056
0.943SerTrp: 0.943 ± 0.021
1.507SerTyr: 1.507 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
4.613ThrAla: 4.613 ± 0.055
0.575ThrCys: 0.575 ± 0.019
3.107ThrAsp: 3.107 ± 0.048
3.432ThrGlu: 3.432 ± 0.047
2.27ThrPhe: 2.27 ± 0.037
4.722ThrGly: 4.722 ± 0.067
1.165ThrHis: 1.165 ± 0.023
3.325ThrIle: 3.325 ± 0.049
2.225ThrLys: 2.225 ± 0.043
5.447ThrLeu: 5.447 ± 0.061
1.102ThrMet: 1.102 ± 0.024
1.904ThrAsn: 1.904 ± 0.04
3.394ThrPro: 3.394 ± 0.048
2.171ThrGln: 2.171 ± 0.038
2.802ThrArg: 2.802 ± 0.039
3.749ThrSer: 3.749 ± 0.048
3.214ThrThr: 3.214 ± 0.045
4.028ThrVal: 4.028 ± 0.062
0.759ThrTrp: 0.759 ± 0.022
1.357ThrTyr: 1.357 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
6.101ValAla: 6.101 ± 0.067
0.913ValCys: 0.913 ± 0.03
4.248ValAsp: 4.248 ± 0.056
4.904ValGlu: 4.904 ± 0.056
2.549ValPhe: 2.549 ± 0.036
4.77ValGly: 4.77 ± 0.054
1.459ValHis: 1.459 ± 0.032
3.984ValIle: 3.984 ± 0.043
2.914ValLys: 2.914 ± 0.044
6.586ValLeu: 6.586 ± 0.071
1.491ValMet: 1.491 ± 0.029
2.465ValAsn: 2.465 ± 0.04
3.338ValPro: 3.338 ± 0.046
2.755ValGln: 2.755 ± 0.042
4.027ValArg: 4.027 ± 0.051
4.879ValSer: 4.879 ± 0.063
4.178ValThr: 4.178 ± 0.07
5.35ValVal: 5.35 ± 0.064
0.963ValTrp: 0.963 ± 0.023
1.648ValTyr: 1.648 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
0.972TrpAla: 0.972 ± 0.025
0.174TrpCys: 0.174 ± 0.008
0.8TrpAsp: 0.8 ± 0.024
0.873TrpGlu: 0.873 ± 0.023
0.599TrpPhe: 0.599 ± 0.021
0.977TrpGly: 0.977 ± 0.022
0.369TrpHis: 0.369 ± 0.016
0.853TrpIle: 0.853 ± 0.024
0.891TrpLys: 0.891 ± 0.025
1.497TrpLeu: 1.497 ± 0.034
0.435TrpMet: 0.435 ± 0.017
0.632TrpAsn: 0.632 ± 0.021
0.602TrpPro: 0.602 ± 0.019
0.633TrpGln: 0.633 ± 0.018
0.83TrpArg: 0.83 ± 0.025
1.04TrpSer: 1.04 ± 0.028
0.872TrpThr: 0.872 ± 0.024
0.924TrpVal: 0.924 ± 0.024
0.241TrpTrp: 0.241 ± 0.013
0.348TrpTyr: 0.348 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.912TyrAla: 1.912 ± 0.029
0.373TyrCys: 0.373 ± 0.014
1.545TyrAsp: 1.545 ± 0.026
1.669TyrGlu: 1.669 ± 0.033
1.14TyrPhe: 1.14 ± 0.027
1.982TyrGly: 1.982 ± 0.037
0.63TyrHis: 0.63 ± 0.019
0.969TyrIle: 0.969 ± 0.023
0.831TyrLys: 0.831 ± 0.024
2.532TyrLeu: 2.532 ± 0.04
0.41TyrMet: 0.41 ± 0.016
0.85TyrAsn: 0.85 ± 0.023
1.191TyrPro: 1.191 ± 0.029
1.239TyrGln: 1.239 ± 0.023
1.829TyrArg: 1.829 ± 0.031
1.716TyrSer: 1.716 ± 0.032
1.146TyrThr: 1.146 ± 0.033
1.567TyrVal: 1.567 ± 0.031
0.42TyrTrp: 0.42 ± 0.016
0.786TyrTyr: 0.786 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4824 proteins (1776901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski