Amino acid dipepetide frequency for Taibaiella soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.65AlaAla: 7.65 ± 0.093	0.849AlaCys: 0.849 ± 0.032	4.313AlaAsp: 4.313 ± 0.058	3.802AlaGlu: 3.802 ± 0.073	3.464AlaPhe: 3.464 ± 0.052	6.405AlaGly: 6.405 ± 0.092	1.455AlaHis: 1.455 ± 0.031	5.347AlaIle: 5.347 ± 0.068	4.192AlaLys: 4.192 ± 0.063	6.832AlaLeu: 6.832 ± 0.079	2.002AlaMet: 2.002 ± 0.036	4.332AlaAsn: 4.332 ± 0.07	3.023AlaPro: 3.023 ± 0.064	3.37AlaGln: 3.37 ± 0.049	2.582AlaArg: 2.582 ± 0.043	5.116AlaSer: 5.116 ± 0.079	5.821AlaThr: 5.821 ± 0.142	5.218AlaVal: 5.218 ± 0.062	0.792AlaTrp: 0.792 ± 0.022	2.99AlaTyr: 2.99 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.03	0.167CysCys: 0.167 ± 0.011	0.512CysAsp: 0.512 ± 0.018	0.404CysGlu: 0.404 ± 0.015	0.514CysPhe: 0.514 ± 0.019	0.882CysGly: 0.882 ± 0.028	0.215CysHis: 0.215 ± 0.014	0.705CysIle: 0.705 ± 0.022	0.51CysLys: 0.51 ± 0.023	0.844CysLeu: 0.844 ± 0.021	0.252CysMet: 0.252 ± 0.013	0.592CysAsn: 0.592 ± 0.025	0.448CysPro: 0.448 ± 0.021	0.324CysGln: 0.324 ± 0.017	0.355CysArg: 0.355 ± 0.014	0.746CysSer: 0.746 ± 0.031	0.729CysThr: 0.729 ± 0.037	0.624CysVal: 0.624 ± 0.022	0.115CysTrp: 0.115 ± 0.01	0.421CysTyr: 0.421 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.262AspAla: 4.262 ± 0.058	0.463AspCys: 0.463 ± 0.018	2.562AspAsp: 2.562 ± 0.043	3.014AspGlu: 3.014 ± 0.056	2.776AspPhe: 2.776 ± 0.048	3.927AspGly: 3.927 ± 0.067	0.989AspHis: 0.989 ± 0.026	3.64AspIle: 3.64 ± 0.049	3.257AspLys: 3.257 ± 0.059	4.406AspLeu: 4.406 ± 0.058	1.254AspMet: 1.254 ± 0.029	2.732AspAsn: 2.732 ± 0.047	1.947AspPro: 1.947 ± 0.041	1.746AspGln: 1.746 ± 0.04	1.973AspArg: 1.973 ± 0.037	3.612AspSer: 3.612 ± 0.06	3.391AspThr: 3.391 ± 0.065	3.613AspVal: 3.613 ± 0.061	0.782AspTrp: 0.782 ± 0.023	2.469AspTyr: 2.469 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	3.876GluAla: 3.876 ± 0.064	0.337GluCys: 0.337 ± 0.017	2.496GluAsp: 2.496 ± 0.05	3.232GluGlu: 3.232 ± 0.077	1.994GluPhe: 1.994 ± 0.039	3.07GluGly: 3.07 ± 0.047	1.161GluHis: 1.161 ± 0.031	3.743GluIle: 3.743 ± 0.064	4.077GluLys: 4.077 ± 0.073	4.822GluLeu: 4.822 ± 0.082	1.591GluMet: 1.591 ± 0.039	2.838GluAsn: 2.838 ± 0.051	1.484GluPro: 1.484 ± 0.034	2.385GluGln: 2.385 ± 0.056	2.339GluArg: 2.339 ± 0.055	2.438GluSer: 2.438 ± 0.044	2.832GluThr: 2.832 ± 0.049	3.235GluVal: 3.235 ± 0.051	0.657GluTrp: 0.657 ± 0.023	1.937GluTyr: 1.937 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.443PheAla: 3.443 ± 0.052	0.587PheCys: 0.587 ± 0.02	2.695PheAsp: 2.695 ± 0.04	2.312PheGlu: 2.312 ± 0.046	2.397PhePhe: 2.397 ± 0.057	3.172PheGly: 3.172 ± 0.046	0.907PheHis: 0.907 ± 0.028	3.016PheIle: 3.016 ± 0.061	2.495PheLys: 2.495 ± 0.042	4.035PheLeu: 4.035 ± 0.071	1.077PheMet: 1.077 ± 0.03	2.691PheAsn: 2.691 ± 0.046	1.749PhePro: 1.749 ± 0.038	1.559PheGln: 1.559 ± 0.037	1.937PheArg: 1.937 ± 0.043	3.601PheSer: 3.601 ± 0.061	3.393PheThr: 3.393 ± 0.062	2.945PheVal: 2.945 ± 0.052	0.574PheTrp: 0.574 ± 0.024	2.154PheTyr: 2.154 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.289GlyAla: 5.289 ± 0.086	0.879GlyCys: 0.879 ± 0.04	3.507GlyAsp: 3.507 ± 0.059	2.905GlyGlu: 2.905 ± 0.056	3.416GlyPhe: 3.416 ± 0.052	5.485GlyGly: 5.485 ± 0.11	1.308GlyHis: 1.308 ± 0.032	5.086GlyIle: 5.086 ± 0.07	4.654GlyLys: 4.654 ± 0.063	5.723GlyLeu: 5.723 ± 0.066	1.948GlyMet: 1.948 ± 0.035	4.56GlyAsn: 4.56 ± 0.091	1.764GlyPro: 1.764 ± 0.043	2.42GlyGln: 2.42 ± 0.043	2.501GlyArg: 2.501 ± 0.043	4.877GlySer: 4.877 ± 0.089	5.365GlyThr: 5.365 ± 0.129	4.593GlyVal: 4.593 ± 0.071	0.942GlyTrp: 0.942 ± 0.027	3.185GlyTyr: 3.185 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.336HisAla: 1.336 ± 0.032	0.234HisCys: 0.234 ± 0.013	1.008HisAsp: 1.008 ± 0.028	1.018HisGlu: 1.018 ± 0.026	1.271HisPhe: 1.271 ± 0.03	1.197HisGly: 1.197 ± 0.03	0.52HisHis: 0.52 ± 0.02	1.416HisIle: 1.416 ± 0.033	1.048HisLys: 1.048 ± 0.029	1.89HisLeu: 1.89 ± 0.039	0.459HisMet: 0.459 ± 0.017	1.001HisAsn: 1.001 ± 0.022	1.009HisPro: 1.009 ± 0.028	0.726HisGln: 0.726 ± 0.024	0.814HisArg: 0.814 ± 0.023	1.215HisSer: 1.215 ± 0.03	1.18HisThr: 1.18 ± 0.027	1.135HisVal: 1.135 ± 0.029	0.273HisTrp: 0.273 ± 0.014	1.047HisTyr: 1.047 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.015IleAla: 6.015 ± 0.078	0.839IleCys: 0.839 ± 0.032	3.989IleAsp: 3.989 ± 0.049	3.496IleGlu: 3.496 ± 0.062	2.898IlePhe: 2.898 ± 0.055	4.692IleGly: 4.692 ± 0.069	1.369IleHis: 1.369 ± 0.03	4.388IleIle: 4.388 ± 0.071	3.812IleLys: 3.812 ± 0.055	5.392IleLeu: 5.392 ± 0.072	1.386IleMet: 1.386 ± 0.033	3.804IleAsn: 3.804 ± 0.053	3.061IlePro: 3.061 ± 0.05	2.329IleGln: 2.329 ± 0.039	2.919IleArg: 2.919 ± 0.048	4.948IleSer: 4.948 ± 0.056	4.64IleThr: 4.64 ± 0.062	4.364IleVal: 4.364 ± 0.055	0.728IleTrp: 0.728 ± 0.025	2.612IleTyr: 2.612 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.531LysAla: 4.531 ± 0.072	0.391LysCys: 0.391 ± 0.017	3.606LysAsp: 3.606 ± 0.064	4.149LysGlu: 4.149 ± 0.067	2.066LysPhe: 2.066 ± 0.04	3.779LysGly: 3.779 ± 0.055	1.225LysHis: 1.225 ± 0.031	4.255LysIle: 4.255 ± 0.055	4.681LysLys: 4.681 ± 0.086	5.075LysLeu: 5.075 ± 0.06	2.023LysMet: 2.023 ± 0.04	3.533LysAsn: 3.533 ± 0.054	2.324LysPro: 2.324 ± 0.046	2.665LysGln: 2.665 ± 0.051	2.455LysArg: 2.455 ± 0.047	3.232LysSer: 3.232 ± 0.055	3.684LysThr: 3.684 ± 0.052	3.745LysVal: 3.745 ± 0.054	0.794LysTrp: 0.794 ± 0.024	2.346LysTyr: 2.346 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.656LeuAla: 6.656 ± 0.074	0.973LeuCys: 0.973 ± 0.028	4.32LeuAsp: 4.32 ± 0.063	4.253LeuGlu: 4.253 ± 0.085	4.27LeuPhe: 4.27 ± 0.071	5.483LeuGly: 5.483 ± 0.067	1.97LeuHis: 1.97 ± 0.035	5.552LeuIle: 5.552 ± 0.079	5.744LeuLys: 5.744 ± 0.076	9.157LeuLeu: 9.157 ± 0.128	2.259LeuMet: 2.259 ± 0.041	4.818LeuAsn: 4.818 ± 0.065	4.156LeuPro: 4.156 ± 0.059	4.192LeuGln: 4.192 ± 0.072	3.656LeuArg: 3.656 ± 0.057	6.548LeuSer: 6.548 ± 0.08	5.248LeuThr: 5.248 ± 0.068	5.087LeuVal: 5.087 ± 0.061	0.902LeuTrp: 0.902 ± 0.027	3.322LeuTyr: 3.322 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.995MetAla: 1.995 ± 0.04	0.179MetCys: 0.179 ± 0.01	1.25MetAsp: 1.25 ± 0.029	1.352MetGlu: 1.352 ± 0.029	0.916MetPhe: 0.916 ± 0.024	1.597MetGly: 1.597 ± 0.033	0.587MetHis: 0.587 ± 0.02	1.58MetIle: 1.58 ± 0.031	1.937MetLys: 1.937 ± 0.037	2.417MetLeu: 2.417 ± 0.046	0.707MetMet: 0.707 ± 0.026	1.451MetAsn: 1.451 ± 0.03	1.313MetPro: 1.313 ± 0.026	1.294MetGln: 1.294 ± 0.034	1.153MetArg: 1.153 ± 0.023	1.573MetSer: 1.573 ± 0.033	1.47MetThr: 1.47 ± 0.032	1.533MetVal: 1.533 ± 0.032	0.208MetTrp: 0.208 ± 0.013	0.799MetTyr: 0.799 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.602AsnAla: 4.602 ± 0.078	0.61AsnCys: 0.61 ± 0.027	3.056AsnAsp: 3.056 ± 0.049	2.722AsnGlu: 2.722 ± 0.043	2.449AsnPhe: 2.449 ± 0.046	5.03AsnGly: 5.03 ± 0.088	1.002AsnHis: 1.002 ± 0.027	4.166AsnIle: 4.166 ± 0.059	3.08AsnLys: 3.08 ± 0.045	4.394AsnLeu: 4.394 ± 0.054	1.341AsnMet: 1.341 ± 0.032	3.823AsnAsn: 3.823 ± 0.083	2.963AsnPro: 2.963 ± 0.058	1.84AsnGln: 1.84 ± 0.039	2.067AsnArg: 2.067 ± 0.041	3.325AsnSer: 3.325 ± 0.054	3.917AsnThr: 3.917 ± 0.078	3.756AsnVal: 3.756 ± 0.059	0.792AsnTrp: 0.792 ± 0.023	2.587AsnTyr: 2.587 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.801ProAla: 3.801 ± 0.068	0.338ProCys: 0.338 ± 0.018	2.578ProAsp: 2.578 ± 0.045	2.636ProGlu: 2.636 ± 0.049	1.97ProPhe: 1.97 ± 0.044	3.0ProGly: 3.0 ± 0.058	0.714ProHis: 0.714 ± 0.02	2.281ProIle: 2.281 ± 0.039	2.052ProLys: 2.052 ± 0.037	3.291ProLeu: 3.291 ± 0.044	0.856ProMet: 0.856 ± 0.025	2.222ProAsn: 2.222 ± 0.046	1.308ProPro: 1.308 ± 0.038	1.518ProGln: 1.518 ± 0.033	1.076ProArg: 1.076 ± 0.027	2.475ProSer: 2.475 ± 0.049	2.49ProThr: 2.49 ± 0.07	3.553ProVal: 3.553 ± 0.062	0.371ProTrp: 0.371 ± 0.017	1.655ProTyr: 1.655 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.628GlnAla: 2.628 ± 0.045	0.283GlnCys: 0.283 ± 0.012	1.599GlnAsp: 1.599 ± 0.033	1.972GlnGlu: 1.972 ± 0.043	1.714GlnPhe: 1.714 ± 0.038	2.029GlnGly: 2.029 ± 0.037	0.899GlnHis: 0.899 ± 0.022	2.618GlnIle: 2.618 ± 0.04	2.682GlnLys: 2.682 ± 0.052	4.049GlnLeu: 4.049 ± 0.057	1.207GlnMet: 1.207 ± 0.029	2.3GlnAsn: 2.3 ± 0.041	1.769GlnPro: 1.769 ± 0.04	2.369GlnGln: 2.369 ± 0.055	1.644GlnArg: 1.644 ± 0.042	2.406GlnSer: 2.406 ± 0.04	2.575GlnThr: 2.575 ± 0.043	2.303GlnVal: 2.303 ± 0.04	0.686GlnTrp: 0.686 ± 0.028	1.802GlnTyr: 1.802 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.359ArgAla: 2.359 ± 0.042	0.342ArgCys: 0.342 ± 0.016	1.936ArgAsp: 1.936 ± 0.044	2.059ArgGlu: 2.059 ± 0.041	2.124ArgPhe: 2.124 ± 0.042	1.947ArgGly: 1.947 ± 0.035	0.79ArgHis: 0.79 ± 0.021	3.024ArgIle: 3.024 ± 0.052	2.878ArgLys: 2.878 ± 0.048	3.65ArgLeu: 3.65 ± 0.057	1.29ArgMet: 1.29 ± 0.033	2.204ArgAsn: 2.204 ± 0.038	1.312ArgPro: 1.312 ± 0.037	1.597ArgGln: 1.597 ± 0.034	1.659ArgArg: 1.659 ± 0.032	2.186ArgSer: 2.186 ± 0.042	2.128ArgThr: 2.128 ± 0.036	2.39ArgVal: 2.39 ± 0.04	0.529ArgTrp: 0.529 ± 0.017	1.804ArgTyr: 1.804 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.226SerAla: 5.226 ± 0.084	0.779SerCys: 0.779 ± 0.032	3.223SerAsp: 3.223 ± 0.046	2.806SerGlu: 2.806 ± 0.051	3.735SerPhe: 3.735 ± 0.05	5.631SerGly: 5.631 ± 0.095	1.076SerHis: 1.076 ± 0.025	4.546SerIle: 4.546 ± 0.054	3.29SerLys: 3.29 ± 0.057	6.095SerLeu: 6.095 ± 0.064	1.518SerMet: 1.518 ± 0.029	3.605SerAsn: 3.605 ± 0.062	2.335SerPro: 2.335 ± 0.054	2.094SerGln: 2.094 ± 0.038	2.195SerArg: 2.195 ± 0.047	4.435SerSer: 4.435 ± 0.073	4.112SerThr: 4.112 ± 0.089	4.782SerVal: 4.782 ± 0.067	0.866SerTrp: 0.866 ± 0.028	2.931SerTyr: 2.931 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	6.044ThrAla: 6.044 ± 0.137	0.583ThrCys: 0.583 ± 0.026	3.673ThrAsp: 3.673 ± 0.064	2.935ThrGlu: 2.935 ± 0.05	2.896ThrPhe: 2.896 ± 0.056	5.607ThrGly: 5.607 ± 0.111	1.11ThrHis: 1.11 ± 0.029	4.705ThrIle: 4.705 ± 0.062	2.939ThrLys: 2.939 ± 0.048	5.762ThrLeu: 5.762 ± 0.074	1.289ThrMet: 1.289 ± 0.03	3.603ThrAsn: 3.603 ± 0.085	3.29ThrPro: 3.29 ± 0.071	2.275ThrGln: 2.275 ± 0.039	1.948ThrArg: 1.948 ± 0.039	4.292ThrSer: 4.292 ± 0.094	4.918ThrThr: 4.918 ± 0.142	5.141ThrVal: 5.141 ± 0.112	0.694ThrTrp: 0.694 ± 0.023	2.807ThrTyr: 2.807 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	5.407ValAla: 5.407 ± 0.071	0.733ValCys: 0.733 ± 0.024	3.366ValAsp: 3.366 ± 0.047	2.876ValGlu: 2.876 ± 0.052	3.105ValPhe: 3.105 ± 0.047	3.872ValGly: 3.872 ± 0.05	1.302ValHis: 1.302 ± 0.032	4.343ValIle: 4.343 ± 0.059	4.025ValLys: 4.025 ± 0.06	5.8ValLeu: 5.8 ± 0.072	1.579ValMet: 1.579 ± 0.036	3.918ValAsn: 3.918 ± 0.064	2.822ValPro: 2.822 ± 0.052	2.366ValGln: 2.366 ± 0.04	2.497ValArg: 2.497 ± 0.042	4.676ValSer: 4.676 ± 0.061	4.777ValThr: 4.777 ± 0.108	4.581ValVal: 4.581 ± 0.068	0.758ValTrp: 0.758 ± 0.024	2.954ValTyr: 2.954 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.734TrpAla: 0.734 ± 0.023	0.119TrpCys: 0.119 ± 0.009	0.685TrpAsp: 0.685 ± 0.021	0.611TrpGlu: 0.611 ± 0.017	0.547TrpPhe: 0.547 ± 0.018	0.818TrpGly: 0.818 ± 0.025	0.277TrpHis: 0.277 ± 0.015	0.77TrpIle: 0.77 ± 0.024	0.797TrpLys: 0.797 ± 0.025	1.183TrpLeu: 1.183 ± 0.028	0.39TrpMet: 0.39 ± 0.016	0.753TrpAsn: 0.753 ± 0.024	0.341TrpPro: 0.341 ± 0.015	0.684TrpGln: 0.684 ± 0.023	0.525TrpArg: 0.525 ± 0.023	0.74TrpSer: 0.74 ± 0.023	0.76TrpThr: 0.76 ± 0.025	0.741TrpVal: 0.741 ± 0.025	0.189TrpTrp: 0.189 ± 0.013	0.563TrpTyr: 0.563 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.904TyrAla: 2.904 ± 0.046	0.478TyrCys: 0.478 ± 0.02	2.44TyrAsp: 2.44 ± 0.055	1.993TyrGlu: 1.993 ± 0.04	2.219TyrPhe: 2.219 ± 0.044	2.784TyrGly: 2.784 ± 0.051	0.918TyrHis: 0.918 ± 0.024	2.499TyrIle: 2.499 ± 0.047	2.408TyrLys: 2.408 ± 0.046	3.749TyrLeu: 3.749 ± 0.059	0.878TyrMet: 0.878 ± 0.026	2.743TyrAsn: 2.743 ± 0.059	1.769TyrPro: 1.769 ± 0.039	1.78TyrGln: 1.78 ± 0.037	1.909TyrArg: 1.909 ± 0.04	2.839TyrSer: 2.839 ± 0.053	3.083TyrThr: 3.083 ± 0.072	2.418TyrVal: 2.418 ± 0.043	0.572TyrTrp: 0.572 ± 0.023	2.255TyrTyr: 2.255 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4294 proteins (1541204 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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