Amino acid dipepetide frequency for Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.399AlaAla: 7.399 ± 0.042	1.203AlaCys: 1.203 ± 0.011	3.253AlaAsp: 3.253 ± 0.019	4.196AlaGlu: 4.196 ± 0.024	2.752AlaPhe: 2.752 ± 0.016	4.111AlaGly: 4.111 ± 0.024	1.308AlaHis: 1.308 ± 0.011	3.744AlaIle: 3.744 ± 0.023	3.883AlaLys: 3.883 ± 0.024	6.313AlaLeu: 6.313 ± 0.03	1.678AlaMet: 1.678 ± 0.012	2.691AlaAsn: 2.691 ± 0.017	2.852AlaPro: 2.852 ± 0.023	1.943AlaGln: 1.943 ± 0.015	3.372AlaArg: 3.372 ± 0.02	5.594AlaSer: 5.594 ± 0.024	3.497AlaThr: 3.497 ± 0.018	5.136AlaVal: 5.136 ± 0.024	0.734AlaTrp: 0.734 ± 0.009	1.842AlaTyr: 1.842 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.027CysAla: 1.027 ± 0.01	0.501CysCys: 0.501 ± 0.008	0.887CysAsp: 0.887 ± 0.009	0.903CysGlu: 0.903 ± 0.01	0.897CysPhe: 0.897 ± 0.01	1.474CysGly: 1.474 ± 0.013	0.431CysHis: 0.431 ± 0.006	0.999CysIle: 0.999 ± 0.01	1.103CysLys: 1.103 ± 0.014	1.831CysLeu: 1.831 ± 0.014	0.429CysMet: 0.429 ± 0.007	0.868CysAsn: 0.868 ± 0.009	0.926CysPro: 0.926 ± 0.011	0.494CysGln: 0.494 ± 0.007	1.093CysArg: 1.093 ± 0.011	1.751CysSer: 1.751 ± 0.015	0.931CysThr: 0.931 ± 0.01	1.157CysVal: 1.157 ± 0.011	0.231CysTrp: 0.231 ± 0.005	0.555CysTyr: 0.555 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.427AspAla: 3.427 ± 0.022	0.952AspCys: 0.952 ± 0.011	3.839AspAsp: 3.839 ± 0.031	4.297AspGlu: 4.297 ± 0.026	2.575AspPhe: 2.575 ± 0.016	3.729AspGly: 3.729 ± 0.024	1.155AspHis: 1.155 ± 0.01	3.047AspIle: 3.047 ± 0.019	2.798AspLys: 2.798 ± 0.017	5.025AspLeu: 5.025 ± 0.023	1.253AspMet: 1.253 ± 0.011	2.217AspAsn: 2.217 ± 0.016	2.584AspPro: 2.584 ± 0.018	1.657AspGln: 1.657 ± 0.011	2.468AspArg: 2.468 ± 0.018	4.312AspSer: 4.312 ± 0.024	2.137AspThr: 2.137 ± 0.014	3.672AspVal: 3.672 ± 0.019	0.7AspTrp: 0.7 ± 0.009	1.707AspTyr: 1.707 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	4.5GluAla: 4.5 ± 0.026	0.918GluCys: 0.918 ± 0.011	3.819GluAsp: 3.819 ± 0.024	6.113GluGlu: 6.113 ± 0.044	2.542GluPhe: 2.542 ± 0.015	3.507GluGly: 3.507 ± 0.021	1.161GluHis: 1.161 ± 0.01	4.209GluIle: 4.209 ± 0.024	4.861GluLys: 4.861 ± 0.03	5.813GluLeu: 5.813 ± 0.031	1.787GluMet: 1.787 ± 0.014	3.403GluAsn: 3.403 ± 0.019	1.971GluPro: 1.971 ± 0.015	1.981GluGln: 1.981 ± 0.017	3.295GluArg: 3.295 ± 0.023	4.707GluSer: 4.707 ± 0.025	3.121GluThr: 3.121 ± 0.018	3.95GluVal: 3.95 ± 0.024	0.76GluTrp: 0.76 ± 0.009	1.827GluTyr: 1.827 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	2.679PheAla: 2.679 ± 0.019	0.911PheCys: 0.911 ± 0.01	2.639PheAsp: 2.639 ± 0.015	2.383PheGlu: 2.383 ± 0.016	2.108PhePhe: 2.108 ± 0.019	3.172PheGly: 3.172 ± 0.018	1.101PheHis: 1.101 ± 0.01	2.165PheIle: 2.165 ± 0.017	2.107PheLys: 2.107 ± 0.013	4.389PheLeu: 4.389 ± 0.022	0.947PheMet: 0.947 ± 0.008	1.83PheAsn: 1.83 ± 0.014	2.129PhePro: 2.129 ± 0.015	1.474PheGln: 1.474 ± 0.011	2.214PheArg: 2.214 ± 0.016	4.14PheSer: 4.14 ± 0.018	2.123PheThr: 2.123 ± 0.014	3.062PheVal: 3.062 ± 0.019	0.56PheTrp: 0.56 ± 0.008	1.329PheTyr: 1.329 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	3.997GlyAla: 3.997 ± 0.023	1.259GlyCys: 1.259 ± 0.013	3.467GlyAsp: 3.467 ± 0.02	3.678GlyGlu: 3.678 ± 0.021	3.261GlyPhe: 3.261 ± 0.02	6.269GlyGly: 6.269 ± 0.044	1.407GlyHis: 1.407 ± 0.013	3.694GlyIle: 3.694 ± 0.02	4.048GlyLys: 4.048 ± 0.023	5.825GlyLeu: 5.825 ± 0.024	1.419GlyMet: 1.419 ± 0.013	3.168GlyAsn: 3.168 ± 0.021	2.532GlyPro: 2.532 ± 0.018	1.947GlyGln: 1.947 ± 0.012	3.549GlyArg: 3.549 ± 0.021	5.638GlySer: 5.638 ± 0.025	3.054GlyThr: 3.054 ± 0.016	4.401GlyVal: 4.401 ± 0.022	0.885GlyTrp: 0.885 ± 0.01	2.1GlyTyr: 2.1 ± 0.016	0.0GlyXaa: 0.0 ± 0.0
His	1.355HisAla: 1.355 ± 0.012	0.489HisCys: 0.489 ± 0.006	1.073HisAsp: 1.073 ± 0.012	1.255HisGlu: 1.255 ± 0.01	1.073HisPhe: 1.073 ± 0.011	1.584HisGly: 1.584 ± 0.014	1.032HisHis: 1.032 ± 0.014	1.199HisIle: 1.199 ± 0.011	1.21HisLys: 1.21 ± 0.01	2.414HisLeu: 2.414 ± 0.016	0.538HisMet: 0.538 ± 0.007	0.973HisAsn: 0.973 ± 0.009	1.302HisPro: 1.302 ± 0.011	0.946HisGln: 0.946 ± 0.01	1.368HisArg: 1.368 ± 0.011	1.812HisSer: 1.812 ± 0.013	0.992HisThr: 0.992 ± 0.011	1.516HisVal: 1.516 ± 0.011	0.299HisTrp: 0.299 ± 0.005	0.703HisTyr: 0.703 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	3.632IleAla: 3.632 ± 0.02	1.151IleCys: 1.151 ± 0.011	3.095IleAsp: 3.095 ± 0.018	3.425IleGlu: 3.425 ± 0.02	2.501IlePhe: 2.501 ± 0.017	3.649IleGly: 3.649 ± 0.021	1.334IleHis: 1.334 ± 0.012	3.055IleIle: 3.055 ± 0.02	3.095IleLys: 3.095 ± 0.015	5.406IleLeu: 5.406 ± 0.025	1.186IleMet: 1.186 ± 0.012	2.411IleAsn: 2.411 ± 0.014	3.075IlePro: 3.075 ± 0.023	1.911IleGln: 1.911 ± 0.014	2.774IleArg: 2.774 ± 0.018	5.153IleSer: 5.153 ± 0.024	2.778IleThr: 2.778 ± 0.016	3.71IleVal: 3.71 ± 0.02	0.72IleTrp: 0.72 ± 0.009	1.619IleTyr: 1.619 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.749LysAla: 3.749 ± 0.021	0.986LysCys: 0.986 ± 0.011	3.122LysAsp: 3.122 ± 0.019	4.38LysGlu: 4.38 ± 0.026	2.307LysPhe: 2.307 ± 0.015	3.489LysGly: 3.489 ± 0.019	1.321LysHis: 1.321 ± 0.012	3.664LysIle: 3.664 ± 0.02	4.988LysLys: 4.988 ± 0.034	5.975LysLeu: 5.975 ± 0.024	1.571LysMet: 1.571 ± 0.012	3.021LysAsn: 3.021 ± 0.018	2.662LysPro: 2.662 ± 0.018	2.124LysGln: 2.124 ± 0.017	3.507LysArg: 3.507 ± 0.024	4.885LysSer: 4.885 ± 0.026	3.024LysThr: 3.024 ± 0.018	3.611LysVal: 3.611 ± 0.02	0.867LysTrp: 0.867 ± 0.009	1.785LysTyr: 1.785 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	6.221LeuAla: 6.221 ± 0.029	1.858LeuCys: 1.858 ± 0.017	5.078LeuAsp: 5.078 ± 0.024	6.105LeuGlu: 6.105 ± 0.03	3.919LeuPhe: 3.919 ± 0.019	5.568LeuGly: 5.568 ± 0.025	2.57LeuHis: 2.57 ± 0.017	4.879LeuIle: 4.879 ± 0.025	6.067LeuLys: 6.067 ± 0.028	9.615LeuLeu: 9.615 ± 0.04	2.105LeuMet: 2.105 ± 0.015	3.964LeuAsn: 3.964 ± 0.02	5.052LeuPro: 5.052 ± 0.026	3.901LeuGln: 3.901 ± 0.019	5.354LeuArg: 5.354 ± 0.024	8.601LeuSer: 8.601 ± 0.037	4.534LeuThr: 4.534 ± 0.023	6.413LeuVal: 6.413 ± 0.029	1.126LeuTrp: 1.126 ± 0.013	2.609LeuTyr: 2.609 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	2.091MetAla: 2.091 ± 0.016	0.334MetCys: 0.334 ± 0.005	1.379MetAsp: 1.379 ± 0.011	1.849MetGlu: 1.849 ± 0.015	0.825MetPhe: 0.825 ± 0.009	1.59MetGly: 1.59 ± 0.014	0.54MetHis: 0.54 ± 0.007	1.197MetIle: 1.197 ± 0.013	1.642MetLys: 1.642 ± 0.012	2.065MetLeu: 2.065 ± 0.013	0.666MetMet: 0.666 ± 0.009	1.041MetAsn: 1.041 ± 0.01	1.027MetPro: 1.027 ± 0.01	0.89MetGln: 0.89 ± 0.01	1.157MetArg: 1.157 ± 0.011	1.711MetSer: 1.711 ± 0.014	1.019MetThr: 1.019 ± 0.01	1.599MetVal: 1.599 ± 0.015	0.287MetTrp: 0.287 ± 0.005	0.649MetTyr: 0.649 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.682AsnAla: 2.682 ± 0.016	0.926AsnCys: 0.926 ± 0.01	2.117AsnAsp: 2.117 ± 0.014	2.699AsnGlu: 2.699 ± 0.016	2.029AsnPhe: 2.029 ± 0.014	3.518AsnGly: 3.518 ± 0.022	1.111AsnHis: 1.111 ± 0.011	2.727AsnIle: 2.727 ± 0.019	2.526AsnLys: 2.526 ± 0.016	4.787AsnLeu: 4.787 ± 0.026	1.125AsnMet: 1.125 ± 0.01	3.117AsnAsn: 3.117 ± 0.029	2.531AsnPro: 2.531 ± 0.018	1.656AsnGln: 1.656 ± 0.014	2.15AsnArg: 2.15 ± 0.015	4.121AsnSer: 4.121 ± 0.022	2.119AsnThr: 2.119 ± 0.016	2.88AsnVal: 2.88 ± 0.016	0.602AsnTrp: 0.602 ± 0.008	1.516AsnTyr: 1.516 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	2.98ProAla: 2.98 ± 0.018	0.749ProCys: 0.749 ± 0.007	2.46ProAsp: 2.46 ± 0.015	2.985ProGlu: 2.985 ± 0.018	2.051ProPhe: 2.051 ± 0.014	2.584ProGly: 2.584 ± 0.017	1.152ProHis: 1.152 ± 0.012	2.479ProIle: 2.479 ± 0.016	2.676ProLys: 2.676 ± 0.017	4.271ProLeu: 4.271 ± 0.022	0.926ProMet: 0.926 ± 0.01	2.445ProAsn: 2.445 ± 0.017	4.313ProPro: 4.313 ± 0.043	1.723ProGln: 1.723 ± 0.015	2.32ProArg: 2.32 ± 0.016	4.785ProSer: 4.785 ± 0.026	2.671ProThr: 2.671 ± 0.016	2.963ProVal: 2.963 ± 0.017	0.593ProTrp: 0.593 ± 0.008	1.339ProTyr: 1.339 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	1.989GlnAla: 1.989 ± 0.014	0.52GlnCys: 0.52 ± 0.008	1.512GlnAsp: 1.512 ± 0.013	2.197GlnGlu: 2.197 ± 0.016	1.374GlnPhe: 1.374 ± 0.012	1.851GlnGly: 1.851 ± 0.015	0.819GlnHis: 0.819 ± 0.009	2.109GlnIle: 2.109 ± 0.016	2.163GlnLys: 2.163 ± 0.016	3.41GlnLeu: 3.41 ± 0.02	0.909GlnMet: 0.909 ± 0.009	1.721GlnAsn: 1.721 ± 0.014	1.522GlnPro: 1.522 ± 0.015	1.878GlnGln: 1.878 ± 0.034	1.919GlnArg: 1.919 ± 0.015	2.626GlnSer: 2.626 ± 0.017	1.733GlnThr: 1.733 ± 0.013	2.136GlnVal: 2.136 ± 0.015	0.428GlnTrp: 0.428 ± 0.006	0.931GlnTyr: 0.931 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	3.315ArgAla: 3.315 ± 0.018	0.953ArgCys: 0.953 ± 0.009	2.635ArgAsp: 2.635 ± 0.02	3.326ArgGlu: 3.326 ± 0.022	2.331ArgPhe: 2.331 ± 0.013	3.232ArgGly: 3.232 ± 0.02	1.259ArgHis: 1.259 ± 0.011	3.109ArgIle: 3.109 ± 0.017	3.772ArgLys: 3.772 ± 0.022	4.959ArgLeu: 4.959 ± 0.023	1.275ArgMet: 1.275 ± 0.012	2.629ArgAsn: 2.629 ± 0.017	2.229ArgPro: 2.229 ± 0.017	1.727ArgGln: 1.727 ± 0.013	4.046ArgArg: 4.046 ± 0.026	4.251ArgSer: 4.251 ± 0.026	2.445ArgThr: 2.445 ± 0.013	3.482ArgVal: 3.482 ± 0.021	0.73ArgTrp: 0.73 ± 0.008	1.486ArgTyr: 1.486 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	5.493SerAla: 5.493 ± 0.026	1.712SerCys: 1.712 ± 0.014	4.639SerAsp: 4.639 ± 0.023	4.768SerGlu: 4.768 ± 0.025	3.929SerPhe: 3.929 ± 0.02	5.852SerGly: 5.852 ± 0.028	1.87SerHis: 1.87 ± 0.014	4.699SerIle: 4.699 ± 0.022	4.827SerLys: 4.827 ± 0.021	8.38SerLeu: 8.38 ± 0.036	1.961SerMet: 1.961 ± 0.014	4.161SerAsn: 4.161 ± 0.021	4.418SerPro: 4.418 ± 0.03	2.61SerGln: 2.61 ± 0.018	4.457SerArg: 4.457 ± 0.025	10.462SerSer: 10.462 ± 0.046	4.701SerThr: 4.701 ± 0.021	5.354SerVal: 5.354 ± 0.025	1.165SerTrp: 1.165 ± 0.012	2.381SerTyr: 2.381 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	3.518ThrAla: 3.518 ± 0.019	0.981ThrCys: 0.981 ± 0.011	2.311ThrAsp: 2.311 ± 0.015	2.764ThrGlu: 2.764 ± 0.019	2.086ThrPhe: 2.086 ± 0.015	3.227ThrGly: 3.227 ± 0.018	1.066ThrHis: 1.066 ± 0.011	2.836ThrIle: 2.836 ± 0.018	2.759ThrLys: 2.759 ± 0.019	4.619ThrLeu: 4.619 ± 0.023	1.144ThrMet: 1.144 ± 0.011	2.297ThrAsn: 2.297 ± 0.016	2.553ThrPro: 2.553 ± 0.018	1.415ThrGln: 1.415 ± 0.012	2.544ThrArg: 2.544 ± 0.017	4.456ThrSer: 4.456 ± 0.023	3.272ThrThr: 3.272 ± 0.022	3.463ThrVal: 3.463 ± 0.018	0.638ThrTrp: 0.638 ± 0.01	1.438ThrTyr: 1.438 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	4.803ValAla: 4.803 ± 0.024	1.2ValCys: 1.2 ± 0.011	3.918ValAsp: 3.918 ± 0.02	4.469ValGlu: 4.469 ± 0.023	2.948ValPhe: 2.948 ± 0.018	4.24ValGly: 4.24 ± 0.021	1.541ValHis: 1.541 ± 0.012	3.55ValIle: 3.55 ± 0.022	3.98ValLys: 3.98 ± 0.022	6.38ValLeu: 6.38 ± 0.027	1.536ValMet: 1.536 ± 0.012	2.772ValAsn: 2.772 ± 0.016	3.012ValPro: 3.012 ± 0.018	2.158ValGln: 2.158 ± 0.017	3.229ValArg: 3.229 ± 0.019	5.402ValSer: 5.402 ± 0.023	3.176ValThr: 3.176 ± 0.019	5.355ValVal: 5.355 ± 0.027	0.81ValTrp: 0.81 ± 0.009	2.055ValTyr: 2.055 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.807TrpAla: 0.807 ± 0.009	0.239TrpCys: 0.239 ± 0.005	0.702TrpAsp: 0.702 ± 0.008	0.785TrpGlu: 0.785 ± 0.01	0.542TrpPhe: 0.542 ± 0.008	0.759TrpGly: 0.759 ± 0.011	0.28TrpHis: 0.28 ± 0.006	0.748TrpIle: 0.748 ± 0.01	0.92TrpLys: 0.92 ± 0.009	1.191TrpLeu: 1.191 ± 0.011	0.343TrpMet: 0.343 ± 0.006	0.733TrpAsn: 0.733 ± 0.009	0.488TrpPro: 0.488 ± 0.007	0.409TrpGln: 0.409 ± 0.006	0.86TrpArg: 0.86 ± 0.009	0.957TrpSer: 0.957 ± 0.011	0.647TrpThr: 0.647 ± 0.009	0.778TrpVal: 0.778 ± 0.009	0.237TrpTrp: 0.237 ± 0.005	0.362TrpTyr: 0.362 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.838TyrAla: 1.838 ± 0.015	0.647TyrCys: 0.647 ± 0.007	1.609TyrAsp: 1.609 ± 0.013	1.668TyrGlu: 1.668 ± 0.013	1.41TyrPhe: 1.41 ± 0.013	2.193TyrGly: 2.193 ± 0.016	0.675TyrHis: 0.675 ± 0.007	1.569TyrIle: 1.569 ± 0.013	1.611TyrLys: 1.611 ± 0.014	2.87TyrLeu: 2.87 ± 0.019	0.76TyrMet: 0.76 ± 0.008	1.476TyrAsn: 1.476 ± 0.014	1.29TyrPro: 1.29 ± 0.011	0.901TyrGln: 0.901 ± 0.01	1.517TyrArg: 1.517 ± 0.014	2.476TyrSer: 2.476 ± 0.015	1.413TyrThr: 1.413 ± 0.013	1.894TyrVal: 1.894 ± 0.015	0.413TyrTrp: 0.413 ± 0.007	1.082TyrTyr: 1.082 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 28677 proteins (10799916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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