Amino acid dipepetide frequency for Daldinia sp. EC12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.489AlaAla: 8.489 ± 0.061	1.026AlaCys: 1.026 ± 0.016	4.148AlaAsp: 4.148 ± 0.033	4.988AlaGlu: 4.988 ± 0.038	3.063AlaPhe: 3.063 ± 0.027	5.486AlaGly: 5.486 ± 0.039	1.68AlaHis: 1.68 ± 0.019	4.377AlaIle: 4.377 ± 0.033	4.092AlaLys: 4.092 ± 0.038	7.438AlaLeu: 7.438 ± 0.045	1.799AlaMet: 1.799 ± 0.021	3.05AlaAsn: 3.05 ± 0.027	4.565AlaPro: 4.565 ± 0.04	3.225AlaGln: 3.225 ± 0.029	4.756AlaArg: 4.756 ± 0.034	6.87AlaSer: 6.87 ± 0.039	5.095AlaThr: 5.095 ± 0.033	5.17AlaVal: 5.17 ± 0.034	1.129AlaTrp: 1.129 ± 0.015	2.194AlaTyr: 2.194 ± 0.02	0.001AlaXaa: 0.001 ± 0.0
Cys	0.911CysAla: 0.911 ± 0.014	0.258CysCys: 0.258 ± 0.007	0.642CysAsp: 0.642 ± 0.01	0.599CysGlu: 0.599 ± 0.011	0.53CysPhe: 0.53 ± 0.01	0.909CysGly: 0.909 ± 0.016	0.328CysHis: 0.328 ± 0.008	0.736CysIle: 0.736 ± 0.012	0.527CysLys: 0.527 ± 0.011	1.227CysLeu: 1.227 ± 0.017	0.262CysMet: 0.262 ± 0.007	0.423CysAsn: 0.423 ± 0.009	0.651CysPro: 0.651 ± 0.013	0.432CysGln: 0.432 ± 0.01	0.729CysArg: 0.729 ± 0.014	0.874CysSer: 0.874 ± 0.015	0.692CysThr: 0.692 ± 0.013	0.743CysVal: 0.743 ± 0.012	0.206CysTrp: 0.206 ± 0.007	0.37CysTyr: 0.37 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.54AspAla: 4.54 ± 0.03	0.598AspCys: 0.598 ± 0.013	4.437AspAsp: 4.437 ± 0.051	4.625AspGlu: 4.625 ± 0.038	2.217AspPhe: 2.217 ± 0.026	4.074AspGly: 4.074 ± 0.033	1.197AspHis: 1.197 ± 0.017	3.352AspIle: 3.352 ± 0.028	2.549AspLys: 2.549 ± 0.021	4.997AspLeu: 4.997 ± 0.035	1.218AspMet: 1.218 ± 0.017	2.066AspAsn: 2.066 ± 0.02	3.4AspPro: 3.4 ± 0.029	1.821AspGln: 1.821 ± 0.021	3.017AspArg: 3.017 ± 0.03	4.176AspSer: 4.176 ± 0.033	2.981AspThr: 2.981 ± 0.027	3.699AspVal: 3.699 ± 0.027	0.919AspTrp: 0.919 ± 0.013	1.661AspTyr: 1.661 ± 0.02	0.002AspXaa: 0.002 ± 0.001
Glu	5.293GluAla: 5.293 ± 0.039	0.61GluCys: 0.61 ± 0.012	4.35GluAsp: 4.35 ± 0.033	5.477GluGlu: 5.477 ± 0.051	2.012GluPhe: 2.012 ± 0.022	3.765GluGly: 3.765 ± 0.03	1.36GluHis: 1.36 ± 0.017	3.196GluIle: 3.196 ± 0.027	3.918GluLys: 3.918 ± 0.04	5.313GluLeu: 5.313 ± 0.037	1.347GluMet: 1.347 ± 0.015	2.481GluAsn: 2.481 ± 0.022	2.879GluPro: 2.879 ± 0.031	2.39GluGln: 2.39 ± 0.025	3.938GluArg: 3.938 ± 0.03	4.345GluSer: 4.345 ± 0.032	3.488GluThr: 3.488 ± 0.029	3.575GluVal: 3.575 ± 0.027	0.901GluTrp: 0.901 ± 0.011	1.781GluTyr: 1.781 ± 0.018	0.001GluXaa: 0.001 ± 0.001
Phe	2.99PheAla: 2.99 ± 0.025	0.559PheCys: 0.559 ± 0.01	2.307PheAsp: 2.307 ± 0.021	2.218PheGlu: 2.218 ± 0.023	1.666PhePhe: 1.666 ± 0.02	2.86PheGly: 2.86 ± 0.029	0.866PheHis: 0.866 ± 0.013	1.921PheIle: 1.921 ± 0.021	1.61PheLys: 1.61 ± 0.018	3.498PheLeu: 3.498 ± 0.032	0.773PheMet: 0.773 ± 0.013	1.503PheAsn: 1.503 ± 0.017	1.974PhePro: 1.974 ± 0.023	1.372PheGln: 1.372 ± 0.017	2.029PheArg: 2.029 ± 0.02	3.005PheSer: 3.005 ± 0.021	2.191PheThr: 2.191 ± 0.024	2.432PheVal: 2.432 ± 0.024	0.659PheTrp: 0.659 ± 0.013	1.181PheTyr: 1.181 ± 0.016	0.001PheXaa: 0.001 ± 0.0
Gly	5.11GlyAla: 5.11 ± 0.034	0.849GlyCys: 0.849 ± 0.015	3.626GlyAsp: 3.626 ± 0.029	3.642GlyGlu: 3.642 ± 0.029	2.826GlyPhe: 2.826 ± 0.023	5.72GlyGly: 5.72 ± 0.056	1.646GlyHis: 1.646 ± 0.019	3.71GlyIle: 3.71 ± 0.03	3.562GlyLys: 3.562 ± 0.031	5.987GlyLeu: 5.987 ± 0.036	1.498GlyMet: 1.498 ± 0.017	2.772GlyAsn: 2.772 ± 0.023	3.372GlyPro: 3.372 ± 0.029	2.438GlyGln: 2.438 ± 0.022	4.083GlyArg: 4.083 ± 0.033	5.689GlySer: 5.689 ± 0.035	3.99GlyThr: 3.99 ± 0.027	4.361GlyVal: 4.361 ± 0.037	1.179GlyTrp: 1.179 ± 0.016	2.191GlyTyr: 2.191 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.664HisAla: 1.664 ± 0.019	0.31HisCys: 0.31 ± 0.007	1.274HisAsp: 1.274 ± 0.016	1.299HisGlu: 1.299 ± 0.018	0.908HisPhe: 0.908 ± 0.013	1.642HisGly: 1.642 ± 0.02	0.836HisHis: 0.836 ± 0.016	1.294HisIle: 1.294 ± 0.016	0.943HisLys: 0.943 ± 0.013	2.112HisLeu: 2.112 ± 0.019	0.488HisMet: 0.488 ± 0.01	0.874HisAsn: 0.874 ± 0.015	1.622HisPro: 1.622 ± 0.019	0.944HisGln: 0.944 ± 0.015	1.471HisArg: 1.471 ± 0.02	1.722HisSer: 1.722 ± 0.022	1.23HisThr: 1.23 ± 0.015	1.374HisVal: 1.374 ± 0.018	0.323HisTrp: 0.323 ± 0.008	0.704HisTyr: 0.704 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.267IleAla: 4.267 ± 0.033	0.756IleCys: 0.756 ± 0.012	3.049IleAsp: 3.049 ± 0.026	3.089IleGlu: 3.089 ± 0.025	2.119IlePhe: 2.119 ± 0.025	3.35IleGly: 3.35 ± 0.028	1.209IleHis: 1.209 ± 0.015	2.835IleIle: 2.835 ± 0.032	2.403IleLys: 2.403 ± 0.022	4.752IleLeu: 4.752 ± 0.037	1.07IleMet: 1.07 ± 0.014	1.985IleAsn: 1.985 ± 0.023	3.319IlePro: 3.319 ± 0.03	1.965IleGln: 1.965 ± 0.017	3.054IleArg: 3.054 ± 0.026	4.096IleSer: 4.096 ± 0.028	2.999IleThr: 2.999 ± 0.024	3.323IleVal: 3.323 ± 0.03	0.791IleTrp: 0.791 ± 0.013	1.538IleTyr: 1.538 ± 0.02	0.001IleXaa: 0.001 ± 0.0
Lys	4.304LysAla: 4.304 ± 0.04	0.507LysCys: 0.507 ± 0.009	2.97LysAsp: 2.97 ± 0.026	3.545LysGlu: 3.545 ± 0.036	1.562LysPhe: 1.562 ± 0.017	3.115LysGly: 3.115 ± 0.027	1.112LysHis: 1.112 ± 0.016	2.436LysIle: 2.436 ± 0.022	3.528LysLys: 3.528 ± 0.048	4.322LysLeu: 4.322 ± 0.029	0.992LysMet: 0.992 ± 0.015	1.856LysAsn: 1.856 ± 0.016	2.94LysPro: 2.94 ± 0.027	1.882LysGln: 1.882 ± 0.023	3.448LysArg: 3.448 ± 0.03	3.704LysSer: 3.704 ± 0.027	2.894LysThr: 2.894 ± 0.028	2.936LysVal: 2.936 ± 0.027	0.719LysTrp: 0.719 ± 0.012	1.506LysTyr: 1.506 ± 0.021	0.001LysXaa: 0.001 ± 0.0
Leu	7.629LeuAla: 7.629 ± 0.046	1.166LeuCys: 1.166 ± 0.017	5.152LeuAsp: 5.152 ± 0.036	5.525LeuGlu: 5.525 ± 0.039	3.355LeuPhe: 3.355 ± 0.033	5.933LeuGly: 5.933 ± 0.04	2.059LeuHis: 2.059 ± 0.021	4.146LeuIle: 4.146 ± 0.033	4.325LeuLys: 4.325 ± 0.036	8.204LeuLeu: 8.204 ± 0.057	1.661LeuMet: 1.661 ± 0.018	3.242LeuAsn: 3.242 ± 0.025	5.403LeuPro: 5.403 ± 0.035	3.536LeuGln: 3.536 ± 0.034	5.725LeuArg: 5.725 ± 0.045	7.202LeuSer: 7.202 ± 0.041	4.822LeuThr: 4.822 ± 0.032	5.434LeuVal: 5.434 ± 0.038	1.237LeuTrp: 1.237 ± 0.016	2.421LeuTyr: 2.421 ± 0.023	0.001LeuXaa: 0.001 ± 0.001
Met	2.107MetAla: 2.107 ± 0.021	0.231MetCys: 0.231 ± 0.007	1.211MetAsp: 1.211 ± 0.016	1.187MetGlu: 1.187 ± 0.017	0.712MetPhe: 0.712 ± 0.012	1.39MetGly: 1.39 ± 0.017	0.445MetHis: 0.445 ± 0.009	1.005MetIle: 1.005 ± 0.016	1.007MetLys: 1.007 ± 0.015	1.751MetLeu: 1.751 ± 0.021	0.547MetMet: 0.547 ± 0.011	0.774MetAsn: 0.774 ± 0.014	1.193MetPro: 1.193 ± 0.014	0.79MetGln: 0.79 ± 0.014	1.24MetArg: 1.24 ± 0.017	1.778MetSer: 1.778 ± 0.019	1.233MetThr: 1.233 ± 0.015	1.251MetVal: 1.251 ± 0.018	0.258MetTrp: 0.258 ± 0.008	0.54MetTyr: 0.54 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.131AsnAla: 3.131 ± 0.023	0.465AsnCys: 0.465 ± 0.011	2.083AsnAsp: 2.083 ± 0.021	2.184AsnGlu: 2.184 ± 0.022	1.473AsnPhe: 1.473 ± 0.017	3.143AsnGly: 3.143 ± 0.032	0.882AsnHis: 0.882 ± 0.014	2.228AsnIle: 2.228 ± 0.017	1.688AsnLys: 1.688 ± 0.018	3.391AsnLeu: 3.391 ± 0.025	0.832AsnMet: 0.832 ± 0.014	1.75AsnAsn: 1.75 ± 0.025	2.604AsnPro: 2.604 ± 0.024	1.406AsnGln: 1.406 ± 0.019	2.061AsnArg: 2.061 ± 0.024	3.04AsnSer: 3.04 ± 0.026	2.331AsnThr: 2.331 ± 0.023	2.395AsnVal: 2.395 ± 0.024	0.586AsnTrp: 0.586 ± 0.011	1.186AsnTyr: 1.186 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.842ProAla: 4.842 ± 0.043	0.525ProCys: 0.525 ± 0.012	3.288ProAsp: 3.288 ± 0.026	3.98ProGlu: 3.98 ± 0.035	2.091ProPhe: 2.091 ± 0.02	3.993ProGly: 3.993 ± 0.035	1.289ProHis: 1.289 ± 0.018	2.794ProIle: 2.794 ± 0.021	2.854ProLys: 2.854 ± 0.028	4.749ProLeu: 4.749 ± 0.03	1.06ProMet: 1.06 ± 0.015	2.422ProAsn: 2.422 ± 0.023	5.26ProPro: 5.26 ± 0.073	2.487ProGln: 2.487 ± 0.034	3.463ProArg: 3.463 ± 0.033	5.826ProSer: 5.826 ± 0.048	4.038ProThr: 4.038 ± 0.038	3.521ProVal: 3.521 ± 0.029	0.758ProTrp: 0.758 ± 0.012	1.634ProTyr: 1.634 ± 0.019	0.001ProXaa: 0.001 ± 0.001
Gln	3.216GlnAla: 3.216 ± 0.029	0.433GlnCys: 0.433 ± 0.011	2.039GlnAsp: 2.039 ± 0.02	2.372GlnGlu: 2.372 ± 0.023	1.295GlnPhe: 1.295 ± 0.015	2.329GlnGly: 2.329 ± 0.025	1.017GlnHis: 1.017 ± 0.017	1.915GlnIle: 1.915 ± 0.021	1.97GlnLys: 1.97 ± 0.022	3.365GlnLeu: 3.365 ± 0.028	0.805GlnMet: 0.805 ± 0.016	1.567GlnAsn: 1.567 ± 0.019	2.55GlnPro: 2.55 ± 0.033	2.253GlnGln: 2.253 ± 0.048	2.469GlnArg: 2.469 ± 0.027	2.934GlnSer: 2.934 ± 0.031	2.221GlnThr: 2.221 ± 0.021	2.156GlnVal: 2.156 ± 0.02	0.582GlnTrp: 0.582 ± 0.011	1.179GlnTyr: 1.179 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.55ArgAla: 4.55 ± 0.035	0.71ArgCys: 0.71 ± 0.012	3.503ArgAsp: 3.503 ± 0.032	3.875ArgGlu: 3.875 ± 0.035	2.16ArgPhe: 2.16 ± 0.017	3.789ArgGly: 3.789 ± 0.035	1.529ArgHis: 1.529 ± 0.019	3.102ArgIle: 3.102 ± 0.027	3.531ArgLys: 3.531 ± 0.028	5.321ArgLeu: 5.321 ± 0.034	1.286ArgMet: 1.286 ± 0.016	2.403ArgAsn: 2.403 ± 0.023	3.506ArgPro: 3.506 ± 0.031	2.518ArgGln: 2.518 ± 0.024	5.166ArgArg: 5.166 ± 0.046	4.676ArgSer: 4.676 ± 0.039	3.24ArgThr: 3.24 ± 0.026	3.388ArgVal: 3.388 ± 0.029	0.957ArgTrp: 0.957 ± 0.013	1.762ArgTyr: 1.762 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.221SerAla: 6.221 ± 0.042	0.85SerCys: 0.85 ± 0.015	4.205SerAsp: 4.205 ± 0.031	4.216SerGlu: 4.216 ± 0.031	3.054SerPhe: 3.054 ± 0.026	5.516SerGly: 5.516 ± 0.039	1.89SerHis: 1.89 ± 0.024	4.221SerIle: 4.221 ± 0.034	3.915SerLys: 3.915 ± 0.032	7.029SerLeu: 7.029 ± 0.041	1.622SerMet: 1.622 ± 0.021	3.229SerAsn: 3.229 ± 0.029	5.421SerPro: 5.421 ± 0.053	3.291SerGln: 3.291 ± 0.032	5.045SerArg: 5.045 ± 0.045	8.789SerSer: 8.789 ± 0.083	5.529SerThr: 5.529 ± 0.045	4.429SerVal: 4.429 ± 0.027	1.174SerTrp: 1.174 ± 0.015	2.202SerTyr: 2.202 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	4.989ThrAla: 4.989 ± 0.035	0.757ThrCys: 0.757 ± 0.013	2.786ThrAsp: 2.786 ± 0.021	3.14ThrGlu: 3.14 ± 0.026	2.281ThrPhe: 2.281 ± 0.023	4.147ThrGly: 4.147 ± 0.03	1.264ThrHis: 1.264 ± 0.018	3.209ThrIle: 3.209 ± 0.028	2.768ThrLys: 2.768 ± 0.023	5.088ThrLeu: 5.088 ± 0.034	1.176ThrMet: 1.176 ± 0.015	2.266ThrAsn: 2.266 ± 0.024	4.35ThrPro: 4.35 ± 0.038	2.054ThrGln: 2.054 ± 0.02	3.197ThrArg: 3.197 ± 0.026	5.384ThrSer: 5.384 ± 0.046	4.317ThrThr: 4.317 ± 0.04	3.604ThrVal: 3.604 ± 0.027	0.887ThrTrp: 0.887 ± 0.013	1.737ThrTyr: 1.737 ± 0.018	0.001ThrXaa: 0.001 ± 0.0
Val	5.105ValAla: 5.105 ± 0.033	0.792ValCys: 0.792 ± 0.013	3.748ValAsp: 3.748 ± 0.03	3.889ValGlu: 3.889 ± 0.027	2.46ValPhe: 2.46 ± 0.026	3.987ValGly: 3.987 ± 0.03	1.313ValHis: 1.313 ± 0.018	3.102ValIle: 3.102 ± 0.026	3.027ValLys: 3.027 ± 0.027	5.514ValLeu: 5.514 ± 0.038	1.239ValMet: 1.239 ± 0.018	2.329ValAsn: 2.329 ± 0.021	3.626ValPro: 3.626 ± 0.03	2.219ValGln: 2.219 ± 0.02	3.416ValArg: 3.416 ± 0.028	4.544ValSer: 4.544 ± 0.035	3.518ValThr: 3.518 ± 0.032	4.278ValVal: 4.278 ± 0.036	0.856ValTrp: 0.856 ± 0.013	1.79ValTyr: 1.79 ± 0.017	0.001ValXaa: 0.001 ± 0.0
Trp	1.121TrpAla: 1.121 ± 0.014	0.204TrpCys: 0.204 ± 0.006	0.939TrpAsp: 0.939 ± 0.013	0.892TrpGlu: 0.892 ± 0.014	0.563TrpPhe: 0.563 ± 0.012	0.961TrpGly: 0.961 ± 0.013	0.352TrpHis: 0.352 ± 0.009	0.834TrpIle: 0.834 ± 0.012	0.841TrpLys: 0.841 ± 0.013	1.365TrpLeu: 1.365 ± 0.017	0.349TrpMet: 0.349 ± 0.008	0.665TrpAsn: 0.665 ± 0.011	0.632TrpPro: 0.632 ± 0.012	0.551TrpGln: 0.551 ± 0.01	0.966TrpArg: 0.966 ± 0.013	1.042TrpSer: 1.042 ± 0.016	0.929TrpThr: 0.929 ± 0.013	0.919TrpVal: 0.919 ± 0.013	0.278TrpTrp: 0.278 ± 0.008	0.456TrpTyr: 0.456 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.161TyrAla: 2.161 ± 0.021	0.442TyrCys: 0.442 ± 0.01	1.789TyrAsp: 1.789 ± 0.021	1.676TyrGlu: 1.676 ± 0.018	1.264TyrPhe: 1.264 ± 0.016	2.142TyrGly: 2.142 ± 0.022	0.76TyrHis: 0.76 ± 0.012	1.556TyrIle: 1.556 ± 0.019	1.219TyrLys: 1.219 ± 0.017	2.753TyrLeu: 2.753 ± 0.024	0.629TyrMet: 0.629 ± 0.011	1.206TyrAsn: 1.206 ± 0.017	1.608TyrPro: 1.608 ± 0.023	1.093TyrGln: 1.093 ± 0.017	1.697TyrArg: 1.697 ± 0.019	2.151TyrSer: 2.151 ± 0.022	1.66TyrThr: 1.66 ± 0.017	1.763TyrVal: 1.763 ± 0.018	0.463TyrTrp: 0.463 ± 0.009	1.045TyrTyr: 1.045 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.048XaaXaa: 0.048 ± 0.014

Statistics based on 11156 proteins (5199705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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