Amino acid dipepetide frequency for Fragilariopsis cylindrus CCMP1102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.839AlaAla: 6.839 ± 0.053	1.054AlaCys: 1.054 ± 0.014	3.278AlaAsp: 3.278 ± 0.025	3.368AlaGlu: 3.368 ± 0.032	2.394AlaPhe: 2.394 ± 0.021	3.694AlaGly: 3.694 ± 0.026	1.066AlaHis: 1.066 ± 0.015	4.044AlaIle: 4.044 ± 0.026	3.547AlaLys: 3.547 ± 0.029	5.539AlaLeu: 5.539 ± 0.035	1.711AlaMet: 1.711 ± 0.016	2.768AlaAsn: 2.768 ± 0.02	2.651AlaPro: 2.651 ± 0.031	1.939AlaGln: 1.939 ± 0.02	2.8AlaArg: 2.8 ± 0.023	5.417AlaSer: 5.417 ± 0.032	5.125AlaThr: 5.125 ± 0.033	4.238AlaVal: 4.238 ± 0.029	0.641AlaTrp: 0.641 ± 0.011	1.704AlaTyr: 1.704 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.905CysAla: 0.905 ± 0.011	0.506CysCys: 0.506 ± 0.01	1.015CysAsp: 1.015 ± 0.012	0.776CysGlu: 0.776 ± 0.011	0.672CysPhe: 0.672 ± 0.009	1.204CysGly: 1.204 ± 0.018	0.406CysHis: 0.406 ± 0.008	1.029CysIle: 1.029 ± 0.012	0.813CysLys: 0.813 ± 0.012	1.38CysLeu: 1.38 ± 0.016	0.371CysMet: 0.371 ± 0.007	0.87CysAsn: 0.87 ± 0.012	0.747CysPro: 0.747 ± 0.011	0.579CysGln: 0.579 ± 0.009	0.845CysArg: 0.845 ± 0.01	1.346CysSer: 1.346 ± 0.017	0.985CysThr: 0.985 ± 0.013	0.991CysVal: 0.991 ± 0.012	0.218CysTrp: 0.218 ± 0.007	0.544CysTyr: 0.544 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.935AspAla: 3.935 ± 0.024	1.008AspCys: 1.008 ± 0.013	8.719AspAsp: 8.719 ± 0.063	5.33AspGlu: 5.33 ± 0.036	2.156AspPhe: 2.156 ± 0.017	4.636AspGly: 4.636 ± 0.028	1.36AspHis: 1.36 ± 0.016	3.805AspIle: 3.805 ± 0.024	3.132AspLys: 3.132 ± 0.025	4.39AspLeu: 4.39 ± 0.028	1.326AspMet: 1.326 ± 0.014	4.718AspAsn: 4.718 ± 0.034	2.62AspPro: 2.62 ± 0.024	1.81AspGln: 1.81 ± 0.017	2.636AspArg: 2.636 ± 0.021	4.803AspSer: 4.803 ± 0.028	3.615AspThr: 3.615 ± 0.024	3.917AspVal: 3.917 ± 0.026	0.722AspTrp: 0.722 ± 0.01	1.992AspTyr: 1.992 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	3.772GluAla: 3.772 ± 0.032	0.941GluCys: 0.941 ± 0.012	4.756GluAsp: 4.756 ± 0.037	6.918GluGlu: 6.918 ± 0.056	1.967GluPhe: 1.967 ± 0.016	3.254GluGly: 3.254 ± 0.024	1.181GluHis: 1.181 ± 0.013	3.695GluIle: 3.695 ± 0.026	4.275GluLys: 4.275 ± 0.03	5.196GluLeu: 5.196 ± 0.039	1.521GluMet: 1.521 ± 0.016	3.381GluAsn: 3.381 ± 0.023	1.748GluPro: 1.748 ± 0.019	2.749GluGln: 2.749 ± 0.026	3.231GluArg: 3.231 ± 0.028	4.401GluSer: 4.401 ± 0.031	3.372GluThr: 3.372 ± 0.024	3.164GluVal: 3.164 ± 0.022	0.79GluTrp: 0.79 ± 0.011	1.959GluTyr: 1.959 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.29PheAla: 2.29 ± 0.019	0.769PheCys: 0.769 ± 0.011	2.479PheAsp: 2.479 ± 0.02	1.966PheGlu: 1.966 ± 0.018	1.591PhePhe: 1.591 ± 0.017	2.62PheGly: 2.62 ± 0.024	0.871PheHis: 0.871 ± 0.012	1.919PheIle: 1.919 ± 0.018	1.517PheLys: 1.517 ± 0.014	3.421PheLeu: 3.421 ± 0.026	0.772PheMet: 0.772 ± 0.012	1.637PheAsn: 1.637 ± 0.018	1.56PhePro: 1.56 ± 0.017	1.39PheGln: 1.39 ± 0.014	1.693PheArg: 1.693 ± 0.016	2.786PheSer: 2.786 ± 0.022	1.872PheThr: 1.872 ± 0.018	2.468PheVal: 2.468 ± 0.021	0.459PheTrp: 0.459 ± 0.007	1.109PheTyr: 1.109 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	3.582GlyAla: 3.582 ± 0.031	1.09GlyCys: 1.09 ± 0.013	3.946GlyAsp: 3.946 ± 0.024	3.186GlyGlu: 3.186 ± 0.024	2.284GlyPhe: 2.284 ± 0.019	6.541GlyGly: 6.541 ± 0.052	1.168GlyHis: 1.168 ± 0.012	3.915GlyIle: 3.915 ± 0.026	3.596GlyLys: 3.596 ± 0.026	4.501GlyLeu: 4.501 ± 0.029	1.591GlyMet: 1.591 ± 0.017	3.475GlyAsn: 3.475 ± 0.024	2.033GlyPro: 2.033 ± 0.024	1.748GlyGln: 1.748 ± 0.016	3.25GlyArg: 3.25 ± 0.028	5.374GlySer: 5.374 ± 0.032	3.847GlyThr: 3.847 ± 0.026	3.562GlyVal: 3.562 ± 0.027	0.797GlyTrp: 0.797 ± 0.01	1.912GlyTyr: 1.912 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.175HisAla: 1.175 ± 0.014	0.404HisCys: 0.404 ± 0.008	1.346HisAsp: 1.346 ± 0.015	1.091HisGlu: 1.091 ± 0.014	0.79HisPhe: 0.79 ± 0.011	1.323HisGly: 1.323 ± 0.013	1.038HisHis: 1.038 ± 0.017	1.143HisIle: 1.143 ± 0.013	1.06HisLys: 1.06 ± 0.012	1.751HisLeu: 1.751 ± 0.018	0.422HisMet: 0.422 ± 0.009	1.253HisAsn: 1.253 ± 0.015	1.197HisPro: 1.197 ± 0.015	1.207HisGln: 1.207 ± 0.015	1.267HisArg: 1.267 ± 0.014	1.609HisSer: 1.609 ± 0.015	1.125HisThr: 1.125 ± 0.012	1.209HisVal: 1.209 ± 0.014	0.269HisTrp: 0.269 ± 0.005	0.786HisTyr: 0.786 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.043IleAla: 4.043 ± 0.026	1.019IleCys: 1.019 ± 0.012	4.142IleAsp: 4.142 ± 0.025	3.81IleGlu: 3.81 ± 0.026	2.18IlePhe: 2.18 ± 0.02	3.612IleGly: 3.612 ± 0.027	1.357IleHis: 1.357 ± 0.015	3.891IleIle: 3.891 ± 0.03	3.056IleLys: 3.056 ± 0.023	5.263IleLeu: 5.263 ± 0.037	1.4IleMet: 1.4 ± 0.015	2.973IleAsn: 2.973 ± 0.021	3.06IlePro: 3.06 ± 0.019	2.423IleGln: 2.423 ± 0.018	2.971IleArg: 2.971 ± 0.021	4.696IleSer: 4.696 ± 0.031	3.595IleThr: 3.595 ± 0.025	3.903IleVal: 3.903 ± 0.022	0.617IleTrp: 0.617 ± 0.01	1.57IleTyr: 1.57 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.532LysAla: 3.532 ± 0.03	0.81LysCys: 0.81 ± 0.009	3.575LysAsp: 3.575 ± 0.023	4.74LysGlu: 4.74 ± 0.033	1.844LysPhe: 1.844 ± 0.017	2.961LysGly: 2.961 ± 0.023	1.249LysHis: 1.249 ± 0.015	3.536LysIle: 3.536 ± 0.023	6.275LysLys: 6.275 ± 0.049	4.738LysLeu: 4.738 ± 0.028	1.46LysMet: 1.46 ± 0.016	3.869LysAsn: 3.869 ± 0.024	2.026LysPro: 2.026 ± 0.022	2.769LysGln: 2.769 ± 0.025	3.633LysArg: 3.633 ± 0.027	4.744LysSer: 4.744 ± 0.034	3.522LysThr: 3.522 ± 0.027	3.086LysVal: 3.086 ± 0.027	0.648LysTrp: 0.648 ± 0.009	1.833LysTyr: 1.833 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	5.236LeuAla: 5.236 ± 0.037	1.444LeuCys: 1.444 ± 0.017	4.598LeuAsp: 4.598 ± 0.025	5.029LeuGlu: 5.029 ± 0.034	3.238LeuPhe: 3.238 ± 0.028	4.99LeuGly: 4.99 ± 0.085	1.841LeuHis: 1.841 ± 0.016	4.356LeuIle: 4.356 ± 0.032	4.709LeuLys: 4.709 ± 0.029	8.627LeuLeu: 8.627 ± 0.057	1.889LeuMet: 1.889 ± 0.017	3.51LeuAsn: 3.51 ± 0.021	4.158LeuPro: 4.158 ± 0.034	3.733LeuGln: 3.733 ± 0.026	4.217LeuArg: 4.217 ± 0.028	7.059LeuSer: 7.059 ± 0.038	4.35LeuThr: 4.35 ± 0.026	4.871LeuVal: 4.871 ± 0.032	0.942LeuTrp: 0.942 ± 0.012	2.379LeuTyr: 2.379 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.657MetAla: 1.657 ± 0.017	0.325MetCys: 0.325 ± 0.007	1.434MetAsp: 1.434 ± 0.015	1.587MetGlu: 1.587 ± 0.016	0.818MetPhe: 0.818 ± 0.015	1.381MetGly: 1.381 ± 0.015	0.417MetHis: 0.417 ± 0.008	1.573MetIle: 1.573 ± 0.015	1.784MetLys: 1.784 ± 0.015	1.788MetLeu: 1.788 ± 0.017	0.967MetMet: 0.967 ± 0.015	1.408MetAsn: 1.408 ± 0.015	0.895MetPro: 0.895 ± 0.011	0.755MetGln: 0.755 ± 0.011	1.005MetArg: 1.005 ± 0.013	1.843MetSer: 1.843 ± 0.017	1.673MetThr: 1.673 ± 0.017	1.438MetVal: 1.438 ± 0.016	0.232MetTrp: 0.232 ± 0.006	0.642MetTyr: 0.642 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.1AsnAla: 3.1 ± 0.023	0.78AsnCys: 0.78 ± 0.011	5.354AsnAsp: 5.354 ± 0.042	3.673AsnGlu: 3.673 ± 0.027	1.62AsnPhe: 1.62 ± 0.017	3.659AsnGly: 3.659 ± 0.025	1.315AsnHis: 1.315 ± 0.014	3.375AsnIle: 3.375 ± 0.024	3.799AsnLys: 3.799 ± 0.029	3.516AsnLeu: 3.516 ± 0.024	1.172AsnMet: 1.172 ± 0.016	8.817AsnAsn: 8.817 ± 0.089	2.157AsnPro: 2.157 ± 0.017	1.94AsnGln: 1.94 ± 0.018	2.54AsnArg: 2.54 ± 0.022	5.091AsnSer: 5.091 ± 0.039	3.684AsnThr: 3.684 ± 0.026	2.903AsnVal: 2.903 ± 0.02	0.491AsnTrp: 0.491 ± 0.008	1.61AsnTyr: 1.61 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	2.437ProAla: 2.437 ± 0.025	0.534ProCys: 0.534 ± 0.009	2.251ProAsp: 2.251 ± 0.021	2.254ProGlu: 2.254 ± 0.021	1.61ProPhe: 1.61 ± 0.016	2.124ProGly: 2.124 ± 0.022	0.871ProHis: 0.871 ± 0.014	2.763ProIle: 2.763 ± 0.021	2.418ProLys: 2.418 ± 0.022	3.558ProLeu: 3.558 ± 0.03	0.914ProMet: 0.914 ± 0.012	2.113ProAsn: 2.113 ± 0.018	3.379ProPro: 3.379 ± 0.045	1.488ProGln: 1.488 ± 0.018	1.838ProArg: 1.838 ± 0.016	4.675ProSer: 4.675 ± 0.045	3.702ProThr: 3.702 ± 0.037	2.505ProVal: 2.505 ± 0.019	0.462ProTrp: 0.462 ± 0.009	1.206ProTyr: 1.206 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.153GlnAla: 2.153 ± 0.021	0.563GlnCys: 0.563 ± 0.009	1.916GlnAsp: 1.916 ± 0.02	2.575GlnGlu: 2.575 ± 0.025	1.231GlnPhe: 1.231 ± 0.012	1.686GlnGly: 1.686 ± 0.019	1.33GlnHis: 1.33 ± 0.017	2.079GlnIle: 2.079 ± 0.018	2.568GlnLys: 2.568 ± 0.021	3.37GlnLeu: 3.37 ± 0.023	0.867GlnMet: 0.867 ± 0.012	1.95GlnAsn: 1.95 ± 0.016	1.608GlnPro: 1.608 ± 0.018	5.809GlnGln: 5.809 ± 0.093	2.534GlnArg: 2.534 ± 0.023	2.85GlnSer: 2.85 ± 0.025	1.946GlnThr: 1.946 ± 0.018	1.932GlnVal: 1.932 ± 0.019	0.439GlnTrp: 0.439 ± 0.009	1.258GlnTyr: 1.258 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	2.608ArgAla: 2.608 ± 0.021	0.833ArgCys: 0.833 ± 0.011	2.62ArgAsp: 2.62 ± 0.02	2.736ArgGlu: 2.736 ± 0.023	1.756ArgPhe: 1.756 ± 0.015	2.839ArgGly: 2.839 ± 0.028	1.193ArgHis: 1.193 ± 0.012	3.028ArgIle: 3.028 ± 0.024	3.7ArgLys: 3.7 ± 0.028	4.246ArgLeu: 4.246 ± 0.029	1.272ArgMet: 1.272 ± 0.012	2.845ArgAsn: 2.845 ± 0.021	1.985ArgPro: 1.985 ± 0.019	2.28ArgGln: 2.28 ± 0.021	4.167ArgArg: 4.167 ± 0.039	4.16ArgSer: 4.16 ± 0.03	2.795ArgThr: 2.795 ± 0.02	2.463ArgVal: 2.463 ± 0.022	0.627ArgTrp: 0.627 ± 0.01	1.58ArgTyr: 1.58 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	4.916SerAla: 4.916 ± 0.029	1.324SerCys: 1.324 ± 0.013	4.673SerAsp: 4.673 ± 0.032	3.823SerGlu: 3.823 ± 0.026	3.219SerPhe: 3.219 ± 0.025	4.831SerGly: 4.831 ± 0.028	1.493SerHis: 1.493 ± 0.015	5.41SerIle: 5.41 ± 0.029	5.14SerLys: 5.14 ± 0.032	6.93SerLeu: 6.93 ± 0.04	2.011SerMet: 2.011 ± 0.019	5.875SerAsn: 5.875 ± 0.047	3.927SerPro: 3.927 ± 0.035	2.644SerGln: 2.644 ± 0.026	3.944SerArg: 3.944 ± 0.027	14.508SerSer: 14.508 ± 0.108	6.916SerThr: 6.916 ± 0.045	4.402SerVal: 4.402 ± 0.025	0.903SerTrp: 0.903 ± 0.013	2.286SerTyr: 2.286 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	4.966ThrAla: 4.966 ± 0.035	0.959ThrCys: 0.959 ± 0.011	3.505ThrAsp: 3.505 ± 0.021	3.25ThrGlu: 3.25 ± 0.024	2.05ThrPhe: 2.05 ± 0.018	3.732ThrGly: 3.732 ± 0.029	1.039ThrHis: 1.039 ± 0.012	4.397ThrIle: 4.397 ± 0.026	4.148ThrLys: 4.148 ± 0.027	4.573ThrLeu: 4.573 ± 0.029	1.579ThrMet: 1.579 ± 0.017	4.089ThrAsn: 4.089 ± 0.03	3.054ThrPro: 3.054 ± 0.026	1.836ThrGln: 1.836 ± 0.018	2.619ThrArg: 2.619 ± 0.02	6.363ThrSer: 6.363 ± 0.039	8.594ThrThr: 8.594 ± 0.071	3.714ThrVal: 3.714 ± 0.024	0.58ThrTrp: 0.58 ± 0.009	1.551ThrTyr: 1.551 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.478ValAla: 4.478 ± 0.031	0.959ValCys: 0.959 ± 0.012	4.02ValAsp: 4.02 ± 0.026	3.772ValGlu: 3.772 ± 0.027	2.102ValPhe: 2.102 ± 0.018	3.689ValGly: 3.689 ± 0.026	1.179ValHis: 1.179 ± 0.014	3.332ValIle: 3.332 ± 0.023	2.855ValLys: 2.855 ± 0.025	5.108ValLeu: 5.108 ± 0.03	1.355ValMet: 1.355 ± 0.013	2.48ValAsn: 2.48 ± 0.019	2.735ValPro: 2.735 ± 0.026	2.063ValGln: 2.063 ± 0.018	2.529ValArg: 2.529 ± 0.019	4.407ValSer: 4.407 ± 0.027	3.582ValThr: 3.582 ± 0.024	4.717ValVal: 4.717 ± 0.028	0.673ValTrp: 0.673 ± 0.011	1.603ValTyr: 1.603 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.568TrpAla: 0.568 ± 0.01	0.229TrpCys: 0.229 ± 0.006	0.742TrpAsp: 0.742 ± 0.012	0.639TrpGlu: 0.639 ± 0.009	0.45TrpPhe: 0.45 ± 0.008	0.61TrpGly: 0.61 ± 0.009	0.231TrpHis: 0.231 ± 0.006	0.725TrpIle: 0.725 ± 0.011	0.847TrpLys: 0.847 ± 0.011	0.922TrpLeu: 0.922 ± 0.012	0.379TrpMet: 0.379 ± 0.008	0.727TrpAsn: 0.727 ± 0.011	0.354TrpPro: 0.354 ± 0.008	0.359TrpGln: 0.359 ± 0.008	0.574TrpArg: 0.574 ± 0.009	0.858TrpSer: 0.858 ± 0.011	0.71TrpThr: 0.71 ± 0.011	0.578TrpVal: 0.578 ± 0.009	0.193TrpTrp: 0.193 ± 0.005	0.401TrpTyr: 0.401 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.625TyrAla: 1.625 ± 0.016	0.654TyrCys: 0.654 ± 0.011	2.261TyrAsp: 2.261 ± 0.019	1.747TyrGlu: 1.747 ± 0.015	1.217TyrPhe: 1.217 ± 0.016	2.012TyrGly: 2.012 ± 0.022	0.86TyrHis: 0.86 ± 0.012	1.563TyrIle: 1.563 ± 0.019	1.612TyrLys: 1.612 ± 0.018	2.36TyrLeu: 2.36 ± 0.018	0.644TyrMet: 0.644 ± 0.01	1.837TyrAsn: 1.837 ± 0.018	1.209TyrPro: 1.209 ± 0.014	1.142TyrGln: 1.142 ± 0.013	1.44TyrArg: 1.44 ± 0.016	2.183TyrSer: 2.183 ± 0.021	1.585TyrThr: 1.585 ± 0.016	1.579TyrVal: 1.579 ± 0.016	0.393TyrTrp: 0.393 ± 0.007	1.281TyrTyr: 1.281 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 18075 proteins (7486704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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