Amino acid dipepetide frequency for Haloarculaceae archaeon HArcel1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.695AlaAla: 14.695 ± 0.222	0.668AlaCys: 0.668 ± 0.03	11.162AlaAsp: 11.162 ± 0.15	7.324AlaGlu: 7.324 ± 0.125	3.641AlaPhe: 3.641 ± 0.081	10.186AlaGly: 10.186 ± 0.131	2.143AlaHis: 2.143 ± 0.058	7.006AlaIle: 7.006 ± 0.11	1.502AlaLys: 1.502 ± 0.056	11.032AlaLeu: 11.032 ± 0.166	2.308AlaMet: 2.308 ± 0.057	2.387AlaAsn: 2.387 ± 0.075	4.508AlaPro: 4.508 ± 0.078	2.255AlaGln: 2.255 ± 0.063	6.804AlaArg: 6.804 ± 0.11	6.137AlaSer: 6.137 ± 0.112	8.546AlaThr: 8.546 ± 0.146	11.205AlaVal: 11.205 ± 0.174	1.169AlaTrp: 1.169 ± 0.045	2.601AlaTyr: 2.601 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.615CysAla: 0.615 ± 0.031	0.065CysCys: 0.065 ± 0.009	0.577CysAsp: 0.577 ± 0.029	0.577CysGlu: 0.577 ± 0.03	0.163CysPhe: 0.163 ± 0.015	0.8CysGly: 0.8 ± 0.04	0.17CysHis: 0.17 ± 0.015	0.229CysIle: 0.229 ± 0.016	0.094CysLys: 0.094 ± 0.011	0.487CysLeu: 0.487 ± 0.024	0.097CysMet: 0.097 ± 0.012	0.161CysAsn: 0.161 ± 0.016	0.524CysPro: 0.524 ± 0.03	0.175CysGln: 0.175 ± 0.016	0.576CysArg: 0.576 ± 0.028	0.442CysSer: 0.442 ± 0.028	0.399CysThr: 0.399 ± 0.027	0.487CysVal: 0.487 ± 0.027	0.101CysTrp: 0.101 ± 0.012	0.165CysTyr: 0.165 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	11.715AspAla: 11.715 ± 0.166	0.816AspCys: 0.816 ± 0.037	8.325AspAsp: 8.325 ± 0.137	6.919AspGlu: 6.919 ± 0.14	1.869AspPhe: 1.869 ± 0.059	8.812AspGly: 8.812 ± 0.162	2.278AspHis: 2.278 ± 0.059	2.866AspIle: 2.866 ± 0.082	0.707AspLys: 0.707 ± 0.033	8.168AspLeu: 8.168 ± 0.134	1.063AspMet: 1.063 ± 0.042	1.126AspAsn: 1.126 ± 0.05	6.449AspPro: 6.449 ± 0.107	2.16AspGln: 2.16 ± 0.054	10.113AspArg: 10.113 ± 0.146	4.151AspSer: 4.151 ± 0.087	4.202AspThr: 4.202 ± 0.074	7.388AspVal: 7.388 ± 0.111	1.339AspTrp: 1.339 ± 0.052	1.687AspTyr: 1.687 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.099GluAla: 8.099 ± 0.133	0.521GluCys: 0.521 ± 0.026	5.223GluAsp: 5.223 ± 0.11	4.771GluGlu: 4.771 ± 0.109	2.546GluPhe: 2.546 ± 0.057	5.093GluGly: 5.093 ± 0.088	1.758GluHis: 1.758 ± 0.047	3.804GluIle: 3.804 ± 0.082	1.233GluLys: 1.233 ± 0.047	5.657GluLeu: 5.657 ± 0.108	1.7GluMet: 1.7 ± 0.051	1.888GluAsn: 1.888 ± 0.05	3.16GluPro: 3.16 ± 0.085	2.412GluGln: 2.412 ± 0.069	7.563GluArg: 7.563 ± 0.104	5.272GluSer: 5.272 ± 0.089	6.705GluThr: 6.705 ± 0.114	4.731GluVal: 4.731 ± 0.094	1.098GluTrp: 1.098 ± 0.042	2.407GluTyr: 2.407 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.208PheAla: 3.208 ± 0.068	0.215PheCys: 0.215 ± 0.015	3.326PheAsp: 3.326 ± 0.077	3.194PheGlu: 3.194 ± 0.075	0.857PhePhe: 0.857 ± 0.035	2.868PheGly: 2.868 ± 0.07	0.566PheHis: 0.566 ± 0.026	0.763PheIle: 0.763 ± 0.034	0.409PheLys: 0.409 ± 0.029	2.158PheLeu: 2.158 ± 0.063	0.41PheMet: 0.41 ± 0.025	0.542PheAsn: 0.542 ± 0.028	1.2PhePro: 1.2 ± 0.038	0.766PheGln: 0.766 ± 0.03	1.522PheArg: 1.522 ± 0.044	1.366PheSer: 1.366 ± 0.042	1.59PheThr: 1.59 ± 0.048	3.123PheVal: 3.123 ± 0.067	0.371PheTrp: 0.371 ± 0.02	0.71PheTyr: 0.71 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.835GlyAla: 8.835 ± 0.144	0.586GlyCys: 0.586 ± 0.029	7.039GlyAsp: 7.039 ± 0.114	6.171GlyGlu: 6.171 ± 0.107	2.64GlyPhe: 2.64 ± 0.06	7.106GlyGly: 7.106 ± 0.136	1.81GlyHis: 1.81 ± 0.051	3.752GlyIle: 3.752 ± 0.076	1.359GlyLys: 1.359 ± 0.041	7.62GlyLeu: 7.62 ± 0.138	1.458GlyMet: 1.458 ± 0.051	1.633GlyAsn: 1.633 ± 0.054	4.318GlyPro: 4.318 ± 0.087	2.216GlyGln: 2.216 ± 0.06	5.296GlyArg: 5.296 ± 0.093	5.401GlySer: 5.401 ± 0.103	6.252GlyThr: 6.252 ± 0.158	7.744GlyVal: 7.744 ± 0.119	1.174GlyTrp: 1.174 ± 0.045	2.272GlyTyr: 2.272 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.121HisAla: 2.121 ± 0.06	0.218HisCys: 0.218 ± 0.016	1.922HisAsp: 1.922 ± 0.053	1.482HisGlu: 1.482 ± 0.04	0.499HisPhe: 0.499 ± 0.026	1.792HisGly: 1.792 ± 0.06	0.557HisHis: 0.557 ± 0.027	0.573HisIle: 0.573 ± 0.031	0.264HisLys: 0.264 ± 0.019	1.832HisLeu: 1.832 ± 0.049	0.254HisMet: 0.254 ± 0.019	0.386HisAsn: 0.386 ± 0.021	1.348HisPro: 1.348 ± 0.041	0.501HisGln: 0.501 ± 0.024	1.564HisArg: 1.564 ± 0.042	0.928HisSer: 0.928 ± 0.037	1.111HisThr: 1.111 ± 0.038	1.979HisVal: 1.979 ± 0.053	0.267HisTrp: 0.267 ± 0.019	0.487HisTyr: 0.487 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.97IleAla: 5.97 ± 0.101	0.282IleCys: 0.282 ± 0.016	5.782IleAsp: 5.782 ± 0.096	4.906IleGlu: 4.906 ± 0.091	0.874IlePhe: 0.874 ± 0.043	4.259IleGly: 4.259 ± 0.085	0.853IleHis: 0.853 ± 0.033	0.89IleIle: 0.89 ± 0.038	0.625IleLys: 0.625 ± 0.031	2.649IleLeu: 2.649 ± 0.073	0.444IleMet: 0.444 ± 0.023	0.852IleAsn: 0.852 ± 0.032	2.007IlePro: 2.007 ± 0.054	1.157IleGln: 1.157 ± 0.038	2.596IleArg: 2.596 ± 0.056	1.958IleSer: 1.958 ± 0.057	2.54IleThr: 2.54 ± 0.064	4.628IleVal: 4.628 ± 0.088	0.354IleTrp: 0.354 ± 0.025	0.857IleTyr: 0.857 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	1.353LysAla: 1.353 ± 0.048	0.094LysCys: 0.094 ± 0.011	0.837LysAsp: 0.837 ± 0.04	0.856LysGlu: 0.856 ± 0.038	0.445LysPhe: 0.445 ± 0.024	0.976LysGly: 0.976 ± 0.044	0.32LysHis: 0.32 ± 0.019	0.707LysIle: 0.707 ± 0.032	0.31LysLys: 0.31 ± 0.028	1.262LysLeu: 1.262 ± 0.048	0.277LysMet: 0.277 ± 0.019	0.402LysAsn: 0.402 ± 0.026	0.714LysPro: 0.714 ± 0.03	0.521LysGln: 0.521 ± 0.028	1.245LysArg: 1.245 ± 0.043	0.942LysSer: 0.942 ± 0.036	1.08LysThr: 1.08 ± 0.041	0.876LysVal: 0.876 ± 0.035	0.191LysTrp: 0.191 ± 0.017	0.445LysTyr: 0.445 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	11.751LeuAla: 11.751 ± 0.177	0.511LeuCys: 0.511 ± 0.025	9.284LeuAsp: 9.284 ± 0.138	5.791LeuGlu: 5.791 ± 0.115	2.759LeuPhe: 2.759 ± 0.073	7.119LeuGly: 7.119 ± 0.122	1.317LeuHis: 1.317 ± 0.042	3.268LeuIle: 3.268 ± 0.076	1.243LeuLys: 1.243 ± 0.046	7.057LeuLeu: 7.057 ± 0.141	1.183LeuMet: 1.183 ± 0.039	1.536LeuAsn: 1.536 ± 0.046	3.907LeuPro: 3.907 ± 0.07	2.064LeuGln: 2.064 ± 0.056	5.02LeuArg: 5.02 ± 0.083	5.041LeuSer: 5.041 ± 0.099	5.081LeuThr: 5.081 ± 0.087	8.067LeuVal: 8.067 ± 0.147	0.821LeuTrp: 0.821 ± 0.033	2.031LeuTyr: 2.031 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.016MetAla: 2.016 ± 0.052	0.111MetCys: 0.111 ± 0.012	1.321MetAsp: 1.321 ± 0.043	0.953MetGlu: 0.953 ± 0.04	0.429MetPhe: 0.429 ± 0.024	1.359MetGly: 1.359 ± 0.041	0.357MetHis: 0.357 ± 0.021	0.712MetIle: 0.712 ± 0.03	0.309MetLys: 0.309 ± 0.023	1.26MetLeu: 1.26 ± 0.041	0.296MetMet: 0.296 ± 0.019	0.476MetAsn: 0.476 ± 0.021	0.799MetPro: 0.799 ± 0.031	0.443MetGln: 0.443 ± 0.024	0.929MetArg: 0.929 ± 0.029	1.279MetSer: 1.279 ± 0.042	1.433MetThr: 1.433 ± 0.045	1.247MetVal: 1.247 ± 0.038	0.148MetTrp: 0.148 ± 0.014	0.328MetTyr: 0.328 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.356AsnAla: 2.356 ± 0.065	0.166AsnCys: 0.166 ± 0.014	1.596AsnAsp: 1.596 ± 0.052	1.388AsnGlu: 1.388 ± 0.057	0.544AsnPhe: 0.544 ± 0.03	1.77AsnGly: 1.77 ± 0.075	0.44AsnHis: 0.44 ± 0.025	0.654AsnIle: 0.654 ± 0.031	0.329AsnLys: 0.329 ± 0.022	1.805AsnLeu: 1.805 ± 0.053	0.376AsnMet: 0.376 ± 0.024	0.458AsnAsn: 0.458 ± 0.032	1.179AsnPro: 1.179 ± 0.042	0.54AsnGln: 0.54 ± 0.032	1.453AsnArg: 1.453 ± 0.046	0.916AsnSer: 0.916 ± 0.041	1.23AsnThr: 1.23 ± 0.055	2.03AsnVal: 2.03 ± 0.053	0.306AsnTrp: 0.306 ± 0.021	0.581AsnTyr: 0.581 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.59ProAla: 5.59 ± 0.112	0.275ProCys: 0.275 ± 0.021	5.773ProAsp: 5.773 ± 0.097	4.303ProGlu: 4.303 ± 0.083	1.411ProPhe: 1.411 ± 0.044	4.155ProGly: 4.155 ± 0.09	0.859ProHis: 0.859 ± 0.035	2.669ProIle: 2.669 ± 0.06	0.659ProLys: 0.659 ± 0.027	3.57ProLeu: 3.57 ± 0.066	0.795ProMet: 0.795 ± 0.028	1.01ProAsn: 1.01 ± 0.035	2.492ProPro: 2.492 ± 0.067	0.971ProGln: 0.971 ± 0.036	2.422ProArg: 2.422 ± 0.059	2.708ProSer: 2.708 ± 0.067	3.831ProThr: 3.831 ± 0.076	4.385ProVal: 4.385 ± 0.091	0.599ProTrp: 0.599 ± 0.029	1.148ProTyr: 1.148 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.506GlnAla: 2.506 ± 0.059	0.199GlnCys: 0.199 ± 0.016	1.601GlnAsp: 1.601 ± 0.049	1.41GlnGlu: 1.41 ± 0.051	1.185GlnPhe: 1.185 ± 0.036	1.533GlnGly: 1.533 ± 0.054	0.52GlnHis: 0.52 ± 0.026	1.42GlnIle: 1.42 ± 0.044	0.491GlnLys: 0.491 ± 0.029	1.925GlnLeu: 1.925 ± 0.058	0.472GlnMet: 0.472 ± 0.026	0.669GlnAsn: 0.669 ± 0.032	1.125GlnPro: 1.125 ± 0.041	0.857GlnGln: 0.857 ± 0.042	2.041GlnArg: 2.041 ± 0.053	1.792GlnSer: 1.792 ± 0.053	1.779GlnThr: 1.779 ± 0.05	1.905GlnVal: 1.905 ± 0.057	0.353GlnTrp: 0.353 ± 0.024	0.772GlnTyr: 0.772 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	7.867ArgAla: 7.867 ± 0.125	0.462ArgCys: 0.462 ± 0.027	5.542ArgAsp: 5.542 ± 0.103	6.385ArgGlu: 6.385 ± 0.106	2.151ArgPhe: 2.151 ± 0.049	4.328ArgGly: 4.328 ± 0.073	1.272ArgHis: 1.272 ± 0.04	3.536ArgIle: 3.536 ± 0.065	1.029ArgLys: 1.029 ± 0.044	6.44ArgLeu: 6.44 ± 0.091	1.239ArgMet: 1.239 ± 0.042	1.288ArgAsn: 1.288 ± 0.041	3.355ArgPro: 3.355 ± 0.074	1.87ArgGln: 1.87 ± 0.047	5.325ArgArg: 5.325 ± 0.111	4.528ArgSer: 4.528 ± 0.079	4.307ArgThr: 4.307 ± 0.081	6.013ArgVal: 6.013 ± 0.1	0.873ArgTrp: 0.873 ± 0.039	1.805ArgTyr: 1.805 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.989SerAla: 5.989 ± 0.096	0.309SerCys: 0.309 ± 0.025	4.839SerAsp: 4.839 ± 0.088	4.337SerGlu: 4.337 ± 0.087	1.591SerPhe: 1.591 ± 0.047	5.563SerGly: 5.563 ± 0.11	0.952SerHis: 0.952 ± 0.036	3.13SerIle: 3.13 ± 0.068	0.928SerLys: 0.928 ± 0.042	4.381SerLeu: 4.381 ± 0.087	1.042SerMet: 1.042 ± 0.037	1.281SerAsn: 1.281 ± 0.053	2.583SerPro: 2.583 ± 0.063	1.247SerGln: 1.247 ± 0.041	3.044SerArg: 3.044 ± 0.059	2.893SerSer: 2.893 ± 0.076	3.813SerThr: 3.813 ± 0.083	5.708SerVal: 5.708 ± 0.096	0.586SerTrp: 0.586 ± 0.028	1.234SerTyr: 1.234 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.697ThrAla: 7.697 ± 0.139	0.366ThrCys: 0.366 ± 0.023	6.599ThrAsp: 6.599 ± 0.129	4.178ThrGlu: 4.178 ± 0.086	1.921ThrPhe: 1.921 ± 0.057	5.948ThrGly: 5.948 ± 0.11	1.324ThrHis: 1.324 ± 0.043	3.705ThrIle: 3.705 ± 0.063	0.777ThrLys: 0.777 ± 0.034	6.142ThrLeu: 6.142 ± 0.083	0.976ThrMet: 0.976 ± 0.036	1.359ThrAsn: 1.359 ± 0.047	3.722ThrPro: 3.722 ± 0.075	1.401ThrGln: 1.401 ± 0.044	3.446ThrArg: 3.446 ± 0.066	2.937ThrSer: 2.937 ± 0.075	4.989ThrThr: 4.989 ± 0.131	7.886ThrVal: 7.886 ± 0.141	0.707ThrTrp: 0.707 ± 0.032	1.681ThrTyr: 1.681 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	11.056ValAla: 11.056 ± 0.183	0.664ValCys: 0.664 ± 0.029	8.101ValAsp: 8.101 ± 0.116	7.901ValGlu: 7.901 ± 0.121	2.577ValPhe: 2.577 ± 0.067	8.146ValGly: 8.146 ± 0.152	1.754ValHis: 1.754 ± 0.046	3.557ValIle: 3.557 ± 0.08	1.059ValLys: 1.059 ± 0.04	7.943ValLeu: 7.943 ± 0.128	1.311ValMet: 1.311 ± 0.044	1.811ValAsn: 1.811 ± 0.058	4.495ValPro: 4.495 ± 0.086	1.927ValGln: 1.927 ± 0.052	5.756ValArg: 5.756 ± 0.096	4.948ValSer: 4.948 ± 0.085	6.509ValThr: 6.509 ± 0.118	9.016ValVal: 9.016 ± 0.16	0.885ValTrp: 0.885 ± 0.039	1.982ValTyr: 1.982 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	1.163TrpAla: 1.163 ± 0.043	0.114TrpCys: 0.114 ± 0.012	0.795TrpAsp: 0.795 ± 0.038	0.721TrpGlu: 0.721 ± 0.036	0.376TrpPhe: 0.376 ± 0.023	0.853TrpGly: 0.853 ± 0.034	0.225TrpHis: 0.225 ± 0.02	0.611TrpIle: 0.611 ± 0.031	0.208TrpLys: 0.208 ± 0.016	1.221TrpLeu: 1.221 ± 0.047	0.191TrpMet: 0.191 ± 0.014	0.316TrpAsn: 0.316 ± 0.023	0.619TrpPro: 0.619 ± 0.03	0.421TrpGln: 0.421 ± 0.029	0.887TrpArg: 0.887 ± 0.039	0.661TrpSer: 0.661 ± 0.033	1.025TrpThr: 1.025 ± 0.048	0.9TrpVal: 0.9 ± 0.042	0.229TrpTrp: 0.229 ± 0.018	0.343TrpTyr: 0.343 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.678TyrAla: 2.678 ± 0.069	0.261TyrCys: 0.261 ± 0.018	2.511TyrAsp: 2.511 ± 0.063	2.075TyrGlu: 2.075 ± 0.058	0.685TyrPhe: 0.685 ± 0.029	2.016TyrGly: 2.016 ± 0.055	0.613TyrHis: 0.613 ± 0.032	0.628TyrIle: 0.628 ± 0.031	0.318TyrLys: 0.318 ± 0.021	2.243TyrLeu: 2.243 ± 0.062	0.311TyrMet: 0.311 ± 0.018	0.538TyrAsn: 0.538 ± 0.029	1.121TyrPro: 1.121 ± 0.038	0.649TyrGln: 0.649 ± 0.031	2.012TyrArg: 2.012 ± 0.053	1.148TyrSer: 1.148 ± 0.041	1.34TyrThr: 1.34 ± 0.048	2.082TyrVal: 2.082 ± 0.055	0.306TyrTrp: 0.306 ± 0.022	0.775TyrTyr: 0.775 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2532 proteins (790179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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