Amino acid dipepetide frequency for Thauera chlorobenzoica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.453AlaAla: 20.453 ± 0.24
1.521AlaCys: 1.521 ± 0.046
7.044AlaAsp: 7.044 ± 0.092
8.282AlaGlu: 8.282 ± 0.108
4.3AlaPhe: 4.3 ± 0.057
12.07AlaGly: 12.07 ± 0.129
2.988AlaHis: 2.988 ± 0.06
5.424AlaIle: 5.424 ± 0.078
3.178AlaLys: 3.178 ± 0.072
16.442AlaLeu: 16.442 ± 0.174
3.172AlaMet: 3.172 ± 0.058
2.519AlaAsn: 2.519 ± 0.048
6.418AlaPro: 6.418 ± 0.106
4.751AlaGln: 4.751 ± 0.075
10.929AlaArg: 10.929 ± 0.137
5.845AlaSer: 5.845 ± 0.084
5.703AlaThr: 5.703 ± 0.072
9.461AlaVal: 9.461 ± 0.106
1.84AlaTrp: 1.84 ± 0.047
2.372AlaTyr: 2.372 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.291CysAla: 1.291 ± 0.04
0.153CysCys: 0.153 ± 0.013
0.612CysAsp: 0.612 ± 0.028
0.565CysGlu: 0.565 ± 0.025
0.356CysPhe: 0.356 ± 0.017
1.091CysGly: 1.091 ± 0.035
0.308CysHis: 0.308 ± 0.019
0.427CysIle: 0.427 ± 0.019
0.242CysLys: 0.242 ± 0.017
0.926CysLeu: 0.926 ± 0.029
0.183CysMet: 0.183 ± 0.014
0.246CysAsn: 0.246 ± 0.015
0.614CysPro: 0.614 ± 0.028
0.23CysGln: 0.23 ± 0.015
0.81CysArg: 0.81 ± 0.028
0.509CysSer: 0.509 ± 0.024
0.554CysThr: 0.554 ± 0.026
0.709CysVal: 0.709 ± 0.027
0.136CysTrp: 0.136 ± 0.011
0.246CysTyr: 0.246 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.245AspAla: 7.245 ± 0.095
0.522AspCys: 0.522 ± 0.022
2.95AspAsp: 2.95 ± 0.062
3.776AspGlu: 3.776 ± 0.058
2.145AspPhe: 2.145 ± 0.046
5.026AspGly: 5.026 ± 0.079
1.209AspHis: 1.209 ± 0.034
2.589AspIle: 2.589 ± 0.062
1.71AspLys: 1.71 ± 0.042
5.249AspLeu: 5.249 ± 0.071
1.086AspMet: 1.086 ± 0.031
1.178AspAsn: 1.178 ± 0.038
3.203AspPro: 3.203 ± 0.061
1.415AspGln: 1.415 ± 0.039
3.589AspArg: 3.589 ± 0.062
2.229AspSer: 2.229 ± 0.039
2.587AspThr: 2.587 ± 0.068
3.645AspVal: 3.645 ± 0.068
0.967AspTrp: 0.967 ± 0.027
1.5AspTyr: 1.5 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
8.33GluAla: 8.33 ± 0.097
0.487GluCys: 0.487 ± 0.02
2.649GluAsp: 2.649 ± 0.052
2.956GluGlu: 2.956 ± 0.059
1.908GluPhe: 1.908 ± 0.043
4.285GluGly: 4.285 ± 0.069
1.719GluHis: 1.719 ± 0.042
3.191GluIle: 3.191 ± 0.056
1.792GluLys: 1.792 ± 0.043
6.929GluLeu: 6.929 ± 0.09
1.315GluMet: 1.315 ± 0.034
1.279GluAsn: 1.279 ± 0.036
2.483GluPro: 2.483 ± 0.047
2.566GluGln: 2.566 ± 0.05
5.927GluArg: 5.927 ± 0.092
2.429GluSer: 2.429 ± 0.05
2.744GluThr: 2.744 ± 0.049
4.466GluVal: 4.466 ± 0.066
0.76GluTrp: 0.76 ± 0.03
1.168GluTyr: 1.168 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.652PheAla: 4.652 ± 0.063
0.428PheCys: 0.428 ± 0.021
2.579PheAsp: 2.579 ± 0.053
2.277PheGlu: 2.277 ± 0.047
1.353PhePhe: 1.353 ± 0.037
3.449PheGly: 3.449 ± 0.059
0.806PheHis: 0.806 ± 0.027
1.63PheIle: 1.63 ± 0.042
0.9PheLys: 0.9 ± 0.029
3.124PheLeu: 3.124 ± 0.059
0.718PheMet: 0.718 ± 0.025
0.991PheAsn: 0.991 ± 0.031
1.514PhePro: 1.514 ± 0.037
0.878PheGln: 0.878 ± 0.029
2.275PheArg: 2.275 ± 0.042
1.948PheSer: 1.948 ± 0.042
1.751PheThr: 1.751 ± 0.04
2.768PheVal: 2.768 ± 0.054
0.481PheTrp: 0.481 ± 0.022
0.828PheTyr: 0.828 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.89GlyAla: 9.89 ± 0.113
0.992GlyCys: 0.992 ± 0.034
4.077GlyAsp: 4.077 ± 0.071
5.635GlyGlu: 5.635 ± 0.08
3.313GlyPhe: 3.313 ± 0.06
7.301GlyGly: 7.301 ± 0.104
2.007GlyHis: 2.007 ± 0.047
4.07GlyIle: 4.07 ± 0.067
2.987GlyLys: 2.987 ± 0.061
9.372GlyLeu: 9.372 ± 0.115
2.342GlyMet: 2.342 ± 0.052
1.95GlyAsn: 1.95 ± 0.054
2.786GlyPro: 2.786 ± 0.056
2.766GlyGln: 2.766 ± 0.053
6.858GlyArg: 6.858 ± 0.091
4.234GlySer: 4.234 ± 0.069
4.072GlyThr: 4.072 ± 0.058
6.564GlyVal: 6.564 ± 0.087
1.413GlyTrp: 1.413 ± 0.039
2.13GlyTyr: 2.13 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
3.118HisAla: 3.118 ± 0.052
0.297HisCys: 0.297 ± 0.019
1.351HisAsp: 1.351 ± 0.034
1.23HisGlu: 1.23 ± 0.035
1.002HisPhe: 1.002 ± 0.03
2.416HisGly: 2.416 ± 0.05
0.692HisHis: 0.692 ± 0.028
0.99HisIle: 0.99 ± 0.033
0.572HisLys: 0.572 ± 0.022
2.517HisLeu: 2.517 ± 0.046
0.469HisMet: 0.469 ± 0.02
0.48HisAsn: 0.48 ± 0.02
1.679HisPro: 1.679 ± 0.042
0.727HisGln: 0.727 ± 0.026
1.774HisArg: 1.774 ± 0.043
1.047HisSer: 1.047 ± 0.032
1.067HisThr: 1.067 ± 0.032
1.506HisVal: 1.506 ± 0.038
0.407HisTrp: 0.407 ± 0.019
0.676HisTyr: 0.676 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.368IleAla: 6.368 ± 0.082
0.443IleCys: 0.443 ± 0.023
3.466IleAsp: 3.466 ± 0.065
3.602IleGlu: 3.602 ± 0.057
1.281IlePhe: 1.281 ± 0.035
4.381IleGly: 4.381 ± 0.071
1.047IleHis: 1.047 ± 0.028
1.603IleIle: 1.603 ± 0.047
1.293IleLys: 1.293 ± 0.041
3.756IleLeu: 3.756 ± 0.066
0.721IleMet: 0.721 ± 0.028
1.258IleAsn: 1.258 ± 0.035
2.14IlePro: 2.14 ± 0.045
1.142IleGln: 1.142 ± 0.034
3.221IleArg: 3.221 ± 0.059
2.12IleSer: 2.12 ± 0.05
2.325IleThr: 2.325 ± 0.056
3.575IleVal: 3.575 ± 0.059
0.402IleTrp: 0.402 ± 0.021
0.931IleTyr: 0.931 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.541LysAla: 3.541 ± 0.074
0.201LysCys: 0.201 ± 0.013
1.436LysAsp: 1.436 ± 0.041
1.384LysGlu: 1.384 ± 0.035
0.822LysPhe: 0.822 ± 0.031
2.156LysGly: 2.156 ± 0.048
0.654LysHis: 0.654 ± 0.023
1.374LysIle: 1.374 ± 0.041
1.168LysLys: 1.168 ± 0.043
3.122LysLeu: 3.122 ± 0.061
0.716LysMet: 0.716 ± 0.027
0.819LysAsn: 0.819 ± 0.029
1.716LysPro: 1.716 ± 0.048
0.993LysGln: 0.993 ± 0.032
2.08LysArg: 2.08 ± 0.05
1.444LysSer: 1.444 ± 0.036
1.545LysThr: 1.545 ± 0.036
2.332LysVal: 2.332 ± 0.052
0.314LysTrp: 0.314 ± 0.017
0.637LysTyr: 0.637 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
16.449LeuAla: 16.449 ± 0.172
1.096LeuCys: 1.096 ± 0.038
6.394LeuAsp: 6.394 ± 0.087
6.581LeuGlu: 6.581 ± 0.096
3.78LeuPhe: 3.78 ± 0.064
9.154LeuGly: 9.154 ± 0.094
2.472LeuHis: 2.472 ± 0.05
4.749LeuIle: 4.749 ± 0.072
3.174LeuLys: 3.174 ± 0.058
11.931LeuLeu: 11.931 ± 0.164
2.32LeuMet: 2.32 ± 0.049
2.446LeuAsn: 2.446 ± 0.05
6.506LeuPro: 6.506 ± 0.087
3.654LeuGln: 3.654 ± 0.067
8.563LeuArg: 8.563 ± 0.104
5.773LeuSer: 5.773 ± 0.079
5.091LeuThr: 5.091 ± 0.077
7.837LeuVal: 7.837 ± 0.099
1.272LeuTrp: 1.272 ± 0.042
2.23LeuTyr: 2.23 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.674MetAla: 2.674 ± 0.055
0.168MetCys: 0.168 ± 0.013
1.003MetAsp: 1.003 ± 0.031
1.05MetGlu: 1.05 ± 0.033
0.708MetPhe: 0.708 ± 0.027
1.588MetGly: 1.588 ± 0.041
0.515MetHis: 0.515 ± 0.02
1.094MetIle: 1.094 ± 0.031
1.037MetLys: 1.037 ± 0.031
2.563MetLeu: 2.563 ± 0.052
0.579MetMet: 0.579 ± 0.026
0.88MetAsn: 0.88 ± 0.029
1.363MetPro: 1.363 ± 0.038
0.825MetGln: 0.825 ± 0.03
1.667MetArg: 1.667 ± 0.038
1.509MetSer: 1.509 ± 0.038
1.276MetThr: 1.276 ± 0.037
1.617MetVal: 1.617 ± 0.046
0.204MetTrp: 0.204 ± 0.013
0.34MetTyr: 0.34 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.886AsnAla: 2.886 ± 0.052
0.257AsnCys: 0.257 ± 0.016
1.116AsnAsp: 1.116 ± 0.033
1.15AsnGlu: 1.15 ± 0.034
0.791AsnPhe: 0.791 ± 0.026
1.893AsnGly: 1.893 ± 0.042
0.539AsnHis: 0.539 ± 0.023
1.106AsnIle: 1.106 ± 0.037
0.658AsnLys: 0.658 ± 0.03
2.556AsnLeu: 2.556 ± 0.05
0.528AsnMet: 0.528 ± 0.025
0.623AsnAsn: 0.623 ± 0.025
1.692AsnPro: 1.692 ± 0.043
0.705AsnGln: 0.705 ± 0.027
1.754AsnArg: 1.754 ± 0.04
0.945AsnSer: 0.945 ± 0.032
1.192AsnThr: 1.192 ± 0.036
1.575AsnVal: 1.575 ± 0.042
0.361AsnTrp: 0.361 ± 0.021
0.583AsnTyr: 0.583 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
7.833ProAla: 7.833 ± 0.116
0.446ProCys: 0.446 ± 0.022
3.046ProAsp: 3.046 ± 0.053
3.559ProGlu: 3.559 ± 0.065
1.796ProPhe: 1.796 ± 0.042
4.805ProGly: 4.805 ± 0.073
1.158ProHis: 1.158 ± 0.032
1.828ProIle: 1.828 ± 0.047
1.251ProLys: 1.251 ± 0.046
5.442ProLeu: 5.442 ± 0.07
1.153ProMet: 1.153 ± 0.033
1.099ProAsn: 1.099 ± 0.035
3.023ProPro: 3.023 ± 0.064
1.851ProGln: 1.851 ± 0.038
3.243ProArg: 3.243 ± 0.058
2.263ProSer: 2.263 ± 0.048
2.195ProThr: 2.195 ± 0.051
4.129ProVal: 4.129 ± 0.065
0.726ProTrp: 0.726 ± 0.028
1.051ProTyr: 1.051 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.039GlnAla: 5.039 ± 0.075
0.314GlnCys: 0.314 ± 0.016
1.49GlnAsp: 1.49 ± 0.041
1.497GlnGlu: 1.497 ± 0.037
0.999GlnPhe: 0.999 ± 0.032
2.491GlnGly: 2.491 ± 0.049
0.819GlnHis: 0.819 ± 0.029
1.56GlnIle: 1.56 ± 0.045
0.935GlnLys: 0.935 ± 0.031
3.678GlnLeu: 3.678 ± 0.068
0.797GlnMet: 0.797 ± 0.03
0.653GlnAsn: 0.653 ± 0.023
1.8GlnPro: 1.8 ± 0.043
1.458GlnGln: 1.458 ± 0.041
3.034GlnArg: 3.034 ± 0.056
1.452GlnSer: 1.452 ± 0.038
1.458GlnThr: 1.458 ± 0.043
2.522GlnVal: 2.522 ± 0.052
0.503GlnTrp: 0.503 ± 0.023
0.662GlnTyr: 0.662 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
9.305ArgAla: 9.305 ± 0.128
0.729ArgCys: 0.729 ± 0.029
3.913ArgAsp: 3.913 ± 0.058
4.843ArgGlu: 4.843 ± 0.075
3.182ArgPhe: 3.182 ± 0.058
5.237ArgGly: 5.237 ± 0.07
2.296ArgHis: 2.296 ± 0.053
4.222ArgIle: 4.222 ± 0.058
2.059ArgLys: 2.059 ± 0.047
9.53ArgLeu: 9.53 ± 0.133
1.969ArgMet: 1.969 ± 0.042
1.844ArgAsn: 1.844 ± 0.04
3.792ArgPro: 3.792 ± 0.074
2.797ArgGln: 2.797 ± 0.055
6.57ArgArg: 6.57 ± 0.092
3.818ArgSer: 3.818 ± 0.064
3.406ArgThr: 3.406 ± 0.052
5.388ArgVal: 5.388 ± 0.073
1.175ArgTrp: 1.175 ± 0.033
2.044ArgTyr: 2.044 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.444SerAla: 6.444 ± 0.083
0.5SerCys: 0.5 ± 0.02
2.305SerAsp: 2.305 ± 0.049
2.383SerGlu: 2.383 ± 0.051
1.857SerPhe: 1.857 ± 0.037
4.946SerGly: 4.946 ± 0.075
1.044SerHis: 1.044 ± 0.032
2.234SerIle: 2.234 ± 0.046
1.226SerLys: 1.226 ± 0.037
5.175SerLeu: 5.175 ± 0.069
1.13SerMet: 1.13 ± 0.031
1.063SerAsn: 1.063 ± 0.035
2.571SerPro: 2.571 ± 0.046
1.363SerGln: 1.363 ± 0.035
3.464SerArg: 3.464 ± 0.068
2.436SerSer: 2.436 ± 0.048
2.387SerThr: 2.387 ± 0.043
3.37SerVal: 3.37 ± 0.057
0.663SerTrp: 0.663 ± 0.023
1.055SerTyr: 1.055 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.815ThrAla: 5.815 ± 0.085
0.44ThrCys: 0.44 ± 0.022
2.33ThrAsp: 2.33 ± 0.047
2.433ThrGlu: 2.433 ± 0.052
1.504ThrPhe: 1.504 ± 0.034
4.221ThrGly: 4.221 ± 0.071
1.083ThrHis: 1.083 ± 0.031
1.96ThrIle: 1.96 ± 0.049
1.013ThrLys: 1.013 ± 0.031
6.122ThrLeu: 6.122 ± 0.079
0.956ThrMet: 0.956 ± 0.033
0.96ThrAsn: 0.96 ± 0.033
3.17ThrPro: 3.17 ± 0.055
1.4ThrGln: 1.4 ± 0.043
3.518ThrArg: 3.518 ± 0.063
1.987ThrSer: 1.987 ± 0.049
2.361ThrThr: 2.361 ± 0.057
4.062ThrVal: 4.062 ± 0.074
0.563ThrTrp: 0.563 ± 0.024
0.929ThrTyr: 0.929 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.547ValAla: 9.547 ± 0.105
0.793ValCys: 0.793 ± 0.026
4.28ValAsp: 4.28 ± 0.065
4.497ValGlu: 4.497 ± 0.069
2.863ValPhe: 2.863 ± 0.052
5.457ValGly: 5.457 ± 0.081
1.736ValHis: 1.736 ± 0.04
3.584ValIle: 3.584 ± 0.06
2.214ValLys: 2.214 ± 0.046
8.587ValLeu: 8.587 ± 0.114
1.756ValMet: 1.756 ± 0.041
1.693ValAsn: 1.693 ± 0.044
3.613ValPro: 3.613 ± 0.061
2.166ValGln: 2.166 ± 0.052
5.672ValArg: 5.672 ± 0.084
3.909ValSer: 3.909 ± 0.063
3.434ValThr: 3.434 ± 0.065
6.136ValVal: 6.136 ± 0.092
0.89ValTrp: 0.89 ± 0.033
1.398ValTyr: 1.398 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.289TrpAla: 1.289 ± 0.033
0.165TrpCys: 0.165 ± 0.012
0.542TrpAsp: 0.542 ± 0.023
0.608TrpGlu: 0.608 ± 0.023
0.532TrpPhe: 0.532 ± 0.021
0.868TrpGly: 0.868 ± 0.024
0.368TrpHis: 0.368 ± 0.021
0.666TrpIle: 0.666 ± 0.025
0.458TrpLys: 0.458 ± 0.022
1.948TrpLeu: 1.948 ± 0.053
0.375TrpMet: 0.375 ± 0.019
0.369TrpAsn: 0.369 ± 0.018
0.674TrpPro: 0.674 ± 0.026
0.72TrpGln: 0.72 ± 0.025
1.209TrpArg: 1.209 ± 0.04
0.697TrpSer: 0.697 ± 0.027
0.617TrpThr: 0.617 ± 0.025
1.014TrpVal: 1.014 ± 0.035
0.244TrpTrp: 0.244 ± 0.015
0.283TrpTyr: 0.283 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.544TyrAla: 2.544 ± 0.051
0.258TyrCys: 0.258 ± 0.015
1.238TyrAsp: 1.238 ± 0.036
1.073TyrGlu: 1.073 ± 0.029
0.859TyrPhe: 0.859 ± 0.03
1.926TyrGly: 1.926 ± 0.045
0.558TyrHis: 0.558 ± 0.024
0.774TyrIle: 0.774 ± 0.025
0.586TyrLys: 0.586 ± 0.024
2.505TyrLeu: 2.505 ± 0.049
0.373TyrMet: 0.373 ± 0.017
0.559TyrAsn: 0.559 ± 0.025
1.141TyrPro: 1.141 ± 0.034
0.756TyrGln: 0.756 ± 0.028
1.962TyrArg: 1.962 ± 0.043
1.02TyrSer: 1.02 ± 0.036
1.06TyrThr: 1.06 ± 0.032
1.55TyrVal: 1.55 ± 0.036
0.324TyrTrp: 0.324 ± 0.016
0.622TyrTyr: 0.622 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3343 proteins (1097188 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski