Amino acid dipepetide frequency for Eimeria tenella (Coccidian parasite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	59.454AlaAla: 59.454 ± 0.805	1.72AlaCys: 1.72 ± 0.022	4.764AlaAsp: 4.764 ± 0.04	8.175AlaGlu: 8.175 ± 0.08	3.056AlaPhe: 3.056 ± 0.033	7.529AlaGly: 7.529 ± 0.079	1.682AlaHis: 1.682 ± 0.026	2.373AlaIle: 2.373 ± 0.029	3.874AlaLys: 3.874 ± 0.054	9.828AlaLeu: 9.828 ± 0.063	1.214AlaMet: 1.214 ± 0.018	2.184AlaAsn: 2.184 ± 0.024	7.98AlaPro: 7.98 ± 0.086	3.983AlaGln: 3.983 ± 0.038	5.091AlaArg: 5.091 ± 0.041	8.565AlaSer: 8.565 ± 0.066	6.716AlaThr: 6.716 ± 0.072	7.15AlaVal: 7.15 ± 0.053	0.833AlaTrp: 0.833 ± 0.014	1.354AlaTyr: 1.354 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.486CysAla: 1.486 ± 0.024	1.957CysCys: 1.957 ± 0.042	0.591CysAsp: 0.591 ± 0.015	0.823CysGlu: 0.823 ± 0.015	0.782CysPhe: 0.782 ± 0.015	1.466CysGly: 1.466 ± 0.022	0.325CysHis: 0.325 ± 0.008	0.663CysIle: 0.663 ± 0.014	0.615CysLys: 0.615 ± 0.014	2.117CysLeu: 2.117 ± 0.025	0.396CysMet: 0.396 ± 0.01	0.493CysAsn: 0.493 ± 0.013	0.985CysPro: 0.985 ± 0.025	0.524CysGln: 0.524 ± 0.013	1.33CysArg: 1.33 ± 0.018	2.883CysSer: 2.883 ± 0.036	0.966CysThr: 0.966 ± 0.019	1.127CysVal: 1.127 ± 0.019	0.28CysTrp: 0.28 ± 0.008	0.34CysTyr: 0.34 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.498AspAla: 4.498 ± 0.041	0.831AspCys: 0.831 ± 0.017	1.678AspAsp: 1.678 ± 0.035	2.747AspGlu: 2.747 ± 0.033	1.383AspPhe: 1.383 ± 0.021	2.59AspGly: 2.59 ± 0.033	0.519AspHis: 0.519 ± 0.012	1.346AspIle: 1.346 ± 0.021	1.477AspLys: 1.477 ± 0.024	3.529AspLeu: 3.529 ± 0.032	0.666AspMet: 0.666 ± 0.013	0.808AspAsn: 0.808 ± 0.016	2.359AspPro: 2.359 ± 0.03	1.083AspGln: 1.083 ± 0.017	1.898AspArg: 1.898 ± 0.033	3.598AspSer: 3.598 ± 0.039	1.93AspThr: 1.93 ± 0.027	2.073AspVal: 2.073 ± 0.029	0.454AspTrp: 0.454 ± 0.011	0.654AspTyr: 0.654 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	8.999GluAla: 8.999 ± 0.09	0.822GluCys: 0.822 ± 0.022	2.987GluAsp: 2.987 ± 0.035	6.308GluGlu: 6.308 ± 0.068	1.38GluPhe: 1.38 ± 0.02	4.925GluGly: 4.925 ± 0.052	0.979GluHis: 0.979 ± 0.017	1.652GluIle: 1.652 ± 0.025	3.056GluLys: 3.056 ± 0.051	5.539GluLeu: 5.539 ± 0.049	1.035GluMet: 1.035 ± 0.017	1.469GluAsn: 1.469 ± 0.023	2.705GluPro: 2.705 ± 0.034	4.814GluGln: 4.814 ± 0.076	3.607GluArg: 3.607 ± 0.038	3.54GluSer: 3.54 ± 0.038	3.233GluThr: 3.233 ± 0.036	3.305GluVal: 3.305 ± 0.033	0.594GluTrp: 0.594 ± 0.013	0.779GluTyr: 0.779 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.991PheAla: 2.991 ± 0.026	0.853PheCys: 0.853 ± 0.013	1.2PheAsp: 1.2 ± 0.021	1.553PheGlu: 1.553 ± 0.021	1.249PhePhe: 1.249 ± 0.022	1.937PheGly: 1.937 ± 0.029	0.528PheHis: 0.528 ± 0.011	0.971PheIle: 0.971 ± 0.018	1.071PheLys: 1.071 ± 0.02	3.128PheLeu: 3.128 ± 0.031	0.463PheMet: 0.463 ± 0.011	0.685PheAsn: 0.685 ± 0.015	1.509PhePro: 1.509 ± 0.021	0.967PheGln: 0.967 ± 0.016	1.582PheArg: 1.582 ± 0.022	2.586PheSer: 2.586 ± 0.031	1.146PheThr: 1.146 ± 0.02	2.021PheVal: 2.021 ± 0.022	0.361PheTrp: 0.361 ± 0.009	0.625PheTyr: 0.625 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	8.591GlyAla: 8.591 ± 0.072	1.377GlyCys: 1.377 ± 0.024	2.909GlyAsp: 2.909 ± 0.037	3.858GlyGlu: 3.858 ± 0.044	1.924GlyPhe: 1.924 ± 0.026	6.811GlyGly: 6.811 ± 0.076	1.074GlyHis: 1.074 ± 0.017	1.713GlyIle: 1.713 ± 0.024	2.256GlyLys: 2.256 ± 0.033	5.498GlyLeu: 5.498 ± 0.049	0.799GlyMet: 0.799 ± 0.015	1.462GlyAsn: 1.462 ± 0.019	5.854GlyPro: 5.854 ± 0.086	2.165GlyGln: 2.165 ± 0.025	3.715GlyArg: 3.715 ± 0.033	6.438GlySer: 6.438 ± 0.053	2.924GlyThr: 2.924 ± 0.033	3.604GlyVal: 3.604 ± 0.036	0.653GlyTrp: 0.653 ± 0.013	0.944GlyTyr: 0.944 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	2.016HisAla: 2.016 ± 0.025	0.482HisCys: 0.482 ± 0.011	0.634HisAsp: 0.634 ± 0.014	1.231HisGlu: 1.231 ± 0.02	0.784HisPhe: 0.784 ± 0.013	1.211HisGly: 1.211 ± 0.018	0.693HisHis: 0.693 ± 0.019	0.639HisIle: 0.639 ± 0.014	0.848HisLys: 0.848 ± 0.015	2.361HisLeu: 2.361 ± 0.027	0.401HisMet: 0.401 ± 0.014	0.464HisAsn: 0.464 ± 0.01	1.342HisPro: 1.342 ± 0.021	1.718HisGln: 1.718 ± 0.03	1.554HisArg: 1.554 ± 0.024	1.745HisSer: 1.745 ± 0.022	0.869HisThr: 0.869 ± 0.017	1.04HisVal: 1.04 ± 0.017	0.278HisTrp: 0.278 ± 0.008	0.389HisTyr: 0.389 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.292IleAla: 2.292 ± 0.029	0.742IleCys: 0.742 ± 0.015	1.237IleAsp: 1.237 ± 0.022	1.606IleGlu: 1.606 ± 0.024	0.952IlePhe: 0.952 ± 0.02	1.427IleGly: 1.427 ± 0.022	0.583IleHis: 0.583 ± 0.014	0.879IleIle: 0.879 ± 0.02	1.169IleLys: 1.169 ± 0.02	2.284IleLeu: 2.284 ± 0.03	0.396IleMet: 0.396 ± 0.011	0.771IleAsn: 0.771 ± 0.016	1.43IlePro: 1.43 ± 0.021	1.119IleGln: 1.119 ± 0.018	1.697IleArg: 1.697 ± 0.024	2.328IleSer: 2.328 ± 0.029	1.088IleThr: 1.088 ± 0.023	1.465IleVal: 1.465 ± 0.023	0.287IleTrp: 0.287 ± 0.01	0.563IleTyr: 0.563 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	4.026LysAla: 4.026 ± 0.064	0.601LysCys: 0.601 ± 0.014	1.662LysAsp: 1.662 ± 0.024	3.439LysGlu: 3.439 ± 0.051	0.829LysPhe: 0.829 ± 0.015	2.669LysGly: 2.669 ± 0.032	0.836LysHis: 0.836 ± 0.014	1.136LysIle: 1.136 ± 0.02	2.487LysLys: 2.487 ± 0.044	3.255LysLeu: 3.255 ± 0.037	0.642LysMet: 0.642 ± 0.014	1.019LysAsn: 1.019 ± 0.018	1.924LysPro: 1.924 ± 0.03	3.162LysGln: 3.162 ± 0.041	2.908LysArg: 2.908 ± 0.03	2.47LysSer: 2.47 ± 0.036	1.937LysThr: 1.937 ± 0.028	1.872LysVal: 1.872 ± 0.029	0.377LysTrp: 0.377 ± 0.01	0.688LysTyr: 0.688 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	8.024LeuAla: 8.024 ± 0.051	1.966LeuCys: 1.966 ± 0.025	3.157LeuAsp: 3.157 ± 0.03	5.609LeuGlu: 5.609 ± 0.056	3.008LeuPhe: 3.008 ± 0.034	5.457LeuGly: 5.457 ± 0.05	2.727LeuHis: 2.727 ± 0.027	2.178LeuIle: 2.178 ± 0.028	3.835LeuLys: 3.835 ± 0.041	17.957LeuLeu: 17.957 ± 0.146	1.451LeuMet: 1.451 ± 0.021	2.018LeuAsn: 2.018 ± 0.024	6.496LeuPro: 6.496 ± 0.05	11.58LeuGln: 11.58 ± 0.135	7.396LeuArg: 7.396 ± 0.046	7.15LeuSer: 7.15 ± 0.051	3.453LeuThr: 3.453 ± 0.033	4.46LeuVal: 4.46 ± 0.038	1.162LeuTrp: 1.162 ± 0.019	1.61LeuTyr: 1.61 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.304MetAla: 1.304 ± 0.02	0.208MetCys: 0.208 ± 0.006	0.556MetAsp: 0.556 ± 0.012	0.997MetGlu: 0.997 ± 0.017	0.341MetPhe: 0.341 ± 0.01	0.999MetGly: 0.999 ± 0.018	0.425MetHis: 0.425 ± 0.01	0.338MetIle: 0.338 ± 0.013	0.653MetLys: 0.653 ± 0.014	1.585MetLeu: 1.585 ± 0.022	0.264MetMet: 0.264 ± 0.009	0.357MetAsn: 0.357 ± 0.01	0.866MetPro: 0.866 ± 0.017	1.34MetGln: 1.34 ± 0.022	1.09MetArg: 1.09 ± 0.017	0.931MetSer: 0.931 ± 0.015	0.591MetThr: 0.591 ± 0.013	0.602MetVal: 0.602 ± 0.014	0.162MetTrp: 0.162 ± 0.006	0.263MetTyr: 0.263 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.226AsnAla: 2.226 ± 0.026	0.612AsnCys: 0.612 ± 0.012	0.837AsnAsp: 0.837 ± 0.015	1.396AsnGlu: 1.396 ± 0.019	0.781AsnPhe: 0.781 ± 0.018	1.582AsnGly: 1.582 ± 0.023	0.375AsnHis: 0.375 ± 0.01	0.799AsnIle: 0.799 ± 0.017	1.116AsnLys: 1.116 ± 0.019	1.835AsnLeu: 1.835 ± 0.024	0.407AsnMet: 0.407 ± 0.012	0.857AsnAsn: 0.857 ± 0.018	1.379AsnPro: 1.379 ± 0.02	0.785AsnGln: 0.785 ± 0.016	1.28AsnArg: 1.28 ± 0.017	3.056AsnSer: 3.056 ± 0.04	1.111AsnThr: 1.111 ± 0.018	1.156AsnVal: 1.156 ± 0.021	0.25AsnTrp: 0.25 ± 0.008	0.45AsnTyr: 0.45 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.641ProAla: 7.641 ± 0.076	0.979ProCys: 0.979 ± 0.022	1.814ProAsp: 1.814 ± 0.023	3.611ProGlu: 3.611 ± 0.04	1.854ProPhe: 1.854 ± 0.024	3.975ProGly: 3.975 ± 0.051	1.503ProHis: 1.503 ± 0.019	1.219ProIle: 1.219 ± 0.018	2.096ProLys: 2.096 ± 0.03	6.656ProLeu: 6.656 ± 0.053	0.775ProMet: 0.775 ± 0.018	1.153ProAsn: 1.153 ± 0.019	6.372ProPro: 6.372 ± 0.079	4.676ProGln: 4.676 ± 0.053	3.632ProArg: 3.632 ± 0.04	5.423ProSer: 5.423 ± 0.048	2.837ProThr: 2.837 ± 0.03	3.079ProVal: 3.079 ± 0.034	0.724ProTrp: 0.724 ± 0.014	0.916ProTyr: 0.916 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.902GlnAla: 3.902 ± 0.039	0.639GlnCys: 0.639 ± 0.014	1.721GlnAsp: 1.721 ± 0.019	4.764GlnGlu: 4.764 ± 0.065	0.955GlnPhe: 0.955 ± 0.017	3.174GlnGly: 3.174 ± 0.036	2.914GlnHis: 2.914 ± 0.043	1.295GlnIle: 1.295 ± 0.017	2.824GlnLys: 2.824 ± 0.037	8.935GlnLeu: 8.935 ± 0.107	1.064GlnMet: 1.064 ± 0.019	1.121GlnAsn: 1.121 ± 0.02	3.707GlnPro: 3.707 ± 0.054	39.228GlnGln: 39.228 ± 0.622	5.626GlnArg: 5.626 ± 0.06	2.634GlnSer: 2.634 ± 0.031	2.273GlnThr: 2.273 ± 0.025	2.293GlnVal: 2.293 ± 0.027	0.623GlnTrp: 0.623 ± 0.013	0.652GlnTyr: 0.652 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.549ArgAla: 5.549 ± 0.044	1.48ArgCys: 1.48 ± 0.021	2.385ArgAsp: 2.385 ± 0.033	4.014ArgGlu: 4.014 ± 0.039	1.621ArgPhe: 1.621 ± 0.02	4.68ArgGly: 4.68 ± 0.048	1.578ArgHis: 1.578 ± 0.02	1.735ArgIle: 1.735 ± 0.023	2.727ArgLys: 2.727 ± 0.035	6.705ArgLeu: 6.705 ± 0.052	1.084ArgMet: 1.084 ± 0.017	1.488ArgAsn: 1.488 ± 0.019	3.124ArgPro: 3.124 ± 0.033	4.597ArgGln: 4.597 ± 0.05	6.183ArgArg: 6.183 ± 0.068	5.332ArgSer: 5.332 ± 0.054	2.38ArgThr: 2.38 ± 0.031	3.193ArgVal: 3.193 ± 0.031	0.74ArgTrp: 0.74 ± 0.014	0.913ArgTyr: 0.913 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	8.416SerAla: 8.416 ± 0.064	2.259SerCys: 2.259 ± 0.031	2.847SerAsp: 2.847 ± 0.033	3.913SerGlu: 3.913 ± 0.042	2.692SerPhe: 2.692 ± 0.032	5.796SerGly: 5.796 ± 0.058	1.439SerHis: 1.439 ± 0.022	2.116SerIle: 2.116 ± 0.029	3.358SerLys: 3.358 ± 0.033	7.461SerLeu: 7.461 ± 0.053	1.034SerMet: 1.034 ± 0.018	3.083SerAsn: 3.083 ± 0.04	5.426SerPro: 5.426 ± 0.056	2.868SerGln: 2.868 ± 0.033	5.713SerArg: 5.713 ± 0.061	23.597SerSer: 23.597 ± 0.308	4.087SerThr: 4.087 ± 0.059	4.081SerVal: 4.081 ± 0.041	0.873SerTrp: 0.873 ± 0.017	1.133SerTyr: 1.133 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	7.515ThrAla: 7.515 ± 0.071	0.804ThrCys: 0.804 ± 0.02	1.843ThrAsp: 1.843 ± 0.021	2.986ThrGlu: 2.986 ± 0.048	1.197ThrPhe: 1.197 ± 0.019	2.854ThrGly: 2.854 ± 0.037	0.844ThrHis: 0.844 ± 0.016	1.161ThrIle: 1.161 ± 0.021	1.625ThrLys: 1.625 ± 0.024	3.776ThrLeu: 3.776 ± 0.039	0.559ThrMet: 0.559 ± 0.013	1.119ThrAsn: 1.119 ± 0.018	3.166ThrPro: 3.166 ± 0.031	1.995ThrGln: 1.995 ± 0.024	2.296ThrArg: 2.296 ± 0.03	3.602ThrSer: 3.602 ± 0.042	2.496ThrThr: 2.496 ± 0.045	2.462ThrVal: 2.462 ± 0.029	0.404ThrTrp: 0.404 ± 0.009	0.706ThrTyr: 0.706 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	6.509ValAla: 6.509 ± 0.048	1.213ValCys: 1.213 ± 0.02	2.262ValAsp: 2.262 ± 0.031	3.249ValGlu: 3.249 ± 0.033	1.739ValPhe: 1.739 ± 0.022	3.324ValGly: 3.324 ± 0.038	1.174ValHis: 1.174 ± 0.017	1.226ValIle: 1.226 ± 0.022	1.767ValLys: 1.767 ± 0.028	5.47ValLeu: 5.47 ± 0.046	0.728ValMet: 0.728 ± 0.015	1.078ValAsn: 1.078 ± 0.019	3.076ValPro: 3.076 ± 0.034	2.513ValGln: 2.513 ± 0.027	2.852ValArg: 2.852 ± 0.026	4.336ValSer: 4.336 ± 0.044	2.122ValThr: 2.122 ± 0.028	3.116ValVal: 3.116 ± 0.039	0.577ValTrp: 0.577 ± 0.012	1.228ValTyr: 1.228 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.843TrpAla: 0.843 ± 0.015	0.201TrpCys: 0.201 ± 0.007	0.411TrpAsp: 0.411 ± 0.011	0.565TrpGlu: 0.565 ± 0.011	0.265TrpPhe: 0.265 ± 0.008	1.099TrpGly: 1.099 ± 0.02	0.2TrpHis: 0.2 ± 0.008	0.299TrpIle: 0.299 ± 0.011	0.452TrpLys: 0.452 ± 0.01	1.205TrpLeu: 1.205 ± 0.019	0.2TrpMet: 0.2 ± 0.006	0.262TrpAsn: 0.262 ± 0.008	0.456TrpPro: 0.456 ± 0.011	0.653TrpGln: 0.653 ± 0.014	0.961TrpArg: 0.961 ± 0.017	0.686TrpSer: 0.686 ± 0.016	0.428TrpThr: 0.428 ± 0.011	0.519TrpVal: 0.519 ± 0.011	0.163TrpTrp: 0.163 ± 0.006	0.134TrpTyr: 0.134 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.242TyrAla: 1.242 ± 0.02	0.407TyrCys: 0.407 ± 0.011	0.628TyrAsp: 0.628 ± 0.014	0.884TyrGlu: 0.884 ± 0.019	0.637TyrPhe: 0.637 ± 0.014	1.064TyrGly: 1.064 ± 0.016	0.298TyrHis: 0.298 ± 0.009	0.576TyrIle: 0.576 ± 0.014	0.633TyrLys: 0.633 ± 0.014	1.573TyrLeu: 1.573 ± 0.022	0.291TyrMet: 0.291 ± 0.009	0.399TyrAsn: 0.399 ± 0.012	0.776TyrPro: 0.776 ± 0.015	0.575TyrGln: 0.575 ± 0.012	1.096TyrArg: 1.096 ± 0.017	1.295TyrSer: 1.295 ± 0.022	0.822TyrThr: 0.822 ± 0.017	0.94TyrVal: 0.94 ± 0.018	0.207TyrTrp: 0.207 ± 0.007	0.379TyrTyr: 0.379 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8595 proteins (4341326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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